Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RCC1P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:53206381-53206938  UCSC
Coordinates (T2T) chr6:53045918-53046475  UCSC
Coordinates (hg19) chr6:53071179-53071736  UCSC
Strand -
Parental Sequence NM_001048195.4
Parental seq. overlap 459 bp
Parental seq. overlap (%) 19.1%
Genomic Region Intragenic (GCM1)
Retrocopy Summary RCC1P1, located on chr6:53206381-53206938, is a retrocopy of the parental gene RCC1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RCC1
Full Name regulator of chromosome condensation 1
Also known as CHC1|RCC1-I
Coordinate chr1:28506043-28538989
Strand +
Gene summary Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RCC1P1
Bonobo Pan paniscus RCC1P1
Gorilla Gorilla gorilla RCC1P1
Orangutan Pongo abelii RCC1P1
Green monkey Chlorocebus sabaeus RCC1P2
Crab-eating macaque Macaca fascicularis RCC1P1
Rhesus Macaca mulatta RCC1P1
Baboon Papio anubis RCC1P1
Golden snub-nosed monkey Rhinopithecus roxellana RCC1P1
Marmoset Callithrix jacchus RCC1P1
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RCC1P1
CTCTACCAAGTCCAGGTAGGCTTCTCTGGTGGCCAGCACCATACAGTCTTCGGGGATTCAGAAGGAAAAGCATGCAGCCTGGGCCAGGCTGAATATAGACGGTGGGCCTTCATGGGTGCTAAGGAGAAGAACATGCCCACCCTCATCTCCAGGCTGGTGCCATCTTCTCAGTCTCCTCAGTGGCTTTGGGCCTCTGTAGGGTAAACTGTGATCAGTGATGGACGTGTTTTTGCCTGGGACATGGACAGCAACTACCAGCCGGGCTTAGAGCGGGATGAGGATGCCTGGAGCTTGGTGGAGATGACAGGCAAAGAGCTGGAGAACCATGTGGTCCTCTATTAGTCAAGGGCAAGGAGTGGAGCTGATGAAGCCTCTGAGCGACCGGTTCATGGCCCCAGGACCCTTCCACACAGAACAGGGAAGCAGTGACAGCTACAAATTCTAGCAGGCCTCTCCTAGCCCTGAGCACTCTGCCATTTGTCTTTTTCCCATCAGCATGACAGAATCCTTTTCTTCTTTGTCTTCCTCCTTTCTGGAATCATCCTGGGACCTG
>NM_001048195.4
AGAGGCCTGCAGAGCGCATGCTCTGGGGCAGTTCGCGGCCCGGCGGGGAGCGCCGGAGTTCCTTGTGGCCGACGTGCACCAAGGACAGGAAGATGTCACCCAAGCGCATAGCTAAAAGAAGGTCCCCCCCAGCAGATGCCATCCCCAAAAGCAAGAAGGTGAAGGACACGAGGGCCGCTGCCTCCCGCCGCGTTCCTGGCGCCCGCTCCTGCCAAGTCTCACACAGGTCCCACAGCACAGAACCCGGCTTGGTGCTGACACTAGGCCAGGGCGACGTGGGCCAGCTGGGGCTGGGTGAGAATGTGATGGAGAGGAAGAAGCCGGCCCTGGTATCCATTCCGGAGGATGTTGTGCAGGCTGAGGCTGGGGGCATGCACACCGTGTGTCTAAGCAAAAGTGGCCAGGTCTATTCCTTCGGCTGCAATGATGAGGGTGCCCTGGGAAGGGACACATCAGTGGAGGGCTCGGAGATGGTCCCTGGGAAAGTGGAGCTGCAAGAGAAGGTGGTACAGGTGTCAGCAGGAGACAGTCACACAGCAGCCCTCACCGATGATGGCCGTGTCTTCCTCTGGGGCTCCTTCCGGGACAATAACGGTGTGATTGGACTGTTGGAGCCCATGAAGAAGAgcatggtgcctgtgcaggtgcagctggatgtgcctgtgGTAAAGGTGGCCTCAGGAAACGACCACTTGGTGATGCTGACAGCTGATGGTGACCTCTACACCTTGGGCTGCGGGGAACAGGGCCAGCTAGGCCGTGTGCCTGAGTTATTTGCCAACCGTGGTGGCCGGCAAGGCCTCGAACGACTCCTGGTCCCCAAGTGTGTGATGCTGAAATCCAGGGGAAGCCGGGGCCACGTGAGATTCCAGGATGCCTTTTGTGGTGCCTATTTCACCTTTGCCATCTCCCATGAGGGCCACGTGTACGGCTTCGGCCTCTCCAACTACCATCAGCTTGGAACTCCGGGCACAGAATCTTGCTTCATACCCCAGAACCTAACATCCTTCAAGAATTCCACCAAGTCCTGGGTGGGCTTCTCTGGTGGCCAGCACCATACAGTCTGCATGGATTCGGAAGGAAAAGCATACAGCCTGGGCCGGGCTGAGTATGGGCGGCTGGGCCTTGGAGAGGGTGCTGAGGAGAAGAGCATACCCACCCTCATCTCCAGGCTGCCTGCTGTCTCCTCGGTGGCTTGTGGGGCCTCTGTGGGGTATGCTGTGACCAAGGATGGTCGTGTTTTCGCCTGGGGCATGGGCACCAACTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTGTGTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCACAACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTTTCTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACAGGGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCCTGGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAGTCATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGAACGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAACGATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCCATCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAGAGGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGACTAGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGAGAACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATA

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