Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ISCUP1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:55680365-55681004  UCSC
Coordinates (T2T) chr6:55520003-55520642  UCSC
Coordinates (hg19) chr6:55545163-55545802  UCSC
Strand -
Parental Sequence NM_213595.4
Parental seq. overlap 543 bp
Parental seq. overlap (%) 55.1%
Genomic Region Intergenic
Retrocopy Summary ISCUP1, located on chr6:55680365-55681004, is a retrocopy of the parental gene ISCU. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ISCU
Full Name iron-sulfur cluster assembly enzyme
Also known as 2310020H20Rik|HML|ISU2|NIFU|NIFUN|hnifU
Coordinate chr12:108561463-108569384
Strand +
Gene summary This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ISCUP2
Bonobo Pan paniscus ISCUP1
Gorilla Gorilla gorilla ISCUP1
Orangutan Pongo abelii ISCUP2
Gibbon Nomascus leucogenys ISCUP2
Green monkey Chlorocebus sabaeus ISCUP1
Baboon Papio anubis ISCUP2
Golden snub-nosed monkey Rhinopithecus roxellana ISCUP1
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ISCUP1
TGAAAATCCTGCAAATGTGGTGTCCCATGATAAGACATCTAAAAATATTGGAATTGGATTGGTGTGGGCTTCAGCATGAGGTGATAAAATACAGATTCAAGTGGACAAAAAGGGGAAGATTGTGGACATGAGGTTTAAAACATCTGGCTGCAGTTCTGCAGTTGCCTCCAGCCCGTTAGCCACTGACCGGGTGAAAAAGAATATGATAGAGGAAGCCTATACCCTCAAAAACACAGACATCACCAAGGAGCCCTGCCTTCCTCCTGTGAAACTGCCTGCTCCATGCTGGCTGAGGATGCAACTAAGGCCACTTGGCTGGTTACAAACTAAAATAAGGACCCGAGAAAGGAGAGGTGGAGAAGAAATGTGCCCTCCGAGAAGCCTTAAGCCGGCCACACCAGCTGTTTGCCCACCTGCTGTGCAGTCACCTTAGGTGTTCAGAAGCTGCTCACACTGCACAAAACACCTGTGAGATACACACAATATTTGTTCTTCATATCGTGACTCTAATGCAAGCAAAATACAAAGTTTAATTGTTCTGAAAACTGTGGTTTCTTTCAATCCACTTTTATTGCCTTAACTCAGTGAATGTGTATTTTGAATTGTGCGTATGGCCTCAGAACTGAAATTGATCATGAAT
>NM_213595.4
GGACTGGCGCAGGCGCAAGCCGGCAAGATGGCGGCGGCTGGGGCTTTCCGTCTGAGGCGGGCGGCATCGGCTCTGCTGCTGCGGAGCCCCCGCCTGCCCGCCCGGGAGCTGTCGGCCCCGGCCCGACTCTATCACAAGAAGGTTGTTGATCATTATGAAAATCCTAGAAACGTGGGGTCCCTTGACAAGACATCTAAAAATGTTGGAACTGGACTGGTGGGGGCTCCAGCATGTGGTGACGTAATGAAATTACAGATTCAAGTGGATGAAAAGGGGAAGATTGTGGATGCTAGGTTTAAAACATTTGGCTGTGGTTCCGCAATTGCCTCCAGCTCATTAGCCACTGAATGGGTGAAAGGAAAGACGGTGGAGGAAGCCTTGACTATCAAAAACACAGATATCGCCAAGGAGCTCTGCCTTCCTCCCGTGAAACTGCACTGCTCCATGCTGGCTGAAGATGCAATCAAGGCCGCCCTGGCTGATTACAAATTGAAACAAGAACCCAAAAAAGGAGAGGCAGAGAAGAAATGAGCCCTCCCTCGGCGAAGCCTCCAGCAGGCCACACCAGCTGTTTCCCACCTGCTGTGCAGTCACCTTAGATGTTCAGAAGCCGCTTCCTCTCCACTGAAGAGCTATGAGATACGCACAATACTTGCTGTTCACGTTATGACTCTCATGCAAGCAAAATACACAGTTTCATTGTTCTGAATCCTGTGGTTTCTTTCAGCCCACTTTTATCGCCTTAACCTAGTTAATGTATATTTTGAATTGTGTGTATGACCTCAGAACTGAAATTGATAATGAAGTTGCAAGTTTTGATAGCCCGTGAAGTGCATAAGTATCTAATTTTACCTGAATTGATTTGGGGGGAAATTACCAGTAGAATGCCTTGGTCTGAATATTTGATAGAACCAATTGTTGTACATAAAACAGATTGCGCATATATATATATGTATAAAAAATAATAAAATAATGGAAGATGA

Publications

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