Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PKMP5
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:5972364-5974626  UCSC
Coordinates (T2T) chr6:5841230-5843492  UCSC
Coordinates (hg19) chr6:5972597-5974859  UCSC
Strand +
Parental Sequence NM_001206797.3
Parental seq. overlap 1818 bp
Parental seq. overlap (%) 78.1%
Genomic Region Intergenic
Retrocopy Summary PKMP5, located on chr6:5972364-5974626, is a retrocopy of the parental gene PKM. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PKM
Full Name pyruvate kinase M1/2
Also known as CTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1|p58
Coordinate chr15:72199029-72231389
Strand -
Gene summary This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PKMP1
Bonobo Pan paniscus PKMP2
Gorilla Gorilla gorilla PKMP2
Orangutan Pongo abelii PKMP2
Gibbon Nomascus leucogenys PKMP1
Green monkey Chlorocebus sabaeus PKMP2
Crab-eating macaque Macaca fascicularis PKMP3
Rhesus Macaca mulatta PKMP3
Baboon Papio anubis PKMP2
Golden snub-nosed monkey Rhinopithecus roxellana PKMP1
Marmoset Callithrix jacchus PKMP3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PKMP5
GTTTGCAGCGTAGCCCAAGTCGGTCAGCACTGGAGGACCTCAGAAGCCATGTTGAAGCCCCATAGTGAAGCCAGGGCTGCCTTCATTCAGACCCAGCAGCTGCACGCAGCCATGGCTGACACATTCTTGGAGCACATGTGCTGCCTGGACACTGACTCGCCACCCATCACAGCCTGGAGCACTGGCATCATCTGTACTATGGGCCCAGCTTCTCCATTGCTAGAGATGCTGAAGAAAACGATTAAGTCTGGAATTAATGTGGCTCATCTGAACTCTCATGGAGCCCATGAGTACCATACAGAGACCATCAAGAACGTGCGCACAGCCACGGAAAGCTTTGCTTCTGACTCCATCCTCTACCAGCCCATTGCTGTGGCTCCAGACACTAAAGGACCTGAGATCCCAACTGGGCCCGTCAAGGGCAGCGGCACTGCAGAGGTGGAGCTGAAGAAGGGAGCCACTCTCAAGTTCACGCTGGATAATACCTACATGGAAAAGGGTAAGAGAACATCCTGTGGCGGGACTACAAGAACATCTGCAAGGTGGTGGAAGTGGGCTGCAAGATCTACGTGGATGATGGGCTAATTTCTCTCCAAGTGAAGCAGAAGGATGCTCACTTTCTGGTGACAGAGGTGGAAAATGGTGGCTCCTTGGGCAGCAAGAAGAGTGTGAACCTTCCTGGGGCTGCCGTGGACCTGTCTGCCATGTTGGAGAAGGACATCCAGGACCTGAAGTTTGGGGGCGAGCAAGATGTCGATATGATGTTTTCATCATTCATCTGCAAGACATCTGATGTCCATGAAGTTAGGAAGGTCTTGGGAGAGAAAGGAAAGAACAGCAAGATAACCAGCAAAATTGAGAATCATGATGGGGGTTGGAGGTTTGATGAAATCCTGGAGGCCAGCGATGGGATTATGGTAGCTCGTGGTGATCCACCACAAGCCGTCGAGATGAGATTCCTGCAGGGAAGGTCTGCCTTGCTCAGAGGATGATGATTGGGTGGTGCAACCAAGCTGGGAAGCCTGTCATCTTGCCACTCAGATGCTAGAGGATGTGATCAAGAAGCTCCACCCCACTTGGGCTGAGGGCAGTGGTGTGGCCAATGCAGTTCTGGTGGAAGCTGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGAACTATCCTCTGGAGGCTGTGCACATGCAGCACCTGATTGCCTGTGAGGCAGAGGCCACCATCTACCACTTGCAATTATTTGAGGAGTTCTGCCACCTGGCACCCATTACCAGTGACCCCGCAGAAGCTACTGCCATGGGCACTGTGGAGGCCTCCTTCAAGTGCTGCAGTGGGGCCATAATCGTCCTCACCAAGTCTGCAGGTGTGCCCACCAGGTGGCCAGATACTGCCCACGTGCCCCCATGATTGTTGTGACATGGCATCCCCAGGCAGCTCGCCAGGCCCACCTGTACCGTGGTATCTTCCCTGTGCTGTGTAAGGACCCCATCCAGGAGCCCTAGGCTGAGGATGTGGACCTCCGAGTGAACTTGGCCATGAATGTTGGTAAGGCCTGAGGCTTCTTCAAGAAGGATGATGTGGTCATTGTGCTGACCTGGTGACACCCTGGCCCTGGCTTCTCCACCACCCTGTGTGTTATTCCTGTGCTGTGATGGACTCCAGAGCTCTTCCTCCAGCCCCTGTCCCACCCCCTTCCCCCAATGCATCCATTAGGCCAGCAATGCTTATAGAGCTCACTCTGGGCTGTAGTGTGGCACTGGTGGGCTGGAACACCAGGGAAGAAGATTTATGCCTCGCTGAAACGTGGCTGTTTTTAGAGCCTGCTGTGGCGGGAGAGCCCGGAGCCTGGCTGCCCATCATGTGGCCCCACCCAAGCAAGAGAAGAAGGAGGAATGCAGAACAGAGGCCCCCAGAGTGTATGGCAAGAGGGTGGCAGCTTCCTTTCTTCTGTGTACTCTGTTTAGTTGCTTTAGAAAATGGAAGCCCAGAGGACTCCCAACCCTGTCCTGGGGTCAGGAAACAGCCAGTGAGAGTTAGGGACCTTAGGGCATGGGGCAGTAGTTCCAGTTTAAGCAGATCCTGACCCTGGCCCTTACTTGCTTCCCAATCCCCTGGGCCTTCCTCACTGGCACCTGTGCCCGCTCTCCACTCAGCTGTCCTGCAGCAAACACTTCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCCGCCTCTGAGCCTGTGGCTATAGAGCCTATCTCTATGTCAATAAACAACAGCTGAAG
>NM_001206797.3
GCACAGCAGCTGCACGCGCCGTGGCTCCGGATCTCTTCGTCTTTGCAGCGTAGCCCGAGTCGGTCAGCGCCGGAGGACCTCAGCAGCCATGTCGAAGCCCCATAGTGAAGCCGGGACTGCCTTCATTCAGACCCAGCAGCTGCACGCAGCCATGGCTGACACATTCCTGGAGCACATGTGCCGCCTGGACATTGATTCACCACCCATCACAGCCCGGAACACTGGCATCATCTGTACCATTGGCCCAGCTTCCCGATCAGTGGAGCTGAAGAAGGGAGCCACTCTCAAAATCACGCTGGATAACGCCTACATGGAAAAGTGTGACGAGAACATCCTGTGGCTGGACTACAAGAACATCTGCAAGGTGGTGGAAGTGGGCAGCAAGATCTACGTGGATGATGGGCTTATTTCTCTCCAGGTGAAGCAGAAAGGTGCCGACTTCCTGGTGACGGAGGTGGAAAATGGTGGCTCCTTGGGCAGCAAGAAGGGTGTGAACCTTCCTGGGGCTGCTGTGGACTTGCCTGCTGTGTCGGAGAAGGACATCCAGGATCTGAAGTTTGGGGTCGAGCAGGATGTTGATATGGTGTTTGCGTCATTCATCCGCAAGGCATCTGATGTCCATGAAGTTAGGAAGGTCCTGGGAGAGAAGGGAAAGAACATCAAGATTATCAGCAAAATCGAGAATCATGAGGGGGTTCGGAGGTTTGATGAAATCCTGGAGGCCAGTGATGGGATCATGGTGGCTCGTGGTGATCTAGGCATTGAGATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCTGGGAAGCCTGTCATCTGTGCTACTCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCCACTCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTCCTGGATGGAGCCGACTGCATCATGCTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGCACCTGATTGCCCGTGAGGCAGAGGCTGCCATCTACCACTTGCAATTATTTGAGGAACTCCGCCGCCTGGCGCCCATTACCAGCGACCCCACAGAAGCCACCGCCGTGGGTGCCGTGGAGGCCTCCTTCAAGTGCTGCAGTGGGGCCATAATCGTCCTCACCAAGTCTGGCAGGTCTGCTCACCAGGTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTGTGACCCGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAGGCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGGCAAGGCCCGAGGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATGGCGCCCTGGCTCCGGCTTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGATGGACCCCAGAGCCCCTCCTCCAGCCCCTGTCCCACCCCCTTCCCCCAGCCCATCCATTAGGCCAGCAACGCTTGTAGAACTCACTCTGGGCTGTAACGTGGCACTGGTAGGTTGGGACACCAGGGAAGAAGATCAACGCCTCACTGAAACATGGCTGTGTTTGCAGCCTGCTCTAGTGGGACAGCCCAGAGCCTGGCTGCCCATCATGTGGCCCCACCCAATCAAGGGAAGAAGGAGGAATGCTGGACTGGAGGCCCCTGGAGCCAGATGGCAAGAGGGTGACAGCTTCCTTTCCTGTGTGTACTCTGTCCAGTTCCTTTAGAAAAAATGGATGCCCAGAGGACTCCCAACCCTGGCTTGGGGTCAAGAAACAGCCAGCAAGAGTTAGGGGCCTTAGGGCACTGGGCTGTTGTTCCATTGAAGCCGACTCTGGCCCTGGCCCTTACTTGCTTCTCTAGCTCTCTAGGCCTCTCCAGTTTGCACCTGTCCCCACCCTCCACTCAGCTGTCCTGCAGCAAACACTCCACCCTCCACCTTCCATTTTCCCCCACTACTGCAGCACCTCCAGGCCTGTTGCTATAGAGCCTACCTGTATGTCAATAAACAACAGCTGAAGCACC

Publications

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