Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name FKBP1C
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:63211500-63213022  UCSC
Coordinates (T2T) chr6:64357390-64358906  UCSC
Coordinates (hg19) chr6:63921405-63922927  UCSC
Strand +
Parental Sequence NM_000801.5
Parental seq. overlap 1403 bp
Parental seq. overlap (%) 92.3%
Genomic Region Intergenic
Retrocopy Summary FKBP1C, located on chr6:63211500-63213022, is a retrocopy of the parental gene FKBP1A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FKBP1A
Full Name FKBP prolyl isomerase 1A
Also known as FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE
Coordinate chr20:1368977-1393172
Strand -
Gene summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FKBP1AP2
Bonobo Pan paniscus FKBP1AP3
Gorilla Gorilla gorilla FKBP1AP2
Orangutan Pongo abelii FKBP1AP2
Gibbon Nomascus leucogenys FKBP1AP2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FKBP1C
CGCTGTCGGTCCACGCCGCCCGTCGCGCTGCCCGCCCGCTCGGCGTCGGCCGCCGCCATGGGAGTGCACGTGGAAACCATCTCCCCAGGAGACTGGCGCACCTTCCCGAAGCGCAGCCAGACCTGCGTGATGCACTACACCGGGATGCTTGAAGATGGAAAGAAATTTGATTCCTCCCGGGACAGAAACAAGCCCTTTAAGTTTATGCTAGGCAAGCAGGAGGTGATCCGAGGCTGGGAAGAAGGGGTTGTCCAGATGAGTGTGGGTCAGAGAGCCAAACTGACTATATCTCCAGATTATGCCTATGGTGCCACTGGGCACCCAGGCATCATCCCACCACATGCCACTCTCGTCTTCGATGTGGAGCTTCTAAAACTGGAATGACAGGAATGGCCTCCTCCCTTAGCTCCCTGTTCTTGGATCTGCCATGGAGGGATCTGGTGCCTCCAGACGTGTGCACATAAATCCATATGGAGCTTTTCCTGATGTTCCACTCCACTTTGTATAGACATCTGCCCCAACTGAATGTGTTCTGTCACTCAGCTTTGCTTCCGACACCTCTGTTTCCTCTTCCCCTTTCTCCTGGTATGTGCGTTTACCTAAACTATATGCCATAAACGTCAAGTTATTCATTTTACTTTTTCATTTTGGGGTGAAGATTCAGTTTCAGTCTTTTGAATATAGGTTTCCAATTAAGTACATGGTCAAGTGTTAACAGCACAAGTGATAAGTTAACGTTAGGATAGGAATTGGTGTTGAGGGGGTTGCAAGAACTTGCTGCTGCGCTGCAAAACCATAGCAGATTTGAGGCACTGTTGAGGACTGAATTATTCTCCAAGTTGAGAGATGTCCTTGGGTTAAATTAAAAGCCCTACCTAAAACTGAGGTGGGGATGGGGAGAGGCTTTGCCTCCACCATTCCCACCCCACCCTCCCCTTAAACCCTCTGCCTTTGAAAGCAGGTCATGTTCACTGCGATGCTGGACACTACAGGTATCTGTCCCTGGGCCAGCAGGGACCTCTGAAGCCTTCTTTGTGGCCtCATCCTGTGGTTTTTCTAACGGACTTTCAGGAATTTTGTAATCTCATAACTTTCCAAGCTCCACCACTTCCTAAATCTTAAGAACTTTAATTGACAGTTTCAATTGAAGGTGCTGTTTGTAGACTTAACACCCAGTGAAAGCCCAGCCATCATGACAAATCCTTGAATGTTCTCTTAAGAAAATGATGCTGGTCATCCCAGCTTCAGCATCTCCTGTTTTTTGATGCTTGGCTCCCTCTGCTGATCTCAGAGTTTCCTGGCTTTTCCTCCCTCAGCCACTTCTCACCCCTTTGCTGTCCTGTGTAGTGATTTGGTGAGAGGAATCGTTGCTGCCCCCTTCCCCTAGCACCATATATGAGTCTCAAGTTTTATTATTGCAATAAAAGTGCTTTATGCTGGCTTTTCTCA
>NM_000801.5
GCTGTTGGTCCAcgccgcccgtcgcgccgcccgcccgctcagcgtccgccgccgccATGGGAGTGCAGGTGGAAACCATCTCCCCAGGAGACGGGCGCACCTTCCCCAAGCGCGGCCAGACCTGCGTGGTGCACTACACCGGGATGCTTGAAGATGGAAAGAAATTTGATTCCTCCCGGGACAGAAACAAGCCCTTTAAGTTTATGCTAGGCAAGCAGGAGGTGATCCGAGGCTGGGAAGAAGGGGTTGCCCAGATGAGTGTGGGTCAGAGAGCCAAACTGACTATATCTCCAGATTATGCCTATGGTGCCACTGGGCACCCAGGCATCATCCCACCACATGCCACTCTCGTCTTCGATGTGGAGCTTCTAAAACTGGAATGACAGGAATGGCCTCCTCCCTTAGCTCCCTGTTCTTGGATCTGCCATGGAGGGATCTGGTGCCTCCAGACATGTGCACATGAATCCATATGGAGCTTTTCCTGATGTTCCACTCCACTTTGTATAGACATCTGCCCTGACTGAATGTGTTCTGTCACTCAGCTTTGCTTCCGACACCTCTGTTTCCTCTTCCCCTTTCTCCTCGTATGTGTGTTTACCTAAACTATATGCCATAAACCTCAAGTTATTCATTTTATTTTGTTTTCATTTTGGGGTGAAGATTCAGTTTCAGTCTTTTGGATATAGGTTTCCAATTAAGTACATGGTCAAGTATTAACAGCACAAGTGGTAGGTTAACATTAGAATAGGAATTGGTGTTGGGGGGGGGGTTTGCAAGAAtattttattttaattttttggatgaaatttttatctattatatattaaacattCTTGCTGCTGCGCTGCAAAGCCATAGCAGATTTGAGGCGCTGTTGAGGACTGAATTACTCTCCAAGTTGAGAGATGTCTTTGGGTTAAATTAAAAGCCCTACCTAAAACTGAGGTGGGGATGGGGAGAGCCTTTGCCTCCACCATTCCCACCCACCCTCCCCTTAAACCCTCTGCCTTTGAAAGTAGATCATGTTCACTGCAATGCTGGACACTACAGGTATCTGTCCCTGGGCCAGCAGGGACCTCTGAAGCCTTCTTTGTGGCCTTTTTTTTTTTTCATCCTGTGGTTTTTCTAATGGACTTTCAGGAATTTTGTAATCTCATAACTTTCCAAGCTCCACCACTTCCTAAATCTTAAGAACTTTAATTGACAGTTTCAATTGAAGGTGCTGTTTGTAGACTTAACACCCAGTGAAAGCCCAGCCATCATGACAAATCCTTGAATGTTCTCTTAAGAAAATGATGCTGGTCATCGCAGCTTCAGCATCTCCTGTTTTTTGATGCTTGGCTCCCTCTGCTGATCTCAGTTTCCTGGCTTTTCCTCCCTCAGCCCCTTCTCACCCCTTTGCTGTCCTGTGTAGTGATTTGGTGAGAAATCGTTGCTGCACCCTTCCCCCAGCACCATTTATGAGTCTCAAGTTTTATTATTGCAATAAAAGTGCTTTATGCCGGCTTTTCTCA

Publications

PMID - Link Title