RCPedia: Rtcs

Summary

Retrocopy Name	EEF1B2P5	Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr6:63480099-63481926 UCSC
Coordinates (T2T)	chr6:64626038-64627867 UCSC
Coordinates (hg19)	chr6:64190004-64191831 UCSC
Strand	+
Parental Sequence	NM_001959.4_2
Parental seq. overlap	653 bp
Parental seq. overlap (%)	77.3%
Genomic Region	Intragenic (LGSN)
Retrocopy Summary	EEF1B2P5, located on chr6:63480099-63481926, is a retrocopy of the parental gene EEF1B2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	EEF1B2
Full Name	eukaryotic translation elongation factor 1 beta 2
Also known as	EEF1B\|EEF1B1\|EF1B
Coordinate	chr2:206159609-206162928
Strand	+
Gene summary	This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	EEF1B2P3
Bonobo	Pan paniscus	EEF1B2P4
Gorilla	Gorilla gorilla	EEF1B2P3
Orangutan	Pongo abelii	EEF1B2P4
Gibbon	Nomascus leucogenys	EEF1B2P1
Green monkey	Chlorocebus sabaeus	EEF1B2P7
Crab-eating macaque	Macaca fascicularis	EEF1B2P2
Rhesus	Macaca mulatta	EEF1B2P2
Baboon	Papio anubis	EEF1B2P3
Golden snub-nosed monkey	Rhinopithecus roxellana	EEF1B2P3
Marmoset	Callithrix jacchus	EEF1B2P2
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>EEF1B2P5
TTGCTGCTACCCAGCTCTCAGATGCAGCTGATGCCATGGGTTTCAGAGACCTGAAAAGCCCCACTGGCCTCCAGGTGCACAATGGTTACCTGGCTGACCAGAGCTGCAACAAGGGGTATGTGCCATCACAAGCAGACGTGGCAGTAATTGAAGCAGTCTCCAGTCCATTGTCCGGTAATTTGTGTCATGCTCTACATTGGTATAATTACATCAAGTCTTACGAAAAGGAAAAAGCCAGCCTAGCAGGAATGAAGAAAGCTTTGGGCAAGTATGGACCTGCTAATGTGGAAGATAGTAGAGGAAGTGGAGCTACAGATAGTGAAGATGACAATGACATTTATCTATTTGGATTTGATAAGGGGGAGGAAAGCAAAGAATCAAAAAGGCAAAGGGAAGAATACCCTGCATAGTATGAATCAAAGAAAGCCAAAAAAAAAACCTGCCCCTGTTGCCATCTTTCATCTCACTAGATGTGAAACCTTGTGATAATGAGACAGATATGACAAAATTAGAAGAGTGTCaTTTTTTAAAAAAAATTAGAGAAATGAGTCAGAAGAATTCAAGCAGTCCGCTTAGTCTGGGGCTCCTCTCAACTAGTTACAGTGGGATACGGAATTTTAAAACTTCAAAGATCATGTTGAAGATGATAAAGTTGGAACAGATATGCGGGAGGAGCAGATCACTGCTTTGAGAACTATATGCAATCCATGGATGTGGCTGCGTTCAACAAGATCTTAAATCCATCCTGGATCACTGCACTTAAATAAAAGCTTGAAAGATTA

>NM_001959.4_2
CCTTTTTCCTCTCTTCAGCGTGGGGCGCCCACAATTTGCGCGCTCTCTTTCTGCTGCTCCCCAGCTCTCGGATACAGCCGACACCATGGGTTTCGGAGACCTGAAAAGCCCTGCCGGCCTCCAGGTGCTCAACGATTACCTGGCGGACAAGAGCTACATCGAGGGGTATGTGCCATCACAAGCAGATGTGGCAGTATTTGAAGCCGTGTCCAGCCCACCGCCTGCCGACTTGTGTCATGCCCTACGTTGGTATAATCACATCAAGTCTTACGAAAAGGAAAAGGCCAGCCTGCCAGGAGTGAAGAAAGCTTTGGGCAAATATGGTCCTGCCGATGTGGAAGACACTACAGGAAGTGGAGCTACAGATAGTAAAGATGATGATGACATTGACCTCTTTGGATCTGATGATGAGGAGGAAAGTGAAGAAGCAAAGAGGCTAAGGGAAGAACGTCTTGCACAATATGAATCAAAGAAAGCCAAAAAACCTGCACTTGTTGCCAAGTCTTCCATCTTACTAGATGTGAAACCTTGGGATGATGAGACAGATATGGCGAAATTAGAGGAGTGCGTCAGAAGCATTCAAGCAGACGGCTTAGTCTGGGGCTCATCTAAACTAGTTCCAGTGGGATACGGAATTAAGAAACTTCAAATACAGTGTGTAGTTGAAGATGATAAAGTTGGAACAGATATGCTGGAGGAGCAGATCACTGCTTTTGAGGACTATGTGCAGTCCATGGATGTGGCTGCTTTCAACAAGATCTAAAATCCATCCTGGATCATGGCATTTAAATAAAAGATTGAAAGATTA

>NM_001959.4_2 

CCTTTTTCCTCTCTTCAGCGTGGGGCGCCCACAATTTGCGCGCTCTCTTTCTGCTGCTCCCCAGCTCTCGGATACAGCCGACACCATGGGTTTCGGAGACCTGAAAAGCCCTGCCGGCCTCCAGGTGCTCAACGATTACCTGGCGGACAAGAGCTACATCGAGGGGTATGTGCCATCACAAGCAGATGTGGCAGTATTTGAAGCCGTGTCCAGCCCACCGCCTGCCGACTTGTGTCATGCCCTACGTTGGTATAATCACATCAAGTCTTACGAAAAGGAAAAGGCCAGCCTGCCAGGAGTGAAGAAAGCTTTGGGCAAATATGGTCCTGCCGATGTGGAAGACACTACAGGAAGTGGAGCTACAGATAGTAAAGATGATGATGACATTGACCTCTTTGGATCTGATGATGAGGAGGAAAGTGAAGAAGCAAAGAGGCTAAGGGAAGAACGTCTTGCACAATATGAATCAAAGAAAGCCAAAAAACCTGCACTTGTTGCCAAGTCTTCCATCTTACTAGATGTGAAACCTTGGGATGATGAGACAGATATGGCGAAATTAGAGGAGTGCGTCAGAAGCATTCAAGCAGACGGCTTAGTCTGGGGCTCATCTAAACTAGTTCCAGTGGGATACGGAATTAAGAAACTTCAAATACAGTGTGTAGTTGAAGATGATAAAGTTGGAACAGATATGCTGGAGGAGCAGATCACTGCTTTTGAGGACTATGTGCAGTCCATGGATGTGGCTGCTTTCAACAAGATCTAAAATCCATCCTGGATCATGGCATTTAAATAAAAGATTGAAAGATTA

Publications

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