Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SMSP5
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:70607757-70609414  UCSC
Coordinates (T2T) chr6:71788308-71789965  UCSC
Coordinates (hg19) chr6:71317460-71319117  UCSC
Strand -
Parental Sequence NM_004595.5
Parental seq. overlap 1406 bp
Parental seq. overlap (%) 75.5%
Genomic Region Intergenic
Retrocopy Summary SMSP5, located on chr6:70607757-70609414, is a retrocopy of the parental gene SMS. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SMS
Full Name spermine synthase
Also known as MRSR|MRXSSR|SPMSY|SRS|SpS
Coordinate chrX:21940709-21994837
Strand +
Gene summary This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SMSP3
Bonobo Pan paniscus SMSP3
Gorilla Gorilla gorilla SMSP1
Orangutan Pongo abelii SMSP3
Gibbon Nomascus leucogenys SMSP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SMSP5
AGACCTTCAATTTGGATATTTGGAGGAGTGAACATCATTGTTTTGCTGGAGGGAAGATCTTGATGGTGTTTCTTTTCCCAAAAATTGACTTAGATATTAAAATTTGGTGCTTATAAGAGAAAGTTAAAAAAATAGGATTACTTCAATTAAAATTACAAAAGAGACCGGCCGCAGCCTGACACGCCACGCGGCCCCCCAGTCTCCTGCCGCCCCTCCCCCAGGCATGGCACAGGGCCTCGCCTCACTATGGCAGCAGCACGGCACAGCATGCTCGACTTCACGCTCGGCGCCAAAGCTGATGGTGAGACTGTTCTAAAAGGCCTCCAGTCCATTTTCCAGGAGCAGGGGATGGCAGAGTCGGTGCACACCTGGCAGGACCATGGCTATTTAGCAACCTACACAAAAAAGAACGGCAGCTTTGCCAATTTGAGAATTTACCCACATGGATTGGTGTTGCTGGACCTTCAGAGTTATGATGGTGATGTGCAAGGCAAAGAAGAGATCGACAGTATTTTGAACAAAGTAGAAGAAAGAATGAAAGAATTGAGTCAGGACAGTACTGGGCGGGTGAAACGATTACCACCCATAGTGCGAGGAGGAGCCATTGACAGATACTGGCTCACCGCCGATGGGCGCCTGGTTGAATATGACATAGATGAAGTGGTATATGACGAAGATTAATCTTATCAAAATATAAAAATTCTACACTCGAAGCAGTTTGGAAATATTCTCATCGTTAGTGGGGATGTTAATTTGGCAGAGAGTGATTTGGCATATACCCGGGCCATCATGGGCAGTGGCGAAGAAGATTACACTGGCAAAGATGTACTCATTCTGGGAGGTGGAGATGGAGGCATATTGTGTGAAATAGTCAAACTAAAACCAAAGATGGTCACTATGGTAGAGATTGACGAAATGGTGATTGATGGGTGTAAGAAATACATGCAAAAAACGTATGGCGATGTCTTAGACAATCTTAAAGGAGACTGCTATCAGGTTCTAATAGAAGACTGTATTCCGGTACTCAAGAGGTACGCCAAAGAAGGGAGATAATTTGATTATGCGATTAATGATTTGACAGCTGTTCCAATCTCCACTTCTCCAGAAGAAGATTCCACATGGGAGTTTCTCAGACTGATTCTTGAACTCTCAATGAAAGTGTTGAAACAGGATGGGAAATATTTTACACAGGGGAACTGTGTCAGTCTGACCAAAGCACTGTCGCTCTGTGAAGAACAGCTGGGGCGCCTGTATTGTCCTGTGGAATTTTCAAAGGAGATTCTCTGTGTCCCTTCATACTTGGAATCGTGGGTATTTTACACTGTTTGGAAGAAAGCTAAACCCTGACGATCAATAGCCCCTAATCACATGTGCTGCAAATAGCCTTCCTGACCTCCATATGCTGTACATGACATCGAAATGAGTCAGGCAATTGATTGTGAATTCCTTAAAGTTTTCCTTTTTTTAATAATTATTTTTAATTTAAAAAAGCAAATGGAAAATGTATATTTTGATGAGCTTAGGGTGTTATTTTTTTGAAAGTCAGATGAAGGATGGTTAGACAGCACAGCGAAGACTGCTAAATGCACTGATCCCCCCATTAGAATGt
>NM_004595.5
AGTCCTGGCCTCCCCGGGCGCAGCACACTCCCAGCCGGCCGCAGCCTGACACGCCGCGCGGCCCCCCAGTCTCCCGCGGCTGCTCCCCCAGGCATGGCACAGGGCCTCGCCTCACTATGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGCTGATGGTGAGACCATTCTAAAAGGCCTCCAGTCCATTTTCCAGGAGCAGGGGATGGCGGAGTCGGTGCACACCTGGCAGGACCATGGCTATTTAGCAACCTACACAAACAAGAACGGCAGCTTTGCCAATTTGAGAATTTACCCACATGGATTGGTGTTGCTGGACCTTCAGAGTTATGATGGTGATGCGCAAGGCAAAGAAGAGATCGACAGTATTTTGAACAAAGTAGAGGAAAGAATGAAAGAATTGAGTCAGGACAGTACTGGGCGGGTGAAACGATTACCACCCATAGTGCGAGGAGGAGCCATCGACAGATACTGGCCCACCGCCGACGGGCGCCTGGTTGAATATGACATAGATGAAGTGGTATATGACGAAGATTCACCTTATCAAAATATAAAAATTCTACACTCGAAGCAGTTTGGAAATATTCTCATCCTTAGTGGGGATGTTAATTTGGCAGAGAGTGATTTGGCATATACCCGGGCCATCATGGGCAGTGGCAAAGAAGATTACACTGGCAAAGATGTACTCATTCTGGGAGGTGGAGACGGAGGCATATTGTGTGAAATAGTCAAACTAAAACCAAAGATGGTCACTATGGTAGAGATTGACCAAATGGTGATTGATGGGTGTAAGAAATACATGCGAAAAACGTGTGGCGATGTCTTAGACAATCTTAAAGGAGACTGCTATCAGGTTCTAATAGAAGACTGTATCCCGGTACTGAAGAGGTACGCCAAAGAAGGGAGAGAATTTGATTATGTGATTAATGATTTGACAGCTGTTCCAATCTCCACGTCTCCAGAAGAAGATTCCACATGGGAGTTTCTCAGACTGATTCTTGACCTCTCAATGAAAGTGTTGAAACAGGATGGGAAATATTTTACACAGGGGAACTGTGTCAATCTGACAGAAGCACTGTCGCTCTATGAAGAACAGCTGGGGCGCCTGTATTGTCCTGTGGAATTTTCAAAGGAGATCGTCTGTGTCCCTTCATACTTGGAATTGTGGGTATTTTACACTGTTTGGAAGAAAGCTAAACCCTGAAGATCAGTAGCCCCTAATCACATGTGCTGCAAATAGCCTTCCTGACCTCCATATGCTGTACATGACATCAAAATGAGTCAGGCAATTGATTGTGAATTCCTTAAAGTTTTCCTTTTTTTAATAATTATTTTTAATTTAAAAAAGCAAATGGAAAATGTATATTTTGATGAGCTTAGGGTGTTTTTTTTTTGAAAGTCAGCTGAAGGATGGTTAGACAGCACAGCGAAGACTGCTAAATGCACTGACCCCCCCCATTAGAATGtgatttttgttcctttttatttctctgtgggcttttgtttttgtttttgttttggtAGATCTTCAATTTGGATATTTGGAGGAGTGAACATCGTTGTTTTGCTGGAGGGAAGATCTTGATGGTGTTTCTTTCCCCAAAAATTGACTTAGATATTAAAATTTGGTGCTTATAAGAGAGAGTTAAAAAAAAATAGGATTGCTTCAATTAAAATTACAAAAGAGACA

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