Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HNRNPLP1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:7481022-7482595  UCSC
Coordinates (T2T) chr6:7350070-7351643  UCSC
Coordinates (hg19) chr6:7481255-7482828  UCSC
Strand -
Parental Sequence NM_001533.3_2
Parental seq. overlap 1463 bp
Parental seq. overlap (%) 68%
Genomic Region Intergenic
Retrocopy Summary HNRNPLP1, located on chr6:7481022-7482595, is a retrocopy of the parental gene HNRNPL. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HNRNPL
Full Name heterogeneous nuclear ribonucleoprotein L
Also known as HNRPL|P/OKcl.14|hnRNP-L
Coordinate chr19:38836370-38852347
Strand -
Gene summary Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HNRNPLP1
Bonobo Pan paniscus HNRNPLP1
Gorilla Gorilla gorilla HNRNPLP1
Orangutan Pongo abelii HNRNPLP1
Gibbon Nomascus leucogenys HNRNPLP1
Green monkey Chlorocebus sabaeus HNRNPLP1
Crab-eating macaque Macaca fascicularis HNRNPLP1
Rhesus Macaca mulatta HNRNPLP1
Baboon Papio anubis HNRNPLP1
Golden snub-nosed monkey Rhinopithecus roxellana HNRNPLP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HNRNPLP1
GGAGAACTGTGATGACCCACACAAAACCTCTGCCTCCCCAGTTGTCCACATCAGGGGCCTAATTGATGGTGTGGTGGAAGCTGACATTGTGGAGGCCTTGCAGGAGTTTGGACTCATCAGCTATGTGATGGTAATGTCTAAAAAGAGACAAGCACTGGTGGAGTTTGAAGATGTGCTAGAGGCTTGCAACGCAGTGAACTACACAGCCGACAACCAAATACATATTGCCGGTCACCCAGCTTTTGTCAACTACTCTACCAGCCAGAAGATCTCCCGCCCCGGGAACTCGGATGATCCGGAGCGTGAACAGTGTGCTTCTCTTTACCATCCTGAACCCCATCTATTCGATCACCACGGATGTTCTTTACACTATCGGTAATCCTTGTGGCCCTGTCCAGAGAATTGCCATTTTCCGGAAGAATGGAGTTCAGGCCATGGTGGAATTTGACTGTGTTCAAAGTGCCCAGTGGGCCAAGGCCTCACTCAATGGGGCTGAAATCTATTCCGGCTGTTGCACTCTGAAGATCAAATACACGAAGCCTACACGCTTGAATGTGTTCAAGAATGATCAGGATACTTGGGACTACACAAACCCCAATCTCAGTGGACAAGGTGACCCTGGCAGCAACCCCAACAAACGCCAGAGGCAGCCCCCTCTCCTGGGAGATCACCCCACAGAATATGGAGGGCCCCACCGTGGGTATCACACCCATTGCCATGATGAGGGCTATGGCCCCCCAGCCCGCGACCTCACTACGAAGGGAGAAGGACGGGTCCACCAGTGAGGGGGAGTCACCCTTGGGGCCCAAGTCGCAACGGCCCCTAGTATGGGCACCCCCCACCCCCTCCCCACCACCCGAGCATGGCCCTCACCCCGACAGCCCTGTCCTCATGGTCTACAGTTTGGATCAGTCTAAGATGAACTGTGACCAAGTCTTCAATGTCTTCTGCTTGTATAGCAATGTGGAGAAGGTGAAAGTCATGAAAAGCAAGCCGGGGACCGCCATGGTGGAGATGGCTGACGGCTACACTGTGGACCGGGCCACTACCCACCTCAGCAACAACTTCATGTTTGGGCAGAAGCTGAATGTCTGTCTCCAAGCAGCCAGCCATCATGCCCTGTCAGTCATGCGGGTTGGAAGTCACGTCTTGCAGTTACAGAGACTTCAGTGAATCCCGAACAATCGGTTCCCCTCGCTGGAGCGGGCAGGGAAGAACCGCATCCAGCACCCCAGCAACGTGCTGCACCTCTTCAACGCCCCGCTGGAGGTGACTGACAACTTCTTTGAGATCTGAGATGAGCTGGGCGTGAAGCGGCCATCTTCTGTGAAAGTATTCTCAGGCAAAAGTGAGCGCAGCTCTTCTGGACTGCTGGAGTGGGAATCCAAGAGCGATGCCCTGGAGGCTCGGGGCTTCCTGAACCATTACCAGATGAAAAACCCAAGTGGTCCATACCTTACACTCTGAAGCTGTGTTTCTCCACCGCTCAGCATGCCTCCTAATTAGGTGGCTAGGAAGAGTCCCATCAGAGCAGGAAGTCATTTCTCTTCCCTTTATGCCATTTTTCg
>NM_001533.3_2
GAGGCGGGTTCTGCGCCGCCATGTCgcggaggctgctgccccgggcggagaagcggcgtcggcggctggagcagaggcagcagccggacgagcagcggaggcggtcgggagcgatggtgaagatggcggcggcgggcggcggaggcggcggtggccgctactacggcggcggcagtgagggcggccgggcccctaagcggctcaagactgacaacgccggcgaccagcacggaggcggcggcggtggcggtggaggagccggggcggcgggcggcggcggcggtggGGAGAACTACGATGACCCGCACAAAACCCCTGCCTCCCCAGTTGTCCACATCAGGGGCCTGATTGACGGTGTGGTGGAAGCAGACCTTGTGGAGGCCTTGCAGGAGTTTGGACCCATCAGCTATGTGGTGGTAATGCCTAAAAAGAGACAAGCACTGGTGGAGTTTGAAGATGTGTTGGGGGCTTGCAACGCAGTGAACTACGCAGCCGACAACCAAATATACATTGCTGGTCACCCAGCTTTTGTCAACTACTCTACCAGCCAGAAGATCTCCCGCCCTGGGGACTCGGATGACTCCCGGAGCGTGAACAGTGTGCTTCTCTTTACCATCCTGAACCCCATTTATTCGATCACCACGGATGTTCTTTACACTATCTGTAATCCTTGTGGCCCTGTCCAGAGAATTGTCATTTTCAGGAAGAATGGAGTTCAGGCGATGGTGGAATTTGACTCAGTTCAAAGTGCCCAGCGGGCCAAGGCCTCTCTCAATGGGGCTGATATCTATTCTGGCTGTTGCACTCTGAAGATCGAATACGCAAAGCCTACACGCTTGAATGTGTTCAAGAATGATCAGGATACTTGGGACTACACAAACCCCAATCTCAGTGGACAAGGTGACCCTGGCAGCAACCCCAACAAACGCCAGAGGCAGCCCCCTCTCCTGGGAGATCACCCCGCAGAATATGGAGGGCCCCACGGTGGGTACCACAGCCATTACCATGATGAGGGCTACGGGCCCCCCCCACCTCACTACGAAGGGAGAAGGATGGGTCCACCAGTGGGGGGTCACCGTCGGGGCCCAAGTCGCTACGGCCCCCAGTATGGGCACCCCCCACCCCCTCCCCCACCACCCGAGTATGGCCCTCACGCCGACAGCCCTGTGCTCATGGTCTATGGCTTGGATCAATCTAAGATGAACTGTGACCGAGTCTTCAATGTCTTCTGCTTATATGGCAATGTGGAGAAGGTGAAATTCATGAAAAGCAAGCCGGGGGCCGCCATGGTGGAGATGGCTGATGGCTACGCTGTAGACCGGGCCATTACCCACCTCAACAACAACTTCATGTTTGGGCAGAAGCTGAATGTCTGTGTCTCCAAGCAGCCAGCCATCATGCCTGGTCAGTCATACGGGTTGGAAGACGGGTCTTGCAGTTACAAAGACTTCAGTGAATCCCGGAACAATCGGTTCTCCACCCCAGAGCAGGCAGCCAAGAACCGCATCCAGCACCCCAGCAACGTGCTGCACTTCTTCAACGCCCCGCTGGAGGTGACCGAGGAGAACTTCTTTGAGATCTGCGATGAGCTGGGAGTGAAGCGGCCATCTTCTGTGAAAGTATTCTCAGGCAAAAGTGAGCGCAGCTCCTCTGGACTGCTGGAGTGGGAATCCAAGAGCGATGCCCTGGAGACTCTGGGCTTCCTGAACCATTACCAGATGAAAAACCCAAATGGTCCATACCCTTACACTCTGAAGTTGTGTTTCTCCACTGCTCAGCACGCCTCCTAATTAGGTGCCTAGGAAGAGTCCCATCTGAGCAGGAAGACATTTCTCTTTCCTTTATGCCATtttttgtttttgttatttgcaaaagatcttgtattccttttttttttttttttttttttttttAAATGCTAGGTTTGTAGAGGCTTACTTAACCTTAATGGAAACGCTGGAAATCTGCAGGGGGAGGGAGAGGGGAACTGTTATCTCCCAAGATTAACCTTCACTTTTAAAAAATTATTGTACATGTGATTTTTTTTTTTCCTGTTCATACATTTGTGCTGCCCATGTACTCTTGGCACATTTCAATAAAATTGTTTGGAAAATAAACACAGCACTTGCTGGGATTCCAGGA

Publications

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