Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name THAP12P10
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:76660562-76661546  UCSC
Coordinates (T2T) chr6:77837605-77838589  UCSC
Coordinates (hg19) chr6:77370279-77371263  UCSC
Strand +
Parental Sequence NM_004705.4
Parental seq. overlap 813 bp
Parental seq. overlap (%) 23.2%
Genomic Region Intergenic
Retrocopy Summary THAP12P10, located on chr6:76660562-76661546, is a retrocopy of the parental gene THAP12. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name THAP12
Full Name THAP domain containing 12
Also known as DAP4|P52rIPK|PRKRIR|THAP0
Coordinate chr11:76349956-76381132
Strand -
Gene summary Predicted to enable DNA binding activity; metal ion binding activity; and protein dimerization activity. Predicted to be involved in negative regulation of cell population proliferation and signal transduction. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes THAP12P4
Bonobo Pan paniscus THAP12P5
Gorilla Gorilla gorilla THAP12P4
Orangutan Pongo abelii LOC100450093P2
Gibbon Nomascus leucogenys THAP12P2
Green monkey Chlorocebus sabaeus PRKRIRP5
Crab-eating macaque Macaca fascicularis PRKRIRP2
Rhesus Macaca mulatta THAP12P2
Baboon Papio anubis THAP12P2
Mouse lemur Microcebus murinus THAP12P1
Rabbit Oryctolagus cuniculus THAP12P1
Horse Equus caballus THAP12P3
Cat Felis catus THAP12P4
Velvety free-tailed bat Molossus molossus THAP12P6
Greater mouse-eared bat Myotis myotis THAP12P9
Greater horseshoe bat Rhinolophus ferrumequinum THAP12P1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>THAP12P10
GGCCAGATGCCAGGAGAGGGTGGAGAATTGTAGCAGAGCAGAGACTTAGAAAATAAAACACCTAATCAACTAAATAAACATTATAAATTATATGCCGAACACTTTGAGAACTCTATGATCTGTAGACCTTGTATTTATAGGGCAGTTCTTTGAGATAATGCAACATCCACACGATGCGCTCTTACCAATCATTTAGACAATCCACATAGTAGACATAGAAAATGAATAAAAGAGTTGAGTGAAGATGAAATCAGAACATGGAAACAGAAAAAAAAAAAATGACCAAACTTCTCAACAGGAAAAGAAAATAATATAAAGAAACTAGTAACAGCAATGCTTAGAATCCCAAGTGCGGAAGAAGGAGATGAGGACATTTTATCTTTAACCCTTGAAGAGAAGCAAAACAAAGAATACCTAAAATTTCTATTAGAAATTTGTATTCTTACAGGAAAGCAAAACGTACCTCTATATAAACATGAAGCTGATGAAATCCCAGAAGGTCTCTTTACTCCTGATAACTTCTAAGAACTGGTAGAGTGGCTGGTAAATTCTGTTCAAGAGGTCCTGAGAAAGCACTTTGAGACAACTGCAGTTAACACACTGTTCTGTTAAGAAACCTATCAGAAACAGATGCTAGAGATCTGTCACAGCTATATTCAGGAAGAAATGTTCAGGGAAGTAAGAGACTCGCTCTTCTTTCCCTTATCACTGTCAATATAGAGGACATAATGGGGGAAGAGCATCACCTATGTTGGTGAGATTTGTCCATGAATCTCATAACCTGAAAGAGGATGTTGTAGGCTTCCCACCTTAGGAAGCTGATGCACAAAGTTTGGCTTTAAAATTCCACACTGTGGCAACTGAGAAGTGGGGGCTACAAATGGAGTATCATTATGGGCAGGCTTCCATTCTGTCCACTGAATTTTCTTCCAAAATGAAGTACTTGCTTCTAGACTTTGAAAAACATATCCCCAAGATACCTACA
>NM_004705.4
GCATTGTGGGAAggaggcggcagcgtctcgggcgggcgggaggtgcaccagcggcggcggcggcggTAAATCCTCCCGGCCGCTCACAGCACTGTGGAGCCGCGTCCCCAGCCCGGCCTCGGACCGCGGCACCCCTCCTGGCCCTCGCGGCTTCTAgcccgcccgcccctcccccgcgcgtcggccctgccgagccggccggccggcctggctcccctcccCGGCCCCGAcgggcgggcggactgccctgaggaggcggggaggggagggctgggccggccggcgggcgggcgACGATGCCGAACTTCTGCGCTGCCCCCAACTGCACGCGGAAGAGCACGCAGTCCGACTTGGCCTTCTTCAGGTTCCCGCGGGACCCTGCCAGATGCCAGAAGTGGGTGGAGAACTGTAGGAGAGCAGACTTAGAAGATAAAACACCTGATCAGCTAAATAAACATTATCGATTATGTGCCAAACATTTTGAGACCTCTATGATCTGTAGAACTAGTCCTTATAGGACAGTTCTTCGAGATAATGCAATACCAACAATATTTGATCTTACCAGTCATTTGAACAACCCACATAGTAGACACAGAAAACGAATAAAAGAACTGAGTGAAGATGAAATCAGGACACTGAAACAGAAAAAAATTGATGAAACTTCTGAGCAGGAACAAAAACATAAAGAAACCAACAATAGCAATGCTCAGAACCCCAGCGAAGAAGAGGGTGAAGGGCAAGATGAGGACATTTTACCTCTAACCCTTGAAGAGAAGGAAAACAAAGAATACCTAAAATCTCTATTTGAAATCTTGATTCTGATGGGAAAGCAAAACATACCTCTGGATGGACATGAGGCTGATGAAATCCCAGAAGGTCTCTTTACTCCAGATAACTTTCAGGCACTGCTGGAGTGTCGGATAAATTCTGGTGAAGAGGTTCTGAGAAAGCGGTTTGAGACAACAGCAGTTAACACGTTGTTTTGTTCAAAAACACAGCAGAGGCAGATGCTAGAGATCTGTGAGAGCTGTATTCGAGAAGAAACTCTCAGGGAAGTGAGAGACTCACACTTCTTTTCCATTATCACTGACGATGTAGTGGACATAGCAGGGGAAGAGCACCTACCTGTGTTGGTGAGGTTTGTTGATGAATCTCATAACCTAAGAGAGGAATTTATAGGCTTCCTGCCTTATGAAGCCGATGCAGAAATTTTGGCTGTGAAATTTCACACTATGATAACTGAGAAGTGGGGATTAAATATGGAGTATTGTCGTGGCCAGGCTTACATTGTCTCTAGTGGATTTTCTTCCAAAATGAAAGTTGTTGCTTCTAGACTTTTAGAGAAATATCCCCAAGCTATCTACACACTCTGCTCTTCCTGTGCCTTAAATATGTGGTTGGCAAAATCAGTACCTGTTATGGGAGTATCTGTTGCATTAGGAACAATTGAGGAAGTTTGTTCTTTTTTCCATCGATCACCACAACTGCTTTTAGAACTTGACAACGTAATTTCTGTTCTTTTTCAGAACAGTAAAGAAAGGGGTAAAGAACTGAAGGAAATCTGCCATTCTCAGTGGACAGGCAGGCATGATGCTTTTGAAATTTTAGTGGAACTCCTGCAAGCACTTGTTTTATGTTTAGATGGTATAAATAGTGACACAAATATTAGATGGAATAACTATATAGCTGGCCGAGCATTTGTACTCTGCAGTGCAGTGTCAGATTTTGATTTCATTGTTACTATTGTTGTTCTTAAAAATGTCCTATCTTTTACAAGAGCCTTTGGGAAAAACCTCCAGGGGCAAACCTCTGATGTCTTCTTTGCGGCCGGTAGCTTGACTGCAGTACTGCATTCACTCAACGAAGTGATGGAAAATATTGAAGTTTATCATGAATTTTGGTTTGAGGAAGCCACAAATTTGGCAACCAAACTTGATATTCAAATGAAACTCCCTGGGAAATTCCGCAGAGCTCACCAGGGTAACTTGGAATCTCAGCTAACCTCTGAGAGTTACTATAAAGAAACCCTAAGTGTCCCAACAGTGGAGCACATTATTCAGGAACTTAAAGATATATTCTCAGAACAGCACCTCAAAGCTCTTAAATGCTTATCTCTGGTACCCTCAGTCATGGGACAACTCAAATTCAATACGTCGGAGGAACACCATGCTGACATGTATAGAAGTGACTTACCCAATCCTGACACGCTGTCAGCTGAGCTTCATTGTTGGAGAATCAAATGGAAACACAGGGGGAAAGATATAGAGCTTCCGTCCACCATCTATGAAGCCCTCCACCTGCCTGACATCAAGTTTTTTCCTAATGTGTATGCATTGCTGAAGGTCCTGTGTATTCTTCCTGTGATGAAGGTTGAGAATGAGCGGTATGAAAATGGACGAAAGCGTCTTAAAGCATATTTGAGGAACACTTTGACAGACCAAAGGTCAAGTAACTTGGCTTTGCTTAACATAAATTTTGATATAAAACACGACCTGGATTTAATGGTGGACACATATATTAAACTCTATACAAGTAAGTCAGAGCTTCCTACAGATAATTCCGAAACTGTGGAAAATACCTAAGAGACTTTTAAAAATAGGCTTTCTTATATTTGATATTTGGAAGAAAAAGCCGTAAGGTGTATGTAGACCACTTAATCACTAAATATCTTTGCCTATAGGACTCCATTGAATACATTAGCCATTGATAATCTACCTGTTTAAATGGCCCCTGTTTGAACTCTCAAGCTTTGAAGACCTACCTGTTCTTCCAGAAGAGAACGTTGAAAGTGCCATGTTTCCTTTTGCGTGATCTCTGTTGATGGCACTCTGGAATTGTTTCAGTTAAGTCATTTTAGACATAGCATTTATTATCACTGTGGATCTCTACTTGTTGGGTGTTATGAATTCTTTGAAGAAATATATTTTGAAGAGGTGTGGGAGGAAGGAATACATTTTATAAAATGTTGTAGTGAAGCCCACAATTGACCTTTGACTAATAGGAGTTTTAAGTATGTTAAAAATCTATACTGGACAGTTACAAGAAATTACCGGAGAAAAGCTTGTGAGCTCACCAAACAAGGATTTCAGTGTAGATTTTGTCTTTCTTGAACTTAAAGAAACAAATGACAAAGTTTGAATGGAAAAGCCTGCTGTTGTTCCACATCTCGTTGCTGTTTACATTCCTTTGTGGAGCCTACATCTTCCTAAGCTTTTTAGCAGGTATATGTTGAACACTTCTGTTTCATGGTTGAGACAGAATCAGAGGCCATGGATACTGACAACTGATTTGTCTGTTTTTTTTCTCTGTCTTTTTCCATGACTCTTATATACTGCCTCATCTTGATTTATAAGCAAAACCTGGAAAACCTACAAAATAAGTGTTGTGGTTTATCTAGAAAAATATGGAAAATATTGCTGTTATTTTTGGTGAAGAAAATCAATTTTGTATAGTTTATTTCAATCTAAATAAAATGTGAATTTTGTTTAAA

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