Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TPT1P6
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:85427254-85428047  UCSC
Coordinates (T2T) chr6:86644380-86645173  UCSC
Coordinates (hg19) chr6:86136972-86137765  UCSC
Strand -
Parental Sequence NM_003295.4
Parental seq. overlap 721 bp
Parental seq. overlap (%) 15.8%
Genomic Region Intergenic
Retrocopy Summary TPT1P6, located on chr6:85427254-85428047, is a retrocopy of the parental gene TPT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TPT1
Full Name tumor protein, translationally-controlled 1
Also known as HRF|TCTP|p02|p23
Coordinate chr13:45333471-45341183
Strand -
Gene summary This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TPT1P8
Bonobo Pan paniscus TPT1P8
Gorilla Gorilla gorilla TPT1P7
Orangutan Pongo abelii TPT1P7
Green monkey Chlorocebus sabaeus TPT1P11
Crab-eating macaque Macaca fascicularis TPT1P7
Rhesus Macaca mulatta TPT1P7
Baboon Papio anubis TPT1P9
Golden snub-nosed monkey Rhinopithecus roxellana TPT1P4
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TPT1P6
GCTCAGGCTGCACCCCGCTCGCTCTGAGCTCTGGGCTCCTGCTATGCTAATGCCGCCATCGTCTGCCTTCAGCCACCATCATGATTTATCTACTGGGACCTCATCAGCCATGATGAGATGTTCTCCCACATTTACAAAATCCGGGAGACTGCGGATGGGCTGTGCCTGGAGGTGGAGGGGAAATTGGTAAGTAGGACAGAGGGTAACATTGATGACTTGCTCATTGGTGGAAATGCCTCCGCTGAAGGCACTGAAAGCGAAGGTACCAAAAGCACAGTAATCACTGGTATCCTTACTGTCATGAACCATCACCTGCAGGAAACAAGCTTCACAAAAGAAGCCTACAAGAAGTATAATACACCAAAGATTACATGAAATCAACCAAAGGCAAACTTGAAGAACAGAGACCAGAAAGAGTAAAACCTTTTATGACAGGGGCTGCAGAACAAATCAAACACATCCTTGCTAATTTCAAAAGCTACCACTTCTTTATTGGTGAAAACATGAATCCAGATGGCATGGTTGCTCCACAGGACTACCGTGAGGTTGGTGTAACCCATGTGGGATTTCCTTTAAGGATGGCTTAGAAATGGAAAAAAAATTAACAAATTTGGCAATGACTGGATCTATTACCTGTCATCATAACTGGCTTCTGCTTGTCAGCCACACAACACCAGGACTTAAGACAAATGGGACTGATGTCATCTTGAGCTCTTCATTTATTTTGACCATGATTTATTTGGAGTGGAGGCATTGTTTTTAAGAAAAACATGTCATGTAGGTTGTCTAAAAAA
>NM_003295.4
CTTTTCCGCCCGCTCCCCCCTCCCCCCGAGCGCCGCTCCGGCTGCACCGCGCTCGCTCCGAGTTTCAGGCTCGTGCTAAGCTAGCGCCGTCGTCGTCTCCCTTCAGTCGCCATCATGATTATCTACCGGGACCTCATCAGCCACGATGAGATGTTCTCCGACATCTACAAGATCCGGGAGATCGCGGACGGGTTGTGCCTGGAGGTGGAGGGGAAGATGGTCAGTAGGACAGAAGGTAACATTGATGACTCGCTCATTGGTGGAAATGCCTCCGCTGAAGGCCCCGAGGGCGAAGGTACCGAAAGCACAGTAATCACTGGTGTCGATATTGTCATGAACCATCACCTGCAGGAAACAAGTTTCACAAAAGAAGCCTACAAGAAGTACATCAAAGATTACATGAAATCAATCAAAGGGAAACTTGAAGAACAGAGACCAGAAAGAGTAAAACCTTTTATGACAGGGGCTGCAGAACAAATCAAGCACATCCTTGCTAATTTCAAAAACTACCAGTTCTTTATTGGTGAAAACATGAATCCAGATGGCATGGTTGCTCTATTGGACTACCGTGAGGATGGTGTGACCCCATATATGATTTTCTTTAAGGATGGTTTAGAAATGGAAAAATGTTAACAAATGTGGCAATTATTTTGGATCTATCACCTGTCATCATAACTGGCTTCTGCTTGTCATCCACACAACACCAGGACTTAAGACAAATGGGACTGATGTCATCTTGAGCTCTTCATTTATTTTGACTGTGATTTATTTGGAGTGGAGGCATTGTTTTTAAGAAAAACATGTCATGTAGGTTGTCTAAAAATAAAATGCATTTAAACTCATTTGAGAGAATGCCTTTTAGTTTAATGCATATTTAAACTAAATTGATCCTGTAGTGTTCCTGGAGAAGCTAGAGCCTGATTGTAGGCTACTACTCATCAATTAACTTCTACAGTGGAGACTACTTCTGGGACTGGAATATAAAAAAGAATCAAAGGTTCTGATTTTGAGTTGCAATAAAGGGAAAGACCATGCTCATAGCAGTGCCAACATCTGAAGTGTGGAGCCTTACCCATTTCATCACCTACAACGGAAGTAGTTAACTGGAAGAGATTACCAAGAGAATAAAAAGAGACTCATTCAGTGGAAGCAACTTTGTCTCAGCTTATTTCACATAAAGAGAGCGAAGTCTTTTGGGATGAATGTTAATTAAACTCCCTGGTAACTAGAACAGGGACTGGCAAACTAGCCTATCTGACCACCTGTTTTGTACACTTTAAGGTGGTTGGTTGCCTTTTTAAATGGTTGAGGGGAAAAGAATACCTTGTGGGatatggaatttaagttcgagtccagttttattggaacgtggctatgcttattcatttatggattgactgtggctgttgtcagtgcatgagcagagttgtgtCTAACAGACTAGAGCCTGCAAGTTTGCCAGCCCCTGATTTAAAAGATGAAGGTACACAGAATGTGGGCTGGCTGGTGGGCAAAGGGGTAAAAATGTTCTCTATATTGTATCTGAAAAGATGGGGTGTCTGAATAAGAAAATGCATCTATTTGACAGACCTGGAGCAGTTGCTATCTGCTGCTATGGTTTCCACCACAGATGCAAGAAGAACATGTCCTTGCGCTTTCCGTCTGTCTAATTGTGGCAGCTGAGATTGAATAGAGGAATACAGGAGGAAAAAAAGCGGGAAGAGtttttgaggcaggtcggtcacccaggcttgtagtgcagtggcacaagcaactcactgcattctctgcatcctgtgctcaagccattttcccacctcagtctcactagttgctgggactgcaggcatgcacccctatgcccagctaatttttgtagagaccgagtatcgcttagttgcccagggtggtctcaactcctgggctcaaggagatctgcccacctcagcctcccaaagtgcaggCCTAGCCTGGGAGGGGAATTTTCAAAACGTGAGTTTTGGGAAATAGTCTATCAGCCTTACCTGGTTGATTACACTTGTAAAAGAAAGATTAAAAGCAGGCCAGTGACTCTGGTCTGCTTGAACATGTGAATGTAGTGGTTTGAGCAATCTGGAGTTTGCCCTAGTGTCAAATTCCAGACTGTCCATAGTGTCCAAAACCTGAGGCAGATACTAATGTTAACCCCCAGCACCCCGTGATTGGAAACAAACCTAAATACGTATTGGGAACTTAATAGCAATTTTAAGCATTCTGATAGattttttgtagggatggggtcatgccatgtggcccaggctggtctgaaaactctggcctcaagtgatctcaagctttggccttctaaagtgttgggattacaggtgtgaggcattgcacctggcTTAGCGTTCTGATTTGACATTGTAATGAAAAGTGTGAGTCTCATCTACAGGGCCTTTTGTCCTCTGAAATGATAGCAGGAAGGGAATTTTCAGGCAGTGGTCAAAGCTGGGGAAACCAGGATAGTGAAGAAGGCCTTGAGGTGAGAGATGGAAGCTAATTGGTGAACTAGCCTTGGAAGCCTGAAACAGACAAGTAGCAATTCAGAGACTTTGTGGGCTCCACTGCTCCAACTTGTTTTGAAGATTTTCAGTTCTGCAGAAGAGGTATTTCCCCAGTTGTCCTTTCAGTGCTCTTAGCTGTTTTCCCAACATCCAGATCCAATCAAGGCTGGGACATAGCATTTTATCATGTCTATTTAAGTCAGAAGTGATGAACCCCAGCTGTTTACCTCATGGTAAACCTTTGAAGATTCCAGGTAGAATCTTCTCAGACTTTGAAGACTGTCTCATTTTATATCTTTTTCTCGTTATTCCTAGGGTCAAGACGTTTTGGGCAAGAATAAGGATGTGAACATCAGAAAGCTCATAACATTTTGTTTTTGATGCTAAGTTTAACAAAGGCATGCTTTAGTAGCCTGTGGGCCCTAGGGTTTGTTAAAGTGTGGAGAACAACTGAGTGGAGCAAGAGGACTTTtctaggaaggtccttgtaatgtgacatttgaaaacaaatgaaggtgtggaagtaggccatgtggatatcaggacaaaccattccaggccaagacaacagcagttagtctggagtgtgatgtgttctgggaaaaaagtggccactttgctaacccaagaagacaggaagggttgtaaagcagtgggagtgtgcaaggaaggaagaccagacctcaaggaaaccacaggcgctctgagcagaagagttacatgatatgactcaaatttttaaaggatcactttggctgccaggtggcagggtaaaagcatagaataattgtgtataatgtgtttttaaggcaaagatagtggcttagtctagggtagtagactgaggtggtaggaaatgaagatagagacaacaggatatgctggtgggtgaggatggatttaatgttgatacaagtattttggtctgagcgtttggaagaaagttggcactgaggtgggaagtcgagtttagttttgttagttttggatgtgttaagtttgagatgctgattcttcagagaagtctaagctggagaactatatagagagtggaaagataacaatagacattgaaagccatgatacaggataaggtcatttggagagaggatagactgcattccaacatgagattggttgacaaagagaaaccaacaaaggtaattaagaggTGCTCCCACTGCACTTGTACTCAGAAGGCTGAGGTAGGATTgttagaggccagcctgggcaccacagggagaccccatctctaaaaTTTAgccaggaaccatggctcatgcctgtagccccaggaatttgggaggctgagtggggaggatcgcttgaggtcaggagtttgagaccagcctgggcaacatagggagacctaaaaaaattaattgggcatctgtagtcccagctactcaggcggctgagctgagaggatggcttgagtccgagagattgagggtgcagtgagctgtgatcataccactgcactccagcctgggcggcagtgagacactatctgaaaaaagtttaaaaattttaaaaaagaaggaactgcccctgaggtaagaaccaagggagggcctcccagaggtcaggtggaaaaagttttaggaaggaggaagtagtcaacagggttacctgttgcaaagtacttaagtaatatgaggcctgatagtggtaaacttgactaccgttggatttCACTAGTGGGAAAGGAAGTCTAATTAAAATGCACTCAAGAGACTAACAGTCGCAGGCATGAAATACAATACAGGTACATGGTTTTTTattatgtgtgcatctgcttcagtaataggtgtgaattactcatttggatcattaggagtttcaaaatctagttaaatgactagatttttgttgatgtaaattctgtcattctgaactgcagggattgtcagtaacttaactgcaaactaaactggtgataattatggtaaaATTGCAAGACGAGCAATAAATCTCAACCAACTTGAGAGAACACTGATAA

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