Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RCN1P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:87120295-87122813  UCSC
Coordinates (T2T) chr6:88329023-88331540  UCSC
Coordinates (hg19) chr6:87830013-87832531  UCSC
Strand -
Parental Sequence NM_002901.4
Parental seq. overlap 1258 bp
Parental seq. overlap (%) 41.7%
Genomic Region Intergenic
Retrocopy Summary RCN1P1, located on chr6:87120295-87122813, is a retrocopy of the parental gene RCN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RCN1
Full Name reticulocalbin 1
Also known as HEL-S-84|PIG20|RCAL|RCN
Coordinate chr11:32091074-32105722
Strand +
Gene summary Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RCN1P1
Bonobo Pan paniscus RCN1P1
Gorilla Gorilla gorilla RCN1P1
Orangutan Pongo abelii RCN1P1
Gibbon Nomascus leucogenys RCN1P1
Green monkey Chlorocebus sabaeus RCN1P1
Crab-eating macaque Macaca fascicularis RCN1P1
Rhesus Macaca mulatta RCN1P1
Baboon Papio anubis RCN1P1
Golden snub-nosed monkey Rhinopithecus roxellana RCN1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RCN1P1
CCTTTTTATTATTTTTTTTTAAATTAAAACTTAAAGGGGAACAAAACTTGAAAAAGCTCTGTTCTTCAGAAGTTGGGTGGGTTGGGGGAGGCAGTAATATGAAGTGACTACTATGTATTTTAACTACCAGATTTTATATATTTACCACTGTTAACTAGTTGGAAAGTGGAAATTCTGATCAAAAGTGGTATCATCCTAGGTAAGCTTATTTCAGAATAAGTCTAATATTTCAGATTCTTCCTTCTCGACTTTATACTCTGAGCTGTTACTGTAAGTGATGTGTATGAAACCTCCATGCATTTTCCAGGATGGACCTGCTAATATGCACAATAAATCCATGTCTTTGTTTTTCTACTAAAAAGCAATCAAGAAAGATAATGTGAAAAAGAAAGGAATTTAGAGGTAGGGAAAAAGATGAATGTCATACATTTGAAGAACTATAGGAAAATTATAAACACTAAATATACTTGAGAAAACTTTCTTGATATGCCAGTGAGGTAGGCCTGATCTTTGAAATAGTGAATAGGAATACAATGCGTTTCCTCGATGATCACTGATTAGAAGGAGGTGGTGGGATCCTTGGGAAGCCAAATGTAGTAAAGTTCTGGATCATGTCCCATCTAGTCCAGTGAATCCACGACCCTCGGGCCTCTCCCCCAAGAACAGCTTATGCTATGGAATGAGGACAAGGTGATACTCTGAGTCATGGACTGAATTGGCAGACACAACCTGTACTTATTAAAATTCCACCTTGTAAGGAGGAGGTGAATGAAATAAAGGATCCCCCTAAGGATTTACGGGCCAAGCCCACCGTGCGCAAGGAGCGCGTGGTGCGGCCTGACTCGGAGCTGGGCGAGCGGCTTCCAGAGGTCAACCGGAGCTTCCGGTACCGCCATGAGGCCTTCCTGGGCAAGGAGGACTCTAAGACCTTCGACCAGCTCACCCCGGACAAGAGCAAGGAGAGGCTGGGGAAGATTGTTGATCGAATCAACAATGATGGAGATGGCTTTGGCACTACTGAGGAGCTGAAAACCTGGATCAAACGGGTGCAGAAAAGATACATCTTCGATGATGTCGCCAAAGTCTGGCGGGATTACGATAGGGACAAGGATGATAAAATTTACTAGGAAGAATACAAACAAGCCACCTATGACCTAGGAAACCCCGCGGAGTTTCATGATTCTTCAGATCATTACACCTTTAAAAAGATGCTGCCGCGTGACGAGAGAAGATTCAAAGCTGCAGACCTCGATGGCGCCCTGACAGCCACTCGGGAGGAGTTCACTGCCTTTCTGCATACCGAAGAGTTTGAGCATATGAAGGAAATTGTGGTTTTGGAAACCCTGGAGGACAACGACAAGAACGGTGATGGGTTTGTGGATCAGGATGAATATATTGTGGTTATGTTTTCCCATGAGAATGGCTCTGAGCCAGACTGGGTTTTATCAGAACTGGAGCAATTTAACGAATTCCGGGATCTGAACAAGGACCGGAAGTTGGACAAAGACGAGATTCGCCACTGGATCCTCTCTCAAGATTATGATCATGCACAGGGTGAGGCCAGGCATCTAGTATATATGAGTCAGACAAAAACAAGAATCAGAGGCTAAAGAGGAAATATTGGAGAACTGGAACATGTTTGTTGGAAGCCAAACTACCAATTATGGGGAAGATCCCACAAAAAATCATGATGAGCTTTGATAGACACTCACCAGAATATGCCAGACTGTCATAGGCGTTGTTATTGTCTTGGATGGTTGCTACAATTGTCTAATTTACAGCAGTTGTGTTCCTAAAAAAGCAAGTTTATACCTCAGATTGGGGTATAAAAATTGTTTTTCACTCAGTATTTACTGGAAAATGGACATTACTATTCTTTCAGTAAGATTTCTCTCAAAACACATGAAAACCTTGGTAAATTGCAGTTCTCTCTGGGGATATATTGGTACAGCATGACTTTTTAAAAGTTTTTTTTTTCAGCTGCGAGACCCCATTCCCGAGCTACCGCTGTTGTCGCTCACTCGGCGCCTCCCTCCCGGACGCCCTCTCCTGTCCCTTc
>NM_002901.4
AGTCCCCTCCTCCGCGCCGGCCCCAACCCTGTCGCTGCCGCCGCGCTCCGAGTCCCCATTCCCGAGCTGCCGCTGTTGTCGCTCGCTCAGCGTCTCCCTCTCGGCCGCCCTCTCCTCGGGACGATGGCGCGCGGTGGCCGCGGCCGCCGCCTGGGGTTAGCCCTGGGGCTGCTGCTGGCGCTGGTGCTGGCGCCGCGGGTTCTGCGGGCCAAGCCCACGGTGCGCAAAGAGCGCGTGGTGCGGCCCGACTCGGAGCTGGGCGAGCGGCCCCCTGAGGACAACCAGAGCTTCCAGTACGACCACGAGGCCTTCCTGGGCAAGGAGGACTCCAAGACCTTCGACCAGCTCACCCCGGACGAGAGCAAGGAGAGGCTAGGGAAGATTGTTGATCGAATCGACAATGATGGGGATGGCTTTGTCACTACTGAGGAGCTGAAAACCTGGATCAAACGGGTGCAGAAAAGATACATCTTTGATAATGTCGCCAAAGTCTGGAAGGATTATGATAGGGACAAGGATGATAAAATTTCCTGGGAAGAATACAAACAAGCCACCTATGGTTACTACCTAGGAAACCCCGCAGAGTTTCATGATTCTTCAGATCATCACACCTTTAAAAAGATGCTGCCACGTGATGAGAGAAGATTCAAAGCTGCAGACCTCAATGGTGACCTGACAGCTACTCGGGAGGAGTTCACTGCCTTTCTGCATCCTGAAGAGTTTGAACATATGAAGGAAATTGTGGTTTTGGAAACCCTGGAGGACATCGACAAGAACGGGGATGGGTTTGTGGATCAGGATGAGTATATTGCGGATATGTTTTCCCATGAGGAGAATGGCCCTGAGCCAGACTGGGTTTTATCAGAACGGGAGCAGTTTAACGAATTCCGGGATCTGAACAAGGACGGGAAGTTAGACAAAGATGAGATTCGCCACTGGATCCTCCCTCAAGATTATGATCATGCACAGGCTGAGGCCAGGCATCTGGTATATGAATCAGACAAAAACAAGGATGAGAAGCTAACTAAAGAGGAAATATTGGAGAACTGGAACATGTTTGTCGGAAGCCAAGCTACCAATTACGGGGAAGATCTCACAAAAAATCATGATGAGCTTTGATAGACACTCACCAGAATATGGCAGACTGTCATAGGCATTCTGTTATTGTCTTGGATTGTTGCTACAATTGTCTAATTTACAGCAGTTGTGATCCCACAAAAAGCAAGTTTATACCTCAGATTGGGGTATAAAAATTGTTTTTCGCTCAGTATTTACTGGAAAATGGACATCACTAGTCTTTCAGTAAGATTTCTCTCAAAACACGTGAAAACCTTGGTAAATTGCAATTCTTTCTGGGGATATATTGGTACAACATGACTTAAAACTTTTTTTTTTCTATTAAAACTTAAAGGGGAACAAAACTTGAAAAAGCCCTGTTCTTCAGAAGGTGAGTGGGTTGAGGGAGGCAGTAATATGAAGTGACTGCTGTGTATTTTAACTACCAGATTTTTTATATTTGCCACTGTTAAATAGTTGGAAAGGGGAAATTCTGATTAAGCGAAAGTGGTATCATCCTAGGTAAGCTTATTTCAGAACAAGTCTAATATTTCAGATTCTTTCTTTTCGACTTTATACTCTGAGTTATTACTTACTGTAAGTGGTGTATATGAAACCTCCATGCATTTTCCAGTATGGATCTGCTAATATGCACAGTAAATCCATGTCTTTGTTTGTTTTTCTATTAAAAAGCAATCAAGAAAGATAATGTGAAAAAGAAAGGAATTTAGAGGTAGGGAAAAGATGAATGTCAGACATTTGAAGAACTATAGTAAAATGATAAACACTAAATATACTTGAGAAAACTTTCTTAATATGCCAATGAGGTAGGCCTGATCTTTGAAATAGTGAATAGGAATACAATGCATTTCCTCAGTGATCACTGATTAGAATGAGTTGGTGGGATCCTTGGGAAGCCAAACGGAGCGGAGTTCTGGATCATGTCCCATCCAGTCCAGTGAATCCACGACCCGCAGACCTGTCCCCCCGCAACAGCTTATACCATGGAATGAGGACAAGGTGATACTCTGAGCTGTGGACTGAACTGGCAGACACAACCTGTACAGATTGAAATTTCACCTTGTAAGGAGGAAGTGAATGAAATAAAGGATCCCCCTAAGGATTTTCTACTGTGTCCTGTGGTGTTTGACTTCACAGATGCTATTTGTGACATTATTCATATAGCATAAAACAGTGGGGTTGGATCCCATGAATAACATTATAAAGGTTCTGGGGTTTTTTTTCATCCAATTACTAGAATGTTCAGAATAGACTCATATTTACTAATTTAATAAATGTATGTACTTAATGCC

Publications

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