Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AKIP1P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:90116624-90117097  UCSC
Coordinates (T2T) chr6:91328325-91328798  UCSC
Coordinates (hg19) chr6:90826343-90826816  UCSC
Strand -
Parental Sequence NM_020642.4
Parental seq. overlap 433 bp
Parental seq. overlap (%) 34%
Genomic Region Intragenic (BACH2)
Retrocopy Summary AKIP1P1, located on chr6:90116624-90117097, is a retrocopy of the parental gene AKIP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AKIP1
Full Name A-kinase interacting protein 1
Also known as BCA3|C11orf17
Coordinate chr11:8911117-8920079
Strand +
Gene summary This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AKIP1P1
Bonobo Pan paniscus AKIP1P1
Gorilla Gorilla gorilla AKIP1P1
Orangutan Pongo abelii AKIP1P1
Gibbon Nomascus leucogenys AKIP1P1
Green monkey Chlorocebus sabaeus AKIP1P1
Crab-eating macaque Macaca fascicularis AKIP1P1
Rhesus Macaca mulatta AKIP1P1
Baboon Papio anubis AKIP1P1
Golden snub-nosed monkey Rhinopithecus roxellana AKIP1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AKIP1P1
AGAGAGACGAGAAACACCCAACCCTTAGTGCTTTCTTCTGAACAATGGCTGAATTCATAGACAGTACTTCAAGTTAGTGTGGGAAATATTATTCATCTGTGCCAGAGAAAGAAGGAGCAACCCATGTCTATCATTTTCACAGAGGGAAGTTGAAGCTGCACATGTACTTGGACATAGGGAATGGTCAGAGAAAAGACAGAAAAAAGACATCCCTTGGTCCTGGAGGCATCTATCAAATATCAAAGCGTGCTCCAGAGGCATCCCAGCCTAGTGAGAACACCTCTACATAGAAGTGTATCCAGGGACCTATTCTGTCACTGTAGGCGCAAATTACTTAACCAAGAAGACTTATGTGGTAGCAGTTGATTGTAGACAAAGTGTGGACCTGGTCTTCCCCATATGGTATTGACCATCACTGCCATCACATCACCTTTTTTTAAGTAGCAAGAATAACACCACTGTATGATTCTCt
>NM_020642.4
AGCGTTGCGCGCATGCGCCTTGACGAGTGAGCCGGGGAGCCATGGACAACTGTTTGGCGGCCGCAGCGCTGAATGGGGTGGACCGACGTTCCCTGCAGCGTTCAGCAAGGCTGGCTCTAGAAGTGCTGGAGAGGGCCAAGAGGAGGGCGGTGGACTGGCATGCCCTGGAGCGTCCCAAAGGCTGCATGGGGGTCCTTGCCCGGGAGGCGCCCCACCTAGAGAAACAGCCGGCAGCCGGCCCGCAGCGCGTTCTCCCGGGAGAGAGAGAAGAGAGACCCCCAACCCTTAGTGCTTCCTTCAGAACAATGGCTGAATTCATGGACTATACTTCAAGTCAGTGTGGGAAATATTATTCATCTGTGCCAGAGGAAGGAGGGGCAACCCATGTCTATCGTTATCACAGAGGCGAGTCGAAGCTGCACATGTGCTTGGACATAGGGAATGGTCAGAGAAAAGACAGAAAAAAGACATCCCTTGGTCCTGGAGGCAGCTATCAAATATCAGAGCATGCTCCAGAGGCATCCCAGCCTGCTGAGAACATCTCTAAGGACCTCTACATAGAAGTATATCCAGGGACCTATTCTGTCACTGTGGGCTCAAATGACTTAACCAAGAAGACTCATGTGGTAGCAGTTGATTCTGGACAAAGCGTGGACCTGGTCTTCCCTGTGTGATGTTGACCATCACTGCCATCACATCACCTTTTTTTAAGTAGTAAGAATAAAGCCACTGTATGATTCTCTTAATAGCTATACATTAATCCTGTTTTTAGTGCTGACTGGGTCAGCCTTCCGGGAACTGGAGTCTGTCTCTTTCAGTGCttttttgtttgtttggttggtttttttttgagacagtctcactctgttgcccaggctggagtgcagtggcgtgatctcggctcactgcaagttccgcctcccgggttcacaccattctcctgcctcagcctcccgagtagctggcactacaggcacccgccaccatgcccggctattttttttgtatttttagtagagacggggtttcaccatgttggccaggatggtctcgatctcttgacctcgtgatccacccaccttggcctcccaaagtgttgggattacaggcgtgagccaccgcgcccggccTCAGTGCCTTTTTTAACTTGAGGGTGTAGAGGTCCTCCACGCTTGTTTGCCTGAAAGTAATATAATGATGCTGTCTGAACAGGTTTTACTGCTTGCTTTCCAAGTAAAGGTTAATTATGATAATAAAGAGATTTGGAAATGAA

Publications

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