Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RHOAP1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:91815128-91816417  UCSC
Coordinates (T2T) chr6:93026767-93028056  UCSC
Coordinates (hg19) chr6:92524846-92526135  UCSC
Strand -
Parental Sequence NM_001664.4
Parental seq. overlap 1115 bp
Parental seq. overlap (%) 61.2%
Genomic Region Intergenic
Retrocopy Summary RHOAP1, located on chr6:91815128-91816417, is a retrocopy of the parental gene RHOA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RHOA
Full Name ras homolog family member A
Also known as ARH12|ARHA|EDFAOB|RHO12|RHOH12
Coordinate chr3:49359145-49411976
Strand -
Gene summary This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RHOAP1
Bonobo Pan paniscus RHOAP1
Gorilla Gorilla gorilla RHOAP1
Orangutan Pongo abelii RHOAP1
Gibbon Nomascus leucogenys RHOAP2
Green monkey Chlorocebus sabaeus RHOAP1
Crab-eating macaque Macaca fascicularis RHOAP1
Rhesus Macaca mulatta RHOAP1
Baboon Papio anubis RHOAP1
Golden snub-nosed monkey Rhinopithecus roxellana RHOAP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RHOAP1
AGCAATGGTTCCCGTCCAGAAGAAGCTGGTAATTGTCGGTGACAGAGTCTGTGGCAAGACATGCTTGCTCATTGTCTTCAGCAAGGACCAGTTCCCAGAGGGGTGAGCACCCTCAGGGTTTCAGAACTATGTGGCCCATATCGAGGTGGATGGGAAAGTGTAGAGCTGACTTTGTGGGACACAGCCAGGCAGGAAGATTAGGATCGCCTGAGGCCCCTCTTTTACTCGGACACTGATGTTATGTGTTCTCCGTTGACAACCCTGAGAGTTTAGAAAACATCCCAGAGAAATGGAGCCCAGAAGTCAAGCATTTCTGTCCCAACGTGCCCACCAGCCTGGTTGGGAACAAGAAGGATCTTCGGAATGATGTGCACACAAGGTGGGAGCTAGCCAGGATGAAGCAGAAGAGGGTGAGACTCGAAGAGGGCAGAGATATGGTCAAGGGAATTGGCTCTTTGGGGTACATGAAGTGTTCAGCAAAGACCAAAGATGGAGTGAGAGAGGTTTTTGAAGTGGCTGCGAAAGCTACTCTGCAAGCCAGATGTGGGAAGAAAAACTCTGGGTGCCTTGTCTTGTGAAACAGTGCTTAAGAGGTGAATTTTGAAGTGCTGTTGGTTAGTCTTAGTGGATGAACACTGGCCTTTATCACTTATATACAGTTTACCTAAGATTACAAATTTAAGGCATGCCATCTTGTTACCAGTATTTAGAAACCAACCCTGATTCTTAATGATGTCAAATCCGTCAGGCCTACCAGGATCCTTTTACCACTACTCTTAACAACCCTCCTCTACACTTCTGCCTGACGCACCACGGCAAATTCAAAGAATTTCTTAACTTCTTGCTTCTGTCTTGAAAGAGAAACAGCTGGTAACTTTGCAAATTAGGCTGCAACTACTTTATAACTAACGTTCCCTGCCTATCATCTGTCAACAGCAAGGTACTCTGGTGAGACACAACTTCAGTGCTTTACTCCTTAACAGGCTTCATTGGCATAGCTCTGGGACAGGCATCTGGTCTTTTGAAAATGGGTTCTACAAGGAAGGCCCAAGTCCATGCAGCTGTGGCACAGTTACAGTTCTGTGGTTTCATGTTAGTTACCTTAGAGTTACTGTGTAATTAGTGCCACTTAATGTACATTACCAAAATAAATATATCTACCCCAGACTGGATATAGTATTTTTTTATAATTGGATTTCCTAATATTGACATTTGTTATCCCCAAAGACAGTGTATTGCTTGTTAAAAAATAAATGTGTTTGGAAATGTCAAATGGAAAATTCATTTTt
>NM_001664.4
GCTCTCTCGCGCTACCCTCCCGCCGCCCGCGGTCCTCCGTCGGTTCTCTCGTTAGTCCACGGTCTGGTCTTCAGCTACCCGCCTTCGTCTCCGAGTTTGCGACTCGCGGACCGGCGTCCCCGGCGCGAAGAGGCTGGACTCGGATTCGTTGCCTGAGCAATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGCTTGCTCATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAGAACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGTAGAGTTGGCTTTGTGGGACACAGCTGGGCAGGAAGATTATGATCGCCTGAGGCCCCTCTCCTACCCAGATACCGATGTTATACTGATGTGTTTTTCCATCGACAGCCCTGATAGTTTAGAAAACATCCCAGAAAAGTGGACCCCAGAAGTCAAGCATTTCTGTCCCAACGTGCCCATCATCCTGGTTGGGAATAAGAAGGATCTTCGGAATGATGAGCACACAAGGCGGGAGCTAGCCAAGATGAAGCAGGAGCCGGTGAAACCTGAAGAAGGCAGAGATATGGCAAACAGGATTGGCGCTTTTGGGTACATGGAGTGTTCAGCAAAGACCAAAGATGGAGTGAGAGAGGTTTTTGAAATGGCTACGAGAGCTGCTCTGCAAGCTAGACGTGGGAAGAAAAAATCTGGGTGCCTTGTCTTGTGAAACCTTGCTGCAAGCACAGCCCTTATGCGGTTAATTTTGAAGTGCTGTTTATTAATCTTAGTGTATGATTACTGGCCTTTTTCATTTATCTATAATTTACCTAAGATTACAAATCAGAAGTCATCTTGCTACCAGTATTTAGAAGCCAACTATGATTATTAACGATGTCCAACCCGTCTGGCCCACCAGGGTCCTTTTGACACTGCTCTAACAGCCCTCCTCTGCACTCCCACCTGACACACCAGGCGCTAATTCAAGGAATTTCTTAACTTCTTGCTTCTTTCTAGAAAGAGAAACAGTTGGTAACTTTTGTGAATTAGGCTGTAACTACTTTATAACTAACATGTCCTGCCTATTATCTGTCAGCTGCAAGGTACTCTGGTGAGTCACCACTTCAGGGCTTTACTCCGTAACAGATTTTGTTGGCATAGCTCTGGGGTGGGCAGTTTTTTGAAAATGGGCTCAACCAGAAAAGCCCAAGTTCATGCAGCTGTGGCAGAGTTACAGTTCTGTGGTTTCATGTTAGTTACCTTATAGTTACTGTGTAATTAGTGCCACTTAATGTATGTTACCAAAAATAAATATATCTACCCCAGACTAGATGTAGTATTTTTTGTATAATTGGATTTCCTAATACTGTCATCCTCAAAGAAAGTGTATTGGTTTTTTAAAAAAGAAAGTGTATTTGGAAATAAAGTCAGATGGAAAATTCATTTTTTAAATTCCCGTTTTGTCACTTTTTCTGATAAAAGATGGCCATATTACCCCTTTTCGGCCCCATGTATCTCAGTACCCCATGGAGCTGGGCTAAGTAAATAGGAATTGGTTTCACGCCTGAGGCAATTAGACACTTTGGAAGATGGCATAACCTGTCTCACCTGGACTTAAGCATCTGGCTCTAATTCACAGTGCTCTTTTCTCCTCACTGTATCCAGGTTCCCTCCCAGAGGAGCCACCAGTTCTCATGGGTGGCACTCAGTCTCTCTTCTCTCCAGCTGACTAAACTTTTTTTCTGTACCAGTTAATTTTTCCAACTACTAATAGAATAAAGGCAGTTTTCTAAA

Publications

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