Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ATF1P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:92886211-92888368  UCSC
Coordinates (T2T) chr6:94098203-94100361  UCSC
Coordinates (hg19) chr6:93595929-93598086  UCSC
Strand -
Parental Sequence NM_005171.5
Parental seq. overlap 994 bp
Parental seq. overlap (%) 33.8%
Genomic Region Intergenic
Retrocopy Summary ATF1P1, located on chr6:92886211-92888368, is a retrocopy of the parental gene ATF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ATF1
Full Name activating transcription factor 1
Also known as EWS-ATF1|FUS/ATF-1|TREB36
Coordinate chr12:50763682-50821162
Strand +
Gene summary This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ATF1P1
Bonobo Pan paniscus ATF1P1
Gorilla Gorilla gorilla ATF1P1
Orangutan Pongo abelii ATF1P1
Green monkey Chlorocebus sabaeus ATF1P1
Crab-eating macaque Macaca fascicularis ATF1P1
Rhesus Macaca mulatta ATF1P1
Baboon Papio anubis ATF1P1
Golden snub-nosed monkey Rhinopithecus roxellana ATF1P1
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ATF1P1
GCTTTTGCAACTCAAGGATAAACATCTTATACAATATATTTGGTGATGGAAGATTAAGTAGAAAATGACCCCAAGGCAGCTACTGGCATGAATGAAAGCTTTGTAAAAATTAAACATACTCAAGAAGCAAGAAATAAACTCTCAGCAATCTGAATTTTCTAAATAACAACAGCTGTCAATCCAAAGTGGCAGAGAAGATAAAATTTGGTAAATTATATTTTTAAAAACAAATTAATTTATACCATAGGATTGCATTTCTAGTTCCTGAAATTTACCGTTTTCAGTTATGTGTGTGTGTGTATTTTATTTCCGCCAACAAATTCTAAATTACAAATGTAAATGAAAACCCATTAAATTAGTAAACATATAAATTATGTGTTTTCATTATTTATACTTGTTCTATTGTCAAGTCTTTAAAATGGGGTTTTAAAAGTTTGTTTGTTGGACTTGAGAAGATTTTCAAGACTGGGTTAATTATTTTTGAGGTCTTGTTCTAAAAGGCATCTAAGGTACATGAATGAAGTATGGTGATTTTGTAACATTTTTAAACAGTTTTCTTTGACTACCTACCAACCTGCCTCCAGGCAATACTCAGGCAATACTCAATACTACCTCAATAAGTATATTTGATTGTATAATACCTTGATAAGTAGTCTACTACTATCAAGTTTACTAACTTGATAAGTAGTCAAAAACAACTGTTTTAAAAAATTAGCTTTACTTTTAAATAGTTGGTTTTTGCTTACTCTGGTAATGTTGGTTTTCTAAGAATACATAATAAATTTTTTGTTTTAATTCTATATTCTGTATGCCATTAAATATTCATTACATAATCTGTTATGTTTTAATAGAATGGAATGTTCACAGGCTCTTAAAATGCCATTTTAAAAAAGCCTTCTGAAGATTCATACCAAAGTTTTTTCAAGAAGGCCACTTCAGAATATCAAAGGAGAAAGAAAGAATATGTGAAAGGCCTAGAAAATTGAGTTATAGTTATGAAAAATAAAAATAAAACTCTAATAGAAGAGTTAAAAACTGAAGAATATTGATTTGAATAAAAGTGCTTGATTCTTAAGAAAGAAGATATTATTGTGGACCTTCATAAAAATTAAATAAAATTTTAGTGGTTTCAGACAAGATAAGAAAAGCCACTTGAGTATGATCTTTATCAGAAGGTGAGGAGTCTCAGGACCCATCTGACAGCTTAGGCTCTTTACAGAAAGCCTACAGGATCCTAGCACGGCATTCATCTTACAGAAAAATTTTAAAAGACCTATCTTCTGAAGATATATGGGGCAGAAAAGGAGATGGAGAAAACCCTGGAGTTTTTGCTGTCACTTCTGTCTGTTCCCACTCCTATCTATCAGAAGGGCAGCAAATAGTACATTGCCATTGTCTCAAGTGGAGACTCACCATTGGCCAGTTCAGGCACAGCTGGAGTACAGAGACTTCAGACATAATTAACCATGACAAATTCAGGCAATACTCAGCAAGGTACAACTATTCTCCAGCATATGCAGGTCCCTGATGGACAGCAAATACTTGCATCCAGCAATCAGTTGGTTGTACAGACTGCATCAGGTGATAGGCAGATATATCAGATCCAAACTGCCTTCAACTACTTCTCTGCCACAAACTATGATGATGACATCTCCTGTGACTCTTACATACCAAACAAATAAGACAGAAGACCCCCAGTTGAAAGGAGAAATAAGGTTAATGAAAa
>NM_005171.5
AGTAGCGGCCCTGACTGCCGAGGAAACGGTAGCTTAGGACAGTTGGCTGTTAAGTGACACTGATTCTCCCCGCCCCGCCTGACCCCCGAGAAGGAGGCTTGTCCCCCGCTGCGTGAGGGGGTGGGGAAGTGGGTAGTGAATTCGGATCTACCTGGGAGGGGGGAGTGGAAGTTCCCGCCCCGGAGAGCGGCGAGGCGGCAGCCACAGTTGATTATGGAAGATTCCCACAAGAGTACCACGTCAGAGACAGCACCTCAACCTGGTTCAGCAGTTCAGGGAGCTCACATTTCTCATATTGCTCAACAGGTATCATCTTTATCAGAAAGTGAGGAGTCCCAGGACTCATCCGACAGCATAGGCTCCTCACAGAAAGCCCACGGGATCCTAGCACGGCGCCCATCTTACAGAAAAATTTTGAAAGACTTATCTTCTGAAGATACACGGGGCAGAAAAGGAGACGGAGAAAATTCTGGAGTTTCTGCTGCTGTCACTTCTATGTCTGTTCCAACTCCCATCTATCAGACTAGCAGCGGACAGTACATTGCCATTGCCCCAAATGGAGCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTACAACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATGCAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAATGCCTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTTTATTCCAATAAAAGTGTTTGATTCCTAAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCCTAGTGGAGTTTTATAAATTAAAAGGTCAAAACTGAAGCTTTTTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCTAGTGACAGAGGAGAAAGTGGAAAATGACCTCAAGGAAGCTACGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAGAAATGAACTTTCAGCAGTCTAAATTTTCTAAATAACCAATAGTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTTTTTTTAAAAATCCATTTACCCTACAGGTTTGCATTTGTTTGCTGAAATTTACCTTTTTTTAGTTATATATAtgtgtgtgtgtgtgtgtAATTTCTGCCAATAAATTCTAAATTACAAAGGTAAGAGAAAACCTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTTGTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTTTAAAAGTTTGTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGGTCTTATCCTAAAAGGCATCTAAGGTACATGAATGGAGTATGGTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAGTTTGATACTTTTAAATAGTTGGTTTTTTTGCTTACTCTGGTAATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTCTGTATGCAGTTGAATATCCATTACTTATTCTGCTGTGCTTTAATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACCTTCTGAAGATACATACCAAAGTTTTTCCAAGAAGATTTTATAATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTATTAAGGCAATTTTATGTTAGAGACTATTTTGTAATGTAGTGAGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGATCTTTATAAATTCTAATGTTGAGTTTTTAATGATTATTTTAAATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTATATTATGGGACGTTTTCAGATTGGCTAATATTTGCATTGTAAATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAGCGTTTAACATCTATATTCCAATTTGTATACAGTTTAAAATTGTACTGCAAAACTATTGTGTGCTCTTACACAGTATGCATCATATTGTTGTCTGTGAAATTAAAGGACATTTGATAGTCTACTGAATGTAAAATATAATGCTTGGTATATGAATGATAA

Publications

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