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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CDK2AP2P4
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:10476404-10477346  UCSC
Coordinates (T2T) chr7:10607061-10608003  UCSC
Coordinates (hg19) chr7:10516031-10516973  UCSC
Strand +
Parental Sequence NM_001271849.2
Parental seq. overlap 777 bp
Parental seq. overlap (%) 72.3%
Genomic Region Intergenic
Retrocopy Summary CDK2AP2P4, located on chr7:10476404-10477346, is a retrocopy of the parental gene CDK2AP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CDK2AP2
Full Name cyclin dependent kinase 2 associated protein 2
Also known as DOC-1R|DOC1R|p14
Coordinate chr11:67506497-67508162
Strand -
Gene summary This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CDK2AP2P1
Bonobo Pan paniscus CDK2AP2P1
Gorilla Gorilla gorilla CDK2AP2P3
Orangutan Pongo abelii CDK2AP2P1
Gibbon Nomascus leucogenys CDK2AP2P1
Green monkey Chlorocebus sabaeus CDK2AP2P3
Crab-eating macaque Macaca fascicularis CDK2AP2P1
Rhesus Macaca mulatta CDK2AP2P1
Baboon Papio anubis CDK2AP2P1
Golden snub-nosed monkey Rhinopithecus roxellana CDK2AP2P1
Marmoset Callithrix jacchus CDK2AP2P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CDK2AP2P4
CGGCTCCAGCACCCCTGGGCCGTGCAACCCGGTCCCTACAGGTGAGGATCCAGCTCCACCCCTGCTCGCCTGCCAGGCGGTGGAGACCTCGAAATGAAGACAGCATGtCACGAAGCGTCTCATCTCCGTCGGGCTCAGTGTCAGGTGCCGTTGCCCCTTTCAGACCGCTGTTTAACAACTTTGGACAGCCTTCCATGGGCTATGTGCAGGCGATGAAGCCACCGGCGCCCAGGGCTCCCAGAGCACCTACAACGACCTGCTGTCGGTCATAGAGGAGAAGGGCAAAGAGATCCGGCCTGCCTATGCTGGCAGCAAGAGCACCATGGAGCGCCTGAAGAGAGGTATCATCCATGCCCGGGCCCTAGTCAGAGAGTGCCTGGCAGAGACAGAGTGCAATGCCCGCACGAAACAGGAAGCCCCTCGGCCTCAGGGGCTGGACCTTTCCTGGCCACTGCAGAGCACCCGCTTCTCCCTGGCCTTCATCCCGAGCTGCGCTAGCCATCCTGGGCTTCCAGTCCTGTGTCCCTTGGTGGGTTCCCTCCAGGAACCAAGGGGCGGCTCTCACTCCAGGTGGCAGCAGGTAGCAGGTAGGTCCGGCTACCCTAAAAACAAGAGTTAGCAGGTAGGTCCCGGTGAGTCCCACCCATGACCTGCCAACATTGTTGCCCACTGGATCTTTCTGTGGTCTCACCACGCAGCTCTTCCCAGCACTTCTCCCACTTTGTCCCGAGCCTCCTTCTCTCCCAGCAGGGGCTCAGGCCTGGCACCTCTCTGCCCTATGTCCTGAGCCACAGTGACTGTTTTCTCAGTGTGTCTTTTGCTAAATATGCCCTTTTCATATTAATAAAAGATTATTTGGAGTTGTGCTCTCA
>NM_001271849.2
AATCAGAGCGCGGCTGAGCGGCCCCGCAGCCAACCCCCGAGGAGCGGCCGGCTGGCGTCCGCCGCGCCCAGGAGTTGGGGATGTCCTACAAACCCATCGCCCCTGCTCCCAGCAGCACCCCTGGCTCCAGCACCCCTGGGCCGGGCACCCCGGTCCCTACAGGTGAGGATCCAGCTCCACCCCTGCTCGCCTGCCGGGCGGTCGAGGTCTCGAAGAGAAGACGGCCTGagttctgcaatactgggcctgccgcctaccctcgctgagcctcagtttgctggcctgtgaagtgggCGTGGTCACGAAGCGTCCCGTCGCCGTCGGGCTCAGTGCCAGGAGCCGGCGCTCCTTTCAGACCGCTGTTTAACGACTTTGGACCGCCTTCCATGGGCTACGTGCAGGCGATGAAGCCACCCGGCGCCCAGGGCTCCCAGAGCACCTACACGGACCTGCTGTCAGTCATAGAGGAGATGGGCAAAGAGATCCGGCCTACCTATGCTGGCAGCAAGAGCGCCATGGAGCGCCTGAAGAGAGGTATCATCCATGCCCGGGCCCTAGTCAGAGAGTGCCTGGCAGAGACAGAGCGGAACGCCCGCACGTAACAGGAAGCGCCTCGGCCTCAGCGTCTGGACCTATCCGGCCACTGCAGAGCACCCGCTTCTCCCTGGCCTTCATCCCGAGTTGCACTAACCATCCTGGGCTTCCTGTCCTGTGTCCCTTGGTGGGTCCCCTCCAGGAACCAAGGAGTGGCCCTCCAGGTGGCAGCACTAAGGACACCCCCCCACAACAAGAGTTAGCAGCGAGGTCCCCATGAGTCCCACCCATGACCTGCCGACAGTGTTGCCCACCGGAACTTTTGTGGCCCCTACCGCTCAGCCCTTCCCAGCACTTCTCCCACTTTGTCCCGAGCCTCCTTCTCCCCCAGCAGGGGCACAGGCCTGGCACCTCCCTGCCTTGTGTCCTGAGCCATAGTGACTCTTTTATCTGTGTGTCTTTTGCTAAATATGCCCTTTTTATATTAATAAAAGATGATTTGGAGTTGTGCTCTCA

Publications

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