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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RNF181P1
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Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:105530189-105530745  UCSC
Coordinates (T2T) chr7:106844384-106844940  UCSC
Coordinates (hg19) chr7:105170636-105171192  UCSC
Strand +
Parental Sequence NM_016494.4
Parental seq. overlap 519 bp
Parental seq. overlap (%) 75.2%
Genomic Region Intergenic
Retrocopy Summary RNF181P1, located on chr7:105530189-105530745, is a retrocopy of the parental gene RNF181. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RNF181
Full Name ring finger protein 181
Also known as HSPC238
Coordinate chr2:85593823-85597708
Strand +
Gene summary RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RNF181P1
Bonobo Pan paniscus RNF181P1
Gorilla Gorilla gorilla RNF181P1
Orangutan Pongo abelii RNF181P1
Gibbon Nomascus leucogenys RNF181P2
Green monkey Chlorocebus sabaeus RNF181P3
Crab-eating macaque Macaca fascicularis RNF181P1
Rhesus Macaca mulatta RNF181P1
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.51
log10(TPM+1)

Related Sequence

>RNF181P1
tCAGACGGCTGGGCAGCCATGGCGTCCTATATCGATGAACACGACTGTGAGCCGTTGGACCCTCAAGCAGGAGACTCGAACCAACATGGTGCTGGAGCTCGTAAGGTCACTTTTGAATAGGATGGACTTTGAAGACTTGGGGTTGGTAGTAGATTGGGACCACCACCTGCCTCCACCGGCTGCCAAGATTGTGGTTGAGAACCTCTCCAGGACAGTCATCAGAGGCTCTCAAGGCTGAGCTCAAGTGCCCCGTGTATCTTTTGGAATCTGAGGAGGAGACTGCCATTGAGATGCTTCCCAACACCTTTTTCATTCCAGTTGCATTCTGCCCTGGCTAAGCAAGACAAATTCCTGTCCCTTGTGCCGCCATGAGCTGCCCACTGATGACTACACTTATGAGGAACACAGACGAGATAAGGCTCGAAAACAGCAGCAGCAGCAGAACCGACTGGAGAACCTCCATGGAGCCATGTACACGTGAGGAGGCTGGGGCTGAGCGCCGGTCCTCTGTGTCTTCCCTACAAACCTTGAATCCTCATTAAAATTTCTTTACCC
>NM_016494.4
GTCAGAAGGCTGGGCAGCCATGGCGTCCTATTTCGATGAACACGACTGCGAGCCGTCGGACCCTGAGCAGGAGACGCGAACCAACATGCTGCTGGAGCTCGCAAGGTCACTTTTCAATAGGATGGACTTTGAAGACTTGGGGTTGGTAGTAGATTGGGACCACCACCTGCCTCCACCAGCTGCCAAGACTGTGGTTGAGAACCTCCCCAGGACAGTCATCAGAGGCTCTCAGGCTGAGCTCAAGTGCCCCGTGTGTCTTTTGGAATTTGAGGAGGAGGAGACTGCCATTGAGATGCCTTGCCATCACCTTTTCCATTCCAGCTGCATTCTGCCCTGGCTAAGCAAGACAAATTCCTGTCCCTTGTGCCGCTATGAGCTGCCCACTGATGACGACACTTATGAGGAGCACAGACGAGATAAGGCTCGAAAACAGCAGCAGCAACACCGACTGGAGAACCTCCATGGAGCCATGTACACGTGAGGAGGTTGGGGCTGAGTGCTGGCCCTCTGCGTCTTCCTTATTAACCTTGAATCCTCATTAAAGGTTTCTTTACCCACCCTGAGGCTGTATTGATCACAGACCTGGCCAGGGGCTCTGCATCCTCCATCAGGTCTCTACTTCTGTTGGGGAAGGTGATCCTAAATCGCAGAAGGCACCAGGCTGCGGTTTTCCTCCCTGCTGGCC

Publications

PMID - Link Title
No publications available for this retrocopy