Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DCAF13P1
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Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:106125342-106127889  UCSC
Coordinates (T2T) chr7:107440762-107443306  UCSC
Coordinates (hg19) chr7:105765788-105768335  UCSC
Strand +
Parental Sequence NM_015420.7
Parental seq. overlap 1769 bp
Parental seq. overlap (%) 88.9%
Genomic Region Intergenic
Retrocopy Summary DCAF13P1, located on chr7:106125342-106127889, is a retrocopy of the parental gene DCAF13. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DCAF13
Full Name DDB1 and CUL4 associated factor 13
Also known as GM83|HSPC064|Sof1|WDSOF1
Coordinate chr8:103415386-103443453
Strand +
Gene summary Enables estrogen receptor binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla DCAF13P1
Orangutan Pongo abelii DCAF13P1
Gibbon Nomascus leucogenys DCAF13P2
Green monkey Chlorocebus sabaeus DCAF13P1
Crab-eating macaque Macaca fascicularis DCAF13P1
Rhesus Macaca mulatta DCAF13P1
Baboon Papio anubis DCAF13P1
Golden snub-nosed monkey Rhinopithecus roxellana DCAF13P2
Marmoset Callithrix jacchus DCAF13P3
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.20.4
log10(TPM+1)

Related Sequence

>DCAF13P1
TGTGGAGTCTGGCAGGAAGAGCAACGAAGGTGAAGGTGAAGACATTGAGCTGGAATCCGGACAACTATGTCCGCAAAACCAAGTTGGACTTACAGATTATTCCAAGAAACTGTGATCCTACCTTACATCCTTTTGAGGTCCTGCAAGAATGTGTAAGAGTTTTAAATGCTACCAAACTGGAAGGAGTATTTGCAAAACCATGCCTGGCTTGGCTGGATGGTCACGAGATGGAGTGAGTTGCTTGGCAAAGCATCCAAAGATCCTGGCTACTCTCCTTTCTAGGGGATGTGATGGAGCAGTTAGAATTTGGAACCTGACTCAGCTGAAATGTATCCGTATAATACAAGCACATGAAGGTTTTGTACAGGGAATACGTGCTCACTTTTGTGGGACTTCTTTTTTCACTGTTGGTGATGACAAAACTGTGAAGCAGTGGAAAATGGATGGGCCAGGCTACGGAGAGGAGGAAGGGCCATTACATACAATATTAGGAAAGACAGTGTATACTGGGATTGATCATCACTGGAAAGAAGCTGTTTTTGCCACATGTGGACAGCAAGTAGACATTTGGGATGAACAAATAACTAATCCTATAAGTTCAATGACCTGGAGATTTGACAGTATAAGTAGTGGTAAATTTAATGCAATTGAGACATTTATCTTGGGAAGTTGTGCTTCCGACAGGACTACAGTACTGTATGATATGAGGCAAGCTACTCCTCTGAAAAAGGTTATCTTAGATATGAGAACAAATACAGTCTGTTGAAACCCTATGGAAGCTTTCATTTTTATGGCAGCAAATGATGATTATAACTTATTTACTTTTGATATGCGTGCACTCATGTAATGGTCCATATGGATCATGTATCTGCAGTGCTTGATGTGGATTACTCTCCCACTGGGAAAGAGTTTGTGTCTGCTAGTTTCAATAAATCTATTTGAATCTTTCCTGTAGATAAAAGTCAAAGCAGGGAGGTATATCACACAAAGTGAAAGCAACATGTTATGTGTGTAAAATGGACTTCTGACAGCAAGTATATTATGTATGGATCTGATGAAATGAACAGTTACCTATGGAAAGCTAATGCTTCTGCAAAATTTGGTATGCTTACATCACAAGAAAAAGCAGCCAAGTATTATAACCAGAAACTGAAGGAGAAATTTCAGCGTCATCCTCATATACAACCGATAGCTCGTCATTGACATCTACCAAATTCTGTCTACAGCCCAATTCAGGAACAGTGCATCATGAAAGAAGCTTGTCGATGAGAGGAAGTGAATCACGTTAAACACAGCAAGCCTGGATCTGTGCCAATTGTGTCAGAGAAGAAGAAACACATAGTGGCAGTTGTAAAATAATATTTGGTATTCCTAACAATCCTGATGTATAATTAGTTGTTACTTTGATTTGAGAACTCTACAAATAAAAGTGCTGGGACTAGATTAATGGTAAACATTTCAGTTATGTATGTAGAGCTTTATTGTTGCTCCTTTTAGCTACCCTGATAAATGATTCTTAAAGGTGGCCTAGTTGATAAGACTGTCGTTTTATCCTTAATCTGTGTTCTTCTTTCATTGAAGGATACAGTACTTACAGTACTAGAAACTAACTCAcTTTTTTCCTTTACAGATATACTTACTTTCTCTCTGATCTATTATTGTAGACACTGTACATTCAAATTGACATTTAAGACCCAACATTTCTTCTGATACCTTTAATATTACTTTGAAAATGATTGCAATGATGTTTCTTCCTATGATTCCACATAACATTTAGAAGAATGATGTCAACTGCTTATAACTGAATTTATTTCTAGTGCTTTATTTTTATTTGGCTTTTTGACTCTTTCAAAACAATCAACCTGCATTTATATAACTTTTATAAATAATATTATAATTTGGGTCAAGTTAAGATAATAAAACTTCCTTTCACCATTGAAA
>NM_015420.7
GTGGCGGTGGGCGGAACTCCTAGCGGACACCTCGTGGAGTCCGGCCGGAAGAGCAACCGAGATGAAGGTGAAGATGCTGAGCCGGAATCCGGACAATTATGTCCGCGAAACCAAGTTGGACTTACAGAGAGTTCCAAGAAACTATGATCCTGCTTTACATCCTTTTGAGGTCCCACGAGAATATATAAGAGCTTTAAATGCTACCAAACTGGAACGAGTATTTGCAAAACCATTCCTTGCTTCGCTGGATGGTCACCGTGATGGAGTCAATTGCTTGGCAAAGCATCCAGAGAAGCTGGCTACTGTCCTTTCTGGGGCGTGTGATGGAGAGGTTAGAATTTGGAATCTAACTCAGCGGAATTGTATCCGTACAATACAAGCACATGAAGGCTTTGTACGAGGAATATGTACTCGCTTTTGTGGGACTTCTTTTTTCACTGTTGGTGATGACAAAACTGTGAAGCAGTGGAAAATGGATGGGCCAGGCTATGGAGACGAGGAAGAGCCATTACATACAATATTAGGAAAGACAGTGTATACTGGGATTGATCATCACTGGAAAGAAGCTGTTTTTGCCACATGTGGACAGCAAGTAGACATTTGGGATGAACAAAGAACTAATCCTATATGTTCAATGACCTGGGGATTTGACAGTATAAGTAGTGTTAAATTTAACCCAATTGAGACATTTCTCTTGGGAAGTTGTGCATCTGACAGGAATATAGTACTGTACGATATGAGGCAAGCTACTCCTTTGAAAAAGGTTATCTTAGATATGAGAACAAATACAATCTGTTGGAACCCTATGGAAGCTTTCATTTTTACAGCAGCAAATGAAGATTATAACTTATATACTTTTGATATGCGTGCACTGGACACTCCTGTAATGGTCCATATGGATCATGTATCTGCAGTGCTTGATGTGGATTACTCTCCCACTGGGAAGGAGTTTGTGTCTGCTAGTTTCGATAAATCTATTCGAATCTTTCCTGTAGACAAAAGTCGAAGCAGGGAGGTATATCATACAAAGAGAATGCAACATGTTATCTGTGTAAAATGGACTTCTGACAGCAAGTATATTATGTGTGGATCTGATGAAATGAACATTCGCCTGTGGAAAGCTAATGCTTCTGAAAAATTGGGTGTGCTTACATCACGAGAAAAAGCAGCCAAGGATTATAACCAGAAATTGAAGGAGAAATTTCAGCATTATCCTCATATAAAACGTATAGCTCGTCATCGACATCTACCAAAATCTATCTATAGCCAGATTCAGGAACAGCGCATCATGAAAGAAGCTCGTCGACGAAAGGAAGTGAATCGTATTAAACACAGCAAGCCTGGATCTGTGCCACTTGTGTCAGAGAAGAAGAAACACGTAGTGGCAGTTGTAAAATAATTGGTATTCCTAACAATCCTGATGTATAATTATTTGTTACTTTTGATTTGAGAACTCTACAAATAAAAGTGCTGGGACTAGATTAATTGCAAACATTTTAGTTATATGTGTAGAGCTTTATTGTTACTCCTTTTAGCTACCCTGAAAAATGATCCTTAAAGGTGGCCTAGTTGGTAAGACTGTTTTATCCTTAATCTGCATTCTTCTTTCATTGTAGAATACAGTATTTGCAACTCATTTTTTCTTGTTTTTATTACAGATATACTTACTTTCTCTTTGATCTATTATTGTAGACACTATACATTCAAATTGACATTTAAGACCAAACATCTCTTATGTTATCTTTAATATTACTTTGAATAATGATTGCAATGATGTTTCTTCCTGTGATTCCACATAACATTTAGAATAATGATGTCAATTTTTTACAACTGAATTTATTTCTAGTGCTTTACTTATATTTGGCTTTTTGACTCTTTTAAAACAATCAGCCTGCATTTATATAACTTTTATAAATAATAATATAATTTGGGTCAAGTTAAGATATTAAAAGTTCCTTTCAGCATTGAAA

Publications

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