RCPedia: Rtcs

Summary

Retrocopy Name	RPL37AP11	Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr7:107450131-107450419 UCSC
Coordinates (T2T)	chr7:108766169-108766457 UCSC
Coordinates (hg19)	chr7:107090576-107090864 UCSC
Strand	+
Parental Sequence	NM_000998.5
Parental seq. overlap	244 bp
Parental seq. overlap (%)	8.1%
Genomic Region	Intragenic (COG5)
Retrocopy Summary	RPL37AP11, located on chr7:107450131-107450419, is a retrocopy of the parental gene RPL37A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	RPL37A
Full Name	ribosomal protein L37a
Also known as	L37A
Coordinate	chr2:216498844-216504086
Strand	+
Gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	RPL37AP3
Bonobo	Pan paniscus	RPL37AP4
Gorilla	Gorilla gorilla	RPL37AP4
Orangutan	Pongo abelii	RPL37AP4
Gibbon	Nomascus leucogenys	RPL37AP5
Green monkey	Chlorocebus sabaeus	RPL37AP11
Crab-eating macaque	Macaca fascicularis	RPL37AP2
Rhesus	Macaca mulatta	RPL37AP2
Baboon	Papio anubis	RPL37AP8
Golden snub-nosed monkey	Rhinopithecus roxellana	RPL37AP5
Marmoset	Callithrix jacchus	RPL37AP8
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>RPL37AP11
TGCTATGGTGCCTCCCTCTGGAAAACACTGAAGAAAACTGAAATCAGCCATCCTGCCAAGTACACTTGCTCCTTCTGTGGCTAAACCAAGATGAAGAAACAAGCAGTTAGGGATCTTACACTGTGGTTCCTACATGAAAACAGTAGCTGATGGTGCCTGGATCTACAATGCCACTTCCACCAACATGGCAAAGATGGCCATCAGAAGACTGAAGAAATTGAAAGGCCAGTAGAAGCTCTATCATTTGAGACAACACTAGCCTAGAATAAAGGTTTAATTTATGTAACAA

>NM_000998.5
CTTTCTGGGCTCGGACCTAGGTCGCGGCGACATGGCCAAACGTACCAAGAAAGTCGGGATCGTCGGTAAATACGGGACCCGCTATGGGGCCTCCCTCCGGAAAATGGTGAAGAAAATTGAAATCAGCCAGCACGCCAAGTACACTTGCTCTTTCTGTGGCAAAACCAAGATGAAGAGACGAGCTGTGGGGATCTGGCACTGTGGTTCCTGCATGAAGACAGTGGCTGGCGGTGCCTGGACGTACAATACCACTTCCGCTGTCACGGTAAAGTCCGCCATCAGAAGACTGAAGGAGTTGAAAGACCAGTAGACGCTCCTCTACTCTTTGAGACATCACTGGCCTATAATAAATGGGTTAATTTATGTAACAAAATTGCCTTGGCTTGTTAACTTTATTAGACATTCTGATGTTTGCATTGTGTAAATACTGTTGTATTGGAAAAGCATGCCAAGATGGATTATTGTAATTCAGTGTCTTTTTTAGTAGTCAAATGGTAAAATGCAGCATAAGAATATAAGTCTTCCAAGTTAGATATGAGTGTTAGCTTTTTATAAGTCTGCTCCTGCCAGTTTGACTTTGAGATACATTGGAGCCAACTGTAAACTTTAGTTTTTAAATTACAGTTAGtttttttgtttgtttttgaggcggagtctctgttacccaggctggagtgcagtataccagtcttggcccacttcaacctccacttcttaggttcaagcgattctcctgcctcagcctcctgagtagctgggattacaggcacgcaccaccatacctggctaatttttgtattttgagtagagatggagttttcaccacattggccaggctgttcttgaactgacctcaagcgatccacctgccttggccttccagagtgctgggattacaggtgtgagccaccacgcccagccTTGCATTTAATATTTTTATAATGTGTCTAggctgggtgcggtgactcacgcctgaaatcccagcactttgggtggctgaggcaggtggattacttgaggccaggagattgagaccagtgtggccaacatagcaaaaacccgtctcgacgaaaaatacaaaaaatagcttggtatggtggcacatgcctgtaatcccagctactttggaggctcaggcacaagaatcacttgaacctacgaggcggaggttgcagtgggccaggatcgtgccactgcactttatttagccaggacaacactctgtctccaaaaaaaaGTTTCTGAAGGTAAAAGATATACTAAAGGATATACATATACTGCCTCTTCTATGATGTTTCATTTGACCTACACCATCAGCATCTTCAGGAAACAGTATGAAACTAATTTCACATTAAATGTTGCAAACGTCTGCAATTCTCCAGTTTTTAGTTTGCACGTAAGGATTCGTAGGATTGATTTCAGATTGACAGATGGTTGTAGTAACAAAAAAATGAATTGCCTTGGAGAATTCGAGTTATTTTAGGCCTGCCTTTGACACTTTTATGCACTTAATTCACTGCCAATTTAGTCTAACTCCTCAACCATCTGTGGTATGGACTTCTCAGTCCTCCTAATTGGTATGTCTTTTATCTATCCCAGAGTCAGTAGTCCTTTAAGGATGCAAATTTAATTCGATAAGAATGTGGATTTACTTCATCTTTAGGACAGAGTAAAAACCTTTATTTCACTTGGTCTGACCCCTATCTTCTATAACTTGTTTTTTTGCTCATTACTGGCCTTTGCACGGATGTCTCCCTTCACCTGTACCTCCTGCATTGCCTCTGGCAGAAACATCGCTACCCCAGGAGAATACTTCACTGGGTCAGGCATTTGCTAGATCCATAGCAGTAACTCATCTGTGGATCTCATTTGTGTCACAAAATGGTACTCCTACTGATTTTGTAATGTGAAGCAAGTACTGTGGGTCAGTAGGGGTAGGACCAGGAGTGACAAGTCAGGATTTTCAGGCTTCATAGGAATGACACAGCTCTCCAGGTGAATCTCCTGGAGAATTCTCCATAGGATCTCCAGGTGAGTGACCAGGATTTCATGTAAGCATAGGGAATTGAATGAGCATTAGATGGTCTAATGCTgcggttaagaacaccaacttagccaaactgcctagatagttgggtgacttgggttaagtgacttaacctctctgcttcagtttcctGTATAATTCTTGGTAGTAGAATGGAGTATATGCTGGGTGTTTGGATTATTAATTTGGAGTCTTACAAAGCTGCTATGTTACATGATTAGGCATGGAAAACTTCGGTTTTTATAATCAGTGAAGTACTGCtttttgtttgttttctgagagagtgtctgtcacccaggctgaagtgcagtggcatgatctcagttcactgcagcctctacctcccgggttcaagcagttctcgtgcctcagcctccgaagtagctgggattacaggcttatgccacaaagctcagctagtttttgtattttttatttttagtagagatgggctttcgccatgttgaccaggctggtctcaaactcccaggctcaactgataacgtctgccttggcctcccaaagtgctgggattctgtaagccacctcacccagccATGTATTGCTTTTTTATGACAGTTAAAAGAGGAAAGGGCGGGGGACAGTTTACAGACCAGTGAAAGTGCTGAGATAAATATTTTTATAcctaaggaaatagtgattttcccaagatgatagggaggcaggtgatgtagatagggctgaagattagatttctggctcctatctgtgattttctgctgtaccagtctgccTTCTATTTTATGGGCTCAGTATTCCTTACCTGCCTCTTCCCATGCTAAAGATGGCCCACCTTCGTTTTGTTATTTAAGCAACTTCATCCCCTGGCTTGTTTTCACAGTGGTTTTCTGAGCCTTTGACTCTAAGTCATCTAATTGAACATTGTGTTGTGATATAAAAAGTAAGTTAGGCTTGTGTTTTTCA

>NM_000998.5 

CTTTCTGGGCTCGGACCTAGGTCGCGGCGACATGGCCAAACGTACCAAGAAAGTCGGGATCGTCGGTAAATACGGGACCCGCTATGGGGCCTCCCTCCGGAAAATGGTGAAGAAAATTGAAATCAGCCAGCACGCCAAGTACACTTGCTCTTTCTGTGGCAAAACCAAGATGAAGAGACGAGCTGTGGGGATCTGGCACTGTGGTTCCTGCATGAAGACAGTGGCTGGCGGTGCCTGGACGTACAATACCACTTCCGCTGTCACGGTAAAGTCCGCCATCAGAAGACTGAAGGAGTTGAAAGACCAGTAGACGCTCCTCTACTCTTTGAGACATCACTGGCCTATAATAAATGGGTTAATTTATGTAACAAAATTGCCTTGGCTTGTTAACTTTATTAGACATTCTGATGTTTGCATTGTGTAAATACTGTTGTATTGGAAAAGCATGCCAAGATGGATTATTGTAATTCAGTGTCTTTTTTAGTAGTCAAATGGTAAAATGCAGCATAAGAATATAAGTCTTCCAAGTTAGATATGAGTGTTAGCTTTTTATAAGTCTGCTCCTGCCAGTTTGACTTTGAGATACATTGGAGCCAACTGTAAACTTTAGTTTTTAAATTACAGTTAGtttttttgtttgtttttgaggcggagtctctgttacccaggctggagtgcagtataccagtcttggcccacttcaacctccacttcttaggttcaagcgattctcctgcctcagcctcctgagtagctgggattacaggcacgcaccaccatacctggctaatttttgtattttgagtagagatggagttttcaccacattggccaggctgttcttgaactgacctcaagcgatccacctgccttggccttccagagtgctgggattacaggtgtgagccaccacgcccagccTTGCATTTAATATTTTTATAATGTGTCTAggctgggtgcggtgactcacgcctgaaatcccagcactttgggtggctgaggcaggtggattacttgaggccaggagattgagaccagtgtggccaacatagcaaaaacccgtctcgacgaaaaatacaaaaaatagcttggtatggtggcacatgcctgtaatcccagctactttggaggctcaggcacaagaatcacttgaacctacgaggcggaggttgcagtgggccaggatcgtgccactgcactttatttagccaggacaacactctgtctccaaaaaaaaGTTTCTGAAGGTAAAAGATATACTAAAGGATATACATATACTGCCTCTTCTATGATGTTTCATTTGACCTACACCATCAGCATCTTCAGGAAACAGTATGAAACTAATTTCACATTAAATGTTGCAAACGTCTGCAATTCTCCAGTTTTTAGTTTGCACGTAAGGATTCGTAGGATTGATTTCAGATTGACAGATGGTTGTAGTAACAAAAAAATGAATTGCCTTGGAGAATTCGAGTTATTTTAGGCCTGCCTTTGACACTTTTATGCACTTAATTCACTGCCAATTTAGTCTAACTCCTCAACCATCTGTGGTATGGACTTCTCAGTCCTCCTAATTGGTATGTCTTTTATCTATCCCAGAGTCAGTAGTCCTTTAAGGATGCAAATTTAATTCGATAAGAATGTGGATTTACTTCATCTTTAGGACAGAGTAAAAACCTTTATTTCACTTGGTCTGACCCCTATCTTCTATAACTTGTTTTTTTGCTCATTACTGGCCTTTGCACGGATGTCTCCCTTCACCTGTACCTCCTGCATTGCCTCTGGCAGAAACATCGCTACCCCAGGAGAATACTTCACTGGGTCAGGCATTTGCTAGATCCATAGCAGTAACTCATCTGTGGATCTCATTTGTGTCACAAAATGGTACTCCTACTGATTTTGTAATGTGAAGCAAGTACTGTGGGTCAGTAGGGGTAGGACCAGGAGTGACAAGTCAGGATTTTCAGGCTTCATAGGAATGACACAGCTCTCCAGGTGAATCTCCTGGAGAATTCTCCATAGGATCTCCAGGTGAGTGACCAGGATTTCATGTAAGCATAGGGAATTGAATGAGCATTAGATGGTCTAATGCTgcggttaagaacaccaacttagccaaactgcctagatagttgggtgacttgggttaagtgacttaacctctctgcttcagtttcctGTATAATTCTTGGTAGTAGAATGGAGTATATGCTGGGTGTTTGGATTATTAATTTGGAGTCTTACAAAGCTGCTATGTTACATGATTAGGCATGGAAAACTTCGGTTTTTATAATCAGTGAAGTACTGCtttttgtttgttttctgagagagtgtctgtcacccaggctgaagtgcagtggcatgatctcagttcactgcagcctctacctcccgggttcaagcagttctcgtgcctcagcctccgaagtagctgggattacaggcttatgccacaaagctcagctagtttttgtattttttatttttagtagagatgggctttcgccatgttgaccaggctggtctcaaactcccaggctcaactgataacgtctgccttggcctcccaaagtgctgggattctgtaagccacctcacccagccATGTATTGCTTTTTTATGACAGTTAAAAGAGGAAAGGGCGGGGGACAGTTTACAGACCAGTGAAAGTGCTGAGATAAATATTTTTATAcctaaggaaatagtgattttcccaagatgatagggaggcaggtgatgtagatagggctgaagattagatttctggctcctatctgtgattttctgctgtaccagtctgccTTCTATTTTATGGGCTCAGTATTCCTTACCTGCCTCTTCCCATGCTAAAGATGGCCCACCTTCGTTTTGTTATTTAAGCAACTTCATCCCCTGGCTTGTTTTCACAGTGGTTTTCTGAGCCTTTGACTCTAAGTCATCTAATTGAACATTGTGTTGTGATATAAAAAGTAAGTTAGGCTTGTGTTTTTCA

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