Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BUB3P1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:108993747-108994861  UCSC
Coordinates (T2T) chr7:110318227-110319341  UCSC
Coordinates (hg19) chr7:108633804-108634918  UCSC
Strand -
Parental Sequence NM_001007793.3
Parental seq. overlap 687 bp
Parental seq. overlap (%) 41.3%
Genomic Region Intergenic
Retrocopy Summary BUB3P1, located on chr7:108993747-108994861, is a retrocopy of the parental gene BUB3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BUB3
Full Name BUB3 mitotic checkpoint protein
Also known as BUB3L|hBUB3
Coordinate chr10:123154402-123170467
Strand +
Gene summary This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BUB3P2
Bonobo Pan paniscus BUB3P2
Gorilla Gorilla gorilla BUB3P2
Orangutan Pongo abelii BUB3P2
Gibbon Nomascus leucogenys BUB3P2
Green monkey Chlorocebus sabaeus BUB3P2
Crab-eating macaque Macaca fascicularis BUB3P1
Rhesus Macaca mulatta BUB3P1
Baboon Papio anubis BUB3P1
Golden snub-nosed monkey Rhinopithecus roxellana BUB3P2
Marmoset Callithrix jacchus BUB3P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BUB3P1
AACTGTGCCAGTTCCATTGGTACCCCATAAGCATTGCATCACTTGCCTTCAGTAATGATGGGACTACGCTTGCAATAGCATCATCATATATTATGAAATGGATGACACGGAACATCCTGAAGATGGTATCTTCATTCACCAAGTGACAGAGGCAGAAACAAAACCCAAGTGCACCTAATCATCTCGTGAAAGTGGTTTCTCTATGGAAAGCTTTGTTTGCTTCCGACAAATACATGCTTATTCCTTAAGGGATGTGTTATAGTGACTGTGGAGTTCTCTGTTTTCTGTCTTGTAAGAACCTTGTCTATGTACCTTAATACTTTGTTTAGGATGAGGAGTCTTTCTGTCCTTATGCAGTAATCTGAAGAATTCCCCCTTCTATCCCTTAGCAAGCTCAGTCGCTGCATAAGAACAATTTGAGCTCTTTTTGTAATATAATCTAAACCTGTTATTTCTGTGCTGTCCATGCGCTCAGGTACCAGCACACTGGCACCATCCTGGACTGAGCCTTCTACGATCCAGCACAGGCCTGGAGAGGACTAGATCATCAATTGAAAATGCATGATTTGAACACTGATCAAGAAAATCTTGTTGGGACCCATGATGCCCCCATCAGATGTATTGAATACTGTCCGGAAGTGAACGTGATGGTTACTGGAAGTTGGGATCAGACAGTTAAATTGTGGGATCCCAGAAATCCTTGTAATGCCAGGACCTTCTCTCAGCCTGAAAAGGTAGATACCTTCTCAGTGCCTGGAGACCAGCTGATTGTGAGAACAGCGGGCTGCAGAGTGTTGGTGTGGGGCTTATGGAACATGGATTACGTGCAGCAGAGCAGGGAGTCCAGCCTGAAATACCAGACTCACTGCATATAAGCGTTTCCAAACAAGCAGAGTTGTGTATTAAGCTCTATAGAAGGCGGAGTGGCAGTTGAATACTTGGCCCAAGCCCTGAGGTACAGAAGAAATATGCCTTCAAATGTCACAGACTAAAAGAAAATAATATTGAGCAGGTTTACCCAGTCAATGCCATTTCTTTCCAGAATATCCAt
>NM_001007793.3
GAGTGTTCTGAGGGAAGCAAGGAGGCGGCGGCGGCCGCAGCGAGTGGCGAGTAGTGGAAACGTTGCTTCTGAGGGGAGCCCAAGATGACCGGTTCTAACGAGTTCAAGCTGAACCAGCCACCCGAGGATGGCATCTCCTCCGTGAAGTTCAGCCCCAACACCTCCCAGTTCCTGCTTGTCTCCTCCTGGGACACGTCCGTGCGTCTCTACGATGTGCCGGCCAACTCCATGCGGCTCAAGTACCAGCACACCGGCGCCGTCCTGGACTGCGCCTTCTACGATCCAACGCATGCCTGGAGTGGAGGACTAGATCATCAATTGAAAATGCATGATTTGAACACTGATCAAGAAAATCTTGTTGGGACCCATGATGCCCCTATCAGATGTGTTGAATACTGTCCAGAAGTGAATGTGATGGTCACTGGAAGTTGGGATCAGACAGTTAAACTGTGGGATCCCAGAACTCCTTGTAATGCTGGGACCTTCTCTCAGCCTGAAAAGGTATATACCCTCTCAGTGTCTGGAGACCGGCTGATTGTGGGAACAGCAGGCCGCAGAGTGTTGGTGTGGGACTTACGGAACATGGGTTACGTGCAGCAGCGCAGGGAGTCCAGCCTGAAATACCAGACTCGCTGCATACGAGCGTTTCCAAACAAGCAGGGTTATGTATTAAGCTCTATTGAAGGCCGAGTGGCAGTTGAGTATTTGGACCCAAGCCCTGAGGTACAGAAGAAGAAGTATGCCTTCAAATGTCACAGACTAAAAGAAAATAATATTGAGCAGATTTACCCAGTCAATGCCATTTCTTTTCACAATATCCACAATACATTTGCCACAGgtggttctgatggctttgtaaatatttgggatccatttaacaaaaagcGACTGTGCCAATTCCATCGGTACCCCACGAGCATCGCATCACTTGCCTTCAGTAATGATGGGACTACGCTTGCAATAGCGTCATCATATATGTATGAAATGGATGACACAGAACATCCTGAAGATGGTATCTTCATTCGCCAAGTGACAGATGCAGAAACAAAACCCAAGTCCACCTAATCATCCTGTGAAAGTGGTTTCTCTATGGAAAGCTTTGTTTGCTTCCTACAAATACATGCTTATTCCTTAAGGGATGTGTTAGAGTTACTGTGGATTTCTCTGTTTTCTGTCTTACAAGAAACTTGTCTATGTACCTTAATACTTTGTTTAGGATGAGGAGTCTTTGTGTCCCTGTACAGTAGTCTGACGTATTTCCCCTTCTGTCCCCTAGTAAGCCCAGTTGCTGTATCTGAACAGTTTGAGCTCTTTTTGTAATATACTCTAAACCTGTTATTTCTGTGCTAATAAACGAGATGCAGAACCCTTGAA

Publications

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