Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TPM3P1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:116970896-116972979  UCSC
Coordinates (T2T) chr7:118286045-118288130  UCSC
Coordinates (hg19) chr7:116610950-116613033  UCSC
Strand -
Parental Sequence NM_153649.4
Parental seq. overlap 1432 bp
Parental seq. overlap (%) 41.1%
Genomic Region Intragenic (LRP12)
Intragenic (ST7)
Retrocopy Summary TPM3P1, located on chr7:116970896-116972979, is a retrocopy of the parental gene TPM3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TPM3
Full Name tropomyosin 3
Also known as CAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30
Coordinate chr1:154155308-154192100
Strand -
Gene summary This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TPM3P3
Bonobo Pan paniscus TPM3P3
Gorilla Gorilla gorilla TPM3P3
Orangutan Pongo abelii TPM3P3
Gibbon Nomascus leucogenys TPM3P4
Green monkey Chlorocebus sabaeus TPM3P8
Crab-eating macaque Macaca fascicularis TPM3P1
Rhesus Macaca mulatta TPM3P1
Baboon Papio anubis TPM3P1
Golden snub-nosed monkey Rhinopithecus roxellana TPM3P3
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TPM3P1
CATTAGAATTGACCAAATCAGGATGTAAGAACTCTGAGACCAAATTTTTGTCCCATCTCTACCCCCTCCCAACTGCTTACAGAATGGATCATGTGACCCTTATGTTGAGGTGACCACTTAATTGCTTTCCTGCCTCCTTGAAAGAAAGATGATTATGTTTTTGCCACTGATTCAGCCATGTGAAACTCATTACCCTTTTCTGGGTTTGAAGCTGCTGTCTCTAAAAGTGCCATCTCATTGTGCTTTGTATCAGTCAGTGCTGCAGAAATCTTGAATAGCTTATGTACAAAACTTTTTAAATTTTATATTATTTTTAAACTTTGCTTCTTTGGGTTTGTGACACCCTGGCCATCCCACCTGGCTGTGACAGCCTCTGCACTCTGTGGGCTGGCAGTTTACTGATTTTTTAAAGTTTCTTTCCCTACCGAGTCCCCATTTTCTGGTAAGGTTTCTAGGAGGTCTGTTAGGTGTACATCCTGCAGCTTACTGGCTTAAAATGTACTCTCCTTTGATGTGGTCTCTTTGGGTCCAATTGGGAGAAAGAGAAATCAATAGTGCAACTGTTTTGATACTGAATATTGACAAATGTCTTTTTGAAATAAAGAACCAGTCCCTCCAAAGCACCAAAGGACAGCGCCTCTGTACACAAAAGATGCTGGTCCAGACTCTGCTTGACCTGAATGAGATGTAGAAAGCCCAGTCCCACCCTGCTGCTGCTCCTCCCTCTGACCCTGACTCTGCCTGAGGCCAGCCTGCCTGAAGCTGACCTTTAACTGAGGACTGATCTTTAACTGGAAGGCTGCTTTCCGCTTTTGCCTCCCGCTCCTCCCCTGTGTCTTTTTCCCCAAACTGTCTCTGCCTCTTCCCGGAGATTCCAGCTGGGCTAGAGGCTGAGCACCTTTGGAAACAACATTTAAGGGAATGTGAGCACAATGCATAATGTCTTTAAAAGGCATATTGTGATGTACACATTTGTGATTACCTTTTTTGTTGCTTTGTAGCAACCATTTGTAAAACATTCCAAGTAATTCCACAGCCCTGAAGCAGCAATCTAATCCTTTTCTCACTTTTGGAAGGTGACTTTTCAGCTTAATGCATATTGCCCGCTCCATAGAGAAGAAAAGGTATAGGCCTGCCTTACTGAGAGCCAAACAGAGCCCAGGGAAAGACTCCACTATTGGAAACCTCATTGCTCTGTACAAAGTACCAGCTAAACCAGAAAGGTGATTCCAGGAGGAGTTAGCCAAATAACAACAAAAACAAACAAAAATGTGCTGTTCAAGTTTTCAGCTTTAATATACCTTTGGACAACATGCAACACCAAGCAGAGGAGGCAGGAATCGGAGTGCGAGCAGTAGCTGAGTGGGCACCATGGCTGGGATCACCACCATCGAGGCGGTTAAGGGCAATATCCAGGTTCTGCAGCAGCAGGCAGATGATGCAGAGGAGCGAGCTGATCGTCTCCAGTGAGAAGTTGAGGGAGAAAGGTGTTCCCAGGAACAGGCTGAGGCTGAGGTGGCCTCCTTGAACCGTAGGATCCAGCTGGTTCATGAGAAGCTGGACTGTGCTCAGGAGCGCCCAGCCACTGCCCTGCAAAAGCTGGAAGAAGCGGAAAAAACTGCTGATGAGAGTGAGAGAGGTATGAAGTTTATTGAAAACCAGCCCTTAAAAGATGAAGAAAAGATGGAACTCCAGGAAATTCAACTCAAAGAAGCTAAGCACATTGCAGAAGAGGCAAATAGGAAATATGAAGAGGTAGCTCATAAGTTGGTGATCATTGAAAGAGACTTGGAACGCACAGAGGAACAAACTGAGCTGGCAGAGTACCGTTGCCGAGAGATGGATGAGCAGATCAGACTGATGGACCAGAATCTGAAGTGTCTGAGTCCTGCTGAAGAAAAGTACTCTCAAAAAGAAGACAAATATGAGAAAGAGATCAAGATTCTTACTGATAAATTCAAGGAGGGAGAGGCCCGTGATGGGTTTGCTGAGAGATCGGTAGCCAA
>NM_153649.4
ATTTCAGGGCGTAGCAGGCGGAAGTAAGGGTGAGAGGAGGCTGCAACGCCGAGCGGAGGAGGCAGGAACCGGAGCGCGAGCAGTAGCTGGGTGGGCACCATGGCTGGGATCACCACCATCGAGGCGGTGAAGCGCAAGATCCAGGTTCTGCAGCAGCAGGCAGATGATGCAGAGGAGCGAGCTGAGCGCCTCCAGCGAGAAGTTGAGGGAGAAAGGCGGGCCCGGGAACAGGCTGAGGCTGAGGTGGCCTCCTTGAACCGTAGGATCCAGCTGGTTGAAGAAGAGCTGGACCGTGCTCAGGAGCGCCTGGCCACTGCCCTGCAAAAGCTGGAAGAAGCTGAAAAAGCTGCTGATGAGAGTGAGAGAGGTATGAAGGTTATTGAAAACCGGGCCTTAAAAGATGAAGAAAAGATGGAACTCCAGGAAATCCAACTCAAAGAAGCTAAGCACATTGCAGAAGAGGCAGATAGGAAGTATGAAGAGGTGGCTCGTAAGTTGGTGATCATTGAAGGAGACTTGGAACGCACAGAGGAACGAGCTGAGCTGGCAGAGTCCCGTTGCCGAGAGATGGATGAGCAGATTAGACTGATGGACCAGAACCTGAAGTGTCTGAGTGCTGCTGAAGAAAAGTACTCTCAAAAAGAAGATAAATATGAGGAAGAAATCAAGATTCTTACTGATAAACTCAAGGAGGCAGAGACCCGTGCTGAGTTTGCTGAGAGATCGGTAGCCAAGCTGGAAAAGACAATTGATGACCTGGAAGATAAACTGAAATGCACCAAAGAGGAGCACCTCTGTACACAAAGGATGCTGGACCAGACCCTGCTTGACCTGAATGAGATGTAGAACGCCCCAGTCCCACCCTGCTGCTGCTCCTCCCTCTGACCCAGACTCCGCCTGAGGCCAGCCTGCGGGAAGCTGACCTTTAACTGAGGGCTGATCTTTAACTGGAAGGCTGCTTTCTCCTTTCACCACCCCCTCCTTCCCTGTGTCTTTTTCGCCAAACTGTCTCTGCCTCTTCCCGGAGAATCCAGCTGGGCTAGAGGCTGAGCACCTTTGGAAACAACATTTAAGGGAATGTGAGCACAATGCATAATGTCTTTAAAAAGCATGTTGTGATGTACACATTTTGTAATTACCTTTTTTGTTGTTTTGTAGCAACCATTTGTAAAACATTCCAAATAATTCCACAGTCCTGAAGCAGCAATCGAATCCCTTTCTCACTTTTGGAAGGTGACTTTTCACCTTAATGCATATTCCCCTCTCCATAGAGGAGAGGAAAAGGTGTAGGCCTGCCTTACCGAGAGCCAAACAGAGCCCAGGGAGACTCCGCTGTGGGAAACCTCATTGTTCTGTACAAAGTACTAGCTAAACCAGAAAGGTGATTCCAGGAGGAGTTAGCCAAACAACAACAAAAACAAAAAATGTGCTGTTCAAGTTTTCAGCTTTAAGATATCTTTGGATAATGTTATTTCTATTTTTTATTTTTTTCATTAGAAGTTACCAAATTAAGATGGTAAGACCTCTGAGACCAAAATTTTGTCCCATCTCTACCCCCTCACAACTGCTTACAGAATGGATCATGTCCCCCTTATGTTGAGGTGACCACTTAATTGCTTTCCTGCCTCCTTGAAAGAAAGAAAGAAAGAAGACTGTGTTTTTGCCACTGATTTAGCCATGTGAAACTCATCTCATTACCCTTTTCTGGGTTTGAAGCTGCTGTCTCTAGAAGTGCCATCTCAATTGTGCTTTGTATCAGTCAGTGCTGGAGAAATCTTGAATAGCTTATGTACAAAACTTTTTAAATTTTATATTATTTTGAAACTTTGCTTTGGGTTTGTGGCACCCTGGCCACCCCATCTGGCTGTGACAGCCTCTGCAGTCCGTGGGCTGGCAGTTTGTTGATCTTTTAAGTTTCCTTCCCTACCCAGTCCCCATTTTCTGGTAAGGTTTCTAGGAGGTCTGTTAGGTGTACATCCTGCAGCTTATTGGCTTAAAATGTACTCTCCTTTTATGTGGTCTCTTTGGGGCCGATTGGGAGAAAGAGAAATCAATAGTGCAACTGTTTTGATACTGAATATTGACAAGTGTCTTTTTGAAATAAAGAACCAGTCCCTCCAACCCTCAGACCTATTTGACTTTTATTTATTAAAACTAAATGTGCTTTCTCCACAGAAGCTATGAGGTTTGGGTTAAAAATAGCATCTTTGTGGGTGGTAGCAACAGGAtttattctttattattattatttttgagatgaagtttcattcttgttgcctgggctggagcgtaatggctcgatctcggctcactgcaacctccgcctcctggttcaagagattctcctgcctcagcctcccgagtagctgggattacaggcacctgccaccatgcccgggtaattttttatattttaagtagagacagggcttcaccatgttggccaggctggtctcgaactcctgaccttcaggtgatccacctgcctcagcttcccaaaatgctgggattacgggcgtgagccaccgcacccagcTGGAGCAACAGGATTTAATATAGAGCAAATGTTTAGTTTTATCATCTGTAAAATGGAGATAAGTATTGTCAGAGTAAACATGAAGATTAGAAAGAACACTTAATGTGCTGGGCCTTTTATAGGTTAACACTGACATCTCAGGCTGAACTATATACATTTTCCTTCACAACCATATCAATCCTTATAAACTATGGATTTATGCTCCTTAAAACAATATATAATGCTGATCACTACTATAAATGCGTGGTTTTAACCAACTGTACTGAAACAGCTTTGAGTTTATATTCTGTTTGGATATTTGGAGAAAACAACAAGTGCTCTCAAGAGTATTTGCTTAGAGGCCGGCTGTGTGAGTGGATAACTTTGAAAGCTGCTTTTGAGACGCCAGTGTCTGGCATTTCCTGCATTCTGGCCTGGAGGCCGGACGTGAATCTGACTTCTAGTAAAAATACACGGTTCCCTTGACAAAGTCGAGCTGTTTATCCCAGAGACTGCACAATTTTCCGTTGATAGGCATGGACCAATGCTAACTGGAAATCATTGCAAAAAGTTTTTTTGTCGGGCGGAGGGTGTGGTGTTAAGATAAACAGTGTGCAACAGAAGAAATTAAAACTGGAAGAAATTAAAGGGTTTTTTTTAGA

Publications

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