Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MTX2P1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:125344971-125345748  UCSC
Coordinates (T2T) chr7:126662362-126663139  UCSC
Coordinates (hg19) chr7:124985025-124985802  UCSC
Strand +
Parental Sequence NM_001006635.3
Parental seq. overlap 674 bp
Parental seq. overlap (%) 43.1%
Genomic Region Intergenic
Retrocopy Summary MTX2P1, located on chr7:125344971-125345748, is a retrocopy of the parental gene MTX2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MTX2
Full Name metaxin 2
Also known as MDPS|metaxin-2
Coordinate chr2:176269423-176338025
Strand +
Gene summary The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jun 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MTX2P1
Bonobo Pan paniscus MTX2P1
Gorilla Gorilla gorilla MTX2P1
Orangutan Pongo abelii MTX2P1
Gibbon Nomascus leucogenys MTX2P1
Green monkey Chlorocebus sabaeus MTX2P1
Crab-eating macaque Macaca fascicularis MTX2P1
Rhesus Macaca mulatta MTX2P1
Baboon Papio anubis MTX2P1
Golden snub-nosed monkey Rhinopithecus roxellana MTX2P1
Marmoset Callithrix jacchus MTX2P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MTX2P1
TTGTATCTTCAGTGGTTTGATGAAGCTAAATCTGGGAGATCACTCATTCTAGGTATGGATCTCCTTACCCTTGGCCTCTGCATCATATTTTGGCCTATCAGAAATGGTGAAAAGTCAAATGTAAGATGAAAGCTATCAGATGGCGTAAGAAAACTCTGGACCAGGTCTTAGAAGATATAGACCAGTGCTGTCAAGCTCTCTCTAAAAGTCTGGTAACACAACCATATTTTTTTAATAAGCAGCTTCCTGAATTTGATACACTGGTATTTGGCCATTTGTACACCATTCTTACCACACGATTGATGAATGATAAACTTTCTGAGGTGAAAAACTACAGCAACCTTCTTGCTCTCTGCAGAAGAATTGAAAGGCACTATTTTGACGATTGTGATAAAGGCAGATTGCCTTAAAATTATGTGTTAATTTTGTTATTATTTTCAAAAGTTTAACTTTTGAAATACGTTTTAGTTGAATGTTATATTAGATATTGGTATCAGAATTTTAAAACCAAATAACTTCCTTTTGAAACCTCAAAACAAATTATACAATGTATCCTATATATGTACTTTATATTGTTATTTGTGTACACGTTAAGATAATTCTGAATTATTTCATTTGATATGTTATATTCTATACCTCGAAAGTTTTGTTTCCTTGAAACATGCATGCATATAAAAATGAAGTTTAAACAACAGCATAGATGTTACATTTACTTTCTTTTGATCTTTCTGAAAGTCACTCACTGAATTTTACACATGTGGAATAAACAGTGTTTTTT
>NM_001006635.3
GTCCCTAGCCAGGCCTGGCGGTAACCTTGGGGGCCTCACTGCAGCCGCCGCTGCTGTTGGAGTGGGCTTTGCGAGTCTGAACGTTGGCGGGGCTAGGCTCGTTAACTGCCGAGAGCCTCCGGGTTTGCGGTGGAGGACGCTGAGGCCCGTGGGGGGCAGGCACCCGGGCGCCGGGCCTCCCAGCCGACATGTCTCTAGTGGCGGAAGCCTTCGTCTCCCAGATTGCAGgctggagtgcagtggcacaacctgggctcactgcaacctccgcttcccgggttcaagcgattctcctgccttagcctcccgagtagttgggattacaggcgcccgccaccacgcccgCGCGGATTCATGGAAAATTTTTAAATCTGCATGTACTTTAAAGAAATACTTTTGAGTCGGTGGACTGAACATGACTGATGTATATAGCTGCAGAACCTTGGCCTGAAAATGCTACATTATATCAGCAATTGAAAGGGGAGCAAATTTTACTTTCTGACAATGCAGCTTCTCTTGCAGTGCAGGCCTTTTTGCAAATGTGTAACTTGCCTATCAAAGTAGTTTGTAGGGCAAATGCAGAATATATGTCTCCATCTGGTAAAGTACCTTTTATTCATGTGGGAAATCAAGTAGTATCAGAACTTGGTCCAATAGTCCAATTTGTTAAAGCCAAGGGCCATTCTCTTAGTGATGGGCTGGAGGAAGTCCAAAAAGCAGAAATGAAAGCTTACATGGAATTAGTCAACAATATGCTGTTGACTGCAGAGCTGTATCTTCAGTGGTGTGATGAAGCTACAGTAGGGGAGATCACTCATGCTAGGTATGGATCTCCTTACCCTTGGCCTCTGAATCATATTTTGGCCTATCAAAAACAGTGGGAAGTCAAACGTAAGATGAAAGCTATTGGATGGGGAAAGAAGACTCTGGACCAGGTCTTAGAGGATGTAGACCAGTGCTGTCAAGCTCTCTCTCAAAGACTGGGAACACAACCGTATTTCTTCAATAAGCAGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTATACACCATTCTTACCACACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATTGAACAGCACTATTTTGAAGATCGTGGTAAAGGCAGGCTGTCATAGAGTTATGTGTTAGTCTCAGGAGTCTTAACTTTTGAAATATGTTTTACTTGAATGTTACATTAGATATTGGTGTCAGAATTTTAAAACCAAATTACTGCTTTTTGAAACCTCAAATTATATAATGTATCTTATGTATGTGCTTTATATTGTTATTTGTGTATACATTAAAATAattctgaattatttaatctgatatgttgtattctgtatCTTGAAATTTTTGTTTCCTTGAAACATGCATGCATTTAAAAATAAAGCTTAAACAACTGTATGGATGTTACATTTACTTTCTTTTGATTTTTCTGAAAGTCATTCACTGAATTTTACACATGTGGAATAAACAGTGTCTTTTCTAAGGCAA

Publications

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