Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ODCP
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:129028874-129030448  UCSC
Coordinates (T2T) chr7:130341739-130343313  UCSC
Coordinates (hg19) chr7:128668928-128670502  UCSC
Strand +
Parental Sequence NM_001287189.2
Parental seq. overlap 1075 bp
Parental seq. overlap (%) 38.1%
Genomic Region Intragenic (TNPO3)
Retrocopy Summary ODCP, located on chr7:129028874-129030448, is a retrocopy of the parental gene ODC1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ODC1
Full Name ornithine decarboxylase 1
Also known as BABS|NEDBA|NEDBIA|ODC
Coordinate chr2:10439968-10448327
Strand -
Gene summary This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ODC1P1
Bonobo Pan paniscus ODC1P1
Gorilla Gorilla gorilla ODC1P1
Orangutan Pongo abelii ODC1P1
Gibbon Nomascus leucogenys ODC1P1
Green monkey Chlorocebus sabaeus ODC1P2
Crab-eating macaque Macaca fascicularis ODC1P1
Rhesus Macaca mulatta ODC1P1
Baboon Papio anubis ODC1P1
Golden snub-nosed monkey Rhinopithecus roxellana ODC1P1
Marmoset Callithrix jacchus ODC1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ODCP
GAGGAACATCAAGAAACCATGAAGAGTTTAATAATGAAGAGTTTCACTGCCACTTGCTTCCTTGATGAAGGTTTTACTGCCAAGGACATTCTGGACCAAAAAATTAATGAATTTTCTTCTGATGATGATTAGGATGCCTTCTATGTCATGGACCTTAGAGACATTCTAAAGACACATCTAAGATAGTTAAAAGCTCTTCCTCATGTCACCCCCTTTTATGCAGTCAATTATAATGACAGCAGAGCCATCATGAAGACTCTTGCTGCCATCGGGACAGGATTTGACTGTGCTAGCAAGGCTGAAATACAATTGGTGCAGATTCTGGGGATGCCCCCAGAGAGGTTTATGTATGCAAATTCTTGTAAACAAATGTCTCAAATTAAGTACACTGCCAATAATGGAGTCCAGATGATGATTTTCGGTAATGAGGTCAAGTTGATGTCAGTTGCCAGAACACACTCAAAGCAGCCCGTCACATCAGTGTTAAATCTGGTGCCATGCTCAAAGCCAGCAGGCTTCTTTTGGAATGAGCAAAAGAACTAAATATTGATGTCACTGGTGTCAGCTTCCATGTAGGAAGTAGCTGTACCAATCCTGAGACCTTCATGCAGGCAGCCTCCAATGTCCACTGTGTCTTTGACACGGGAGTTGAGTTTGGTTTCAGAATGTAACTGCTTAATACTGGCAGTTGCTTTCCTGGATCTGAGGACGTGAGGCTTAAATCTGAAGTATTACCAGTGTAATCAACCCAGCATCAGACAAGTATTTTCCACCAGACTCTAGAGTGAGAGTCACAGCTGAGCCAGGCAGATATTTCATGTGGCATCAGCTTTCATTGCCAAAAAAATCATATTAAAAGAACAGACAGaCAGACAGGCTCTGAAGAGGAAGATGAGTCAAGCGAACAGACCTTTATGTATTACATGAATGATGAAGTATATGGATCATTTAATCAATCCTTTATGATCATGCACATGTAAAGCCCCTGCTGCAAAAGAGACCTAGATCAGTGAGAAGTATTATTCATCCAGTATATGGGAAGAACATGTGATGGCCTTGATCAGATTGTTGAGCACTGTGATCTGCCCAAAATATATGTAGGTAATTGGATGCTCTTTAAAAACATGGGCGCTGACACTGTTGCTGCTACTTGTACTTTTAATGGATTCCAGAGGCCAACAATCTACATGTGATGTCAGGACCAGCATCGAAACTCATGCAGTGTATCTAGAAGCACGATCTCCCACCCCAAGTAGAGGAACAGGA
>NM_001287189.2
ggAGACACGTGGTCGCCGAGCGGGCCACGACCTTGAGGCGCCGCTTCCTCCCGGCCCGGGGTTCTCCCGCGGCTGGATAAGGGTGATCCGGGCGCCTCGTTCTGCCCCCGTCTTCACAGCTCGGGGCTGGAGGGGCCTAGGGGAGACCCACCCGGAGACCCTGCGGCCCCGCGCCGGCCTCTTTCCCAACCCTTCGGCGGCCGCGCGCTGGCCGGGGAGCCGTTGGGGAGGCCCTGGCGGCCGCGCAGCAGGTGCAGGGGCGCAGAGCCCGGGCTCGCCTTGGTACAGACGAGCGGGCCCCGGCCTTGGCGCCTTCAGTTTCCTTCCAGTTTTTATTTTCGCTGTGTCTACAGAGCAGATGACACCAATTTGGAAACCCGCGAGAGTGGGTAGAGCTAAGATAGTCTTGCTGTAGTAGCTGTGATATTAGATGCTCGGCCATGACTTAGAGGTGTTTATTTAAGGACTGTGAATGACTCGGTGATTTCGGAAAAGCTTGGCTTAGATGAACGGACATACACAGGGGAGACAGCCCTAAGATTGTCACTGCTGTTCCAAGGGCACACGCAGAGGGATTTGGAATTCCTGGAGAGTTGCCTTTGTGAGAAGCTGGAAATATTTCTTTCAATTCCATCTCTTAGTTTTCCATAGGAACATCAAGAAATCATGAACAACTTTGGTAATGAAGAGTTTGACTGCCACTTCCTCGATGAAGGTTTTACTGCCAAGGACATTCTGGACCAGAAAATTAATGAAGTTTCTTCTTCTGATGATAAGGATGCCTTCTATGTGGCAGACCTGGGAGACATTCTAAAGAAACATCTGAGGTGGTTAAAAGCTCTCCCTCGTGTCACCCCCTTTTATGCAGTCAAATGTAATGATAGCAAAGCCATCGTGAAGACCCTTGCTGCTACCGGGACAGGATTTGACTGTGCTAGCAAGACTGAAATACAGTTGGTGCAGAGTCTGGGGGTGCCTCCAGAGAGGATTATCTATGCAAATCCTTGTAAACAAGTATCTCAAATTAAGTATGCTGCTAATAATGGAGTCCAGATGATGACTTTTGATAGTGAAGTTGAGTTGATGAAAGTTGCCAGAGCACATCCCAAAGCAAAGTTGGTTTTGCGGATTGCCACTGATGATTCCAAAGCAGTCTGTCGTCTCAGTGTGAAATTCGGTGCCACGCTCAGAACCAGCAGGCTCCTTTTGGAACGGGCGAAAGAGCTAAATATCGATGTTGTTGGTGTCAGCTTCCATGTAGGAAGCGGCTGTACCGATCCTGAGACCTTCGTGCAGGCAATCTCTGATGCCCGCTGTGTTTTTGACATGGGGGCTGAGGTTGGTTTCAGCATGTATCTGCTTGATATTGGCGGTGGCTTTCCTGGATCTGAGGATGTGAAACTTAAATTTGAAGAGATCACCGGCGTAATCAACCCAGCGTTGGACAAATACTTTCCGTCAGACTCTGGAGTGAGAATCATAGCTGAGCCCGGCAGATACTATGTTGCATCAGCTTTCACGCTTGCAGTTAATATCATTGCCAAGAAAATTGTATTAAAGGAACAGACGGGCTCTGATGACGAAGATGAGTCGAGTGAGCAGACCTTTATGTATTATGTGAATGATGGCGTCTATGGATCATTTAATTGCATACTCTATGACCACGCACATGTAAAGCCCCTTCTGCAAAAGAGACCTAAACCAGATGAGAAGTATTATTCATCCAGCATATGGGGACCAACATGTGATGGCCTCGATCGGATTGTTGAGCGCTGTGACCTGCCTGAAATGCATGTGGGTGATTGGATGCTCTTTGAAAACATGGGCGCTTACACTGTTGCTGCTGCCTCTACGTTCAATGGCTTCCAGAGGCCGACGATCTACTATGTGATGTCAGGGCCTGCGTGGCAACTCATGCAGCAATTCCAGAACCCCGACTTCCCACCCGAAGTAGAGGAACAGGATGCCAGCACCCTGCCTGTGTCTTGTGCCTGGGAGAGTGGGATGAAACGCCACAGAGCAGCCTGTGCTTCGGCTAGTATTAATGTGTAGATAGCACTCTGGTAGCTGTTAACTGCAAGTTTAGCTTGAATTAAGGGATTTGGGGGGACCATGTAACTTAATTACTGCTAGTTTTGAAATGTCTTTGTAAGAGTAGGGTCGCCATGATGCAGCCATATGGAAGACTAGGATATGGGTCACACTTATCTGTGTTCCTATGGAAACTATTTGAATATTTGTTTTATATGGATTTTTATTCACTCTTCAGACACGCTACTCAAGAGTGCCCCTCAGCTGCTGAACAAGCATTTGTAGCTTGTACAATGGCAGAATGGGCCAAAAGCTTAGTGTTGTGACCTGTTTTTAAAATAAAGTATCTTGAAATAATTAGGCATTGGGACGTTTTTATGGTGTGTTCATTCCAGACAGTTCACGAATCCCGTATAGCTCGCTCTGATTCTCAGAGAACAATGAGTGGGTCCACCCACACACAGGTAGGAGGACAGGTGAGACGGAAGCCCCATCCTCCCATGTGGACGGTGCACATCTGCTCAGCCCACCCCACATGTCCAGAGTTGGCTGCAAACTCCTTGTCCAGAGCCTCTGGTGGTGGGACCTACTTAAGTCTGACGGACCTGTCCTGTCCAGGCCAGTGCCCAGGGAAGGTGTGGGAGGCCCTTTGAGCCTGGCCTGCAGAGACCATCCGTGTCCCCTCCCACCTTCATGCCTGTGAGAAGTTAGGAATGTATACGGTACCACATTTGGCAGTCAGCTTATTTTAATAAATTCAGCAACAGCAAGTCCCTA

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