Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SDHDP2
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:135444439-135445740  UCSC
Coordinates (T2T) chr7:136752340-136753642  UCSC
Coordinates (hg19) chr7:135129187-135130488  UCSC
Strand +
Parental Sequence NM_003002.4
Parental seq. overlap 1209 bp
Parental seq. overlap (%) 90%
Genomic Region Intragenic (CNOT4)
Retrocopy Summary SDHDP2, located on chr7:135444439-135445740, is a retrocopy of the parental gene SDHD. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SDHD
Full Name succinate dehydrogenase complex subunit D
Also known as CBT1|CII-4|CWS3|MC2DN3|PGL|PGL1|QPs3|SDH4|cybS
Coordinate chr11:112086873-112095794
Strand +
Gene summary This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SDHDP6
Bonobo Pan paniscus SDHDP5
Gorilla Gorilla gorilla SDHDP6
Orangutan Pongo abelii SDHDP5
Gibbon Nomascus leucogenys SDHDP5
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SDHDP2
GGCGGTTCTCTGGAGGCTGAGTGCCCTTTGCAGTGCCCAAGGAGGTCGAGCTCTGTTGCTGTGAACGCCAGTGGTCAGACCTGCTTATATCTCAGCATTTCTTCAGGACCGACCTATCCCAGAATGATGTGGAGTACAGCACATACACTTGTCACCGAGCCACCATTCTGGTTCCAAGGCTGCATCTCTCCACTGGACTAGCAAGAAGGTTTTCAGTGTTTTGCTCCTGGGTCTGCTTCCGGCTGCTTGTTTGAATCCTTGCTCTGCGATGGGCTATTCCCTGGCTGCGACCCTCACTCTTCATGGTCACTGGGGCCTTGGACAAGTTGTTACTGACTATGTTCATGGGGATGCCTCGCAGAAAGCTGCCAAGGCAGGGCTTTTGGCACTTTCAGCTTTAACCTTTGCTGGGCTTTGCTATTTCAACTATCACGATGTGGGCATCTGCAAAGCTGTTGCCATGCTGTGGAAGCTCTGACCTTTTTGACTTCATACTTTGAAGAACTGATGTAAGCCTCTTTGCCTCTGCTTGTCATGCCATTAAGCTCACAATAAGGAAGAAATAACAGATAAGTCTGTTGGTGGACAGCCTTCTTCTCTTAATCACAAGGTTATTTTCAGAATTTAATCTTTGAGGAAAAGGTTTGAGAGGAACTATATCTAAGAAATTGTGAGACTGAGTTCTGTATTCTGGTGAGTTAATGGGGTTGCCTCCCAGCTTCTTATAAGACTCACAGTATAGCTAAACATGATATATGAGCTTTTGCCTTTTAATTTATCAATCTCTTAAAGAGAATCCAGCTTTATTACTATTAGTATATGATCAAACTTCCATATTTGCCCTGGGAATAATGGACAAAGGGAAATACTCTTAATTCATGAATAAAAACTTTGTAGAAAATTAGACAGTGATTAATTTTCGAAAACTTCCCTCTCTAGTCAGTAGATACCACCTACTGATGGTTACATATACCAGGGAAATTTTAAAATTAGGAAGTGCTGATATCTCACATTATAAATTTCTAAATCCTAGGGAGAAATGCTTGGAGTGCTTCTGAATATAGAGAAGTTCCATTTAAGGGCAAGTTTCCCCTTGTAGACGTATCAAAATATTACCAATTGTAAACTTAGATTTATTTCTCAAATGTGTTCTACTTGTTCTAAAACAATCTGTCCACAAATATAAAACTATAAGTAATAAATTGTTATTTTCGCACAATGGGAATCTCTAATGTGAAAATGTATTCTATGAAAATAATTTTTT
>NM_003002.4
GGGTTGGTGGATGACCTTGAGCCCTCAGGAACGAGATGGCGGTTCTCTGGAGGCTGAGTGCCGTTTGCGGTGCCCTAGGAGGCCGAGCTCTGTTGCTTCGAACTCCAGTGGTCAGACCTGCTCATATCTCAGCATTTCTTCAGGACCGACCTATCCCAGAATGGTGTGGAGTGCAGCACATACACTTGTCACCGAGCCACCATTCTGGCTCCAAGGCTGCATCTCTCCACTGGACTAGCGAGAGGGTTGTCAGTGTTTTGCTCCTGGGTCTGCTTCCGGCTGCTTATTTGAATCCTTGCTCTGCGATGGACTATTCCCTGGCTGCAGCCCTCACTCTTCATGGTCACTGGGGCCTTGGACAAGTTGTTACTGACTATGTTCATGGGGATGCCTTGCAGAAAGCTGCCAAGGCAGGGCTTTTGGCACTTTCAGCTTTAACCTTTGCTGGGCTTTGCTATTTCAACTATCACGATGTGGGCATCTGCAAAGCTGTTGCCATGCTGTGGAAGCTCTGACCTTTTTGACTTCATACTTTGAAGAATTGATGTATGCCTCTTTGCCTCTGCTTTGTCATGCCATTAAGCTCACAATAAGGAAGAAATAACAGATAAGTCCATTGGTGGACAGCCTTCTTCTCTTAATCACAAGATTATTTTCAGAATTTAATCTTTGAGGAAAAGGTTTGAGAGGAATTATATCTAAGTTGTGAGACTGAGTTCTATATTCTGGTGAGTTAATGGGGTTGCCTCCCAGCTTCTTATAAGACTCACAGTATAACTAAACATGATATATCAGCTTTTGCCTTTCAATTTATCAATCTCTTAAAGAGAATCCAACTTTATTACGATTAGTATATGATCAAACTTCCATATTTGCCTTGGGAATAATGGACAAAGGGAAATACTCTTAATTCATGAATAAAAACTTTGCAGAAAATTAGACAGTGTTTAATTTTCGAAAACTTCCCTCTCTAGACAGTAGATACCACCTACTGATGGTTACATATACTAGGGAAATTTTAAAATTAGGAAATGCTGATAGCTCATATTATAAATTTCTAAATCCTAGGAAGAAACGCTTGGAGTGCTTCTGAATATACAGAAGTTCCATTTAAGGGCAAGTTTCCCTGTAGATGTATCAAAATACTACCAACTGTAAATTGAGATTTAATTCCCAAATGTATTCTACTTGTTCTAAAACAATCTGTCCACAAATATAAAACTATAAGTAATAAATTGTTATTTTCGCACAATGGGAATCTCTAATGTGAAAATGTATTCTATGAAAATAATTTTTTTAAATAAAATGTTATATAATAAAAGTGTCTTCTATGCTTTTA

Publications

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