Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RCC2P3
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:138123722-138124829  UCSC
Coordinates (T2T) chr7:139433214-139434321  UCSC
Coordinates (hg19) chr7:137808468-137809575  UCSC
Strand +
Parental Sequence NM_018715.4_2
Parental seq. overlap 685 bp
Parental seq. overlap (%) 16.9%
Genomic Region Intergenic
Retrocopy Summary RCC2P3, located on chr7:138123722-138124829, is a retrocopy of the parental gene RCC2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RCC2
Full Name regulator of chromosome condensation 2
Also known as TD-60
Coordinate chr1:17406760-17439677
Strand -
Gene summary The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RCC2P5
Bonobo Pan paniscus RCC2P5
Gorilla Gorilla gorilla RCC2P5
Orangutan Pongo abelii RCC2P5
Gibbon Nomascus leucogenys RCC2P2
Green monkey Chlorocebus sabaeus RCC2P3
Crab-eating macaque Macaca fascicularis RCC2P3
Rhesus Macaca mulatta RCC2P3
Baboon Papio anubis RCC2P4
Golden snub-nosed monkey Rhinopithecus roxellana RCC2P5
Marmoset Callithrix jacchus RCC2P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RCC2P3
TGCTAACCACACATTGATTCTGGACTCCAAGAAATGAGTCTTCTCCTGGGGCTTTGGTGGCTATGGTTGACTGGGCCACTCAGAGCAGAAGGATGAGATGGTCCCCGCTTGGTGAGGTTGGAGTCTGACTTCCTTGGGTGTGGGGCATCCCAGATCCATGTTGGTTACACCTGGTCCTTTGCTGTCTGTGAAGTTGGTAGTCTCTTTTTCTGGGGGAGCCCAATATCTCCCATGAATCTTCCATGTACCTGAAAGCAGTGCAGGACCTCTGCGGCTGCAGAATCCAGAGCCTGGCTTGTGGGAAGAGCAGCAACATTGTGGCCGCCAATGAGAACACCATCAGCTGAGGGCCATAACCAACCTTTAGGTAATTGGGATACAGGGACCATGAGCCCAAGTCTTCCACTGCAGCCCAAGAGGTGAAGACTCTGAATGGCATCTTTTCAAAGCAGGTCTCCATAGGCTACTCACACTCCTTGGTGATAGTGCGAGATGAAAGTGAGACCAGGAAAGAGAAGATCAAGAAACTGCTAGAaCTGCTAGAATACAACCCCTGAACCCTTTGATGCTCCTGGGGACTCCTGCAACTCCACCCGTCTCCCAGAAGCTGTCATTTCCTGTGCAGTGGGAGGTGAAGTCAAACAAGGAATTTTAAAAAGCAAAAGTTAGCCAAAGTTGCATTTTTGTTAGACTCCCTGAGGTTCCATTTTTACAAGGGATCCAATGTTAATTATCCTTTTCTGCATACTTTTAAAAGTCTGTTTTTTTCTCTTCATGTTTAATTAAAATATTTGCTCATA
>NM_018715.4_2
GTATTTACATTTTAAGTGTATCTGGTGAGTGGGCTGGAGCCCTCGTCTGGGCCGGAAAAAAAAAAGCCCTCCGATCCGTCTTTTAGTTGCTTCTCTTCCTTTTTTCTCTCCGGTTTCTCATCACTCCAACCAGCCGCGACCATGCCCAGGAAGAAGGCGGCGGCGGCGGCCTGGGAGGAGCCGAGCTCGGGCAACGGCACTGCCCGCGCCGGGCCCAGGAAACGCGGCGGCCCGGCGGGCAGGAAGCGCGAGCGGCCCGAGCGCTGCAGTAGCAGCAGCGGCGGCGGCAGCAGCGGCGACGAGGACGGCCTGGAGCTCGACGGGGCCCCCGGCGGGGGCAAGCGCGCGGCGCGGCCGGCGACAGCAGGCAAGGCGGGCGGCGCGGCCGTGGTCATCACCGAACCCGAGCACACCAAGGAGCGCGTCAAACTTGAAGGGTCAAAGTGCAAAGGGCAGCTTTTGATTTTTGGGGCAACCAACTGGGACTTGATTGGTCGAAAAGAAGTGCCTAAACAGCAAGCTGCTTACCGCAATCTCGGTCAGAATTTGTGGGGGCCCCACAGATATGGGTGCCTGGCGGGGGTCCGGGTGCGGACAGTGGTCTCGGGCTCGTGTGCTGCACACAGCCTCCTCATCACCACGGAAGGGAAGCTGTGGAGCTGGGGTCGAAATGAGAAGGGGCAGCTGGGACATGGTGACACCAAGAGAGTAGAAGCCCCTAGACTCATCGAGGGTCTTAGCCACGAAGTGATTGTGTCTGCAGCATGTGGGCGGAACCACACCTTGGCCTTGACGGAAACGGGCTCCGTGTTTGCGTTTGGGGAAAACAAGATGGGGCAGCTGGGCCTTGGCAACCAGACAGACGCTGTTCCCAGCCCCGCGCAGATAATGTACAACGGCCAGCCAATTACCAAAATGGCCTGTGGGGCTGAATTCAGTATGATAATGGACTGCAAAGGAAACCTCTATTCCTTTGGGTGCCCTGAATATGGTCAGCTGGGACACAACTCAGATGGGAAGTTCATCGCCCGGGCACAGCGGATAGAGTACGACTGTGAACTAGTTCCCCGGCGAGTGGCCATCTTCATTGAGAAGACGAAAGATGGACAGATTCTGCCTGTACCAAACGTGGTTGTACGAGACGTGGCCTGTGGCGCTAACCACACGCTGGTCCTGGACTCCCAGAAGCGAGTCTTCTCCTGGGGCTTTGGTGGCTATGGCCGGCTGGGCCACGCAGAGCAGAAGGATGAGATGGTCCCCCGCCTGGTGAAGCTGTTTGACTTCCCTGGGCGTGGGGCTTCCCAGATCTATGCTGGTTACACCTGCTCCTTTGCTGTCAGTGAAGTGGGTGGTCTGTTTTTCTGGGGGGCCACCAACACCTCCCGTGAATCTACCATGTACCCAAAAGCAGTGCAGGACCTCTGCGGCTGGAGAATCCGGAGCCTGGCTTGTGGGAAGAGCAGCATCATTGTGGCCGCCGATGAGAGCACCATCAGCTGGGGTCCGTCACCGACCTTTGGGGAACTGGGCTACGGGGACCACAAGCCCAAGTCTTCCACTGCAGCCCAGGAGGTAAAGACTCTGGATGGCATTTTCTCAGAGCAGGTCGCCATGGGCTACTCACACTCCTTGGTGATAGCAAGAGATGAAAGTGAGACTGAGAAAGAGAAGATCAAGAAACTGCCAGAATACAACCCCCGAACCCTCTGATGCTCCCGGAGACTCCTCCGACTCCACACCTCTCGCGGCAGCTGTCATTTCCATGTGCACTGGGACGGGAAGTCAAACGAGGAATTTAAAAAAGCAAAAGTTGACCGAAGGTGCATTTTTGTTTAGACTCCCTGAGGTTCCGTTTTACACATGATCCAACGTTAACTACCTTTTTTTCTGTATGCTTTCCAAAGTCCTTTTTTTTCCCTTAATGTTGAATTAAAATACTTGCTCATAGTTGATTTACCATTCCTACAAAAGAGGCAGAAACTTTGAGCAATCTAGGttttttttttttttaagttttttctttcttCCTCTCCTGAATACACTCCCCAAAACACCCCTTTCCAGTTACAATTAGCATCGTGATCCAAGCAGATGCCACATGGAAGAGGAATCGCCATTTACTCAGAAAAAATGTCCCTTACAGGAACCGGCAGCAGCTAGGCAGTCACCGGCCCGCCTCCATCCAAAATCACGCTCGCGTGCTTCGGAAGCATCCGGGTCACTCCTTCTCCGCTTTTTCTTGCAGATGGGCCTAGGCCGGTGTCGGTTCTGTTTCTCCCCTTGGCTGCCTGTACGCCCACAGCCTTCTGGCTGCGACATTATAGAATCGGCCGTGTCCCCCCTGGTGGGGGATTGGGGATCTGTGTTTAGCCATTTATATCTACTTTAGCTGTTAAAGAGGTCCAAATGAAAATCAGGTGATTGTGGAACCATGGGGACTTGGGGGTGGGGCAGAGGTGGGAACATTTGTATCAGTTGAGTCAGCTTGGTGGCTCCCTGTGGAGCCAGGGCTGAGCCTTGTCACGCGCACTCGCCAATTAAGAGATGGACCAGCCAGCAGTCAAGTGCATTCTCCAGTCCTTGCAAGAAGGATCAGCCCTTTCTGTGCCAGCCTCGATCGCCTTGTGCTTTGGTCTCTTTTTCTCCCCCCCGCCTGGATCCTGCCTCGCGCGGGCCGTCCTGTTGCTGAGACTCGGGGTACCGTTCTGCTGACCCAGCTCCCTTTAGTCACGTTTGCTTGGCTCTGGTACCAAATAGTTGGGATTACCGAAGAGTCCCCTTCCTTGCGTGTCAGCACGGATGCTGTGACTGCCACCTGCGTCCTCGTCAAGTGCCCGAGCTCGCCGCCGTGTGTGCTGCGCTGAGTGAGTTATGAGGTGCCTTTCCCGGAACCCTCCTCTCGCCTGGACCCAAGAGAGGCGACAGCTGTGGCTGGGGCTCTTGGTTTCCAGAGGGTCTGGACTGGTTTGGGTGCTTTAAAATAGATATTTAGTTCAGTGGTGCTTATGGGGGAGATGGGACTAGAACTTAAGTGTGAGACTTGGGTGGATGGGAAAGTTAAATATTGGTCTCTTCAAGTTTTTTTTTTCTTTTGCTTTGTTACCACTTGTCACTGTCTCCATGTTAAAATGCCAAAAATGATGTAGTTGTTGTTGCTTTTTTCCCTATTTTCCACCCCAGTCGCTCCTTACCGTGACTCCTGCCCTTGGAGGGCATGTAGCAGTGTCTGTCCTGCCAGTCCCAAGGCCCTGTGGGAGGAGACTGGCCTGCATCTCTCTAAGACTTAGTCTGACGCCACGCGCATCTCTTGTTCTGTGTTCAATCAGTAGTCCAGGGGAGAAGCTTCTGCTACTTCAGAGCTTTGCTAAACTAACCTAATTTGTCCAAATCACCCCAAAACCACCATCTCTGACGTAAGCTTCCATGCGACAGCCTGATCCGTTTCCCTGGACAGGTCTCTTTCCTGGAATGCAGCCCAGGCACCTGTGCTCCTGGCACCCTTGAGGTCTCTCCTTTGAGCCGTGGTCACCGAGAGGGTTGAGGACGCAGCACCCGAGGTCCCAGCCTTTGCAGGAGCCTCCCTGGGCTTAGCTGGACTTAGATCTTCGGTGGCCTCATGTAAACGTGGCAGCCAGCCTCTTCTAGAACCCTAGCCCAGGGACTGGAGCAGGAAAGGGACCTTCAAAGTGAAGACTGCCTTGTCCCGCAGCTCCTTCTGGCTTAGATTGAAAAATGGGCTTCCTAATGGGTTAAATCCTTTAAAACAAGGAGTTGTGGGGGAAGGGTGTCGTGCACTCCTAGAGAAAGGTACACAGTTGCCCGGTTGGGAATGTGCTTGGCGCTGACCCTGCGGGCATCTGACTGGTCTTCCAGCTCAGGAAAAAGAATTTGAAAGAGGCTTAGCGTGAAGGGGAATCAAAGAGGAGGTTGTGATTTGGTCGAAGGTGCCTGGTTTAGTGCTGTAATTGTCTTATTATTTTTTTTATATATATATTTCTTGGAGTAAACATTTTAAATAAACAACAACATTGTCTACTGTC

Publications

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