Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DUTP3
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:147146444-147146882  UCSC
Coordinates (T2T) chr7:148326743-148327181  UCSC
Coordinates (hg19) chr7:146843536-146843974  UCSC
Strand +
Parental Sequence NM_001948.4
Parental seq. overlap 367 bp
Parental seq. overlap (%) 19.8%
Genomic Region Intragenic (CNTNAP2)
Retrocopy Summary DUTP3, located on chr7:147146444-147146882, is a retrocopy of the parental gene DUT. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DUT
Full Name deoxyuridine triphosphatase
Also known as BMFDMS|dUTPase
Coordinate chr15:48331095-48343373
Strand +
Gene summary This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DUTP6
Bonobo Pan paniscus DUTP6
Gorilla Gorilla gorilla DUTP6
Orangutan Pongo abelii DUTP6
Gibbon Nomascus leucogenys DUTP4
Green monkey Chlorocebus sabaeus DUTP7
Crab-eating macaque Macaca fascicularis DUTP3
Rhesus Macaca mulatta DUTP3
Baboon Papio anubis DUTP5
Golden snub-nosed monkey Rhinopithecus roxellana DUTP5
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DUTP3
GCCACCAATGGAGGAAGCTCTTGTGAAAACAGACATTCAGATAGCTCTTCTGGGTGTTATAAACGAGTAACTCCTTGTTCTGGCTTGGATGCAAAACAGATTATAAATGTATGGCTAGTATCATACTTGAAGATTATAGAGGAAATGTTGCTGTTCTACTGTTTAATTTAGGCAAGGAAAGTTTGAAGTAAAAAAGAAAAAGTGATCCAGTTGCACAGCTCATTTGTGAACAGATTTTTTATCTAAATATAGAAGAAGTTTAAATTTTGAATAACACTGAAGTGGGTTCAGGAGGTTTGGCTTTCATCGGAAACAATTAAAATGTATGCCAAGAATAGAAGATGAGAAATCGTACCTTTTTCTTAAAAATAAAGAGTTTTTGCTTAAAGTGCTTTAGTGTTTTGCAATTCTGTCAACTTATTAGCTTTACTTTCTAAAA
>NM_001948.4
ATCGTGCGCTCTCCTCTTCCCCCGGTGGTCTCCTCGCTCGCCTTCTGGCTCTGCCATGCCCTGCTCTGAAGAGACACCCGCCATTTCACCCAGTAAGCGGGCCCGGCCTGCGGAGGTGGGCGGCATGCAGCTCCGCTTTGCCCGGCTCTCCGAGCACGCCACGGCCCCCACCCGGGGCTCCGCGCGCGCCGCGGGCTACGACCTGTACAGTGCCTATGATTACACAATACCACCTATGGAGAAAGCTGTTGTGAAAACGGACATTCAGATAGCGCTCCCTTCTGGGTGTTATGGAAGAGTGGCTCCACGGTCAGGCTTGGCTGCAAAACACTTTATTGATGTAGGAGCTGGTGTCATAGATGAAGATTATAGAGGAAATGTTGGTGTTGTACTGTTTAATTTTGGCAAAGAAAAGTTTGAAGTCAAAAAAGGTGATCGAATTGCACAGCTCATTTGCGAACGGATTTTTTATCCAGAAATAGAAGAAGTTCAAGCCTTGGATGACACCGAAAGGGGTTCAGGAGGTTTTGGTTCCACTGGAAAGAATTAAAATTTATGCCAAGAACAGAAAACAAGAAGTCATACCTTTTTCTTAAAAAAAAAAAAAAAGTTTTTGCTTCAAGTGTTTTGGTGTTTTGCACTTCTGTAAACTTACTAGCTTTACCTTCTAAAAGTACTGCATTTTTTACTTTTTTTTATGATCAAGGAAAAGATCATTAAAAAAAAACACAAAGAAGTTTTTCTTTGTGTTTGGATCAAAAAGAAACTTTGTTTTTCCGCAATTGAAGGTTGTATGTAAATCTGCTTTGTGGTGACCTGATGTAAACAGTGTCTTCTTAAAATCAAATGTAAATCAATTACAGATTAAAAAAAAAAGCCTGTATTTAACTCATATGATCTCCCTTCAGCAACTTATTTTGCTTTAATTGCTTTAAATCTTAAGCAATATTTTTTATTCAGTAAACAAATTCTTTCACAAGGTACAAAATCTTGCATAAGCTGAACTAAAATAAAAATGAAAAGGAGAGATTAAAGGTATTCCTTGTTCTTCCCTTCTCTTCACTAGTCTAAAAACTTCTTTTTAATCTTAAGATTCTTTGTGATGAGGGTGAGAAAAAGAATCCTCAGTTTATTTTTCCACTATTAATCTTTCTTTTGATAAATCCTCTATTGACTGGGTAGAGGTATGTTTGTGAAAGACATGTAACTTGGGGATTTGTTACTTTAGGTTTGTTCCCTTGAATTTCATCTCATCAGGCAAATTGTACTAGTTGTAGTTACGAGTTTTCCCTCAGTGAAGTAGCAATAGGCTGTAATCAAGAAAATATGCCATTTATAGAGATAAGATAAATGAAATAATACTTCAGCCACCAGGTTTTTCTGTCTCACATACATAAGCAGCATTTCATTGCAGATATGGGACTGATTCTGTGGCTTACCTTGATTAACATCTTTTGGAAGTTTTGCTAGTGTGCTTTCCTTTCTTTACTATGTTTCTCAGATTCCTTTGTATCAGGGTTTTGGGTGTCACTTAGGTTTTGTCCATCAGATTCTGTGAGACACCAGGCATCGTTTTGAGGATGTGGGTTATACACATGGAGTGCTTCTGGAACTATCAGCCCACTTGACCACCCAGTTTGTGGAAGCACAGGCAAGAGTGTTCTTTTCTGGTGATTCTCCAGGCCATTTAATACCCTGCAATGTAATTGTCCCTCTGTGGCTCACATTTcattagtgagccatgaaatcaactcagtgggacatagccagcatttttGCATACCAGGTTGGGCTATAAAATATTTCTGTTGTCAATAAATTTTAAATGTTTTCCTGCTAAACTAA

Publications

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