Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KPNB1P1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:149320580-149322093  UCSC
Coordinates (T2T) chr7:150502355-150503867  UCSC
Coordinates (hg19) chr7:149017671-149019184  UCSC
Strand -
Parental Sequence NM_001276453.2
Parental seq. overlap 1010 bp
Parental seq. overlap (%) 16.6%
Genomic Region Intergenic
Retrocopy Summary KPNB1P1, located on chr7:149320580-149322093, is a retrocopy of the parental gene KPNB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KPNB1
Full Name karyopherin subunit beta 1
Also known as IMB1|IPO1|IPOB|Impnb|NTF97
Coordinate chr17:47649919-47685505
Strand +
Gene summary Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KPNB1P1
Bonobo Pan paniscus KPNB1P1
Orangutan Pongo abelii KPNB1P2
Gibbon Nomascus leucogenys KPNB1P1
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KPNB1P1
ACTCTAGGGAAACACTGACGAATGGTCAGAGCTCCTATCCTGATCTTTTCAGTAAGGCGCCTTTCCTAATACTATGGTTCAACTGTGAATGTAGAAGTGAGGGGGAGGGGGGAGAAAAAGAAAACTCTGGCGTTAGAGAATATAGAAAAATGTAAGTACAATTGTTACAAATAGCGCAGACTTCAAAAACAAAAAAGTCACAAACCAAACCAAAATTTAAATGATCAGAATTGGCAGCACAAAGAAAACGCCCTCTCCTGACTTGTATTTTGGCAGTCTGAACGCCCCCAGAAAATTACGCCAAAGAGTTTAGAAAAATATACAATAAAAGTAAACACACACATACACACAAAACAGCAAACTTCAGATAACTACTTTGGATTGCAAACAGGATAAATTAAATGTTCAAACAATCTGATAAAATAACCATTTGGAAACTGGCACAGAGGAAAGACGCTCTTTAGGAGCTATCTCTTCCCAGGAGAGGCTAGAAGTAGTTTTTCTGTCTTTTGGCCGGTGCCGAGTGGAATGCCTGGTTTCGGGGAGGAGGAGGGACTGGGTTCAGCTGTGGTGCTTTGTTGTAAAAGGCAGCCTGGCCTTTGCTACTGAGGAGAAAGATGGAGCCTGGGTCTCAAGCCCACCTTCTCTGTACCTTTGCCACACGGTACTGTATGCTTGCCGGCTAGAAGGAGGGTGAGGGATTTTTTACAGTCTGAGAATGAGTGTGTGTGAGTGAGGCGGTATCCACATTCTCAAGTTCAAGTCATTACAGTTTCTTTTTCCCAGAAAACAAGGGGTTAGATGTTGCATTTCATAAAACGAACCCAAGTTCTGTCTACTGGTGCAGCACAAGAGATGTACTGTCAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATTGGCTATCTTGGAAAAGAGAAAAACAATGGAGTTACTTATCATTGACCACATTGCTGGAGATGAGGATCATACAGACGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATATACAGCATTTGGGAAGGATGTACTGAAACTAGTAGAAGCTAGGCCACTGATCCATGAATTGTTAACTGAACGGCGGAGATCGAAGACGAACAAAGCAAAAACCCTTGCTACACGGGCAACAAAAGAATTCAAGAAACTGAAGGACCAAGCTTGATCTGTTACCACTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCAATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCATGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTg
>NM_001276453.2
CTGACCTGGATGAATAGAGACCTAATCACTAGGGATCTGCACCCAGAAAACAGACTGAGGCTCATCTTTGAGATGGGGCCTGTTTGCTGATGAAATCACAGGGGAAAGTTCCTCGTTTTTCATATTTTAAAATTTAAGGGGTCCGGAGAAAATGAAGCTAAGTCCGCTAGAGACTGGTCCTTTGTATAAAAATGTGGGATGGATTGGTTGAAACAGCCTAGATGCCAGTTAAGTTTCTCTTTGGTGTCCATCTCCTGTTGGGGGATGGGGTCAGAGGGAAGGATTGGATGATGCTTGACATCTTTGAGAAAGCCCACTTTCCTTGTGGAACTGTCCAGAGTGCTGGCAAATCCAGGAAACAGTCAGGTTGCCAGAGTTGCAGCTGGTCTACAAATCAAGAACTCTTTGACATCTAAAGATCCAGATATCAAGGCACAATATCAGCAGAGGTGGCTTGCTATTGATGCTAATGCTCGACGAGAAGTCAAGAACTATGTTTTGCAGACATTGGGTACAGAAACTTACCGGCCTAGTTCTGCCTCACAGTGTGTGGCTGGTATTGCTTGTGCAGAGATCCCAGTAAACCAGTGGCCAGAACTCATTCCTCAGCTGGTGGCCAATGTCACAAACCCCAACAGCACAGAGCACATGAAGGAGTCGACATTGGAAGCCATCGGTTATATTTGCCAAGATATAGACCCAGAGCAGCTACAAGATAAATCCAATGAGATTCTGACTGCCATAATCCAGGGGATGAGGAAAGAAGAGCCTAGTAATAATGTGAAGCTAGCTGCTACGAATGCACTCCTGAACTCATTGGAGTTCACCAAAGCAAACTTTGATAAAGAGTCTGAAAGGCACTTTATTATGCAGGTGGTCTGTGAAGCCACACAGTGTCCAGATACGAGGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTTATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTACATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGTTTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCATACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTGGGGAATGAGAACGTCCACAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGGAGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCAGGTGGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTTGGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGATGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGGAGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATGTACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATTGTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAACAAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTGAGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGGATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGAAAATCCTgccacagcagcagccgcagccgccaacagcagcGCTGTTAGTGAGCTAAGTAAGCACTGACTTCGTAGAAAACCATAACATCGGCCATCTTGGAAAAGAGAAAAACAATGGAGTTACTTATTTAAAAAAAAAGAAAGAAAGTTATCTCTTCCCAGGAGAGGCTAGAAGTAGCTTTTCTGTCTTTTGGCCAGTGCCGAGTGGAATGCCTGGTTTGGGGGAGGAGGAGGGACTGGGTTCAGCTGTGGTGCTTTGTTGTAAAAGGCAGCCTGGCCTTTGCTACTGAGGAGAAAGATGGAGCCTGGGTCTCAAGCCCACCTTCGCTGTACCTTTGCCACATGGTACTGTATGCTTGCCAGCTAGAAGGAGGGTCAGGGATTTTTTACAGTCTGAGAATGAGTGTGTGTGAGTGAGGCGGTATCCACATTCTCAACTTCAAGTCATTGCAGTTTCTTTTTCCCAGAAAACAAGGGGTTAGATGTTGCATTTCATAAAACTAACCGAAGTTTTGTTTACTGATGCAGCACAAGAGATGTaaaaaaaaaaaaaaaaaaaaaaaaaaaaaCACACACACAGAGGAAAGACGCTCTTTAGGttttgttttgttttttttttttggttttgttttttgttttttttACTCTAGGGAAAACACTGACGAATGGTCAGAGCTCCTATCCTGATCTTTTCATCAAGGCGCCTTTCCTAATAATATGGTTCAACTGTGAATGTAGAAGTGGGGGGGAGGGGGGAGAAAAAGAAAACTCTGGCGTTAGAGGATATAGAAAAATATAAGTACAATTGTTACAAATAACGCAGACTTCAAAAACAAAAAAATCACAACCCAAACAAACCAAAATTTAAATGATCAGAATTGGCAGCACAAAGAAAACGCCCTCTCCTGACTTGTATTGTGGCAGTCTGAACGCCCCCAGAAAATTGTGCCAAAGAGTTTAGaaaaataaatatacaataaaagtaaacacatacacacaaaaCAGCAAACTTCAGGTAACTATTTTGGATTGCAAACAGGATAAATTAAATGTTCAAACAATCTGATAAAATAACCATTTGGAAACTGCTTGGCCTTCTGTTCTTTTATTTGATTGACTACAATGCGGTATTGGTCTCTTGCTGCACTTcaaaagcaaccaacaaaacaaaaacaaaaaaaaGTGTGTGTTGTGTGAATACACACACACACTAACTAGAAGTCTTGTGATGAAAATGGCACTTGGAAAAGGTTTTATTTTTCCACTGAAGTTGAAGGTTAATAAAATGGTGTCAAACGTCCCCTGGTCACACACTTGAATATTTTTTTAGAAGTGTGATGTGGTATGATTACCATAAATCAGACTTAATTATTTTCCCTTTTACAAGGGAACAGGGCATCCTGAATTTTAGAGCCTTTCAGCAATAAGAAGGGATGTTGGTGAGCTTTGATCCTCTTTTGGTTTTGCAGTTGTTAGGAGTTTTTGCTGGCATTTTGAATATGCTGCTTTCAGAAAAACCAAGGAAGTTTTAAAATTGCTTCCTGGTCCTTAGAGGACTAAAAACAAGACCCTCATTCCCACTTTCATTTCCACTCTAGCAAAAACTGGGCTTGCGTTTTTCTCCAACTCCTCGTTTATATCCTCCCTTCCATGTCCAAGCCTTCCATTCCTAAGTGGGATTGGCTCAGTTTTGCCCATCCATATGGCAGCATCTCTAATAGCTCTTGTACAGGGTATCAGATATTGTGCCTTTTGGTGCCAGGTTCAAAGTCAAGTGCCGATCTATGAACCAGTGTACAAAAAAAAAAAAATCCAGGTATTTGAAGGAGAGACGCTCCATTGTGAATAAAGAGCTCATACCAGCTCCTAAGCCCTATTAAGAAGAGGCCTGGTCCTCTAATGCCTTGTTTCCATTTCAGTTGTTCTTTGAGAGACAGAATGATGTACTAACCATTCGTGATTATTAAGATAGGGTTGGGTCAGGGCTTAGGGAGGGGGCAGAAATATTGGGGATAGAAAAAAAATCTGATCATTCCTCAGTGCTACCCATTTCTGTCCTGTGTGGGCTGCTTAGCTAGACAGCAGGAGAATAAAGTACACCGAGAACCATAATGAAAAAACCTTCCGTGTGTTTTGTCATGTTTTGTTCCAGGGAAGCAGTTGATGAGTGCTGTTACTAATGCTTTCTCCCAGATCCATTCAGTGGTGGAGAGGAGGAAAATGGGCTGGTTGGATGTGGTCTTGGTGCCTTGCAGTTACTCTGCACTGGTTATGCATTTAATTCTCCTCTTTTCTAGTTAACCTTTTGCCAGTGGGTTTTCCATAGTCTGGGTATTTGTCCTTATATCAGTTATACCACCTAAGGCAACTGGGTGCAAAATGCATTCTGTTCACTCACTGTCTGGGCCTTCCCCACCCTAGTCTTGGCACATTCCTTCAAGAATGTAGTTACCGTCTGCTTGGGAAGATGTCAGTGCAAATGTGAAGATAATGGGCATCGGACTAGGCTTTGGTTTGCCACAAGTGGCAGCTGCCTGTATCAATTACATTTATTAATTTTGCTTTTCATTTTTCCCAGTTCTCCTCACCCCCCCTTTGTTGAAATGTTGGACTTGCTGTCAGAGGCAACTGTAATATTGCCTTAGGGACTTGTGGAGAAGGGGAATTGCTCAGTGTAGTGTTTTAACTTTCAGAACCAAGCAATCTATTTACTCTTACAAATATTTAAGAAGTGTGTTAGTCCAACTTTAAGAAAAATCCAAACTCATCAGCTTTTGATAGCATCTTGGTTTTTGAAACAACTTCAATCTGTAATTGGCATTCAGAATGCCCTTGGCATGCCAGTCTGTGATGGCATTTAAGACCTGTAAAACACTTGAGCCCAACTCGATTAACCAAAACCGATAACCACCACCTTTATCTTCTAAATAAAGTCCGCTTTATTTTTATTTTCAA

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