Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RAD17P1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:16863880-16866370  UCSC
Coordinates (T2T) chr7:16993410-16995900  UCSC
Coordinates (hg19) chr7:16903504-16905994  UCSC
Strand -
Parental Sequence NM_133339.2_2
Parental seq. overlap 2332 bp
Parental seq. overlap (%) 88.8%
Genomic Region Intragenic (AGR3)
Retrocopy Summary RAD17P1, located on chr7:16863880-16866370, is a retrocopy of the parental gene RAD17. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAD17
Full Name RAD17 checkpoint clamp loader component
Also known as CCYC|HRAD17|R24L|RAD17SP|RAD24
Coordinate chr5:69369293-69414801
Strand +
Gene summary The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RAD17P1
Bonobo Pan paniscus RAD17P1
Gorilla Gorilla gorilla RAD17P1
Orangutan Pongo abelii RAD17P1
Gibbon Nomascus leucogenys RAD17P2
Green monkey Chlorocebus sabaeus RAD17P2
Crab-eating macaque Macaca fascicularis RAD17P1
Rhesus Macaca mulatta RAD17P1
Baboon Papio anubis RAD17P1
Golden snub-nosed monkey Rhinopithecus roxellana RAD17P1
Marmoset Callithrix jacchus RAD17P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RAD17P1
GTGAATTATAGTTTAATGTACTACAGGTCCTATACTATGGATGGGAACTATTACAGTTTATAATGTCAAAAACTTTTCTTAGACCAAAGATATCTTCCACAAAGGTAACAGACTGGATTGACCCATCATTCAATGATTTTCTAGAGTATAGAGACATCTCTACTATTACTGCCACATCATTAGGTGTGAATAACTCAAGTCATAGAGAAAAAAATGAGCCTTCTACATTAGAAAGTAAGATATTTCCAGCTAGAAAAATAGGAAATCTGTCTTCCTTAGAACAGATATATGGTTTAGAAAATTCAAAAGACTATCTGTCTGAAAATGAACCATGGGTAGATAAATATAAACCAGAAAGTTAGCATGAACTTGGCTGTGCATGAAAAGATAATTGAAGAAGTTGAAACCTGGTAAAAAGCTCAAGTCTTAGAAAGGCAACCAAAACAGGATGGATCTATTTTATTAATAACAGGTCCTCCTGGATGTGGAAAGACAACGACCAAAAAAACGCTATCAAAGGAGAATGGTATTCAAGTACAAGAGTGGATTAATCCAGTTTTACCAGATTTCCAAAAAGATGATTTCAAGGAAATGTTTCATACTGAATCAAGCTTCCATATGTTTCCCTATCAGTCTCAGATAGCAGTTTGCAAAGAGTTTCTACTAAGAGCAACAAAGTATAACAAGTTACAAATGCTTGGAGATCATCTGAGAACTGATAAGAAGATAATTCTGGTTGAAGATTTACCTAACCAGTTTATAGGGATTCTCATACTTTACATGAAGTTCTAAGGAAGTATGTGAAGATTGGTCGATATCCTTTTATATTTATAATCTGTGACAGTCTCAGTGGTAAAAATAATCAAAGTTTCTTGTTCCCCAAAGAAATTCGGGAAGAGCATTCTACCTCAAATATTAGTTTCAACCCTGTGGCACCAACAATTACGATGAAATTTCTTAATCGAATAGTGACTATAGAGGCTAACAAGAATGGAGGAAAAATTACTGTCCCTGACAAAACTTCTCTAGAGGTGCTCTGTCAAGGATGTTCTGGTGATATGAGAAGTGCAATAAACAGCCTCCAGATTTCTTCTTCAAAAGGAGAAAACAACTTATGGCCAAGGAAAAAAAGAATGTCTTTAAAATCAAATGCTACGCTGTCAAAATCAAAACAAAGAAAAAAAACTGATAGGGTTTTTGAAAGTCAAGAGGTCCAAGCTACTGGTGGCAAAGACGTTTCTCTGTTTCTCTTCCGAGCTTTGGGGAAAATTTTATACAGTAAAAGAGCATCTTTAACAGAATCAGACTCATCTTGGTTGCCCTCTCATTTATCAGAATATGAACAGGATACATACTTGTTGAACCTGAGGAGGTAGTAGAAATGTCACACATGCCAGGAGACTTATTTAATTTATATCTTCACCAAAACTACATAGACTTCTTCATGGAAATTGATGATATTGTGAGAGCCAGTGAATTTCTAAGTTTTGCAGGTATCCTCAGTGGTGACTGGAATACACGCTCTTTACTCAGGAAATATAGGACATCTATAGCTACAAGAGGTGTGATACATTCCAACAAAGCCGGAGGATATGCTCATTGCCAAGGAGAAGGATCAAGTTTTTGACCCTCGCACACACCGCAGTGGTTTCTAATACATAAAAAGTATGGGGAAAATTGCCTGGCAGCAAAAGCACTTTTTCCTGACTTCTGCCTACCAGCTTTATGCCTCCAAACTCAGCTACTGCCATACCTTGCTCTAATAACCATTCCAATGAGAAATCAAGCTCAGATTTCTCTTATCCAAGATATTGGAAGGCTCCCTCTGAAGCAACACTTCGGAAGACTGAAAATGGAAGCCCTGACTGACAGGGAACATGGAATGATCGACCCTGACAGTGGAGATGAAGCCCAGCTTAACGGAGGACATTCTGCAGAGGAATCTCTGGGTGAACCCGCACAGGACACAGAGCTGGAAACCTGGTCTCTTCCTCTGAGTCAGAATAGTGCCAGTGAACTGCCTGCCAGCCAGCCTCAGCTCTTTTCAGCCCAAGGAGACGTGGAAGAAAATATAATAATAGAAGACTATGAGAGTGATGGGACATAGAAGCCAGCCTGCTAATCAGATTGCTACTTCACAGATTCATTTTTGTTTCATTCAGTGGTACTTCAGCAGAGTTAATATACTTCTCTGATGAATTACACAACAGTTTGTTAATTCTCCGTTCCTGTAGTCTTTCATCACGAAAAACTAACTCTTCTGTCACCTTGAAGTAAATAGAAGATCAAGCTTTCAAGTAATCTCTGAATGTTTTTCTGTAGGATTTATTAAATCTATGAGTGGTTTAAGGAGAGGTCAGTGTGTATAAAGTGTGTTTGAACATTATGCCAAATATCAAAATGTGAAGGACTAATTCAGAATGCAAAAACTTTATGGGGGGCTGTAAATATGAACTATACAAGAGTTTAGGATGCAATTATGGGTGTAAAG
>NM_133339.2_2
GTGAATTATAGTTTAATGTACTGCAAGTCCTAAACTACGGATGGGAACTATTACAGTTTATAATGTCAAAAACTTTTCTTAGACCAAAGGTATCTTCCACAAAGGTAACAGACTGGGTTGACCCATCATTTGATGATTTTCTAGAGTGTAGTGGCGTCTCTACTATTACTGCCACATCATTAGGTGTGAATAACTCAAGTCATAGAAGAAAAAATGGGCCTTCTACATTAGAAAGCAGCAGATTTCCAGCGAGAAAAAGAGGAAATCTATCTTCCTTAGAACAGATTTATGGTTTAGAAAATTCAAAAGAATATCTGTCTGAAAATGAACCATGGGTGGATAAATATAAACCAGAAACTCAGCATGAACTTGCTGTGCATAAAAAGAAAATTGAAGAAGTCGAAACCTGGTTAAAAGCTCAAGTTTTAGAAAGGCAACCAAAACAGGGTGGATCTATTTTATTAATAACAGGTCCTCCTGGATGTGGAAAGACAACGACCTTAAAAATACTATCAAAGGAGCATGGTATTCAAGTACAAGAGTGGATTAATCCAGTTTTACCAGACTTCCAAAAAGATGATTTCAAGGGGATGTTTAATACTGAATCAAGCTTCCATATGTTTCCCTATCAGTCTCAGATAGCAGTTTTCAAAGAGTTTCTACTAAGAGCGACAAAGTATAACAAGTTACAAATGCTTGGAGATGATCTGAGAACTGATAAGAAGATAATTCTGGTTGAAGATTTACCTAACCAGTTTTATCGGGATTCTCATACTTTACATGAAGTTCTAAGGAAGTATGTGAGGATTGGTCGATGTCCTCTTATATTTATAATCTCGGACAGTCTCAGTGGAGATAATAATCAAAGGTTATTGTTTCCCAAAGAAATTCAGGAAGAGTGTTCTATCTCAAATATTAGTTTCAACCCTGTGGCACCAACAATTATGATGAAATTTCTTAATCGAATAGTGACTATAGAAGCTAACAAGAATGGAGGAAAAATTACTGTCCCTGACAAAACTTCTCTAGAGTTGCTCTGTCAGGGATGTTCTGGTGATATCAGAAGTGCAATAAACAGCCTCCAGTTTTCTTCTTCAAAAGGAGAAAACAACTTACGGCCAAGGAAAAAAGGAATGTCTTTAAAATCAGATGCTGTGCTGTCAAAATCAAAACGAAGAAAAAAACCTGATAGGGTTTTTGAAAATCAAGAGGTCCAAGCTATTGGTGGCAAAGATGTTTCTCTGTTTCTCTTCAGAGCTTTGGGGAAAATTCTATATTGTAAAAGAGCATCTTTAACAGAATTAGACTCACCTCGGTTGCCCTCTCATTTATCAGAATATGAACGGGATACATTACTTGTTGAACCTGAGGAGGTAGTAGAAATGTCACACATGCCTGGAGACTTATTTAATTTATATCTTCACCAAAACTACATAGATTTCTTCATGGAAATTGATGATATTGTGAGAGCCAGTGAATTTCTGAGTTTTGCAGATATCCTCAGTGGTGACTGGAATACACGCTCTTTACTCAGGGAATATAGCACATCTATAGCTACGAGAGGTGTGATGCATTCCAACAAAGCCCGAGGATATGCTCATTGCCAAGGAGGAGGATCAAGTTTTCGACCCTTGCACAAACCTCAGTGGTTTCTaataaataaaaagTATCGGGAAAATTGCCTGGCAGCAAAAGCACTTTTTCCTGACTTCTGCCTACCAGCTTTATGCCTCCAAACTCAGCTATTGCCATACCTTGCTCTACTAACCATTCCAATGAGAAATCAAGCTCAGATTTCTTTTATCCAAGATATTGGAAGGCTCCCTCTGAAGCGACACTTTGGAAGATTGAAAATGGAAGCCCTGACTGACAGGGAACATGGAATGATAGACCCTGACAGCGGAGATGAAGCCCAGCTTAATGGAGGACATTCTGCAGAGGAATCTCTGGGTGAACCCACTCAAGCCACTGTGCCGGAAACCTGGTCTCTTCCTTTGAGTCAGAATAGTGCCAGTGAACTGCCTGCTAGCCAGCCCCAGCCCTTTTCAGCCCAAGGAGACATGGAAGAAAACATAATAATAGAAGACTACGAGAGTGATGGGACATAGAAGCCAGCCTGCTAATCAGATTGCTACTTCACAGCTTCATTTTTGTTTCATTCAGTGGTACTTCAGCAGAGTTAATATGCTTTTCTGATGAATTACACAACAGTTTGTTAATTCTTCATTCTTGTAGTATTTCATCACAAGAAACCTACTCTTCTGTCATCTTGAAGTAAATAGAAGATCAAGCCTTCAAATCTCTTAATTTTTTCGGTATTTATTAAATCTGTGAGTGGTTTAAGGAGCGGTCAGTGTGTATAAAGTGTGTTTGAACATTATGCCAAATATCAAGATGTGAAGGACTAATTCAGGATGCAAAAACGTTATTGGGGGGTTGTAAATATCAACTATTCAACAGTTTAGGATGCAATTACGAGTGTAAACTGTGTGCCTTATTTACACTTTATTGTCTCCCGCTTCTCAGATAGTTTTGATGTGTTGTACAGTGGAATATCTTAGATACTTTTTGGAAAGTATTTACATAAGTTATATCACAATTAAAATGTTGAATTTAA

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