Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CLK2P1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:23584715-23586527  UCSC
Coordinates (T2T) chr7:23724066-23725878  UCSC
Coordinates (hg19) chr7:23624334-23626146  UCSC
Strand -
Parental Sequence NM_001294338.2
Parental seq. overlap 1740 bp
Parental seq. overlap (%) 80.7%
Genomic Region Intergenic
Retrocopy Summary CLK2P1, located on chr7:23584715-23586527, is a retrocopy of the parental gene CLK2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CLK2
Full Name CDC like kinase 2
Also known as -
Coordinate chr1:155262868-155273504
Strand -
Gene summary This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CLK2P1
Bonobo Pan paniscus CLK2P1
Gorilla Gorilla gorilla CLK2P1
Orangutan Pongo abelii CLK2P1
Gibbon Nomascus leucogenys CLK2P1
Green monkey Chlorocebus sabaeus CLK3P1
Crab-eating macaque Macaca fascicularis CLK2P1
Rhesus Macaca mulatta CLK2P1
Baboon Papio anubis CLK2P1
Golden snub-nosed monkey Rhinopithecus roxellana CLK2P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CLK2P1
GGCGGGCGGGACTGAAGCAGAGCCCGAGAACGGGGCTGGAGGTCCCAGGGTCCCGGGTTGGTGGGGGTGGAGCAGCACTTCATCGCCGCGGGGGTGCTGGGACTCCGGCCGCAGTGCCGCCGCCATCATGGACTTCCTGTGGGACAAGCGCACGGGCCTGGCCGCCAGAAAGATGCCTCATCCTCGAAGGTACCATTCCTCAGAGCGAGGCAGCCGGGGGAGTTACTGTGAACACTATCGGAGCCGAAAACAAGCAACGAAGAAGCCGTTCCTGGTCAAGTAGTAGTGACCGGACACGACGGCGCCGGCGAGAGGACAGCTACCATGTCCGGAGGAGGTGCAGCCGGACATTTAGCCGCTCGTCTTCGCAGCACAGCAGCCGGAAAGCCAAGAGTGTAGAGGACGACACTGAGGGCCACCTCATCTACCATGTCGGGGACTGGCTACAAGAGCGATATGAAATCGTCAGCACCTTAGGAAAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCATCGCAGGCGTGGGGCTCGAGTTGCCCTGAAGATCATTAAGAATGTGGAGAAGTATAAGGAAGCAGCTCGACTTGAGATCAAAGTGCTGGAGAAAATCAACGAGAAAGACCCTGGCAAGAACCTCTGTGTCCAGATGTTTGACTGGTTCGACTACCATGGCCACATGTGTATCTCCTTGGAGCTTCTGGGCCTTAGCACCTTCGATTTCCTCAAAGACAACAACCACCTGCCCTACCCCATCCACCAAGTGCACCACATGGCCTCCCAGCTGTGCCAGGCTGTCAAGTTCCTCCATGATAACAAGCTGACACATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGACTATGAGCTCACCTACAACCTAGAGAAGAAGCGACATGAGCGCAGTGTGAAGAGCACAGCTGTGCGGGTGGGAGACTTTGGCAGTGCCACCTTTGACCATGAGCACCATAGCACCATTGTCTCCACTCGCCATTACCGAGCACCAGAAGTCATCCTTGAGTTGGGTTGGTCACAGCCTTGTGATGTGTGGAGTATAGGCTGCATCATCTTTGAGTACTATGTGGGCTTCACCCTCTTCCAGACCCATGACAACAGACAGCATCTAGCCACGATGGAAAGGATCTTGGGTCCTATCCCTTCCCGGATGATCCGAAAGACAAGAAAACAGAAATATTTTTACCGGGGTCGCCTGGATTGGGATGAGAACACATCAGCTGGACGCTATGTTCGTGAGAACTGCAAACCGCTGCGGCAGTATCTGACCTCAGAGGCAGAGGAAGACCACCAGCTCTTCGATCTGATTGAAAGCATGCTAGAGTATGAACCAGCTCAGCGGCTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCTCCCGCCTTTGGGCTGAGCCACCCAACAAGTTGTGGGACTCCAGTCAGGATATCAGTCCGTGACCACCAGGCCCTGGGCCTCCCTGCATCTTTTATAGCAGTGAGTGTCCAGTCCAGGACATTGGTGCTTTTTTATAAAAGAGAACAGAGCCAGAGTTCACTCCTTCCTGCTGCTTCTCTATATACCTGTGAATATGTGAAACAGTAAATATGAAAGAACTTGTACCTATCACTTCAACCCCTGCGTTGTACATAATGCTATTCCATCTACACACTTTCCACCCTCACCTGCCCCCTCATACAGAGTTGGATGGGGGCCGAGTGAGGTAACCAGGTGGCATCTACCCCATGTTTTATAAGGAATTTTGTACAGTCTTTGTGAAATGAAATAACATGCTTCATTTGACCCG
>NM_001294338.2
GTGCGTACGTGCTCGCTCAcggcggcggcggcggagcggagaggccagagccggagaccgagctggGATCGGGCCCCGGGCGGGGGCGGTGCGAGCGGCGCCAAGCAGATCTTAGGGGCGGGGACGGAGCCGGGGCGGGCGGGACTGAAGCGGAGCCCGGGAACGGGGCGGGAGGTCCCAGGGTCCCGGGTTGGGGGGGTGGAGCAGCATTTCGTCGCCGCGGGGGTGCCGGGACTCCGGCCGCAGTGTCGCCGCCATCACGGACTTCCTGTGGGACAAGCGCACGGGCCTCGCCGCCAGAACGATGCCGCATCCTCGAAGGTACCACTCCTCAGAGCGAGGCAGCCGGGGGAGTTACCGTGAACACTATCGGAGCCGAAAGCATAAGCGACGAAGAAGTCGCTCCTGGTCAAGTAGTAGTGACCGGACACGACGGCGTCGGCGAGAGGACAGCTACCATGTCCGTTCTCGAAGCAGTTATGATGATCGTTCGTCCGACCGGAGGGTGTATGACCGGCGATACTGTGGCAGCTACAGACGCAACGATTATAGCCGGGATCGGGGAGATGCCTACTATGACACAGACTATCGGCATTCCTATGAATATCAGCGGGAGAACAGCAGTTACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGGAGGCGCAGCCGGACATTTAGCCGCTCATCTTCGCAGCACAGCAGCCGGAGAGCCAAGAGTGTAGAGGACGACGCTGAGGGCCACCTCATCTACCACGTCGGGGACTGGCTACAAGAGCGATATGAAATCGTTAGCACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCATCGCAGGGGTGGGGCTCGAGTTGCCCTGAAGATCATTAAGAATGTGGAGAAGTACAAGGAAGCAGCTCGACTTGAGATCAACGTGCTAGAGAAAATCAATGAGAAAGACCCTGACAACAAGAACCTCTGTGTCCAGATGTTTGACTGGTTTGACTACCATGGCCACATGTGTATCTCCTTTGAGCTTCTGGGCCTTAGCACCTTCGATTTCCTCAAAGACAACAACTACCTGCCCTACCCCATCCACCAAGTGCGCCACATGGCCTTCCAGCTGTGCCAGGCTGTCAAGTTCCTCCATGATAACAAGCTGACACATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGACTATGAGCTCACCTACAACCTAGAGAAGAAGCGAGATGAGCGCAGTGTGAAGAGCACAGCTGTGCGGGTGGTAGACTTTGGCAGTGCCACCTTTGACCATGAGCACCATAGCACCATTGTCTCCACTCGCCATTACCGAGCACCAGAAGTCATCCTTGAGTTGGGCTGGTCACAGCCTTGTGATGTGTGGAGTATAGGCTGCATCATCTTTGAATACTATGTGGGATTCACCCTCTTCCAGACCCATGACAACAGAGAGCATCTAGCCATGATGGAAAGGATCTTGGGTCCTATCCCTTCCCGGATGATCCGAAAGACAAGAAAGCAGAAATATTTTTACCGGGGTCGCCTGGATTGGGATGAGAACACATCAGCTGGGCGCTATGTTCGTGAGAACTGCAAACCGCTGCGGCGGTATCTGACCTCAGAGGCAGAGGAACACCACCAGCTCTTCGATCTGATTGAAAGCATGCTAGAGTATGAACCAGCTAAGCGGCTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCGCCCGCCTTCGGGCTGAGCCGCCCAACAAGTTGTGGGACTCCAGTCGGGATATCAGTCGGTGACGATCAGGCCCTGGGCCCCCCTGCATCTTTTATAGCAGTGGGTGTCCAGTCCAGGACACTGGTGCTTTTTTATACAAGAGAACGAGCCAGAGTTCACTCCTTCCTCCTGGCTCTCTATATACCTGTGAATATGTGAAATAGTGTAAATATGAAAGAACTTGTACCTATCACTTCAACCCCTGCCTTGTACATAATACTATTCCATCCACACAGTTTCCACCCTCACCTGCCCCCTCATACGGAGTTGGATGGGGGCCGAGTGAGGTAACCAGGTGGCATCTACCCCATGTTTTATAAGGAATTTTGTACAGTCTTTGTGAAATAAAATAACGTGCTTCATTTGACCCCCA

Publications

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