Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GMPSP2
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:31330709-31330917  UCSC
Coordinates (T2T) chr7:31468384-31468592  UCSC
Coordinates (hg19) chr7:31370323-31370531  UCSC
Strand +
Parental Sequence NM_003875.3
Parental seq. overlap 192 bp
Parental seq. overlap (%) 2.2%
Genomic Region Intergenic
Retrocopy Summary GMPSP2, located on chr7:31330709-31330917, is a retrocopy of the parental gene GMPS. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GMPS
Full Name guanine monophosphate synthase
Also known as GATD7
Coordinate chr3:155869430-155944020
Strand +
Gene summary In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GMPSP2
Bonobo Pan paniscus GMPSP1
Gorilla Gorilla gorilla GMPSP2
Orangutan Pongo abelii GMPSP2
Green monkey Chlorocebus sabaeus GMPSP1
Crab-eating macaque Macaca fascicularis GMPSP1
Rhesus Macaca mulatta GMPSP1
Baboon Papio anubis GMPSP1
Golden snub-nosed monkey Rhinopithecus roxellana GMPSP1
Marmoset Callithrix jacchus GMPSP3
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GMPSP2
ACCAGAGAACTGTGGTTATTTGAGCCTTTTTTACTAGTGACTTCATGACTGGTATGCCTGGAACACCTGTCAATGAGATCCCTGTAAAGATGGTGTTAAAGATGGTCACTGAGATTGCTAAGATTCCTGGTATTTCTCAAATTATGGATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAATAAAATTCTTGTTCTATT
>NM_003875.3
AGCGTGCGCGCTGCTGGTCTTCTCTCCCGCGGCGCTGGGGCCCGCGCTCCGCTGCTGTTGCTCCATTCGGCGCTTTTCTGGCGGCTGGCTCCTCTCCGCTGCCGGCTGCTCCTCGACCAGGCCTCCTTCTCAACCTCAGCCCGCGGCGccgacccttccggcaccctcccgccccgtctcgtactgtcgccgtcaccgccgcggctccggccctggccccgATGGCTCTGTGCAACGGAGACTCCAAGCTGGAGAATGCTGGAGGAGACCTTAAGGATGGCCACCACCACTATGAAGGAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACGGGAAAGTCATAGACCGAAGAGTGAGGGAACTGTTCGTGCAGTCTGAAATTTTCCCCTTGGAAACACCAGCATTTGCTATAAAGGAACAAGGATTCCGTGCTATTATCATCTCTGGAGGACCTAATTCTGTGTATGCTGAAGATGCTCCCTGGTTTGATCCAGCAATATTCACTATTGGCAAGCCTGTTCTTGGAATTTGCTATGGTATGCAGATGATGAATAAGGTATTTGGAGGTACTGTGCACAAAAAAAGTGTCAGAGAAGATGGAGTTTTCAACATTAGTGTGGATAATACATGTTCATTATTCAGGGGCCTTCAGAAGGAAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAGACAAAGTAGCTGATGGATTCAAGGTTGTGGCACGTTCTGGAAACATAGTAGCAGGCATAGCAAATGAATCTAAAAAGTTATATGGAGCACAGTTCCACCCTGAAGTTGGCCTTACAGAAAATGGAAAAGTAATACTGAAGAATTTCCTTTATGATATAGCTGGATGCAGTGGAACCTTCACCGTGCAGAACAGAGAACTTGAGTGTATTCGAGAGATCAAAGAGAGAGTAGGCACGTCAAAAGTTTTGGTTTTACTCAGTGGTGGAGTAGACTCAACAGTTTGTACAGCTTTGCTAAATCGTGCTTTGAACCAAGAACAAGTCATTGCTGTGCACATTGATAATGGCTTTATGAGAAAACGAGAAAGCCAGTCTGTTGAAGAGGCCCTCAAAAAGCTTGGAATTCAGGTCAAAGTGATAAATGCTGCTCATTCTTTCTACAATGGAACAACAACCCTACCAATATCAGATGAAGATAGAACCCCACGGAAAAGAATTAGCAAAACGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAAAAATCATTGGGGATACTTTTGTTAAGATTGCCAATGAAGTAATTGGAGAAATGAACTTGAAACCAGAGGAGGTTTTCCTTGCCCAAGGTACTTTACGGCCTGATCTAATTGAAAGTGCATCCCTTGTTGCAAGTGGCAAAGCTGAACTCATCAAAACCCATCACAATGACACAGAGCTCATCAGAAAGTTGAGAGAGGAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAACCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCTACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAATAAACTTCTTGTTCTATTAAAGTACCGTGTGCAGTTTAAATTGATTAGAAATCATTCCCATTATTGACATGCAGTACTGTGAAAAGAGTTACTGGAGCAGCTACATCACATCTGAGTTCTCCACAGCAAAAATCTACGGCTTAAGAGCTGAGTTGGGGATAACCAAAAGGGACTGAAGAGTTTGTACGGGTAAATAATCAAAGCACCATTGCCTACACTCAGACAGATTGATACTGCTTTTGCCTTTGCCTCACTTATTCTTTATGTATAAATTCACTGTTGATGTCTCTGTGAATATGTATGAAGGTGGGTGAATTTGGGGGTAATTATGGGCTTCTGTCTCCTTACCAGTTTCTAAGAACTGTTAGAAACGCCCATTATTTACCAGTGTTACTTACTACTTATATATACTTTTTGGAGAATCAGTTTTCTTATAAGTAATCTTATTTCTCCAAAGGGTGAAAAAGAGATGAACATATCAGATAAAGGTATAGGTGGGCTATTCCAGCCACTTTTGAAGGACACTGAGGGTATAAAATGTAAGCTACCATAAGATGGAAAAGCACCAGGAATTTGTTGATGTACTTTTGAATTTTATTTCACAGCCTTGGGAGGAAGAAACTATGAGTGGTCTCAGATGTCTATGAATGGTCTTAAAATGTTTTCAAACCATGTTCCACATAGATGCCATGTTATTCAATGTCAGCTTGTTTATTAGTAAGGAGCTTTATCCTCCTAGCCTTATATTACCAGCCCCCCACAGCCTTGCATAGAAAGTTTCTGTTATCTCCTTAGAAGAAACTGGCTCAATGACGTTTCTGGTGTAGTGCAGATAGAGGTCAAGAGGAGCATTTTCATCTCTTCTTTTGCTGGTCAGAGAAACGGTTCTGAGATCACAGAAGCTATGATGCATACCTACAGCTTACAAAAGGGAGAGGAAAAATGTTTATATCATCTAGTAAACAGTTGTAAAATGAGCTTTTAAATCTAATCTATAGACATATTATTCATTGCTCAGACACCTGTGAACAGTCTTGATACATGCAAGATGTTTGCCAAACTTTGTAATCCTTTCTACTAGCTATAAGagaggatttaagaactggtgtaggacttgttgccatcaccaccagtttctaacagatcttttataacattcaCATAAGTACTGTAGACAGTAGTAGACTTAAACTCTCCGTTTCTCTCAGTATTTTAGCTAAGAATGTTACCATATTTTTCTCTTAACAATTCCATCTCAGGTTGCTGCTGCTTGTCTAGTTTAAAAGGTCAGATCTATTAATCAGGAATGAAATTTTATTTGGGATTCAGTGTTAGACAAACAACAAAATGATGCGTGGCAGAAGTCATCTTTTTATTCTGGCTGGTCCAGGGAACAAGAAAACTGCTGCTGGACCAGCAAGGGAAGAGTTTCTGTCTGTCTTAACAGAAATCTGTCCCCAAGACAAAGGGGTACTTGACTCCTACAAAACTTAAAGGGTACATTCTCTATCTGATGAGGAGGTACTCATTATGGCCTTCTGGAAAGAGGCTATGTTAGTGATCTGGTCTTTACAGATTTAGAGTCATGTTATTTGAAAGCTAGAATAGACAACCTATAAAATGCTTACCAACATGTGTCAGTACACGTTTATGTTTATATGAAAAAAAATTTCTAGCCACAGTGTCTTATGATTTTGTATTGAAGCAAACAGTAGGAATTTTGGAAAAATAGAGAGTAAGAATgtgtgttctatggaacactgctccactgagaaggtccatgtaaaaaggattaggtggtcatataagtttggggaacataagctcacttgtcctttcctggagattcatggtatataatattcaaagctctgagaaattctgaagttaaaaacaattgttaaattctgcttaaattagtgttttcctgatatttgttttttgaacaccttttATATAATCCCTTCTAATATATACTTAGTATATACTTAATATAATATTGGGAAAATTGTTACTCCAAAGCACATCTTGACATGACATAGTTTCTTAAAAATCCAAATTTTCTGGAACTCAGAAATTTCCTAATATTTAGCACACTGTCTTCTTTTGCACAGCACTTTTTGCTTTGTGCCATATAGCATTACTCTGTACCTTCACAGTATTTCATCTGAGCCACTGAGGAAAGTTAAAGGTTGCACTTCCATTTTACAGTTAAGAAAACAAGCTCACCTTAGGCATGGTTACTTAATTAATTTCAGAATTAAATTTCAGGTTTCCTTAGTCCAGATTGTCCTGATGTGTATTCTGACACCTAAAATTATATAAACATTTATGGGATGCTTATTTTACTAAGACTAGAATGGTGGCTACCTGGCTAATAACATTCATCATTGGTTATTCTGGGCATATCATGACTTTATTCCCGTTGCTTACCATCTACCTGGGACACATCTCTCTTTGATTAAATATATTCTTTTTCTTTGTACTTTTTAGGTAGACAGAGAATGTAGATCATTGAAAGCATTATTTATTCCTAAGATTGGCAGGCACAGAATCATTTTTAAGAACCAAATACCCAGTCCTGCCTTAAAGGCCACATCTATGATCATCAGCTCTGTTAGAAATAACAGCCTGGCATAATTCCTAAATACAAGTCTGTAGATATATCCAGGAGATAGGGTTACACTGTTTTCTAACCTTTTTTAAATCCCTTAATCTTGAGGTAAACTGCATGCATTTAGTCAAACAAGCATCATAAAATTTGTTTCCTCACTGTTTGGGCTTAACCTCCTGATAGCCTGTTTTACTGAATAACTTGACCCTAACCTGTAGAGAATAagagcattcaaattaggaaggcaggactatccatctttagtgcttttcctgccgttaaacaacaatgtgaacttggtcaagtcatttctgttctttatctgtgacatgaggtaactgtattaaatTTTCAGCATCAAATCCAGCTATAAATTTGTATTTTGTAAACAAGAGAAAGTAAAGCAGGAGACAGAATGGAGAAGCTGGATAGTGttttttttttttttttttAAGGTTCTTTTATCATCAGATATGACACAAAGGGAAACATCAAAATGCACCGTAAAGTTAAATCCTAGTTACCTTTTTTTGAAGCTGTTGGCAAGGTTTGACCACTTGGGGCATCTTCTGCTGTGAGATGACACTTGAAAAACACCCATCAAAGTTTTCCTGGTAGGAATCTCTCTTTACTGCGTGTTTTTTTGAAAAGCTGACAGAGAATATGCTTTGGCTTTGACACTAATGAAGTCACCCATCATCAATTAcatacagctaattgttgggagctagagctagaatccaagctttctgattcTCTGCATGGAAGAGGAAATGCTCTAGGGCCCTTCAGGGCAAATCTTAAAAGGAAGTTCTTggccgggcgcggtggctcatgcctgtaatcccagcactttgggaggccgaggtgggtggatcacgagatcaggagatcgagaccatcttggctaacacggtgaaaccccatctctactaaaaatacaacaaattagctgggcgcggtggcgggtgcctgtagtcccagctactcgggaggctgaggcaggagaatggcctgaacccaggaggcggagcttgcagtgagctgagatagtgccactgcactccggcctggtgaaagagcgagactcagtctcaaaaaaaaaaaaaaaaGGAAGTTCTTAGTGTGTAATTGACCATCAGGGATAAATGGGCTTCAAAAGTGTTAATTGTCTCCTTACTTACAGTGAGTTTCTAGAGATAGCCCTGTCTTTCAGAAATTCTCTGACATCTGCTTGCGCAATGTTATAACCACTTTCCCACACTACTCCCCTCCAGAAATCTCATTGATATGTGGCGAGGACACGCCTTAGCTATCACCCCAATGGATGCTTCTTTCATTGACCCAAATCCAGAATGTAATGGGGAACTGAATACAAGTTGGATGTCTCCACCCTTGGAAAGCACATCTTTTGTTCTTACTGAAGTAGTTTAACACCACCAGATGATCAAGGGATCAGGGTATCTTTCTGGTATCTTTTTAATCACTGAAGGACTTTGACAGCAGTAATGGTGGCATTGTTGACTCTTAAATTTCTGAACGTTTCACTTAATGGCAAGTGAAGAGATATAGAATCCCCCAAAGAGTGTCAAGATGCTAACTTCCAACCCTATTTTTATGTACTGAAGAGGCCTCAGTGTCTCACTGAACTCTAACCTTTTTGTcagtgttcctcaacactggatgcgtattattacataacctgaggagttaaaaaatacaataaccagatgtccaattaaataaaattagaatctggaggaggtagaactcaagcatttacagttttgttttgttttttttttaagacagagtctcgctctgtccccaagtgcagtggcacaatctcggctcactgcaagctccgcttcgtgggttcacgccattctcctgcctcagtctcccgagtagctgggactacaggcgcccgccactacgcccggctaatttttttgtactttttagtagagacagggtttcactgtgttatacaggatggtctcgatctcccgacctcatgatccgcccgcctcggcctctcagagtgctgggattacaggcgtgagccaccacgcccggcaagcatttacagttttaaatctcccAGTCAGAATAAATTCTTATTGAGGGCCATACCTAGCCTGTCTTCATCAAACTCATAGGTGAATCTTTGTCAAACCTATAGGAGAGAGATGCAGGCCATAGAGATGGTCTTGCTGAAGGTCTTATAGCTAAATTAGTTCAGATCCAGGAACCAGATTCTGGAACTGATTGCACCTATATTATGTTGTGTGTCAGACACTCCCAGGACCTGTTTGGTAATAATTAGGACAGCTGACATACTTGTTGCTAATTTTGAGATCTGGGCAACAACTGTGTAGGCTGTTCTTTCAACCTCTTTCTTCTTACTTCTTTACTTTTCCTTCAGAGAGGAGAAAGCCACCCCTGTGCTATAGCCACCGCTCCAATTCTGACTCTAGCTAGGTCATGAAACAGACTGAGCTATTATTGCATCAACACATAAATCCTGTCATTTGGGTATTATTCTTTAGAGAACTAGAGATTACCTAGCTGCAACCTAAGTTTCCTGAATTAGAATCATTTGAGCAGCACCATCTTAATTGGCTCATTAACATATTTGTgaccaggcacagtggcgcatgcctgtaatcccagcactttgggaggccgaggcgggcggatctcttgaggtcaggagtttgagaccagcgtggccaacatggtgaaaccccatttctactaaaaatgtaaaaattagctgggcttggtggcgcgcgcctgtaatcccagctactcggaaggctgaggtgtgagaatcacttaaacccgggagatggaggttgcagtgagcagagattgcgccactgcactccagcctaggtgacaagaatgagactccgtcttaaaacaaaaaCAACATATTTGTTCACTTTTGAACCCTGTGGTGTCTTTTAACTTTGTTAAGGGCCCTTGGTTAGCAAAATTATGAAAGTTTAGGAAATTTGGCTATTGAGTATATTAAGTACAACTACAAAATCCTCTGAGTTCTCCAGGAAGCCTAAACCTTGAGCAGTATCTTATTCAAGTGGAGTATATATCTTCAAGAATACAGATTTTTAAGGTAAGTAGTTTTTCGTCTTTGCATCTCCTAAGACCATTGTTAACAACCTTGATATTAAACGAAGAAGTGAATGTAAACCTCCTTTTGAACATATTTTTTATAAAGAAATATTTTGTTAATTGGAGTAAGTAGTATTGTTATGAAATCACTGTGTAATTGTTAATTGTAAACTGCAATGTCTATTTTGTGTTGTAACAATGTTGCCATAAAATAGCTTTGCTAAATGTGAAATGACTTTAATCCCTTTTGTCTTCAATATACTTCATAAAGGAGGAAATGATGATTTACACAATTTGTCATGAAGCTTCCGTGTTTATGAGAAATTCCAAGAAGTAAGAGCCAAGAGGACAGATATTATCAGAATATGGGACATAAGAAATTGCATATAGTGTCAAGGGTTTCTATATAACAACTTAATTTATTTCCCTTGCATATATAGTAGGGGTTAACATTTTGCTCAATGTTAACGGGGGACATAATGGACATAAAACATTGGATAGCTTTTTATTTAAATGAGCTAAAGGTGTGCGTATACACATGCACTTATAAAATTAAAGTCATATATGTATATA

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