Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NECAP1P1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:37582954-37586334  UCSC
Coordinates (T2T) chr7:37723438-37726818  UCSC
Coordinates (hg19) chr7:37622557-37625937  UCSC
Strand -
Parental Sequence NM_015509.4
Parental seq. overlap 1268 bp
Parental seq. overlap (%) 33.5%
Genomic Region Intergenic
Retrocopy Summary NECAP1P1, located on chr7:37582954-37586334, is a retrocopy of the parental gene NECAP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NECAP1
Full Name NECAP endocytosis associated 1
Also known as DEE21|EIEE21
Coordinate chr12:8082274-8097881
Strand +
Gene summary This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NECAP1P1
Bonobo Pan paniscus NECAP1P1
Gorilla Gorilla gorilla NECAP1P1
Orangutan Pongo abelii NECAP1P1
Gibbon Nomascus leucogenys NECAP1P2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NECAP1P1
ATGGAGAAAGACCTATTTCCTGGGTCTCTGCTGTATAGCCTTCTTCAGGCTTATCGTACTCAGTGAACATCCAGTGCTGGGTGCAGCTCCATCACCCTCTTGTGTGTTTACATGTATCTTTCTATGACAAGAGGGTTGTGCTGGTGGCACCTCCACTCTTCTTTTCTGTTTGCTGAATTTGAATTGTGAAACATCTTTGACCAATGGGTGTCTCTGTGATGAAGGAGGTTCAAGAGGCTGTGCTTTCCAAGTGATATTCTATAGGAGTGTTTAATTTCTTGCAGCTCCATCTAGTTGCTGCATTTGAAGCATGGCATTAATTTGTATTTGCCATGTTATTTGACCTGAAGTTGAAGAGTATAGAGTTTTTAACCTGATCTGTAGAGCAGAGAGGCTGAAAGCACTTAACTCTTGTTTAGTACCCACATTGTCTTGCTGTCTGGGTATCTGGCCCCTTTCCATAAACATTTCTTTTCAGTTCATGTAGTTCTTTAATAGAAAGCTGCTATTATTTGTATTGTCATTTGTGAAGGAAGTTGGAGAGTCACAGCTTTACCGTGACAGGTTTTGCCCAAGGCTTTGATACCTGTCACCCAGGGTTAAAAGCAAGTTGTTCTCCCATCACTTTCTTTCCCCTCTGCCCTGCCATTCCTTTTACAATGCTGTGAAAAAAGTTCTGCTTCTTAGATGAATGGGTACTTTCTATTTTGTTTCTAAATGAGCAATGTTGAGGATTAAATGGGAAGATATACTTGCTTCCCTTTTGTACCTATTTGGAACGTACACTCTGGCAGAAGGGAGTCCTTATGTTTAGTTTCAAAATATATTACTTTCCTGGATTTCCTTCTTAACTTTTTCTGACTTTGGGTCCATTTTCTTTTCATTGCCTCATTTTCCAGGAAGCTCTATTCTTGAAGAGCCATGGCAAGACATATTAAAATTCCAATAGAAAACACTAAAAGGAAAGTCTGTAGAAGCATTAGTGACTAAATACTGGCAACCTATTTTCTCAATCTTCCTCCACGTTGTGTTCTTTGTATTCTAAGATGATAATATATTATGTATTTGAATTCCTGAAAAATGGGAAATGTTTAAGATATATCTATATAAAGTATATGCTGTATTGGTGCAATAATGGTAATTAAAAATCCAAGATGGTGGCCAAGTTGGAGTATGAGTCTGTGCTGTGTGTGAAGCCAAACATCAGCGTCTACTGGATTCCTCCCTGGGCCTCCAACTGTGATTACAGGGCATCTGACTGGAAATTAGACCAGCCTGATTGGACTGTTCACCTCCGAATCATTTCAAAAGGGAAGACTGCCTATATCAAACTCGAGGATAAAGTTTCAGGGGAGCTCTTCACTCAGATACCAGTAGAACAATATCCTGGTATTGCTGTGGAGACAGTGACAGATTCCAGCTGCTACTTTTTAATCTGGATTCAGGATGGTCCTGGGCAGAGTGCTGTCATTGACACTGCTGGCTTCACAGATCGGGGAGATGCCTTTGAATTTAATGTCTCCTTGCAGGATCACTTCAAATGGGTAAAGCAGGAATCTGAGATTTCCAAGGAATCTCAAGAAATGGACGCTTGTCCTAACTTGGATCTGGGCTTCAAAGAAAGACAAACCATCAAGTTGAGTACGGGGAACATTACAACCAAGAATGGATGTGCTTCTAAGCCCAGGACTGCAATGGGTGGGGGCCTGAGCTTACTCGCATCCCCACCAGGAGGCCAAGTCAGTATTCCCCCACTGTCCTCCTCAGTTGCATCAGCAATCATGTCACCCTACCAGCCATTCCAAAATCTAACCATGGAGGCAGTGATGCAGATATCCTTTTAGATTTGGATTCTCCTGCTCCTGTCACAACACCAGCACCAACTCCAGTTTCTGCAAGCAATGACTTGTGGGGAGACTTCAGCACTGCATCCAGCTCTGTTCCAAACCAGGCACCACAGCCATCCAACTGGGTCCAATTCTGAATGGCATTGGCAGGACATTAAGGCAGACTTGTGGAATAAAAATGACCTTGAGGGCACCAATCTGTGAGGGAAGTCAGAAACCCATTTCCTCTACAGAACCAAAATGACTGGACAATCTTTTTCATAGCTTCTCCATTACATTCAAGCTGGTTTATGTCACTCCCCTGTGTTGTTACTTGTACAGCCAAGAGAGTATCTATTATCTCCTGCTTAGTACCAAGGTAGAGGACTAGTGGATCTTATCATACTTTTGGCTGACTATGCAGGGCTCAAAAGGCCAGTATCTCTTTGAGGAGGAATGATCTAACATCTGTAAAATTTGTCTTATCTTTTAAATTCTTCAACTTATTTCAAAATCATCTCATGACCCTTGTGTGCCTCTTTGTGAAGCCCTATTTAGCAATTCCAGGGAAGTCAAAAACCTTGCAACTTCCTTCTCCACTAACCCAGGACTAAAAATGGACAGGCTGACCTCAGTGTTTACAAATTCAGAATTTTGATAGGGGTAGATATGGAGt
>NM_015509.4
GACAGCGGACCCAAGATGGCGACCGAGTTGGAGTACGAGTCTGTGCTGTGTGTGAAGCCAGACGTCAGCGTCTACCGGATTCCGCCCCGGGCCTCCAACCGCGGTTACAGGGCCTCTGACTGGAAATTAGACCAGCCTGATTGGACTGGTCGCCTCCGAATCACTTCAAAAGGGAAGACTGCCTATATCAAACTCGAGGATAAAGTTTCAGGGGAGCTCTTTGCTCAGGCACCAGTAGAACAATATCCTGGTATTGCTGTGGAGACGGTGACAGATTCTAGCCGCTACTTTGTAATCCGGATCCAGGATGGTACTGGGCGCAGTGCTTTCATTGGCATTGGCTTCACAGATCGGGGAGATGCCTTCGACTTTAATGTCTCCTTGCAGGATCACTTCAAGTGGGTAAAGCAGGAATCTGAGATTTCCAAGGAATCTCAAGAAATGGATGCTCGTCCTAAGTTGGATCTGGGCTTCAAGGAAGGACAAACCATCAAGTTGTGTATCGGGAACATTACAAACAAGAAAGGAGGTGCTTCTAAGCCCAGGACTGCAAGGGGTGGGGGTCTGAGCTTACTCCCACCCCCGCCAGGAGGCAAAGTCACTATTCCCCCACCATCCTCCTCAGTTGCCATCAGCAATCATGTCACCCCACCACCCATTCCGAAATCTAACCATGGAGGCAGTGATGCAGATATCCTTTTAGATTTGGATTCTCCTGCTCCTGTCACGACACCAGCACCAACTCCAGTTTCTGTAAGCAATGACTTGTGGGGAGACTTCAGCACTGCCTCCAGCTCTGTTCCAAACCAGGCACCACAGCCATCCAACTGGGTCCAGTTCTGAATGGCATTGGCAGGACATTAAGGACAGACTTGAGGAATAAAAATGACCTTGAGGGCACCAATCTGTGAGGGAAGTTAGGAACCCATTTCCTCCCCAGAACCAGAATGACTGGACAATCTTTTTCATAGCTTCTCCATCACATTCAAGCTGGTTTATGTCACTCCCCTGTGTTGTTACTTGTACAGCCAAGAAAGTATCTGTTATCTCCTGCGTAGTACCAAGGTAGGGGACTAGTGGATCTTATCATAGTTTTGGCTGACTATGCAGGGCTTAAAAGGCCAGCGTCTGTTTGAGGGGGAATGACCTCTAACATCTGTAAAATTTGTCTCATCTTTTAATTTCTTTAACTTATTTCAAAATCATCTCATGACCCTTGTGTGCCTCTTTGTGAAGCCCTATTTAGCAATTTCAGGGGAGTCAAAAACCTTGCAACTTCCTTCTCCACTAACCCAGGACTAAAAATGGACAGGCTGACCTCAGTGTTTACAAATTCAGAATTTTGATAGGGGTAGATATGGAGAAAGACCTATTTCCTGGGTCTCTGCTGTGTAGTCTCCTTCAGGCTTATTGTGCTCAGTGAACATCCAGTGCTGGGTGCAGCTCCATCACCCTCTTGTGTGTTTACATGTCTCTTTCTATGATAAGAGGGTTGTGTTGGTGGCACCTCCACTACTCTTTTCTGTTTGTTGAGTTTGAATTGTGTTAACATCTTTGATCAGTGGGTGTATCTGTAATGAAGGAGGTTCAAGAGGCTGTGCTTTCCAAGTGATAGTCTATAGGAGTGTTTAATTTCTTGCAGCTCCATCTGGTTGCTGCATTTGAAGCATGGCATTAATTTGTATTTGCCCTGTTCTTTGACCTAAAGTTGAAGGGTTTAGAGTTTTTAACCTGATCTGTAGAGCAGAGAGGTTGAAAGCACTTAACTCTTGTTTAGTATCCTCATTGCCTTGCTGCCTGGGTATCTGGCCCCTTTCCATAAACATTTCTTTTCAGTTCATGTAGTTCTTTAATAGAAAGCTGCTATTATGTATATTGTCATTTGTGAAGGAAGTTGGAGAGTCACAGCTTTACTGTGACAGGTTTTGCCCAAGGCTTTGATACCTGTCACCCAGGGTATCTTAAAAGCAAGTTGTTCTCCCACTACTTTCCTTTCCCTCTGCCCTGCCATTCCTATTACAATGCTGTGAAAAAAGTTCTGCTTCTTAGGTGAATGGGTACTTTCTATTTTGTTTCTAAACGAGCAATTTTGAGGATGAAATGGGAAGATATCATTGCTTCCTTTTTGCACCTATTGGGTATGTACACTCTGGCCGAAGGGAGTCCTTATGTTTAGTTTCAAAATATATTACTTTCCTGGATTCTCTTCTTCACTTTTTCTGACTTTGGGTCCATTTTCTTTTCATTGCCTCCTTTTCCAGGCAGCTCTATTCTTGCAGAGCCATAGCAGGACATGTTAAAATTCCAATAGAAAACACTAAAAGGAAAGTCTGTGGAATCACTAGTGACTAAATACTGGGAACCTATTTTCTCAATCTTCCTCCATGTTGTGTTCTTTGTATTCTTGAGATGATAATATATTATGTATTTGAATTCCTGAAAAATGGAAAATGTTTAAGATATATGTATATAAAGTGTATGCTGTATTGGTGCAATAATGGTAATTAAAAATATGAAAAAAGTGTCTCTTTTATCTTTTAATTTGCTTATTTGATTACCTTTTAAATTTAATTGACCAAATATAAGTGGACCAGTAGTTAATAAAGGATATTTATATCACTCTTTATTAAGAAA

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