Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name YWHAEP6
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Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:56567049-56567991  UCSC
Coordinates (T2T) chr7:56799478-56800421  UCSC
Coordinates (hg19) chr7:56634742-56635684  UCSC
Strand -
Parental Sequence NM_006761.5_2
Parental seq. overlap 703 bp
Parental seq. overlap (%) 33.1%
Genomic Region Intergenic
Retrocopy Summary YWHAEP6, located on chr7:56567049-56567991, is a retrocopy of the parental gene YWHAE. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name YWHAE
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Also known as 14-3-3E|HEL2|KCIP-1|MDCR|MDS
Coordinate chr17:1344275-1400229
Strand -
Gene summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes YWHAEP2
Bonobo Pan paniscus YWHAEP2
Gorilla Gorilla gorilla YWHAEP2
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.20.40.6
log10(TPM+1)

Related Sequence

>YWHAEP6
AACAGTTTTCAAAAGTTCTTAAAGTCAAGAAGTGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACACTAACAGGACCGCAGAGGCTTTTTCAGCATTACTGTATTGTCTCCGTGCCAGATGTGGCAAGATTACCATTAGAAATGGAAATTACGTTTGAAAGCCATTAAGACTTCTAGGTGATGCAAGCATCTAAGGGAGATGTTAATCACACTATAGAGGCATTAAGTGGTATCATTTTTCAGTTTTTCTAATTGTTTGAACCGTATTTTATACCAAATGTTTCAAAGTAATTGGGTGTTAGCTTGAGATGGTTAAACGTTGTTTGCGGAGGGAGGAGTTGTAATGGTTTTGCTGTAAAAAGTGTTTCAAACTCTGCTGAAATATTACTAGAAAGCATGGTGCTGGTAACAGTTCAACAATCGTGGCTGCTCATTCTTGCCTACTTTTACTTCACTCCTCCCCTCTACTAGCTCAATCTCTTTTGTTCAGTATATGTAACTGGAAGCTAATTTGTACTACTGGATATCTGACTGGAGCCACAGACACAGAATCTGTATCATTCTTACTGAAACACAGTATGGAATTAACATTAAATAAAACAAACCTAAATGTAAAAAATGACACTATGGACTTCAGGCATGCAGGGTGATGGTGAAGAACAGAATAAAGAAGCGCTGCAGGACGTGGAAGATGAAAATCAGTGAGACATAAAAGCCAACAAGAGAAACCATCCCTGACCCCCCCACTCTTCCCCATCCCACCCACCCCTTGGAAAGTCCCCATTGTCACTAAGAACCACCAAATCTGACTTTTACATTTGGCCTCAGAATTTAGGTTCCTGCCCTGt
>NM_006761.5_2
GGATTGAGGCGCCGCCATTTTTGCTGCCCGGACGCGGAGCGAGAGGCTGAGAGAGTCGGAGACACTATCCGCTTCCATCCGTCGCGCAGACCCTGCCGGAGCCGCTGCCGCTATGGATGATCGAGAGGATCTGGTGTACCAGGCGAAGCTGGCCGAGCAGGCTGAGCGATACGACGAAATGGTGGAGTCAATGAAGAAAGTAGCAGGGATGGATGTGGAGCTGACAGTTGAAGAAAGAAACCTCCTATCTGTTGCATATAAGAATGTGATTGGAGCTAGAAGAGCCTCCTGGAGAATAATCAGCAGCATTGAACAGAAAGAAGAAAACAAGGGAGGAGAAGACAAGCTAAAAATGATTCGGGAATATCGGCAAATGGTTGAGACTGAGCTAAAGTTAATCTGTTGTGACATTCTGGATGTACTGGACAAACACCTCATTCCAGCAGCTAACACTGGCGAGTCCAAGGTTTTCTATTATAAAATGAAAGGGGACTACCACAGGTATCTGGCAGAATTTGCCACAGGAAACGACAGGAAGGAGGCTGCGGAGAACAGCCTAGTGGCTTATAAAGCTGCTAGTGATATTGCAATGACAGAACTTCCACCAACGCATCCTATTCGCTTAGGTCTTGCTCTCAATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGCAGGTTGGCAAAAGCAGCTTTTGATGATGCAATTGCAGAACTGGATACGCTGAGTGAAGAAAGCTATAAGGACTCTACACTTATCATGCAGTTGTTACGTGATAATCTGACACTATGGACTTCAGACATGCAGGGTGACGGTGAAGAGCAGAATAAAGAAGCGCTGCAGGACGTGGAAGACGAAAATCAGTGAGACATAAGCCAACAAGAGAAACCATCTCTGACCACCCCCTCCTCCCCATCCCACCCTTTGGAAACTCCCCATTGTCACTGAGAACCACCAAATCTGACTTTTACATTTGGTCTCAGAATTTAGGTTCCTGCCCTGTTGGttttttttttttttttttAAACAGTTTTCAAAAGTTCTTAAAGGCAAGAGTGAATTTCTGTGGATTTTACTGGTCCCAGCTTTTAGGTTCTTTAAGACACTAACAGGACTACATAGAGGCTTTTTCAGCATTACTGTGTCGTCTCCGTGCCAGATGTGGCAAGATCACCATTAGCAAATGGAAATTACATTTGAAAGCCATTAGACTTATAGGTGATGCAAGCATCTAAGAGAGAGGTTAATCACACTATAGAGGCATAAGTGGTATCAGTTTTCATTTTTCTAATTGTTTAAACTGTGTTTTATACCAGTGTTTGCAAGTAATTGGGTGTTAGCTTGAGATGGTTAAAGGTGGTTTGGGGAGGGACTTCGTTGTAATGGTTTTGCTGTAAAAAATGTTTCCAACTCCGCTGAAATGTTGCTGAAAAGCATGGTGCTGGTAACAGTTCAACAATCCGTGGCTGCTCATTCTTGCCTACTTTACTCTCCCACTGAAGCAGGTTAGCGTTGAAGGTGGTATGGAAAAGCCTGCATGCCTGTTCAATTCTTTTGTTTCTTCTCCTTCCCCCTCCCCCTACCTCCTTCCCCTCACTCCTCCCCTCCTTCGCTCGCTCAACCTCTTTTGTTCAGTATGTGTAACTTGAAGCTAATTTGTACTACTGGATATCTGACTGGAGCCACAGATACAGAATCTGTATTGTTCTTACTGAAACACAGCATGGAAttaacattaaacttaaataaaacaaacctaaattaaaAATGCCAAATATCGCGCCTCCATCCTTTATACTTCTAAAATAAAATCTCTAGTCCAAACACACTGACAGTATTATGTTTGCCTGAATGTGAAACATTCCTCCTTTTTTCTTCCATAAATAATTTGTTTGCTTCCCAAAGATGTATGTTTTGGAAAAAAATTGCCTGTAGTCTGGTTGTGAAGAACACTGAGTCAGTTGATGGTGTGTCTTGTCCTCCAGACCAGGCAGCAACATGGTATTTATTTTAATCATTAAAGTACAACATGAGTAGTA

Publications

PMID - Link Title
No publications available for this retrocopy