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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EEF1DP4
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:64862950-64864382  UCSC
Coordinates (hg19) chr7:64323328-64324760  UCSC
Strand +
Parental Sequence NM_001195203.4_2
Parental seq. overlap 768 bp
Parental seq. overlap (%) 77%
Genomic Region Intergenic
Retrocopy Summary EEF1DP4, located on chr7:64862950-64864382, is a retrocopy of the parental gene EEF1D. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EEF1D
Full Name eukaryotic translation elongation factor 1 delta
Also known as EF-1D|EF1D|FP1047
Coordinate chr8:143579728-143597422
Strand -
Gene summary This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EEF1DP3
Bonobo Pan paniscus EEF1DP3
Gorilla Gorilla gorilla EEF1DP4
Green monkey Chlorocebus sabaeus EEF1DP6
Crab-eating macaque Macaca fascicularis EEF1DP3
Rhesus Macaca mulatta EEF1DP4
Baboon Papio anubis EEF1DP3
Golden snub-nosed monkey Rhinopithecus roxellana EEF1DP3
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EEF1DP4
GCCTTTCCTCAGGCGTCCCGCATCTGCTGATTCCTCCTTCCTGGTCACTGCGTCCTTGGCTGGCATCAGAAAAGTGGCTACAAACTTCCTAGTACATGAGAAGATCTGGTTCAACAAGTTAAAATGTGACAATGCAGAAAGGAGATTCTTCAAGCAGATGAACAAGGCTGTGGCCAGCACCTCCCGCCAGGAGAACGGCGCCAGCATGATCCTCCATGACATTGCGAGAGCCAGAGAGCATTTCCAGAAATCCCTGGCCAGAAGCTCAGGCCCCGGGGCCTCCAGCAGCCCCAGCGGAGACAAGGCTGAGCTCATCTTTCAGATCACCAGTCTGGAAGTGGAGAACCAGAGCCTGCGCAGGGTTGTGCAGGAGCTGCAGCAGGCCATCTCCAAGCTGGAGGCCCCACTGAACGTGCTGGAGAAGAGCTTGCCTGGCCACCACAGCCCTGCAGACCCAGCACGAGTCTCCTATGTGCCAAGTGGAGCCCCTGGCCAAGAAGCCAGCCAAACCAGCAGAGGATGACAAGGACGATGACATTGACCTACATTGACCTGTTTGGCAGTGACAATGAGGAGGAGGACAGGAGGCAGTACTGCTGCGGGAGGAGCGGCTGCGGCAGTACACAGAGAAAAAGGCCAAGAAGCCCATGCTGGTGGCCGAGTCGTCCATCCTGCTGGACATTAAGCCTTGGGATGATGAGACTAACATGGCCCAGCTGGAGGCCTGTATGTGCTCCATCCAGCTGGACAGGCTGGTCTGGGGGGGCCTCTAAGCTGGTGCCCGTGGGCTATAGTATCCAGAAGCTGCTGGTTCAGTGTGTAGTGGAGGATGACAAGGTGGGGACAGACTTGCTGGAGGAGGAGATCATCAAGTTTGAAGAACACGTGCAGAATGTTGACATTGCAGCTTTCAACAAGATCTGAAGAC
>NM_001195203.4_2
CTCCCTTTCATCAGTCTTCCCGCGTCCGCCGATTCCTCCTCCTTGGTCGCCGCGTCCTTGGCTGGCGTCAGAAAAATGGCTACAAACTTCCTAGCACATGAGAAGATCTGGTTCGACAAGTTCAAATATGACGACGCAGAAAGGAGATTCTACGAGCAGATGAACGGGCCTGTGGCAGGTGCCTCCCGCCAGGAGAACGGCGCCAGCGTGATCCTCCGTGACATTGCGAGAGCCAGAGAGAACATCCAGAAATCCCTGGCTGGAAGCTCAGGCCCCGGGGCCTCCAGCGGCACCAGCGGAGACCACGTGGTACAGGAGCTGCAGCAGGCCATCTCCAAGCTGGAGGCCCGGCTGAACGTGCTGGAGAAGAGCTCGCCTGGCCACCGGGCCACGGCCCCACAGACCCAGCACGTATCTCCCATGCGCCAAGTGGAGCCCCCAGCCAAGAAGCCAGCCACACCAGCAGAGGATGACGAGGATGATGACATTGACCTGTTTGGCAGTGACAATGAGGAGGAGGACAAGGAGGCGGCACAGCTGCGGGAGGAGCGGCTACGGCAGTACGCGGAGAAGAAGGCCAAGAAGCCTGCACTGGTGGCCAAGTCCTCCATCCTGCTGGATGTCAAGCCTTGGGATGATGAGACGGACATGGCCCAGCTGGAGGCCTGTGTGCGCTCTATCCAGCTGGACGGGCTGGTCTGGGGGGCTTCCAAGCTGGTGCCCGTGGGCTACGGTATCCGGAAGCTACAGATTCAGTGTGTGGTGGAGGACGACAAGGTGGGGACAGACTTGCTGGAGGAGGAGATCACCAAGTTTGAGGAGCACGTGCAGAGTGTCGATATCGCAGCTTTCAACAAGATCTGAAGCCTGAGTGTGTGTACGTGCGCGCGTGCGTGAGGCCCTGCCACGATTAAAGACTGAGACCGGC

Publications

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