Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PRRC2AP2
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:72722881-72723277  UCSC
Coordinates (T2T) chr7:73941413-73941809  UCSC
Coordinates (hg19) chr7:72187846-72188242  UCSC
Strand +
Parental Sequence NM_080686.3_3
Parental seq. overlap 373 bp
Parental seq. overlap (%) 5.4%
Genomic Region Intragenic (TYW1B)
Retrocopy Summary PRRC2AP2, located on chr7:72722881-72723277, is a retrocopy of the parental gene PRRC2A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PRRC2A
Full Name proline rich coiled-coil 2A
Also known as BAT2|D6S51|D6S51E|G2
Coordinate chr6:31620715-31637780
Strand +
Gene summary A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PRRC2AP2
Gorilla Gorilla gorilla PRRC2AP1
Bonobo Pan paniscus Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PRRC2AP2
CATTCCTGTCTCAAGGCCACACCTTCCACCTGCAGTGGAGTCTTCCACACCCAGCGCTTCGACCTTTACCAGCAGGCCTCCCCACCAGATGCCCTGCACTGGATACCTAAGCCTTGGGAATGGACACGGCCGCCACCTCGAAAAGGGCCCTCCCAAAAGGCAGAGGAGCCTGGGTCCCAAGGGGACAAGGAGCCTGGTTTGCCCCCACCCCACTGAGGGAGTTCCTCTTGCCCCCTACCCCCAGGGCTTGTATATAGATTATAAATATATAAGGGGGAAAGGGGTGGCGAGGGAGGGGTTGTGGGGCTGGGGCCTCACTTCCCCTCCTTCCCTTTCCCCTGGTCCCCTGTCCCTGGGGTTATTTGTTAAAAAAAGAGTAATAAAAGGATTTAAAAAA
>NM_080686.3_3
AGTCGGGGCTCAGCCGCGGAGTGAGCGAGGGAGACGGGAGGAGCCGAACCCGGCGCCATCCGCCGCCATCCTCCCCCGCCCCACCGCCATCCCGTCCCGGGGAGCCCCTAGGCCCGGGTCCCGGATCCCCGCGCACCCGGCCAGGCTCTGGCACGTTTTGGGGGAGGTGCCTGCAGGACCCAACATACTCAATGAGCTTCCAGCGCAATGTCCGATCGCTCGGGGCCGACTGCCAAGGGAAAGGATGGAAAGAAGTATTCCTCGCTCAACCTGTTTGATACGTATAAGGGCAAGTCCTTAGAGATCCAGAAACCCGCTGTTGCCCCTCGCCATGGCCTGCAGAGTCTCGGGAAAGTTGCCATTGCCCGGCGTATGCCACCTCCAGCCAACCTTCCAAGCCTGAAAGCCGAGAACAAAGGCAATGACCCCAATGTCTCACTAGTGCCAAAAGACGGAACAGGATGGGCAAGCAAACAGGAGCAGTCCGACCCCAAGAGTTCCGATGCCTCAACCGCTCAGCCGCCGGAATCGCAGCCACTGCCGGCTTCACAGACGCCTGCCTCCAACCAGCCGAAACGACCCCCAGCAGCCCCCGAGAACACTCCTTTGGTTCCAAGCGGGGTAAAGTCCTGGGCACAAGCCAGCGTCACCCATGGAGCACATGGAGATGGTGGAAGGGCATCAAGCCTACTGTCACGATTCTCTCGAGAGGAATTTCCGACCCTGCAGGCGGCTGGCGACCAGGACAAGGCTGCCAAGGAAAGGGAGTCTGCCGAACAGTCGTCTGGGCCCGGACCAAGCCTCCGCCCCCAAAATTCTACAACTTGGAGGGACGGAGGTGGGCGTGGCCCTGATGAGCTGGAGGGCCCGGACTCCAAACTTCATCATGGTCATGATCCCCGGGGTGGGCTACAGCCTTCAGGCCCACCCCAGTTCCCTCCCTACCGCGGAATGATGCCGCCTTTCATGTATCCCCCATATCTCCCGTTCCCTCCGCCCTATGGACCCCAGGGGCCTTACCGATACCCCACTCCTGATGGGCCCAGCCGTTTTCCCCGTGTGGCGGGCCCCCGAGGCTCAGGGCCACCAATGCGCTTAGTAGAGCCTGTGGGTCGTCCCTCTATTCTCAAAGAGGATAATCTCAAAGAGTTTGATCAGTTGGATCAGGAGAATGATGATGGTTGGGCAGGGGCCCATGAAGAGGTTGACTACACTGAAAAGCTCAAGTTCAGCGATGAGGAAGATGGGCGAGACTCTGATGAGGAGGGAGCTGAGGGCCACAGGGATTCCCAATCAGCTTCTGGTGAGGAACGGCCCCCTGAAGCAGATGGCAAAAAGGGCAACTCCCCCAACAGCGAACCGCCCACTCCTAAGACGGCCTGGGCAGAAACCTCTCGGCCTCCAGAGACAGAGCCGGGACCTCCTGCCCCAAAGCCTCCCCTACCCCCACCTCACCGGGGCCCCGCCGGGAACTGGGGCCCCCCTGGGGACTACCCAGATCGTGGGGGTCCTCCCTGCAAGCCCCCAGCACCTGAAGATGAGGATGAGGCATGGCGGCAGCGACGAAAGCAGTCGTCATCTGAGATTTCCCTGGCAGTGGAGCGGGCCCGGCGACGGCGAGAAGAAGAGGAGCGGCGCATGCAAGAAGAGCGCCGGGCAGCCTGTGCTGAGAAGCTCAAGCGACTCGATGAAAAGTTTGGGGCACCTGACAAGCGGCTCAAAGCAGAGCCTGCTGCCCCACCTGCTGCCCCTTCTACCCCAGCTCCACCACCTGCAGTCCCTAAAGAACTCCctgcacctccagctccacctccagcatcagccccaacaccagAGAAAGAACCTGAAGAGCCAGCACAGGCCCCTCCTGCCCAATCTACTCCTACTCCAGGTGTGGCTGCGGCTCCCACTCTGGTGAGTGGTGgtggcagtaccagtagcaccagcagtggcagCTTCGAAGCCAGCCCAGTGGAACCACAACTGCCCTCAAAAGAGGGTCCTGAACCACCAGAAGAGGTTCCTCCTCCTACCACACCCCCAGTTCCAAAGGTGGAACCCAAGGGTGATGGGATTGGTCCCACCCGCCAGCCCCCTAGTCAGGGCTTGGGCTACCCCAAATATCAGAAGTCGTTGCCTCCTCGTTTCCAGCGGCAGCAGCAGgagcagctcctgaagcagcagcagcagcaccagtggcagcagcatcaacagGGCTCTGCCCCTCCTACCCCAGTGCCCCCATCACCACCACAGCCTGTGACCCTGGGGGCTGTGCCAGCTCCACAGGCTCCACCCCCGCCCCCCAAGGCCCTGTACCCAGGTGCTCTGGGCCGGCCCCCACCCATGCCCCCAATGAACTTTGATCCCCGATGGATGATGATTCCTCCTTATGTGGACCCCCGGCTCCTCCAGGGTCGTCCCCCTCTAGACTTCTACCCTCCTGGTGTGCATCCCTCTGGCCTAGTTCCCCGAGAGCGTTCAGACAGTGGGGGCTCAAGCTCAGAGCCATTTGACCGTCATGCACCTGCTATGTTACGGGAACGGGGCACTCCACCGGTGGATCCAAAGTTGGCCTGGGTAGGAGATGTCTTCACCGCCACACCCGCTGAACCCCGCCCACTTACCTCACCTCTGCGCCAGGCTGCGGATGAGGATGACAAGGGGATGAGGAGCGAGACTCCTCCAGTACCTCCCCCACCACCCTATCTGGCCAGTTATCCAGGCTTTCCTGAGAATGGAGCCCCTGGGCCCCCAATCTCTCGCTTTCCTCTGGAGGAACCAGGGCCCCGTCCACTCCCCTGGCCCCCAGGCAGTGATGAAGTGGCCAAGATACAAACTCCACCACCCAAGAAGGAGCCCCCTAAGGAGGAGACTGCACAGCTGACGGGGCCAGAAGCAGGCCGAAAGCCTGCCCGCGGAGTCGGGAGTGGAGGCCAGGGCCCCCCACCACCACGCAGAGAGAGTCGCACAGAGACCCGCTGGGGCCCTCGTCCAGGGAGCAGTCGTCGTGGAATCCCTCCAGAGGAGCCAGGGGCCCCACCCCGCCGGGCTGGGCCTATAAAGAAACCTCCACCACCTACAAAAGTAGAAGAGCTGCCTCCCAAGCCCCTCGAACAGGGGGATGAAACCCCCAAACCCCCAAAGCCAGACCCACTCAAGATAACCAAGGGGAAGCTAGGGGGCCCCAAGGAGACCCCACCCAATGGAAATCTTTCCCCTGCCCCAAGGCTTCGGAGGGACTATTCGTATGAAAGAGTGGGTCCTACCTCTTGCCGGGGTCGGGGCCGAGGCGAGTATTTTGCCAGAGGGAGGGGTTTTCGGGGGACCTATGGGGGACGAGGGCGGGGAGCCCGAAGCCGGGAATTCCGCAGTTACCGAGAGTTTCGAGGAGATGATGGGCGTGGAGGTGGGACAGGGGGACCAAACCACCCTCCTGCTCCCCGAGGCCGCACTGCCAGCGAGACACGGAGCGAGGGTTCAGAGTATGAGGAAATCCCCAAGCGGCGCCGGCAGCGGGGCTCAGAAACAGGCAGCGAGACCCATGAGAGTGATCTGGCTCCTTCAGACAAGGAGGCTCCCACACCCAAGGAGGGAACACTCACCCAGGTCCCTCTCGCTCCCCCACCACCAGGAGCCCCACCTTCACCAGCCCCAGCCCGCTTCACTGCCCGGGGTGGGCGAGTCTTCACTCCCAGAGGGGTGCCATCTCGCCGGGGCCGAGGAGGAGGGAGGCCCCCTCCTCAAGTTTGCCCAGGCTGGAGCCCTCCAGCCAAGTCTCTGGCTCCCAAGAAACCTCCCACAGGCCCTTTGCCACCAAGTAAGGAGCCTTTGAAAGAGAAGTTGATCCCAGGGCCTCTGTCCCCTGTGGCGCGCGGAGGCAGCAATGGAGGTAGCAATGTGGGCATGGAAGATGGGGAGCGACCCCGAAGGAGGCGACATGGGAGGGCTCAGCAGCAGGATAAACCGCCTCGTTTCCGGAGGCTGAAGCAGGAACGGGAGAATGCCGCAAGGGGGTCTGAGGGCAAGCCCTCCCTAACCCTTCCAGCCTCCGCTCCTGGACCTGAGGAGGCCCTCACAACAGTCACAGTGGCCCCAGCACCTCGCCGGGCAGCTGCCAAGTCTCCTGATCTGTCAAACCAGAACTCAGACCAAGCCAATGAGGAATGGGAGACTGCATCAGAGAGCAGTGACTTCACCAGTGAGCGCCGAGGGGACAAAGAGGCACCCCCACCAGTACTGCTGACACCCAAGGCTGTGGGAACTCCTGGGGGAGGTGGAGGTGGAGCCGTACCAGGTATTTCAGCCATGTCCCGCGGAGATCTGAGCCAGAGAGCCAAGGATTTGAGTAAACGGAGCTTCTCAAGTCAGCGGCCAGGCATGGAACGGCAGAATCGGCGCCCTGGCCCAGGGGGCAAGGCTGGCAGCAGTGGCAGCAGCAGTGGAGGAGGCGGTGGGGGTCCTGGAGGAAGGACCGGGCCAGGACGAGGCGACAAGAGGAGCTGGCCCTCTCCCAAGAACCGAAGTCGTCCTCCAGAGGAGCGTCCCCCGGGGCTTCCCCTGCCTCCCCCACCTCCCAGCAGTTCTGCTGTCTTCCGCCTGGACCAAGTTATCCACAGCAACCCTGCTGGCATCCAACAGGCTCTGGCCCAGCTTAGTAGCCGTCAAGGGAGTGTAACTGCACCAGGGGGTCATCCAAGGCACAAGCCTGGGCCTCCCCAAGCCCCTCAGGGCCCCTCTCCTAGGCCCCCAACCCGATACGAGCCCCAGAGGGTCAACAGCGGCCTCAGTTCTGACCCCCACTTTGAGGAGCCGGGGCCAATGGTGAGAGGGGTGGGTGGGACTCCTCGGGACTCTGCCGGGGTTAGTCCCTTTCCCCCTAAACGTCGGGAGCGGCCTCCCAGAAAACCAGAGCTGCTACAGGAGGAATCTTTGCCACCTCCTCATAGCTCTGGATTCTTGGGCTCTAAGCCTGAGGGCCCAGGCCCTCAGGCAGAGTCCAGAGATACAGGCACAGAGGCCCTGACCCCTCACATCTGGAACCGTTTACATACTGCCACTAGCCGAAAGAGTTACCGGCCCAGCTCCATGGAGCCTTGGATGGAGCCCCTGAGTCCTTTTGAGGATGTGGCTGGCACAGAAATGAGTCAGTCTGACAGTGGGGTGGACCTGAGTGGGGATTCTCAGGTGTCATCAGGTCCCTGCAGCCAGCGAAGTTCCCCTGATGGAGGACTCAAGGGGGCAGCAGAGGGACCCCCCAAGAGGCCTGGAGGCTCCTCACCCCTGAATGCTGTTCCTTGTGAGGGTCCACCTGGCTCTGAACCTCCTAGGAGACCACCACCTGCCCCCCACGATGGGGACAGAAAGGAGCTGCCCCGGGAGCAGCCTCTGCCCCCTGGCCCCATTGGCACAGAACGATCACAGCGTACAGACCGAGGCACAGAGCCTGGCCCCATTCGGCCATCCCATCGACCTGGTCCCCCAGTCCAGTTTGGCACTAGTGACAAGGACTCAGACTTACGCCTAGTGGTAGGAGACAGCTTGAAAGCAGAGAAGGAGCTAACAGCATCAGTCACTGAGGCCATTCCTGTATCACGAGACTGGGAGCTGCTTCCCAGTGCTGCTGCCTCTGCTGAGCCACAATCCAAGAACCTGGATTCTGGGCACTGTGTCCCGGAGCCCAGCTCCTCAGGCCAGCGCCTGTATCCTGAGGTTTTCTATGGCAGTGCTGGGCCTTCCAGTTCTCAGATCTCTGGGGGAGCCATGGACTCTCAATTACATCCAAACAGTGGAGGCTTCCGCCCTGGGACACCCTCACTGCACCCTTACAGATCACAGCCCCTATACCTACCCCCGGGCCCAGCCCCTCCCTCAGCACTGCTCTCTGGGGTAGCTCTCAAGGGCCAGTTTCTGGATTTCTCCACAATGCAAGCTACAGAGCTGGGGAAGTTGCCGGCTGGAGGAGTTCTCTACCCTCCACCTTCCTTCCTCTACTCTCCGGCTTTCTGCCCCAGTCCTTTGCCTGACACATCGTTGCTTCAGGTACGCCAGGATCTGCCATCCCCTTCGGATTTTTATTCTACTCCTCTGCAGCCTGGTGGCCAAAGTGGATTTCTCCCTTCAGGGGCTCCTGCCCAGCAGATGCTTCTACCCATGGTAGACTCACAGCTGCCTGTGGTGAACTTTGGCTCCCTGCCGCCAGCACCACCTCCTGCCCCACCTCCCCTTTCTCTGTTACCTGTGGGCCCTGCTCTGCAGCCCCCCAGCCTGGCTGTGCGGCCCCCACCTGCTCCTGCTACTCGGGTGCTGCCTTCACCTGCCAGGCCCTTCCCCGCTAGCTTGGGGCGAGCAGAGCTGCATCCAGTGGAACTAAAGCCGTTCCAGGATTATCAAAAACTGAGCAGCAACCTTGGGGGACCTGGATCATCACGGACTCCCCCAACTGGAAGGTCCTTCTCTGGCCTCAATTCCCGTCTCAAGGCCACGCCTTCCACCTACAGTGGAGTCTTCCGCACCCAGCGCGTCGACCTTTACCAGCAGGCCTCCCCACCAGATGCCCTGCGCTGGATACCTAAGCCTTGGGAGCGGACAGGGCCGCCACCTCGAGAAGGGCCCTCCCGACGGGCAGAGGAGCCTGGGTCCCGAGGGGACAAGGAGCCTGGGTTGCCCCCACCCCGCTGAGGGAGTTCCTCTTGCCCCCTACCCCCGGGGCTTGTATATAGATTATAAATATATAAGGGGGAAAGGGGTGGGCGGGGAGGGGTTGTGGGGCTGGGGCCTCACTTCCCCTCCTCCCCCTTCCCCTGGTCCCCTGTCCCTGGGGCTGTTTGTTAAAAAAGAGTAATAAAAGGATTTAAAAAAAAAAA

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