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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HINT1P2
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:95018042-95018397  UCSC
Coordinates (T2T) chr7:96253876-96254231  UCSC
Coordinates (hg19) chr7:94647354-94647709  UCSC
Strand -
Parental Sequence NM_005340.7
Parental seq. overlap 317 bp
Parental seq. overlap (%) 37%
Genomic Region Intragenic (PPP1R9A)
Retrocopy Summary HINT1P2, located on chr7:95018042-95018397, is a retrocopy of the parental gene HINT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HINT1
Full Name histidine triad nucleotide binding protein 1
Also known as HINT|NMAN|PKCI-1|PRKCNH1
Coordinate chr5:131159027-131165256
Strand -
Gene summary This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HINT1P2
Bonobo Pan paniscus HINT1P2
Gorilla Gorilla gorilla HINT1P2
Orangutan Pongo abelii HINT1P2
Gibbon Nomascus leucogenys HINT1P1
Green monkey Chlorocebus sabaeus HINT1P3
Crab-eating macaque Macaca fascicularis HINT1P1
Rhesus Macaca mulatta HINT1P1
Baboon Papio anubis HINT1P3
Golden snub-nosed monkey Rhinopithecus roxellana HINT1P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HINT1P2
CCAACACATTTTCTAGTGATACACAAGAAACATATCCCAGATTTCTGCTGCAGAAGATGATAACGAGAGCCTTCTTGGACATTTAATGATTGTTGGCAAGAAATGTGCTGCTCATCTGGGCCTGAGTAAGGGTTACTGAATGAATGGGTGGTGAATGAACATTCAGATGGTGGACAGTCTGTCTATCATGTTCATCTTCATGTTCTTGGAGTCAGCAGATGAATCAGCCTCCTGGTTAAGCATGTTTTGGGGATAATTTTCCCTTCTCTAGGCAATGATTAAGTTTGCACATTCCAATATGTTAAATAGCACATTTATTTTTGCCTGTGTATGGAGAGATTCAGGAAATAATTTTT
>NM_005340.7
CTCCCTTCTTCCGAGCCTCTCCTCTGGCCGCCGCGCGGGAGAGAGGCCGAGATGGCAGATGAGATTGCCAAGGCTCAGGTCGCTCGGCCTGGTGGCGACACGATCTTTGGGAAGATCATCCGCAAGGAAATACCAGCCAAAATCATTTTTGAGGATGACCGGTGCCTTGCTTTCCATGACATTTCCCCTCAAGCACCAACACATTTTCTGGTGATACCCAAGAAACATATATCCCAGATTTCTGTGGCAGAAGATGATGATGAAAGTCTTCTTGGACACTTAATGATTGTTGGCAAGAAATGTGCTGCTGATCTGGGCCTGAATAAGGGTTATCGAATGGTGGTGAATGAAGGTTCAGATGGTGGACAGTCTGTCTATCACGTTCATCTCCATGTTCTTGGAGGTCGGCAAATGCATTGGCCTCCTGGTTAAGCACGTTTTGGGGATAATTTTCTCTTCTTTAGGCAATGATTAAGTTAGGCAATTTCCAGTATGTTAAGTAACACACTTATTTTTGCCTGTGTATGGAGAGATTCAAGAAATAATTTTAAAACCGCATACATAATAAAAGACATTGTTGCATGGCTTATAGTCTCTCTGAGTGTTGCGTTTGATTTGTTATTTTAAAAACATATTTGTTGGAATATGTGAAGGTGGGTTTATAATTTTGGATGTTTCTTGCTTTTTCTTCCCAAGGAGGACTCAACATATGAACATCGCATTGTTTTAATGGTGTTACTAGTCTTTGAAGACAAATAATGAGAGTTTATAAATTTAGCTTTAACTTCGAAATATCTTTCCAGGCTAAAATAGGTCCAACTTAGATTTTTAAGCTAATTCTCACATTTTCTA

Publications

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