Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TARBP2P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:103659186-103660588  UCSC
Coordinates (T2T) chr8:104786783-104788185  UCSC
Coordinates (hg19) chr8:104671414-104672816  UCSC
Strand +
Parental Sequence NM_134323.2
Parental seq. overlap 1268 bp
Parental seq. overlap (%) 83.9%
Genomic Region Intragenic (RIMS2)
Retrocopy Summary TARBP2P1, located on chr8:103659186-103660588, is a retrocopy of the parental gene TARBP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TARBP2
Full Name TARBP2 subunit of RISC loading complex
Also known as LOQS|TRBP|TRBP1|TRBP2
Coordinate chr12:53500923-53506431
Strand +
Gene summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TARBP2P1
Bonobo Pan paniscus TARBP2P1
Gorilla Gorilla gorilla TARBP2P1
Orangutan Pongo abelii TARBP2P1
Gibbon Nomascus leucogenys TARBP2P1
Green monkey Chlorocebus sabaeus TARBP2P1
Crab-eating macaque Macaca fascicularis TARBP2P1
Rhesus Macaca mulatta TARBP2P1
Baboon Papio anubis TARBP2P1
Golden snub-nosed monkey Rhinopithecus roxellana TARBP2P1
Marmoset Callithrix jacchus TARBP2P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TARBP2P1
GGCAGTCACAGTGGTGCCTGTGGGGACAGAGGAGGGAATGGGTGAAGAGGAGCAAGACTCTGGCACTACCACGGGCTGCGGGCTGCCTAGTGTAGAGAAAATGCTGGCCACCAACCCGGGCAAGACCCCAATCAGCCTTCTGCAGAAGTATGGTACCAGAATAGGGAAGAACACCTGTGTACTACCTTCTCAAAGCCGAGGGCCCACCAGCCTAATTTCACCTTCTGGGTCTGTTGGCAACACCAGCTGCACTGCTCAGGGCCCCAGGAAGAAGGTAGTCAAGCACAAGGCAGCTGAGGTGGCCCTCAGACACCTCAAAGTGGAGAGCATGTTGGAGCCGGCCCCGGAGGACAGCAGTTCTTTTTCTCCCCTAGACTCTTCACTGCCTGAGGACTTTCCAGTTTTTACTGCTGCAGCAGCTGCTACCCCAGTTTCATCTGTTTTCCTAACCAGGAGCACCCCCATGGAAAAGCAGCCCCCGCTCCTCCCTTCAGCAGTCGGAGTGCATCCCTGTTGGTGCTCTTCAGAAACTGGTGGTGCAGAAAGGCTGGTGGTTGCCAGAGCACACAGTGACCTAGGAGTCCAGGCCAGATCAACACGAAGAATTGACCTGACGAGTGGAGCGTTTCACTGAGATTGGCAGTGGCACTTCCAAAAAATCAACAAGTTGTAATGCAGTGACCAAAATGCTGCTTCGAGTGCACACGGTGTCTGTGGATGCCTGGGATGGCAATGAGGCAGAGCCTGATGATGACTACTTCTCCATTGATGTGGGCTCCCGCCTGGATGGTCTTCAGAACCGGGGCCCAGGCCGCACCTGAGATTTTCTACCAAATTCATTGGAGAGAAGATCCTGTCCTTCTGCAATTGCTCCCTGGGCTCCATAGGTGCCCTGGGCCCTGCCTGCTGCCGTGTCCTCAGTGAGCTCTCTGAAGAGCAGGTCTTCCACGTCAATTACCTGGATGTTGAGGAGCTGAGCCTGAGTAGACTCTGCCAGTGTCTGGTGGAACTGTCCTTCCAGCTGGCCACTGCATATCATGGCTCTGCAACCACCAGGGAGGCAGCCCGTGGTGAGGCTGCTTGCCGTGCCCTGCAGTACCACAAGATCATGGCGGGCAGCAAGTGAAGCGCTAGCTGGACTCATGGATGTGCACCCTTTGCTTCCTGCTATTCCTGCCTCTGTGCTCACGTATCTGCTCAGCTCTGGTACCTTCTGTAGGTGCCATCTCTACCTCTGACACAGACTGTCTGCCTCGAGGCTGAGAAGGCACAGGGCAAGGAGCCAAGGACCTCAGGGCCTCAGCCAGCCCGGAATCTGTCCTCATTTTATTGGTGATGATGAGTGGGAATGAAATCAGGGGGCTGTATACTAGGGCCCGGAATAAACATGCTGCTTCGTGGAT
>NM_134323.2
AGCGTGCCCCGCGGCGGGCCCTACCGGCCGCGACTCCGGGCTTGGCCCCGGCCCTAGCTCGTCGGCTGTGTATTGGGGCGCGTGGAGGCTGCAGTCACGGTGGCGCCCGCGGGGACGGAGGAGGGAATGAGTGAAGAGGAGCAAGGCTCCGGCACTACCACGGGCTGCGGGCTGCCTAGTATAGAGCAAATGCTGGCCGCCAACCCAGGCAAGACCCCGATCAGCCTTCTGCAGGAGTATGGGACCAGAATAGGGAAGACGCCTGTGTACGACCTTCTCAAAGCCGAGGGCCAAGCCCACCAGCCTAATTTCACCTTCCGGGTCACCGTTGGCGACACCAGCTGCACTGGTCAGGGCCCCAGCAAGAAGGCAGCCAAGCACAAGGCAGCTGAGGTGGCCCTCAAACACCTCAAAGGGGGGAGCATGCTGGAGCCGGCCCTGGAGGACAGCAGTTCTTTTTCTCCCCTAGACTCTTCACTGCCTGAGGACATTCCGGTTTTTACTGCTGCAGCAGCTGCTACCCCAGTTCCATCTGTAGTCCTAACCAGGAGCCCCCCCATGGAACTGCAGCCCCCTGTCTCCCCTCAGCAGTCTGAGTGCAACCCCGTTGGTGCTCTGCAGGAGCTGGTGGTGCAGAAAGGCTGGCGGTTGCCGGAGTACACAGTGACCCAGGAGTCTGGGCCAGCCCACCGCAAAGAATTCACCATGACCTGTCGAGTGGAGCGTTTCATTGAGATTGGGAGTGGCACTTCCAAAAAATTGGCAAAGCGGAATGCGGCGGCCAAAATGCTGCTTCGAGTGCACACGGTGCCTCTGGATGCCCGGGATGGCAATGAGGTGGAGCCTGATGATGACCACTTCTCCATTGGTGTGGGCTCCCGCCTGGATGGTCTTCGAAACCGGGGCCCAGGTTGCACCTGGGATTCTCTACGAAATTCAGTAGGAGAGAAGATCCTGTCCCTCCGCAGTTGCTCCCTGGGCTCCCTGGGTGCCCTGGGCCCTGCCTGCTGCCGTGTCCTCAGTGAGCTCTCTGAGGAGCAGGCCTTTCACGTCAGCTACCTGGATATTGAGGAGCTGAGCCTGAGTGGACTCTGCCAGTGCCTGGTGGAACTGTCCACCCAGCCGGCCACTGTGTGTCATGGCTCTGCAACCACCAGGGAGGCAGCCCGTGGTGAGGCTGCCCGCCGTGCCCTGCAGTACCTCAAGATCATGGCAGGCAGCAAGTGAAGCCCCAGCTGGACTCATGGATGTGCACCCTTTGCTCCCTGCTCTTTCTGCCTCTGGGCTCATGTATCTGCGCAGCTCTGGTACCCTCTGTGGGTGCCATCTCTACCTCTGACACAGACTGCCTGCCTTGAAGCTGAGAAGGCACAGGGCAAGGAGCCAAGGACCACAGAGCCTCAGCCAGCCCAGGatccgtcctcattttattggtgatgatgaatgggaatgaaatcagggggctgtctactAGAGCCTGGAATAAATATGCTGCTTTGTGGATTTTTAA

Publications

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