Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AURKBP1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:108130961-108131888  UCSC
Coordinates (T2T) chr8:109259502-109260429  UCSC
Coordinates (hg19) chr8:109143189-109144116  UCSC
Strand -
Parental Sequence NM_001313954.2
Parental seq. overlap 787 bp
Parental seq. overlap (%) 61.9%
Genomic Region Intergenic
Retrocopy Summary AURKBP1, located on chr8:108130961-108131888, is a retrocopy of the parental gene AURKB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AURKB
Full Name aurora kinase B
Also known as AIK2|AIM-1|AIM1|ARK-2|ARK2|AurB|IPL1|PPP1R48|STK-1|STK12|STK5|aurkb-sv1|aurkb-sv2
Coordinate chr17:8204731-8210767
Strand -
Gene summary This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AURKBP1
Bonobo Pan paniscus AURKBP1
Gorilla Gorilla gorilla AURKBP1
Orangutan Pongo abelii AURKBP1
Gibbon Nomascus leucogenys AURKBP1
Green monkey Chlorocebus sabaeus AURKBP1
Crab-eating macaque Macaca fascicularis AURKBP1
Rhesus Macaca mulatta AURKBP1
Baboon Papio anubis AURKBP1
Golden snub-nosed monkey Rhinopithecus roxellana AURKBP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AURKBP1
TTGAGACTGGGCGTCCCCTGGGCAAAGACAAGTTTGTACATGTGTACTTGGCTCGAAAGAAGACAAGCCATTTCATCGTGGCCCTCAAGGCCTTCAAGTCTCAGATAGAGGAGGGCGTGGGGAGCACCAGATGCGCAGGCAGATGGAAATCCAGGCCCCCTTTCAGCATCCCAACATATTGAGTCTCTACAACTATTTTTATGACCTGAGAAAAATCTACTGGATTCTAGAGTACGCCCCCGCCACCCCTACCCCCGAGGAGCTGTACCAGGAGCTGCGAAAGAGCCGCACCTTTGACAAGAAGCCAACAGCCACCATCACGGGGGAGGTGGCAGATGCTCTGATGTACTGCCACGGGAAGAAGGTGACTCCCAGACATGAAGCCAGATAATCTACTCTCAGGGCTTGAGGGCGAGCTGAAAGTTGCCGACTTCGGCTGCCCTGTGCACGCCCCCTCACTGAGGAGGAAGACAAATGTGTGGCACCCTGGACTACCTGTCCCCAGAGACAATTGAGGGGCGCGCGCACACCGAGAAGGTGGATTTGTGGTACATCGGAGCACTCGGCTATGAGCCGCTGGTGGGGAACCCCACACACAATGAGGCCTATGGGCGAATCGTCAAGGTGGCCCTAAAATTCCCCCTTCTGTGCCCATGAGAGCCCCAGGACCTCATCTCCAAGCTGCTTAGGCATAACCCCTCAGAACGGCTGCCCCTGGCCCAGGTCTCAGCCCACCCTGGGATCCTGGCCCATTCTCGGAGGGTTTTGCCTCCCTCTGCCCATCAGTCTGTCCCCTGGTGGTCCCTGACATTCACTCGGGGGCGTCTGTGTTTGTAAGTCTGCATATGTGTAGGGGAAAGGAGCGGTCCTGACCTGTTCCCTTAGCTGTCTTCTACTTCCTTTGTTTAATAAAGACTGAAGCt
>NM_001313954.2
AGTTGTTTGCGGGCGGCCGGGAGAGTAGCAGTGCCTTGGACCCCAGctctcctccccctttctctctAAGGATGGCCCAGAAGGAGAACTCCTACCCCTGGCCCTACGGCCGACAGACGGCTCCATCTGGCCTGAGCACCCTGCCCCAGCGAGTCCTCCGGAAAGAGCCTGTCACCCCATCTGCACTTGTCCTCATGAGCCGCTCCAATGTCCAGCCCACAGCTGCCCCTGGCCAGAAGGTGATGGAGAATAGCAGTGGGACACCCGACATCTTAACGCGGCACTTCACAATTGATGACTTTGAGATTGGGCGTCCTCTGGGCAAAGGCAAGTTTGGAAACGTGTACTTGGCTCGGGAGAAGAAAAGCCATTTCATCGTGGCGCTCAAGGTCCTCTTCAAGTCCCAGATAGAGAAGGAGGGCGTGGAGCATCAGCTGCGCAGAGAGATCGAAATCCAGGCCCACCTGCACCATCCCAACATCCTGCGTCTCTACAACTATTTTTATGACCGGAGGAGGATCTACTTGATTCTAGAGTATGCCCCCCGCGGGGAGCTCTACAAGGAGCTGCAGAAGAGCTGCACATTTGACGAGCAGCGAACAGCCACGGTCCGGGCGGATCATGGAGGAGTTGGCAGATGCTCTAATGTACTGCCATGGGAAGAAGGTGATTCACAGAGACATAAAGCCAGAAAATCTGCTCTTAGGGCTCAAGGGAGAGCTGAAGATTGCTGACTTCGGCTGGTCTGTGCATGCGCCCTCCCTGAGGAGGAAGACAATGTGTGGCACCCTGGACTACCTGCCCCCAGAGATGATTGAGGGGCGCATGCACAATGAGAAGGTGGATCTGTGGTGCATTGGAGTGCTTTGCTATGAGCTGCTGGTGGGGAACCCACCCTTTGAGAGTGCATCACACAACGAGACCTATCGCCGCATCGTCAAGGTGGACCTAAAGTTCCCCGCTTCCGTGCCCATGGGAGCCCAGGACCTCATCTCCAAACTGCTCAGGCATAACCCCTCGGAACGGCTGCCCCTGGCCCAGGTCTCAGCCCACCCTTGGGTCCGGGCCAACTCTCGGAGGGTGCTGCCTCCCTCTGCCCTTCAATCTGTCGCCTGATGGTCCCTGTCATTCACTCGGGTGCGTGTGTTTGTATGTCTGTGTATGTATAGGGGAAAGAAGGGATCCCTAACTGTTCCCTTATCTGTTTTCTACCTCCTCCTTTGTTTAATAAAGGCTGAAGCTTTTTGTACTCA

Publications

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