Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name NDUFAF7P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:114318308-114318923  UCSC
Coordinates (T2T) chr8:115443064-115443679  UCSC
Coordinates (hg19) chr8:115330537-115331152  UCSC
Strand -
Parental Sequence NM_001083946.2
Parental seq. overlap 556 bp
Parental seq. overlap (%) 29.4%
Genomic Region Intergenic
Retrocopy Summary NDUFAF7P1, located on chr8:114318308-114318923, is a retrocopy of the parental gene NDUFAF7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NDUFAF7
Full Name NADH:ubiquinone oxidoreductase complex assembly factor 7
Also known as C2orf56|MidA|PRO1853
Coordinate chr2:37231658-37251204
Strand +
Gene summary This gene encodes an assembly factor protein which helps in the assembly and stabilization of Complex I, a large multi-subunit enzyme in the mitochondrial respiratory chain. Complex I is involved in several physiological activities in the cell, including metabolite transport and ATP synthesis. The encoded protein is a methyltransferase which methylates Arg85 of a subunit of Complex I in the early stages of its assembly. A pseudogene related to this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NDUFAF7P1
Bonobo Pan paniscus NDUFAF7P1
Gorilla Gorilla gorilla NDUFAF7P1
Orangutan Pongo abelii NDUFAF7P1
Gibbon Nomascus leucogenys NDUFAF7P1
Green monkey Chlorocebus sabaeus NDUFAF7P1
Crab-eating macaque Macaca fascicularis NDUFAF7P1
Rhesus Macaca mulatta NDUFAF7P1
Baboon Papio anubis NDUFAF7P1
Golden snub-nosed monkey Rhinopithecus roxellana NDUFAF7P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NDUFAF7P1
AAACAAGCAATCAAGTTGAAGTGTTTCCTGAGGCTGGTGTTATCACTGAGGAACTTTCTCAATGCATTGCACTAACTGGAGGTGCTGCAGAGGTTGCTGATTATGGTCATGATGGAACAAAGACAGAGACCTTCAGAGGGTTTTGTGGCCACAAGTTTCATGATGTCTTAATTGCCCCCAGGAACAGCGGATCTAAAAGCTGATGTGGATTTCAGTTATTTGCAAAGAATGGCACAGGGAAAAGTAGCTCTCTGGGCCCAATAAAACAACCCACATTTTTTTAAAATATGGGTATCGATGTCCAGCTGAAGATTCTTTTAGATAAATCAAATGAGACATCAATGAGTCAGCAATTACTTCAAGGATATGATATGTTAATGAATCCGAAGAAGATGGGAGAAAGATTGAACATTTTTGCCTTGCTACTTCATCAGAGACTTCAAGGTGGAAGGAATCAGATGAATCTGTGTCAGTCAAAACCCTATGCATCTCCTGTAGCTGGATTTAGTGAATTTGTTTGGCAGTGATATATTTCAGCAAGGATATTTTACCCTTCAGTCTGCCCAAGAAATCAAAACAAAGGAAACACATTTCATACATTGCAGGTAAAAAAAGA
>NM_001083946.2
GTCTAAGCCCCAGCTCCTGGCGGAGCGAGCTAGCCTGCGAATTTCAGCATGAGTGTACTGCTGAGGTCAGGTTTGGGGCCGTTGTGTGCCGTGGCGCGCGCAGCCATTCCTTTTATTTGGAGAGGGAAATACTTCAGCTCCGGGAATGAGCCTGCAGAAAACCCGGTGACGCCGATGCTGCGGCATCTTATGTACAAAATAAAGTCTACTGGTCCCATCACTGTGGCCGAGTACATGAAGGAGGTGTTGACTAATCCAGCCAAGCTACTAGGTATATGGTTCATTAGTGAATGGATGGCCACTGGAAAAAGCACAGCTTTCCAGCTGGTGGAACTGGGCCCAGGTAGGGGAACCCTCGTGGGAGATATTTTGAGGGTGTTCACTCAACTTGGATCTGTGCTGAAAAATTGTGACATTTCAGTACATCTGGTAGAGAAAACACCACAGGGATGGCGAGAAGTATTTGTTGACATTGATCCACAGGTTTCTGATAAACTGAGGTTTGTTTTGGCACCTTCTGCCACCCCAGCAGAAGCCTTCATACAACATGACGAAACAAGGGATCATGTTGAAGTGTGTCCTGATGCTGGTGTTATCATCGAGGAACTTTCTCAACGCATTGCATTAACTGGAGGTGCTGCACTGGTTGCTGATTATGGTCATGATGGAACAAAGACAGATACCTTCAGAGGGTTTTGCGACCACAAGCTTCATGATGTCTTAATTGCCCCAGGAACAGCAGATCTAACAGCTGATGTGGACTTCAGTTATTTGCGAAGAATGGCACAGGGAAAAGTAGCCTCTCTGGGCCCAATAAAACAACACACATTTTTAAAAAATATGGGTATTGATGTCCGGCTGAAGGTTCTTTTAGATAAATCAAATGAGCCATCAGTGAGGCAGCAGTTACTTCAAGGATATGATATGTTAATGAATCCAAAGAAGATGGGAGAGAGATTTAACTTTTTTGCCTTGCTACCTCATCAGAGACTTCAAGGTGGAAGATATCAGAGGAATGCACGTCAGTCAAAACCCTTTGCATCCGTTGTAGCTGGGTTTAGTGAACTTGCTTGGCAGTGATATTTCAGCTTGGACATTTTACCCTTCAGTCGGCCCAAGAAATCAAAATAAAGGAAACACATTTCATATACTGCAGGTAACAAAAGTCAAAGTATTTTATCTTTTCACAGCAAGAACAGTCCATGTTGTATATAATACAACCAACATTATAGAACTTTTAGGGTTGTGACTGGCTTTGGTGCAAATGTGTGCTCAAGCTAATAAGTTATTGTGAAACTGAGTTTCCTTTAACTTACAAAGCTAGTTGCCATATTTCTATTTTATTTTAAAAAGTAAACATGCggctgggcgtggtggctcatgcctgtaatcccagcactttgggaggctgaggtgggcatatcacctgaggtcagcagttaaagaccagcctgaccaaaatggagaaaccccatctctactaaaaatacaaaactagccgggtatggtggtacatgcctgtaatcccagctactcaggaggctgagacaggagaatcacttgaacctgggaggtggaggttgcggtgagctgagatcgtgccactgcactccagcctgggcaacaagagcaaaaatccctctcaaaaaaaaaaGTAAACATGGGCACTGATTGTTTTAATAAAAATGGGAAACAGACTAAATGGCTATTCACAGGAAACTGATAAGATATATGTTATTTTTTTAAATGAGCTAGGGCAATATGTTTTGACAGAAAACTCTCTAAGATTTAGTAAGTGAAAAAAAGTAGGATGCAAGAGTTTTTATAGTTGATTCCATTTTTGTTGAAGGAGAAAAACTAAATAAATACGAGTAATTTCATAGAAACGAA

Publications

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