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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ZNHIT1P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:142858358-142859018  UCSC
Coordinates (T2T) chr8:144001691-144002351  UCSC
Coordinates (hg19) chr8:143939774-143940434  UCSC
Strand +
Parental Sequence NM_006349.3
Parental seq. overlap 580 bp
Parental seq. overlap (%) 79.6%
Genomic Region Intergenic
Retrocopy Summary ZNHIT1P1, located on chr8:142858358-142859018, is a retrocopy of the parental gene ZNHIT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ZNHIT1
Full Name zinc finger HIT-type containing 1
Also known as CG1I|ZNFN4A1
Coordinate chr7:101218165-101224191
Strand +
Gene summary Predicted to enable histone deacetylase binding activity and nucleosome binding activity. Predicted to be involved in histone exchange. Predicted to act upstream of or within several processes, including negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of histone deacetylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ZNHIT1P1
Bonobo Pan paniscus ZNHIT1P1
Gorilla Gorilla gorilla ZNHIT1P1
Orangutan Pongo abelii ZNHIT1P1
Green monkey Chlorocebus sabaeus ZNHIT1P1
Crab-eating macaque Macaca fascicularis ZNHIT1P1
Rhesus Macaca mulatta ZNHIT1P1
Baboon Papio anubis ZNHIT1P1
Gibbon Nomascus leucogenys Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ZNHIT1P1
ACTCCCAGGACCCTGGGCAGCAACGGGTGCTGGACTGGGCCACCTGGCAGCGTCACATCAACTGGCAGCTAGAAGTCCTGGAGAATGACAACTTCCAGGACGACCCCCATGTGGGACTCCCTCAGCTCAGCAAGAGACTGCCACAGTTCGATGATGATGCAGACACCAGACAGTAAAAGAAGAAAACCCGAGGTGATCATTTTCAACTTCACGTCCAAAAAAACTTTCAGGCCCTGCTGGAGGAGCAGAACTTGAGTGTGGCCAAGGGCCCCAACTACCTGATAGCCTGTGCAGAGTCCCTGTCGCAGCCACAGCGTTCCTTCTGTGCTGTCTGCAGCTTCCCCTCCCCCTACACCTGTGTCAGCTGTGGTGCCTGGTATTGCACCGTGTGCTGTCTGGGGACCCACCAGGAGACCAGATATCTGAAGTGGACCATGTGAGCCCGGGCATTCCTGGAGAGGAAGGGCCTCTGTGCATTGCCAGGCCTCCAAAAAGCCAGTTTCATCACCCAGTGGAGTGGGGGCTCTCCCTGGACTAAGGGAGGAGCTGCTCACTCACCTAACAAAACTGTGTCTTACTTGCTGGGAAAGACCAGCCTCACTCCTGGGAACTGTCTGGCAGGTGGGTTGGGCCCACCCAGTGCTGTTAGAATAAAAAGCCT
>NM_006349.3
AGCAGTTTCTTCCGACAGTTGTGTTGTGCCAATGGTGGAGAAGAAAACTTCGGTTCGCTCCCAGGACCCCGGGCAGCGGCGGGTGCTGGACCGGGCTGCCCGGCAGCGTCGCATCAACCGGCAGCTGGAGGCCCTGGAGAATGACAACTTCCAGGATGACCCCCACGCGGGACTCCCTCAGCTCGGCAAGAGACTGCCTCAGTTTGATGACGATGCGGACACTGGAAAGAAAAAGAAGAAAACCCGAGGTGATCATTTTAAACTTCGCTTCCGAAAAAACTTTCAGGCCCTGTTGGAGGAGCAGAACTTGAGTGTGGCCGAGGGCCCTAACTACCTGACGGCCTGTGCGGGACCCCCATCGCGGCCCCAGCGCCCCTTCTGTGCTGTCTGTGGCTTCCCATCCCCCTACACCTGTGTCAGCTGCGGTGCCCGGTACTGCACTGTGCGCTGTCTGGGGACCCACCAGGAGACCAGGTGTCTGAAGTGGACTGTGTGAGCCTGGGCATTCCCAGAGAGGAAGGGCCGCTGTGCACTGCCCGGCCTTCAGAAAGACAGAATTTCATCACCCAATGCAGGGGGAGCTCTTCCTGGACCAAGGGAGGAGCCGCTCATTCACCCAACAAAACTGTGTCTTATCTGCCAGGAAAGACCAGCCTCACTCCTGGGAACTGTCTGGCAGGTAGGCTGGGCCCCCCAGTGCTGTTAGAATAAAAAGCCTCGTGCCGGAA

Publications

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