RCPedia: Rtcs

Summary

Retrocopy Name	PPM1AP1	Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr8:15805924-15807305 UCSC
Coordinates (T2T)	chr8:16072224-16073604 UCSC
Coordinates (hg19)	chr8:15663433-15664814 UCSC
Strand	-
Parental Sequence	XM_017021387.1
Parental seq. overlap	1260 bp
Parental seq. overlap (%)	15.2%
Genomic Region	Intergenic
Retrocopy Summary	PPM1AP1, located on chr8:15805924-15807305, is a retrocopy of the parental gene PPM1A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	PPM1A
Full Name	protein phosphatase, Mg2+/Mn2+ dependent 1A
Also known as	PP2C-ALPHA\|PP2CA\|PP2Calpha
Coordinate	chr14:60245750-60299087
Strand	+
Gene summary	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	PPM1AP1
Bonobo	Pan paniscus	PPM1AP1
Gorilla	Gorilla gorilla	PPM1AP1
Orangutan	Pongo abelii	PPM1AP1
Gibbon	Nomascus leucogenys	PPM1AP1
Green monkey	Chlorocebus sabaeus	PPM1AP1
Crab-eating macaque	Macaca fascicularis	PPM1AP1
Rhesus	Macaca mulatta	PPM1AP1
Baboon	Papio anubis	PPM1AP1
Golden snub-nosed monkey	Rhinopithecus roxellana	PPM1AP1
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>PPM1AP1
GAGACCTACAGGATTATGACATAATGGGACCATCTTTAGACAAGCAAAGATGGAAGAGCATAATGCCTGGGGGTGGGGTAATTAGTTGCGATACGAGCTACGCAGCATGCAAGGTTGACGTATTGAAATGGAGGATGCACATACGGCTGTGATTGCTTTGCCAAGTGGACTTGAAAGGTGGTCATTCTTTGCTGTGTATAACGGGCATCCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCGCCGATAACCAGGATTTACAGGGTCTGCAGGAGCACCTTCTTTGGAAAATGTAAAGAATGGAATCAGAACAGGTTTCCTGGAGATTGATGAACACGAGAGTTATGTCAGAGAAGAAACATGGTGCAGATAGAAGTGGGTCAACAGATGTAAGCGTCTTACTTTCTCCCCAACATAATTATTTCATTAACTATGAAGACTCTAGACGTTTACTTTGTAGGAACAGGAAAGTTCATTTCTTCACAAATTGCAAATCCGCTAGAAAAAGAATGAATTCAGAATGCAGGTGGCTCTGTAATGCTTTAGCATGTGAAAGCCTCTCTGGCTGTATCCAAAGCCCTTGGGGATTTTGATTACAAATGTATCCATGGGAAAGGTCCTACTGGGCAGCTTGTCTCACCAGAGCCTGAAGTCCATGACACTGAAAGATCTGAAGAAGATGATCACTTCATTATCCTTGCATGTGATAGTATCTGGGATGTTATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGGCTTGAAGTCACTGATGACCCTGAGAAAGTTTACAATGAAATAGTCGACACCTGTTTGCATAAGGGAAGTCAAGACAACATGTGTGTGATTTTTTTCTCTGGTTTCCAAATGCACCCAAAGTATCACCAGAAGCAGCGAAGAAGGAGGCAGAGTTGGGCAAGTACCTGGAATGCAGAGTAGAAGAAATCATAAAGAAGCAGGGGGAAGGTGTCCCTGACTTAGTCCATGTGGTGTACACATTAGCCAATGAGAACATCCCCAGACTGCCACCTGGAGGTGAATTGGCAAACAAGCAAAATGTTATTGAAGCCATTTATAAAAGACGGAATCTTTATAAAAATGATGACAGTGACTCCACATCAACTGATGCTATGTGCTAAAACTGCTCATCTAGCCATGGAGTTTACCTTCACCTCCAAAGCTGAGTACAGCTCAGCTTTGTTGAACCTTTTAACATCCGTCCTCAACTTTAAGGAAGGGGATATGACATGGGTAAGAATGATCACACCAGAGAACTTCAGCAGTACAACTTCTGGCTCATAACTGATTTTTTGTTTTTGTAAATTTGACACTTAAGTAAACATGATTTCAAACCATAATTCA

>XM_017021387.1
ggcgCTAGGGACGGGAGCGCGCGCGGGAGCTAGAGAGCAGTGGTCTCGGCGCTCGTCCGGCCCGCAGCTTCGGGTCCTCAGGCGGCTGTTGCTCCGGAACGGGTGGTTGGGGAGGGGGGGGTGGGGGGACTCTAGACAGCTGAGGCGCGAAAGCGATGAGTCCTCGGCTCTTCCTCCTCCTTCTCCGGGACCCGCTCTCTGCCTCCCTCTCCAACGCCCGGATGATCTGAGCCGCGAGGGCGCCGACAGCCGGGGGCCCGGACGCAGCCCGGCTCCTCCCCTCCTCCGCCCCTTCCCCAGCCTGACCTGGCCCGCCGCTGCAGCGGTGACCCCTCCCCCGGCTGCCGCCGTCGCCGCCGCGGTGACCCCCTCCCCGGCTGCCGCCGCCGCCGCCTCGGCCGACCAGGGACCTGCCCGCCTGCGGCTGCTCCGGAAATAATTTGTTGATCCATGCGGTTTCATTGCTACTGCGGAAACTTATAGTTGGCTGCTTCACCAGGACTCTACAAATTGCTCAGAACCCAAGGAGACCTAGAGGATCAAGACATAATGGGAGCATTTTTAGACAAGCCAAAGATGGAAAAGCATAATGCCCAGGGGCAGGGTAATGGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGTGTTGAAATGGAGGATGCACATACGGCTGTGATCGGTTTGCCAAGTGGACTTGAATCGTGGTCATTCTTTGCTGTGTATGATGGGCATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACCAATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTGGAAAATGTAAAGAATGGAATCAGAACAGGTTTTCTGGAGATTGATGAACACATGAGAGTTATGTCAGAGAAGAAACATGGTGCAGATAGAAGTGGGTCAACAGCTGTAGGTGTCTTAATTTCTCCCCAACATACTTATTTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAACAGGAAAGTTCATTTCTTCACACAAGATCACAAACCAAGTAATCCGCTGGAGAAAGAACGAATTCAGAATGCAGGTGGCTCTGTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTATCGAGGGCCCTTGGGGATTTTGATTACAAATGTGTCCATGGAAAAGGTCCTACTGAGCAGCTTGTCTCACCAGAGCCTGAAGTCCATGATATTGAAAGATCTGAAGAAGATGATCAGTTCATTATCCTTGCATGTGATGGTATCTGGGATGTTATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTCACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACCTGTTTGTATAAGGGAAGTCGAGACAACATGAGTGTGATTTTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAAGCAGTGAAGAAGGAGGCAGAGTTGGACAAGTACCTGGAATGCAGAGTAGAAGAAATCATAAAGAAGCAGGGGGAAGGCGTCCCCGACTTAGTCCATGTGATGCGCACATTAGCGAGTGAGAACATCCCCAGCCTCCCACCAGGGGGTGAATTGGCAAGCAAGAGGAATGTTATTGAAGCCGTTTACAATAGACTGAATCCTTACAAAAATGACGACACTGACTCTACATCAACAGATGATATGTGGTAAAACTGCTCATCTAGCCATGGAGTTTACCTTCACCTCCAAAGGAGAGTACAGCTCAACTTTGTTGAAACTTTTAACATCCATCCTCAACTTTAAGGAAGGGGATATGACATGGGTGAGAATGATTACATCAGAGAACTTCAGCAGTACAACAGCTAGCCCAGAACTGAtttttttttttttttttGTAAATTTGAGACTTATGTAAGCGTGATTTCAAACCATAATTCGTGTTGTAAATCAGACTCCAGCAATTTTTGTTGTATGATTTTGTTTTTTTGTAAAGTGTAATTGTCCTTGTACAAAATGCTCATATTTAATTATGAACTGCTTTAAATCACTATCAAAGTTACAAGAAATGTTTGGCTTATTGTGTGATGCAACAGATATATAGCCCTTTCAAGTCATGTTGTGTTTGGACTTGGGGTTGGAACAGGGAGAGCAGCAGCCATGTCAGCTACACGCTCAAATGTGCAGATGATTATGGAAAATAACCTCAAAATCTTACAAAGCTGAACATCCAAGGAGTTATTGAAAACTATCTTAAATGTTCTTGGTAGGGGAGTTGGCATTGTTGATAAAGCCAGTCCCTTCATTTAACTGTCTTTCAGGATGTTCCTTCGTTGTTTCCATGAGTATTGCAGGTAATAATACAGTGTATTCATAAGAATCTCAATCTTGGGGCTAAATGCCTTGTTTCTTTGCACCTCTTTTCAAGTCCTTACATTTAATTACTAATTGATAAGCAGCAGCTTCCTACATATAGTAGGAAACTGCCACATTTTTGCTATCATGATTGGCTGGGCCTGCTGCTGTTCCTAGTAAGATATTCTGAATTCCATTTTATCAATAAAGCTTGATTTAACAAACAAGAAACTTAATCATGTATGTGTAATTCCTCTTTTACCCTGGCCTTTTAAAACACTGTGCCGTTGTAATGAGACGTTTCTCATAGGGAAAGATGTTAGTCTCTTTTAATTGGACAACACTGTCACTCAAGGCATAGATGAAACTTTCCTTCCATTAGAAAGACTAAAAGATTTAATTCTTGGTTGTACCTTAATCTATTTTTTAAATAGGTTTCTTTCAGGCTGCTTATTTTTCATTAAGATGTGTATCAGCTTGGATTTGCCTACTGTTTAATTAAAATATTTATTGTCAAAGTTTGACAATCTAACACTCTATGGTAGGGgtgtgtgtgtgtgtgtttgtgagtgtgtgtttgcctgtgATTTTTAATTGGCCCATGTCTTTAGAATCCAAGTGGTTAAGATGTATTTGTGATTTGAAATATAGCATGTTGATAATATTTAGCTGTTGGCCTTTACAAATAACTTTCAAAGCTTAAGGAATTGTAGATATAAAAATAACCTAATTTAATTTAGGCTTAAATTCCTCTGATTAAGCATGTGAAAGTAAGTTTTAAAATCTGTCGCATTGAAAAGATTACTGTTCCGTGCCCTTCTGTATTTTTGTCTCTTTAGGTTGAATATTGTATTTATCACCATGTAATCATTCAGTAGGCAGATTCCCACTAGAAAACTGTTGAAATGTAAGACTAAAATACAACATTGAATACAAAATCAAAATTTTGTGTATAAAAACCAGTATAGTCCATTTTGTTATATTTGTTTTTTCCCTAACTTGGAAATATACATATTTGTATATATAGCCTTAAAATTAATGTAAAGTTAGGGGAGTAGTGGGGAAAGTAATGTGAAATGTCTCAGATTTAAGTAGTTAAATACCAGCAAAATCTTTTCATTATCCCTCTTATTTTGTGAGGTGattaaatgtaacttaattgtatttaatttatatcttattCCAGCATGAATGAGGAAAAACTGAAGTACTATTTATATTTAGAAATTCATATCAGTTGAAATTACAGAACCAATTCCATACTTACAATAAATACTTAATGTCTAAATCTGTGGTAGAGTGCGAAGTATGATAATGTTCTAAGTTATGGCTTTGCAAGCATCTAAATGTGCATTTAATGAATACCAGTGCTTCTAGTATAGACTAATTACCAGACATACTGGTACTGAAAGCTAAATCCCTATTATAACAAACCAGTTCCTTAATATTTTAAGTAGACTGACAACTTTAGTTCCAGAAATTGCAAAACTTTGAACTGGACTGTGTAATCTTTTGAGATGCAAAACTTAAGTCACAAGTAGAGTATGTGATGGAAAGCTGTATTTCAAACCATAACAGCATATTTAGAGCCTTTTTTTTTTGAGTCTTTAAACAAGAGAAAATTAAAATATTCCTGTCAAAATTATTAGTATTGAAATTAGGCTTGGACACGAGAGAGAACCGTATTTGAGTGATGTGAGAAGACTAAATCTTTTCCACATGAGTCAGCACTGCCATACTAATAATTTTTTTACTATAAAAATACAGGAAGGAAGTATACATTATAACAGCAGACTGTGTGTGTTCCTGATTCCTGGAGGTAATAGTGGGGGGAAACCAACCATACTTTTTAAAGGCACTTTTGCACCTCTATTGTGCACTTCATTCTTGTACCACTTAAATTCTTCACCCCCATCCCCTTTTTTTGTGCTAATTAGCATCTCAGGGCAATGCCTCAAAAATGTTTGATGTGTTCTGTTCTTTGGAGGGAAAAAGTTCTTATGTGATGATAATATAGTACTCAAAATATACTTTTATCATTTAAATGTCTTATTTGCTGCTATGAATAGGAAATAACATTTTGTATAGCAGGCTCTGTTTTACCCTAACATTAAAAAATTTCACTGATCTTTCTTTCATTAACAGGGTAGAATCTCCTAATTTCCACTTTCTTGGGAATATACTTTTATAGACAATAGAAGCAGTTCTCAATATTAGCATATACTTTAAAAAATCAAAGTGATAACTTAATTCAGCTTTGGAAGTATCTCAAACATATTTTTACTTTATAGTGCATTAACTTGCTTCTAGAGTACTTAATGCAACTGCTCTAGCCACTTAATTTTTTATACTAATCTCAACATTAAGAAATTTGGATTAAGTAATAAATTAGTTATGTAATTCAAGTAATCTGAATTACAGCAGTACTTTTAGTGATCATTCATAGGACTATATATTAACCCAGCTAATAACTCAGTTTTTTTACAAAATGTTTCGAGTATTATTGGTAAAACACTGTTCTAGGCTAAGCACATTGGGACTGTAAAGAAATGAGTAGATCCTTGGCTTCAAGTTTACATCTGGACAATTTATAATCTAGTGTATGTTAGTATTATAACTGGATCACTCATCAAAAAATATATATATatatctattgcccacctgctatctaccaggtacttagctgatcaaggcaggcccctgccctaaagACCTTGTTTATACTTCCTTTACTCACCTGAAAACTGTTCTCCAGTTTATTTTCTTCTCTCTAAAGTTAAAGAGTAATTCAGAAGAAAATTTTGCTTAGCATAAGAATAAAATTGGACTGAAGAGGCTTAAGCCCATTCAGTATCCTTGATTGCATTTATCCAACGGCCTTTATTCTTCCTGCTGACAGCAGTAACTCAGAGGAATAGGTAGTAGATTTCTGAAAATTATCCAGCCATGGAAATGTAGGTGGGGTTTGAGTTTAAGGCATTTAAAAATGTAAATATCTCTAGCTAAATTTATCTTAAGTAGAACTCTGTGTTTTTGTAACACACTGCCAGTGTTAATATCAAATTTTAGCCAAATTATTACTATGTGTTTTAATATTTTAAAATAATTTCACTGCCCATCTTTACTGGACAAACTCATTTGGAGTTCAACTTGTGATTTCTGAAAGAACTGATGAAATTGGGTACTGCTTTTTTTCTCCATTTTTCGTTTTGTTTTAATTTTGAATTTCATGGTATATACTTTTAGTTCAAACTCAGCTGTTTGTACAGTATTGTATTAGGATTTGGTATTAGAAAAGATGTGTAAATATCTTAGTATATAATTGTTTCTCATTTGAGGTTTTTCTTCTAAGGGACCTTAAAGAGTTTTATATACTTTTGCTCACAGAAACTGCTGGTGAGATTACCATTTTTTGAGTATCTAGTCTTCTAGTTTTTCTTTTAGGCATTAGGAAGCCTTCTTTAGAGTTCAAAATTTTAGAAGCCTAATTTGCTCTTACTTCCTTCAATTATGTGCCATGTGTTTTGGTTTGTATATGTTTTAAATTGTATATTTCCTTGGAATATGCTTGAAATATTTAAGAATACATTTTCAAAATGTATAATACTGTATTGTTTTGTTGATCAGAATAATAAGTCTCAGTTAAATGTTTGTTATTACTGATAGTCAAAATGCTCAATAGAAATGATGAGAGGCATTGGTTCCAATTCATTGTCAAATGAACGTTTTCTAATTTTGTTCACAGATTCTTTCCCTTTCGATTGTTCTGTATGTTAAGATAGTGGCTTCTGCTCTCACTGTTTTCCTATTTATATTACTAGCAGGTAGGAGTGCTAATTAGAAAAACTTAGATGGTATTGAAATTACAGTTGACAACTTATATTTTTATGAGATGGAGAAAAAAGATTAAGTTGATATAACAACAAAGTGGACTTTTTTTCTTCCTTATCCTGCACGAAATATTGCCCTTGTTTCCTCTACTTTCCTCTTGGTGTTTTCTCTTTTTTTCAAACAGAAACAGGCCAATTCCATTTTCTTGAGCAAGAAAGCTTAGTGTGTTACTTCATCAAGGCCAGCTAATACTGTGTTAAACCGGGCTGAAAATGAGAAAACTTGGGAGATGGAGGAATGGGGAAATGGCAGTGGGATAGGTAGGGAAGGATTACTCTTAATTGTTTTAAAAGCCATAGGAAAGTCTTCCTTGTACGTGGCTGTAAATTTATAAGAACTATTGTGTCACATAAACCAACAAGAATGAACCTTTGCTGCTTCAGATAATTTGATTTTTCCAGCAAGGAAATTAATAAGTTACTGATTCTTCAGCATAGAAACAACTGAGAAGAATTAATGCAATGTTTCTTCACTAGAAAACCCAACCCTTCATTTCTTTTCATTGCTCCAAAACCCAGTTTTCAACTAATGGTTTTCTCATTAAACTAAATGTTTAGAAAAGTTGTTTAGAGTTTTTCTTTTTCTTTTACATAGTCCTCCTGATCCAGTATAAGACTATTTAGTAACGTGCATTTGTATGGTACTATCTAAAGTAAGTTAGATTGATGTAAGAGATCGGGTAGCTGCGGAACAAAATTAGTTATATCCTAATTAGGTACAGTGAATGACACAAAATCATTTTAGcaatgcttcttaaccttttggggtcacaggcgttttgagactgatgaatcctagggacttatttacccaggaaaatgcgtatataacatacatatctccctaaagtttacaatattgtagtggttcatgggccccctggttaagagcccattcTAAAGTACAATAGGGCATCATCCCTTTTCCTGCAAAGCCCAAAAGTATATTTCTAGGGCATGAAAATAACTTGAGTCTATTTTAAGGAATTGTTTCACTCTAGAGGTAGATAGGGGACCTGGCTAGAATCTGACATTAAAATATACTTTTTAAAAAATATTATATTTGGGGTGGGGAAAGTGATTAAAAGGTGAAAAAAAAACATAGTATTCAGAAGTTTTGGAGGTTAATGTCTTTCTCTAAGATTTGCCACTTTAGAAATTCAACAGAAAAGAGGTAAAACAGAAATGGAATGTATCTGGAACATTTTTGGCCTCCATAGTGCAGATATACTATATTAACAAGTAATACATTTATTTACCTGTCAGATCTCCAGGTTTTAAGATTTTGAGCTTTCTAGTATTAGGATTCATTAAATGTTCAATTCATTTCATATTCTAAGGAATTAGGTTATTTACTTACTAATTCAGGATGTTAAAATAACATCCAAGTCGGACAACCACCACCAATGCACACAGTTAATGAGATTTCTAAAATATAATAAGTACAATGTAACAAACGTATAGAATTTTGCATTTGTTGCCAAAATTAGATGTTTAATGACAGCTTATTTAATTCCCATTTGTGGGACTTCTGGAACATAGAAACCATTATCTTACCTGGTTATCCCTTGACTAAATAGCATATCTGCAGGAAAATATCTTGTTTGTAGTGATATGCCCCAATAGTGATTGATTTCACTCTTGAAATGAGTTATATCACTTAATTTGTATAAATGTTATGAGTGGAGAGACATGTACATGTTAAAAGCATGTTGCATTATATATTCATTTTTTAAACTCTATAAATGTTAAGAATAATATAATTGCAGAAATATTTTTCTTAAATACAATGTGTAACAAAATTCTCCGTAGCAACTCACCCACTTTGCAGTTTATGTGATCCACACTTTTAAAGAAATTCCATAAATGTATATTTTGTATTATGTATTATTTCCTGGTCCAAAGAAAATATGTGAATTCAGTTCTAACTTTAAGAATGTACTGTTTGTTTTCAAGTTCATTGAAAAATTGCATTCAGCCTGCGAATGGTTGCAGATTGTATGTTAGATGAAAAGTAGAAATAATTTCTAGTTTGGAAAACTGGTGCCACTAAATAAACAGGCAATTACATAA

>XM_017021387.1 

ggcgCTAGGGACGGGAGCGCGCGCGGGAGCTAGAGAGCAGTGGTCTCGGCGCTCGTCCGGCCCGCAGCTTCGGGTCCTCAGGCGGCTGTTGCTCCGGAACGGGTGGTTGGGGAGGGGGGGGTGGGGGGACTCTAGACAGCTGAGGCGCGAAAGCGATGAGTCCTCGGCTCTTCCTCCTCCTTCTCCGGGACCCGCTCTCTGCCTCCCTCTCCAACGCCCGGATGATCTGAGCCGCGAGGGCGCCGACAGCCGGGGGCCCGGACGCAGCCCGGCTCCTCCCCTCCTCCGCCCCTTCCCCAGCCTGACCTGGCCCGCCGCTGCAGCGGTGACCCCTCCCCCGGCTGCCGCCGTCGCCGCCGCGGTGACCCCCTCCCCGGCTGCCGCCGCCGCCGCCTCGGCCGACCAGGGACCTGCCCGCCTGCGGCTGCTCCGGAAATAATTTGTTGATCCATGCGGTTTCATTGCTACTGCGGAAACTTATAGTTGGCTGCTTCACCAGGACTCTACAAATTGCTCAGAACCCAAGGAGACCTAGAGGATCAAGACATAATGGGAGCATTTTTAGACAAGCCAAAGATGGAAAAGCATAATGCCCAGGGGCAGGGTAATGGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGTGTTGAAATGGAGGATGCACATACGGCTGTGATCGGTTTGCCAAGTGGACTTGAATCGTGGTCATTCTTTGCTGTGTATGATGGGCATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACCAATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTGGAAAATGTAAAGAATGGAATCAGAACAGGTTTTCTGGAGATTGATGAACACATGAGAGTTATGTCAGAGAAGAAACATGGTGCAGATAGAAGTGGGTCAACAGCTGTAGGTGTCTTAATTTCTCCCCAACATACTTATTTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAACAGGAAAGTTCATTTCTTCACACAAGATCACAAACCAAGTAATCCGCTGGAGAAAGAACGAATTCAGAATGCAGGTGGCTCTGTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTATCGAGGGCCCTTGGGGATTTTGATTACAAATGTGTCCATGGAAAAGGTCCTACTGAGCAGCTTGTCTCACCAGAGCCTGAAGTCCATGATATTGAAAGATCTGAAGAAGATGATCAGTTCATTATCCTTGCATGTGATGGTATCTGGGATGTTATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTCACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACCTGTTTGTATAAGGGAAGTCGAGACAACATGAGTGTGATTTTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAAGCAGTGAAGAAGGAGGCAGAGTTGGACAAGTACCTGGAATGCAGAGTAGAAGAAATCATAAAGAAGCAGGGGGAAGGCGTCCCCGACTTAGTCCATGTGATGCGCACATTAGCGAGTGAGAACATCCCCAGCCTCCCACCAGGGGGTGAATTGGCAAGCAAGAGGAATGTTATTGAAGCCGTTTACAATAGACTGAATCCTTACAAAAATGACGACACTGACTCTACATCAACAGATGATATGTGGTAAAACTGCTCATCTAGCCATGGAGTTTACCTTCACCTCCAAAGGAGAGTACAGCTCAACTTTGTTGAAACTTTTAACATCCATCCTCAACTTTAAGGAAGGGGATATGACATGGGTGAGAATGATTACATCAGAGAACTTCAGCAGTACAACAGCTAGCCCAGAACTGAtttttttttttttttttGTAAATTTGAGACTTATGTAAGCGTGATTTCAAACCATAATTCGTGTTGTAAATCAGACTCCAGCAATTTTTGTTGTATGATTTTGTTTTTTTGTAAAGTGTAATTGTCCTTGTACAAAATGCTCATATTTAATTATGAACTGCTTTAAATCACTATCAAAGTTACAAGAAATGTTTGGCTTATTGTGTGATGCAACAGATATATAGCCCTTTCAAGTCATGTTGTGTTTGGACTTGGGGTTGGAACAGGGAGAGCAGCAGCCATGTCAGCTACACGCTCAAATGTGCAGATGATTATGGAAAATAACCTCAAAATCTTACAAAGCTGAACATCCAAGGAGTTATTGAAAACTATCTTAAATGTTCTTGGTAGGGGAGTTGGCATTGTTGATAAAGCCAGTCCCTTCATTTAACTGTCTTTCAGGATGTTCCTTCGTTGTTTCCATGAGTATTGCAGGTAATAATACAGTGTATTCATAAGAATCTCAATCTTGGGGCTAAATGCCTTGTTTCTTTGCACCTCTTTTCAAGTCCTTACATTTAATTACTAATTGATAAGCAGCAGCTTCCTACATATAGTAGGAAACTGCCACATTTTTGCTATCATGATTGGCTGGGCCTGCTGCTGTTCCTAGTAAGATATTCTGAATTCCATTTTATCAATAAAGCTTGATTTAACAAACAAGAAACTTAATCATGTATGTGTAATTCCTCTTTTACCCTGGCCTTTTAAAACACTGTGCCGTTGTAATGAGACGTTTCTCATAGGGAAAGATGTTAGTCTCTTTTAATTGGACAACACTGTCACTCAAGGCATAGATGAAACTTTCCTTCCATTAGAAAGACTAAAAGATTTAATTCTTGGTTGTACCTTAATCTATTTTTTAAATAGGTTTCTTTCAGGCTGCTTATTTTTCATTAAGATGTGTATCAGCTTGGATTTGCCTACTGTTTAATTAAAATATTTATTGTCAAAGTTTGACAATCTAACACTCTATGGTAGGGgtgtgtgtgtgtgtgtttgtgagtgtgtgtttgcctgtgATTTTTAATTGGCCCATGTCTTTAGAATCCAAGTGGTTAAGATGTATTTGTGATTTGAAATATAGCATGTTGATAATATTTAGCTGTTGGCCTTTACAAATAACTTTCAAAGCTTAAGGAATTGTAGATATAAAAATAACCTAATTTAATTTAGGCTTAAATTCCTCTGATTAAGCATGTGAAAGTAAGTTTTAAAATCTGTCGCATTGAAAAGATTACTGTTCCGTGCCCTTCTGTATTTTTGTCTCTTTAGGTTGAATATTGTATTTATCACCATGTAATCATTCAGTAGGCAGATTCCCACTAGAAAACTGTTGAAATGTAAGACTAAAATACAACATTGAATACAAAATCAAAATTTTGTGTATAAAAACCAGTATAGTCCATTTTGTTATATTTGTTTTTTCCCTAACTTGGAAATATACATATTTGTATATATAGCCTTAAAATTAATGTAAAGTTAGGGGAGTAGTGGGGAAAGTAATGTGAAATGTCTCAGATTTAAGTAGTTAAATACCAGCAAAATCTTTTCATTATCCCTCTTATTTTGTGAGGTGattaaatgtaacttaattgtatttaatttatatcttattCCAGCATGAATGAGGAAAAACTGAAGTACTATTTATATTTAGAAATTCATATCAGTTGAAATTACAGAACCAATTCCATACTTACAATAAATACTTAATGTCTAAATCTGTGGTAGAGTGCGAAGTATGATAATGTTCTAAGTTATGGCTTTGCAAGCATCTAAATGTGCATTTAATGAATACCAGTGCTTCTAGTATAGACTAATTACCAGACATACTGGTACTGAAAGCTAAATCCCTATTATAACAAACCAGTTCCTTAATATTTTAAGTAGACTGACAACTTTAGTTCCAGAAATTGCAAAACTTTGAACTGGACTGTGTAATCTTTTGAGATGCAAAACTTAAGTCACAAGTAGAGTATGTGATGGAAAGCTGTATTTCAAACCATAACAGCATATTTAGAGCCTTTTTTTTTTGAGTCTTTAAACAAGAGAAAATTAAAATATTCCTGTCAAAATTATTAGTATTGAAATTAGGCTTGGACACGAGAGAGAACCGTATTTGAGTGATGTGAGAAGACTAAATCTTTTCCACATGAGTCAGCACTGCCATACTAATAATTTTTTTACTATAAAAATACAGGAAGGAAGTATACATTATAACAGCAGACTGTGTGTGTTCCTGATTCCTGGAGGTAATAGTGGGGGGAAACCAACCATACTTTTTAAAGGCACTTTTGCACCTCTATTGTGCACTTCATTCTTGTACCACTTAAATTCTTCACCCCCATCCCCTTTTTTTGTGCTAATTAGCATCTCAGGGCAATGCCTCAAAAATGTTTGATGTGTTCTGTTCTTTGGAGGGAAAAAGTTCTTATGTGATGATAATATAGTACTCAAAATATACTTTTATCATTTAAATGTCTTATTTGCTGCTATGAATAGGAAATAACATTTTGTATAGCAGGCTCTGTTTTACCCTAACATTAAAAAATTTCACTGATCTTTCTTTCATTAACAGGGTAGAATCTCCTAATTTCCACTTTCTTGGGAATATACTTTTATAGACAATAGAAGCAGTTCTCAATATTAGCATATACTTTAAAAAATCAAAGTGATAACTTAATTCAGCTTTGGAAGTATCTCAAACATATTTTTACTTTATAGTGCATTAACTTGCTTCTAGAGTACTTAATGCAACTGCTCTAGCCACTTAATTTTTTATACTAATCTCAACATTAAGAAATTTGGATTAAGTAATAAATTAGTTATGTAATTCAAGTAATCTGAATTACAGCAGTACTTTTAGTGATCATTCATAGGACTATATATTAACCCAGCTAATAACTCAGTTTTTTTACAAAATGTTTCGAGTATTATTGGTAAAACACTGTTCTAGGCTAAGCACATTGGGACTGTAAAGAAATGAGTAGATCCTTGGCTTCAAGTTTACATCTGGACAATTTATAATCTAGTGTATGTTAGTATTATAACTGGATCACTCATCAAAAAATATATATATatatctattgcccacctgctatctaccaggtacttagctgatcaaggcaggcccctgccctaaagACCTTGTTTATACTTCCTTTACTCACCTGAAAACTGTTCTCCAGTTTATTTTCTTCTCTCTAAAGTTAAAGAGTAATTCAGAAGAAAATTTTGCTTAGCATAAGAATAAAATTGGACTGAAGAGGCTTAAGCCCATTCAGTATCCTTGATTGCATTTATCCAACGGCCTTTATTCTTCCTGCTGACAGCAGTAACTCAGAGGAATAGGTAGTAGATTTCTGAAAATTATCCAGCCATGGAAATGTAGGTGGGGTTTGAGTTTAAGGCATTTAAAAATGTAAATATCTCTAGCTAAATTTATCTTAAGTAGAACTCTGTGTTTTTGTAACACACTGCCAGTGTTAATATCAAATTTTAGCCAAATTATTACTATGTGTTTTAATATTTTAAAATAATTTCACTGCCCATCTTTACTGGACAAACTCATTTGGAGTTCAACTTGTGATTTCTGAAAGAACTGATGAAATTGGGTACTGCTTTTTTTCTCCATTTTTCGTTTTGTTTTAATTTTGAATTTCATGGTATATACTTTTAGTTCAAACTCAGCTGTTTGTACAGTATTGTATTAGGATTTGGTATTAGAAAAGATGTGTAAATATCTTAGTATATAATTGTTTCTCATTTGAGGTTTTTCTTCTAAGGGACCTTAAAGAGTTTTATATACTTTTGCTCACAGAAACTGCTGGTGAGATTACCATTTTTTGAGTATCTAGTCTTCTAGTTTTTCTTTTAGGCATTAGGAAGCCTTCTTTAGAGTTCAAAATTTTAGAAGCCTAATTTGCTCTTACTTCCTTCAATTATGTGCCATGTGTTTTGGTTTGTATATGTTTTAAATTGTATATTTCCTTGGAATATGCTTGAAATATTTAAGAATACATTTTCAAAATGTATAATACTGTATTGTTTTGTTGATCAGAATAATAAGTCTCAGTTAAATGTTTGTTATTACTGATAGTCAAAATGCTCAATAGAAATGATGAGAGGCATTGGTTCCAATTCATTGTCAAATGAACGTTTTCTAATTTTGTTCACAGATTCTTTCCCTTTCGATTGTTCTGTATGTTAAGATAGTGGCTTCTGCTCTCACTGTTTTCCTATTTATATTACTAGCAGGTAGGAGTGCTAATTAGAAAAACTTAGATGGTATTGAAATTACAGTTGACAACTTATATTTTTATGAGATGGAGAAAAAAGATTAAGTTGATATAACAACAAAGTGGACTTTTTTTCTTCCTTATCCTGCACGAAATATTGCCCTTGTTTCCTCTACTTTCCTCTTGGTGTTTTCTCTTTTTTTCAAACAGAAACAGGCCAATTCCATTTTCTTGAGCAAGAAAGCTTAGTGTGTTACTTCATCAAGGCCAGCTAATACTGTGTTAAACCGGGCTGAAAATGAGAAAACTTGGGAGATGGAGGAATGGGGAAATGGCAGTGGGATAGGTAGGGAAGGATTACTCTTAATTGTTTTAAAAGCCATAGGAAAGTCTTCCTTGTACGTGGCTGTAAATTTATAAGAACTATTGTGTCACATAAACCAACAAGAATGAACCTTTGCTGCTTCAGATAATTTGATTTTTCCAGCAAGGAAATTAATAAGTTACTGATTCTTCAGCATAGAAACAACTGAGAAGAATTAATGCAATGTTTCTTCACTAGAAAACCCAACCCTTCATTTCTTTTCATTGCTCCAAAACCCAGTTTTCAACTAATGGTTTTCTCATTAAACTAAATGTTTAGAAAAGTTGTTTAGAGTTTTTCTTTTTCTTTTACATAGTCCTCCTGATCCAGTATAAGACTATTTAGTAACGTGCATTTGTATGGTACTATCTAAAGTAAGTTAGATTGATGTAAGAGATCGGGTAGCTGCGGAACAAAATTAGTTATATCCTAATTAGGTACAGTGAATGACACAAAATCATTTTAGcaatgcttcttaaccttttggggtcacaggcgttttgagactgatgaatcctagggacttatttacccaggaaaatgcgtatataacatacatatctccctaaagtttacaatattgtagtggttcatgggccccctggttaagagcccattcTAAAGTACAATAGGGCATCATCCCTTTTCCTGCAAAGCCCAAAAGTATATTTCTAGGGCATGAAAATAACTTGAGTCTATTTTAAGGAATTGTTTCACTCTAGAGGTAGATAGGGGACCTGGCTAGAATCTGACATTAAAATATACTTTTTAAAAAATATTATATTTGGGGTGGGGAAAGTGATTAAAAGGTGAAAAAAAAACATAGTATTCAGAAGTTTTGGAGGTTAATGTCTTTCTCTAAGATTTGCCACTTTAGAAATTCAACAGAAAAGAGGTAAAACAGAAATGGAATGTATCTGGAACATTTTTGGCCTCCATAGTGCAGATATACTATATTAACAAGTAATACATTTATTTACCTGTCAGATCTCCAGGTTTTAAGATTTTGAGCTTTCTAGTATTAGGATTCATTAAATGTTCAATTCATTTCATATTCTAAGGAATTAGGTTATTTACTTACTAATTCAGGATGTTAAAATAACATCCAAGTCGGACAACCACCACCAATGCACACAGTTAATGAGATTTCTAAAATATAATAAGTACAATGTAACAAACGTATAGAATTTTGCATTTGTTGCCAAAATTAGATGTTTAATGACAGCTTATTTAATTCCCATTTGTGGGACTTCTGGAACATAGAAACCATTATCTTACCTGGTTATCCCTTGACTAAATAGCATATCTGCAGGAAAATATCTTGTTTGTAGTGATATGCCCCAATAGTGATTGATTTCACTCTTGAAATGAGTTATATCACTTAATTTGTATAAATGTTATGAGTGGAGAGACATGTACATGTTAAAAGCATGTTGCATTATATATTCATTTTTTAAACTCTATAAATGTTAAGAATAATATAATTGCAGAAATATTTTTCTTAAATACAATGTGTAACAAAATTCTCCGTAGCAACTCACCCACTTTGCAGTTTATGTGATCCACACTTTTAAAGAAATTCCATAAATGTATATTTTGTATTATGTATTATTTCCTGGTCCAAAGAAAATATGTGAATTCAGTTCTAACTTTAAGAATGTACTGTTTGTTTTCAAGTTCATTGAAAAATTGCATTCAGCCTGCGAATGGTTGCAGATTGTATGTTAGATGAAAAGTAGAAATAATTTCTAGTTTGGAAAACTGGTGCCACTAAATAAACAGGCAATTACATAA

Publications

PMID - Link	Title