Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DEGS1P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:28225986-28226504  UCSC
Coordinates (T2T) chr8:28504187-28504705  UCSC
Coordinates (hg19) chr8:28083503-28084021  UCSC
Strand +
Parental Sequence NM_003676.4
Parental seq. overlap 438 bp
Parental seq. overlap (%) 21.5%
Genomic Region Intergenic
Retrocopy Summary DEGS1P1, located on chr8:28225986-28226504, is a retrocopy of the parental gene DEGS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DEGS1
Full Name delta 4-desaturase, sphingolipid 1
Also known as DEGS|DEGS-1|DES1|Des-1|FADS7|HLD18|MIG15|MLD
Coordinate chr1:224183240-224193441
Strand +
Gene summary This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DEGS1P1
Bonobo Pan paniscus DEGS1P1
Gorilla Gorilla gorilla DEGS1P1
Orangutan Pongo abelii DEGS1P1
Gibbon Nomascus leucogenys DEGS1P1
Marmoset Callithrix jacchus DEGS1P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DEGS1P1
AGGAGATCCTGGCAAGGTACCCAGAGATAAAATCCTAAATGAAACCTGATCCCAACCTGATGTGAACTGTAATTACGATGGTTCAAACCCAGTTGGTTGTGTTTTATTTAGTAAAAGAGTTGGACTGGAAATGGGTCATATTTTGAGCAAATGCCTTTGATAGCTACATTAACCACTCTATGACTCTGGCTATTCATGAGGTTTCCCAAAATAACACCTTTGGCAACTACAAAGCTATGTGGAATCGTGGTTTAAAATGCTTGCTAGTCTTCCTATTGGGGTTCTACATTTGATTTCCATTAAGAGGTATCACATGGAACAATCACTGATAGCTCAGAGGTGATGGCATTGATGTAGATATTCCTACTGATTAAGGGCTGGCCATTTGTACCATTTTCAGATAGTTAATATGAGTTATTCTTCAGCCTCTCTTTTATGCCTTTCAACCTCTGTTCATGCAACCCAAACCAATTTCTTATCTAAAAATTATCAATACTGTGACCCAGGTCACTTTTGACA
>NM_003676.4
ACCACACCAGCCGGGGAgccgccgccgccgccgccaccTCTGAGCAGCCGGCTGGGAGCGAGAGCCGACAGCTAGTCTGCAAGCCACCGCTGTCGCCATGGGGAGCCGCGTCTCGCGGGAAGACTTCGAGTGGGTCTACACCGACCAGCCGCACGCCGACCGGCGCCGGGAGATCCTGGCAAAGTATCCAGAGATAAAGTCCTTGATGAAACCTGATCCCAATTTGATATGGATTATAATTATGATGGTTCTCACCCAGTTGGGTGCATTTTACATAGTAAAAGACTTGGACTGGAAATGGGTCATATTTGGGGCCTATGCGTTTGGCAGTTGCATTAACCACTCAATGACTCTGGCTATTCATGAGATTGCCCACAATGCTGCCTTTGGCAACTGCAAAGCAATGTGGAATCGCTGGTTTGGAATGTTTGCTAATCTTCCTATTGGGATTCCATATTCAATTTCCTTTAAGAGGTATCACATGGATCATCATCGGTACCTTGGAGCTGATGGCGTCGATGTAGATATTCCTACCGATTTTGAGGGCTGGTTCTTCTGTACCGCTTTCAGAAAGTTTATATGGGTTATTCTTCAGCCTCTCTTTTATGCCTTTCGACCTCTGTTCATCAACCCCAAACCAATTACGTATCTGGAAGTTATCAATACCGTGGCACAGGTCACTTTTGACATTTTAATTTATTACTTTTTGGGAATTAAATCCTTAGTCTACATGTTGGCAGCATCTTTACTTGGCCTGGGTTTGCACCCAATTTCTGGACATTTTATAGCTGAGCATTACATGTTCTTAAAGGGTCATGAAACTTACTCATATTATGGGCCTCTGAATTTACTTACCTTCAATGTGGGTTATCATAATGAACATCATGATTTCCCCAACATTCCTGGAAAAAGTCTTCCACTGGTGAGGAAAATAGCAGCTGAATACTATGACAACCTCCCTCACTACAATTCCTGGATAAAAGTACTGTATGATTTTGTGATGGATGATACAATAAGTCCCTACTCAAGAATGAAGAGGCACCAAAAAGGAGAGATGGTGCTGGAGTAAATATCATTAGTGCCAAAGGGATTCTTCTCCAAAACTTTAGATGATAAAATGGAATTTTTGCATTATTAAACTTGAGACCAGTGATGCTCAGAAGCTCCCCTGGCACAATTTCAGAGTAAGAGCTCGGTGATACCAAGAAGTGAATCTGGCTTTTAAACAGTCAGCCTGACTCTGTACTGCTCAGTTTCACTCACAGGAAACTTGTGACTTGTGTATTATCGTCATTGAGGATGTTTCACTCATGTCTGTCATTTTATAAGCATATCATTTAAAAAGCTTCTAAAAAGCTATTTCgccaggcacggtggctcatgcctataatcccagcactttgggaggccaaggtgggtggatcacctgaggtcaggagttcgagaccagcctggccaacacggtgaaaccccatctctactaaaaatgcaaaaattagccgggcgtggcggcacatgcctgtaatcccagctacatgggaggctgaggtgggagaattgcttgaacccaggaggcggaggcagaggctgcagtgacccaagattgtgccactgcactccaccctgggcaacagagcaagaccccatctcaaaaataaataaatatatataaaaaataaaAAGCTATTTCTAGTTTATTTCACTATAAAGTTTTGCTTTATTAAAAAGCTAATAAACAGCTATTAATCACAGTGTATTAGTATTTGTTACATTTTTGTATTTCACTATCTTTATACTATATAATATGGTAACTTGGGTACCGGGGGAACTTTAAAATTTCATCTCAAAAATAATTTTTAAAAAGCCTGAGGTATGATATAGCATAAAAGATTGAGATGAAAATATATTTCCCTGTAAGCTGAATTACTCATTTAAAAATTTTAACTTCTATATGGGACCCGAATTAGACACTGCTGAATCCTGTACAGCCTTACTCATAAATAAAGTACTTACTGAATTTCCACCATTCAAA

Publications

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