Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MAP2K1P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:30027275-30029832  UCSC
Coordinates (T2T) chr8:30306154-30308711  UCSC
Coordinates (hg19) chr8:29884791-29887348  UCSC
Strand +
Parental Sequence NM_002755.4
Parental seq. overlap 2380 bp
Parental seq. overlap (%) 92.6%
Genomic Region Intergenic
Retrocopy Summary MAP2K1P1, located on chr8:30027275-30029832, is a retrocopy of the parental gene MAP2K1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MAP2K1
Full Name mitogen-activated protein kinase kinase 1
Also known as CFC3|MAPKK1|MEK1|MEL|MKK1|PRKMK1
Coordinate chr15:66386912-66491544
Strand +
Gene summary The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MAP2K1P1
Bonobo Pan paniscus MAP2K1P1
Gorilla Gorilla gorilla MAP2K1P1
Orangutan Pongo abelii MAP2K1P1
Gibbon Nomascus leucogenys MAP2K1P1
Green monkey Chlorocebus sabaeus MAP2K1P1
Crab-eating macaque Macaca fascicularis MAP2K1P1
Rhesus Macaca mulatta MAP2K1P1
Baboon Papio anubis MAP2K1P1
Golden snub-nosed monkey Rhinopithecus roxellana MAP2K1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MAP2K1P1
TTCCCTCCCAGGGTCGCTTCGACGAGCGGCTAGGTGCACTGCGGCGGCAGCACTTTCCACGGCAGGAGCTGGAGCTGGGCTCTGGTGCGCGCGCAGCTGGGCCGCCCGAGCCGGAGGGACTGGTTGGTTGAGGGAGAAAGGGAGGGAATCCCGGGCTGCCCAACCGCATGTTCAGCCTGCTCGCTCCTGCAGGGCAGCCCTTCGGCTCTCTGCGTGGGGAGCTGAGTCCCGGGTTGTTGAGGCGGGGGTCCCCTAAGACCGCTACCGGCCCCTCGGCGCTGACGGGCCCGCGAGGGGCTCACCCTCCGAAGGCAGCCTCGCCGAAGGCAGACGCGGACCGGACTTGGTCCTGCACAGCAGGCGCGGAGCAGCGCAGCGGGAGGACGCGAGAGGTGCTGCCCTCCCCCCGGAGTTGGAAGCGCCTTAGTCGGGTCCAAAATGCCCAAGAAGACGCCGACGCCCATCCAGCTGACCCCAGCCCCCGACGGCTCCAGCCGTGGTTAACGGGACCAGCTCTGCGGAAACCAACTTGGAGGCCTTGCAGAAGAAGCTGGAAGAGCTAGAGCTTGACGAGCAGCAGCGAAAGCACCTTGAGGCCTTTCTTACCCAGAGATAGAAGGTGGGAGAACTAAAGGATGACGACTTTGAGAAGATCAGTGAGCTGGGGGCTGGCAATGGCGGTGTGGTGTCCAAAGCCTCCCACAAGCCTTCTGGCCTGGTCGTGGCCAGAAAGCTAATTCATCTGGAGATCAAACCTGCAGTCCGGAACCAGATCATAAGGGAGCTGCAGGTTCTTCATGAGTGCAACTCTCCGTACATCGTGGGCTTCTGTGGTGCATTCTACAGCGAGAGGCGAGATCAGTATCTGCAGGTAGCACATGGATGGAGATTCCCTGGATCAAGTCCTGAAGAAAGCGGGAAGAATTCCTGAACAAATTTTAGAAAAAGTTAGCATTGCTGTAATAAAAGGCCTGACATATCTGAGGGAGAAGCACAAGATCATGCACATAGATGTCCAGCCCTCCCACATCATAGTCAGCTCCCGTGGGGAGATCAAGCTCTGTAACTTTGGGGGGTCAGTGGGCAGCTCATCGACTCCATGGCCAACTCCTTCATGGGCCCAAGGTCCTACATGTCCCCAGAAAGATTCCAGGGGACTCATTACTCTGTGCAGTCAGACATCTGGAGCATGGGACTCTCTCTGGTAGAGATGGCAGTTGGGAGGTATCCCATCCCTTCTCCAGATGCCAAGGAGCTGGAGCTGATGTTTGGGTGCCAGGTGGAGGGAGATGCGGCTGAGACCCCACCCAGGCCAAGGACCCCAGGGAGGCCTCTTAGCTCATATGGAATGGACAGCCGACCTCCCGTGGCAATTTTTGAGTTGTTGGATTACATAGTCAACGAGCCTCCTCCAAAACTGCCCAGTGGAGTGTTCAGTCTGGAATTTCAAGATTTTGTGAATAAATGCCTAATAAAAACCCCGTAGAGAGAGCAGATTTGAAGCAACTCATGGTTCATGCTTTTATCAAGAGATCTGATGCTGAGGAAGTGGATTTTGCGGGTTGGCTCTGCTCCACCATCGGGCTTAACCAGCCCAGCACACCAACCCATGCTGCTGGCGTCTAAGTGTTTGGGAAGCAGCAAAGAGCAAGTCCCCTGCCCAGTGGTTTGCCATGTCACTTTTGGGCCTCCTTCCCATGCCTGTCTCTGTTTAGATGTGCATTTCACCTGTGACAAAGGATGAAGAACACAGCATGTGCCAAGATTATACTCTTGTCATTTTTAATATTACTGTCTTTATTCTTATTACTATTATTGTTCCTCTAAGTGGATTGGCTTTGTGCTTGGGGCTATTTGTGTGTATGTTGATGATCAAAACCCGTGCCAGGCTGAATTACAGTGAAATTCTGGTGACTGTGGGTAGTCATTCTTACAATTGCACTGCTGTTCTTGCTCCATGACTGGCTGTCTGCCTGTATTTTCGGGATTCTTTCACATTTGGTGGTACTTTATTCTTGCTGGGCATACTTTCTCTCTGAGTAGGAGGGAGCTTTTTGTGAGATCCTTCACAGGCAGTGCATGTGAAGCATGCTTTGCTGCTGTGAATATGAGCATCAGAAAGTGTACATCATGTTATTTTATTATTATTTGCTTTTCATGTAGAATTCAGCAGTTTACATCCAAATCTAGCCAGAGCACTTCACTGCCATGATAGCTGGGGCTTCACCAGTCTGTCTACTGTGACGATCTGTAGACCTCCGGTTGTATTTCTACATTTATTTTCAATATACTGTGTGGGATACTCAGTGGTATGTCTCTTTAAGTTTTGATTGTTTCTTAAATGGTGAAATTATTTTGAATGTCACAAATTGATCAAGGCATTAAAATGTCAGATTTATCTTTCCCCATATCCAAGTACCAATGCTGCTATAAACGACACGTACAGTGCCTAATATTGTATGAAAATCCTTTTAACCATTTTAACCTAGATGTTTAACAAATCTAATCTCTTATTCCAATAAATATACTATGAAGTTT
>NM_002755.4
agtccctcccAGGGCCGCTTCGCAGAGCGGCTAGGAGCACGGCGGCGGCGGCACTTTCCCCGGCAGGAGCTGGAGCTGGGCTCTGGTGCGCGCGCGGCTGTGCCGCCCGAGCCGGAGGGACTGGTTGGTTGAGAGAGAGAGAGGAAGGGAATCCCGGGCTGCCGAACCGCACGTTCAGCCCGCTCCGCTCCTGCAGGGCAGCCTTTCGGCTCTCTGCGCGCGAAGCCGAGTCCCGGGCGGGTGGGGCGGGGGTCCACTGAGACCGCTACCGGCCCCTCGGCGCTGACGGGACCGCGCGGGGCGCACCCGCTGAAGGCAGCCCCGGGGCCCGCGGCCCGGACTTGGTCCTgcgcagcgggcgcggggcagcgcagcgGGAGGAAGCGAGAGGTGCTGCCCTCCCCCCGGAGTTGGAAGCGCGTTACCCGGGTCCAAAATGCCCAAGAAGAAGCCGACGCCCATCCAGCTGAACCCGGCCCCCGACGGCTCTGCAGTTAACGGGACCAGCTCTGCGGAGACCAACTTGGAGGCCTTGCAGAAGAAGCTGGAGGAGCTAGAGCTTGATGAGCAGCAGCGAAAGCGCCTTGAGGCCTTTCTTACCCAGAAGCAGAAGGTGGGAGAACTGAAGGATGACGACTTTGAGAAGATCAGTGAGCTGGGGGCTGGCAATGGCGGTGTGGTGTTCAAGGTCTCCCACAAGCCTTCTGGCCTGGTCATGGCCAGAAAGCTAATTCATCTGGAGATCAAACCCGCAATCCGGAACCAGATCATAAGGGAGCTGCAGGTTCTGCATGAGTGCAACTCTCCGTACATCGTGGGCTTCTATGGTGCGTTCTACAGCGATGGCGAGATCAGTATCTGCATGGAGCACATGGATGGAGGTTCTCTGGATCAAGTCCTGAAGAAAGCTGGAAGAATTCCTGAACAAATTTTAGGAAAAGTTAGCATTGCTGTAATAAAAGGCCTGACATATCTGAGGGAGAAGCACAAGATCATGCACAGAGATGTCAAGCCCTCCAACATCCTAGTCAACTCCCGTGGGGAGATCAAGCTCTGTGACTTTGGGGTCAGCGGGCAGCTCATCGACTCCATGGCCAACTCCTTCGTGGGCACAAGGTCCTACATGTCGCCAGAAAGACTCCAGGGGACTCATTACTCTGTGCAGTCAGACATCTGGAGCATGGGACTGTCTCTGGTAGAGATGGCGGTTGGGAGGTATCCCATCCCTCCTCCAGATGCCAAGGAGCTGGAGCTGATGTTTGGGTGCCAGGTGGAAGGAGATGCGGCTGAGACCCCACCCAGGCCAAGGACCCCCGGGAGGCCCCTTAGCTCATACGGAATGGACAGCCGACCTCCCATGGCAATTTTTGAGTTGTTGGATTACATAGTCAACGAGCCTCCTCCAAAACTGCCCAGTGGAGTGTTCAGTCTGGAATTTCAAGATTTTGTGAATAAATGCTTAATAAAAAACCCCGCAGAGAGAGCAGATTTGAAGCAACTCATGGTTCATGCTTTTATCAAGAGATCTGATGCTGAGGAAGTGGATTTTGCAGGTTGGCTCTGCTCCACCATCGGCCTTAACCAGCCCAGCACACCAACCCATGCTGCTGGCGTCTAAGTGTTTGGGAAGCAACAAAGAGCGAGTCCCCTGCCCGGTGGTTTGCCATGTCGCTTTTGGGCCTCCTTCCCATGCCTGTCTCTGTTCAGATGTGCATTTCACCTGTGACAAAGGATGAAGAACACAGCATGTGCCAAGATTCTACTCTTGTCatttttaatattactgtctttattcttattactattattgttCCCCTAAGTGGATTGGCTTTGTGCTTGGGGCTATTTGTGTGTATGCTGATGATCAAAACCTGTGCCAGGCTGAATTACAGTGAAATTTTGGTGAATGTGGGTAGTCATTCTTACAATTGCACTGCTGTTCCTGCTCCATGACTGGCTGTCTGCCTGTATTTTCGGGATTCTTTGACATTTGGTGGTACTTTATTCTTGCTGGGCATACTTTCTCTCTAGGAGGGAGCCTTGTGAGATCCTTCACAGGCAGTGCATGTGAAGCATGCTTTGCTGCTATGAAAATGAGCATCAGAGAGTGTACATCATGttattttattattattattTGCTTTTCATGTAGAACTCAGCAGTTGACATCCAAATCTAGCCAGAGCCCTTCACTGCCATGATAGCTGGGGCTTCACCAGTCTGTCTACTGTGGTGATCTGTAGACTTCTGGTTGTATTTCTATATTTATTTTCAGTATACTGTGTGGGATACTTAGTGGTATGTCTCTTTAAGTTTTGATTAATGTTTCTTAAATGGAATTATTTTGAATGTCACAAATTGATCAAGATATTAAAATGTCGGATTTATCTTTCCCCATATCCAAGTACCAATGCTGTTGTAAACAACGTGTATAGTGCCTAAAATTGTATGAAAATCCTTTTAACCATTTTAACCTAGATGTTTAACAAATCTAATCTCTTATTCTAATAAATATACTATGAAATAAAAAAAAAAGGATGAAAGCTA

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