Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RNF2P2
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:52975109-52975487  UCSC
Coordinates (T2T) chr8:53351532-53351910  UCSC
Coordinates (hg19) chr8:53887669-53888047  UCSC
Strand -
Parental Sequence NM_007212.4
Parental seq. overlap 322 bp
Parental seq. overlap (%) 9.4%
Genomic Region Intergenic
Retrocopy Summary RNF2P2, located on chr8:52975109-52975487, is a retrocopy of the parental gene RNF2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RNF2
Full Name ring finger protein 2
Also known as BAP-1|BAP1|DING|HIPI3|LUSYAM|RING1B|RING2
Coordinate chr1:185045430-185102603
Strand +
Gene summary Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RNF2P1
Bonobo Pan paniscus RNF2P1
Gorilla Gorilla gorilla RNF2P1
Orangutan Pongo abelii RNF2P1
Gibbon Nomascus leucogenys RNF2P2
Green monkey Chlorocebus sabaeus RNF2P1
Crab-eating macaque Macaca fascicularis RNF2P1
Rhesus Macaca mulatta RNF2P1
Baboon Papio anubis RNF2P2
Golden snub-nosed monkey Rhinopithecus roxellana RNF2P2
Marmoset Callithrix jacchus RNF2P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RNF2P2
GAGGCAAGAAACAATAGACTGAAAATGGTAGCAGAGAAGAAGAGAAGAATGCTGACGGTTTGCACTGTCGTGATGCATCCACACAGAACAACAAGGAAACAGGCCATAGTCACAAATGGAACAAAACATCTGCTGATTCTGGGCTTGAGCTTGATATTGACAATGCAACATTTGCCATTGATTCAGAAATGGACGGTGGTAGTGAGATTGAATTAGTATTCAGGCCTCAACCTACATTTATGGAAAAGGATGATAGTGCACAGATAAGATACATAAAGACTTCAGGTAACGCTGCTGTTGATCACTTATCCAGCTATCTGACTGTGAGGTTAGCTTTAGAAGAACTTTGAAGCCAAGGTGCACAAAACCAGATGAACCA
>NM_007212.4
ATATTGTGCGGCGGCGCCGGCGTCCGCGGCAGCTGATACCAGAGTCTTGCTCCGGCCGCGGCCAGCGGAGCCCTGGGCTGGGGCAGGAGCCGCAATGTCTCAGGCTGTGCAGACAAACGGAACTCAACCATTAAGCAAAACATGGGAACTCAGTTTATATGAGTTACAACGAACACCTCAGGAGGCAATAACAGATGGCTTAGAAATTGTGGTTTCACCTCGAAGTCTACACAGTGAATTAATGTGCCCAATTTGTTTGGATATGTTGAAGAACACCATGACTACAAAGGAGTGTTTACATCGTTTTTGTGCAGACTGCATCATCACAGCCCTTAGAAGTGGCAACAAAGAATGTCCTACCTGTCGGAAAAAACTAGTTTCCAAAAGATCACTAAGGCCAGACCCAAACTTTGATGCACTCATCAGCAAAATTTATCCAAGTCGTGATGAGTATGAAGCTCATCAAGAGAGAGTATTAGCCAGGATCAACAAGCACAATAATCAGCAAGCACTCAGTCACAGCATTGAGGAAGGACTGAAGATACAGGCCATGAACAGACTGCAGCGAGGCAAGAAACAACAGATTGAAAATGGTAGTGGAGCAGAAGATAATGGTGACAGTTCACACTGCAGTAATGCATCCACACATAGCAATCAGGAAGCAGGCCCTAGTAACAAACGGACCAAAACATCTGATGATTCTGGGCTAGAGCTTGATAATAACAATGCAGCAATGGCAATTGATCCAGTAATGGATGGTGCTAGTGAAATTGAATTAGTATTCAGGCCTCATCCCACACTTATGGAAAAAGATGACAGTGCACAGACGAGATACATAAAGACTTCTGGTAACGCCACTGTTGATCACTTATCCAAGTATCTGGCTGTGAGGTTAGCTTTAGAAGAACTTCGAAGCAAAGGTGAATCAAACCAGATGAACCTTGATACAGCCAGTGAGAAGCAGTATACCATTTATATAGCAACAGCCAGTGGCCAGTTCACTGTATTAAATGGCTCTTTTTCTTTGGAATTGGTCAGTGAGAAATACTGGAAAGTGAACAAACCCATGGAACTTTATTACGCACCTACAAAGGAGCACAAATGAGCCTTTAAAAACCAATTCTGAGACTGAACTTTTTTATAGCCTATTTCTTTAATATTAAAGATGTACTGGCATTACTTTTATGGACAGATCTTGGATATGTTGTTCAATTTTCTTTCTGAGCCAGACTAGTTTACGCTATTCAAATCTTTTCCCCTTTATTTAAGATTTCCTTTTTGGAAGGGACTGCAATTATTCAGTATTTTTTTCTTTCCTTTAAAAAAATATATCTGAAGTTTCTTGTGTTTTTTTTTTTCCCCACAAAGTGTGTTTCCACTTGGAGCACCATTTTGACCCAGGAATTTTTCATAGTTTCTGTATTCTTATAAGATTCAGTTGGCTGTCCTTTTCCTGCTCCCCTCAAAAGATTTTTAGTCATACAGAATGTTAAATATTATGTATTCTGACTTTTTTTTTCCCCCGGAGTCTTGTATATTTATAGTTTTCTATATAAACTGTAGTATCTTCATGAAGACCCAAGGCTCAAATTTACTGTCCTTAAAAACAATTCTCATAGGATTATTCTTTTCATGGTATTTTCTTCCATAATATCTCATTTTAAAAAGAAGTTCTTTATGAACTTAGTGTCCATTGTCATGCAATGTTTTTTTTTTTCCATTCTTTTTCCCTGTAATTTTGGAATTTCTGGTCCTGGGAAGAATCAAACAAAATCTTAAGTTCTATGAGAACTTGGTTCATTGACATATTCTGCTGAAGAAAGAAAAATTAAATTGGTAGTAAAATATAGTCTTCAAGTATACGTTTGAGAGTGCTTTTTTTTGTATTAGTTCTGCTGTCACTTCATTTCCTGTATTATATGTGATGTTTTTCCCCATTAAAATACCAGAGATAATGGAGATATTTTGCACTTTAGCCTTGATGAAAAGTACAAGATATGTTCAAAGCTTCCCTAATTTTTTTCTTATTTGTAGCCACATAAGTTTCAAGAATAACATGGCACACAGAACAATGGAAAAAAGTTTGTTTCCATTGGAAAATTATATCATTTTGGGTTGCCACATCAGTTTATAAATTTGGCGCTCTTTTAATTACACTCTGTAGAAGGTTAATAGAGCTTGAGCCCTGCTTTAATATGTAGTGAAAGATAATTCTGTAGAAAAACGTCAGCCAGTAGGGTAAAGTCATTCTACTGTTCTTAATTTTTATATTGAGGAACAATATTGGGTGTTTGGGAGCCAGAAAGCTTTGTTGACAGATCAGAAATAAGATTGACTTGGGTGTTATATTTCATCTCTCTCCAGACTCTAGGTATATTTCCAACTTTATATATCACAGTATTTAAAAAGACATGTTTGCATTGAGAAATTAACCCTAAAGGGTTTTCAATAGGGTGTAGACCTCCAGTACCTTTGTAACTAAAGTCTGTCTAGTCATTGTAAATATTTATCTGTCAGTTTTGACAGATTGGGGCCAGCTTGATGTTTTAAATCTTCAGCCCGGTATGAAAACTTAAAGGTATATATTCAATTTTTTACCATTTTATGGAAAATATTTAAAATCTGTTTTTACAGGGttttttttttttttttttttttGTAATCTGTGCCATGAAATTTGAAAACCACCAAAAATCAAGGGAACTTTTATATATTCAATTCCTTTTCTGGTGTAATGTTAAAGTTGTATAGATTATTAATGCATGCCCACTGAATATAACCCTGGTTTTGTGATAAAACTGCTTAGATTTTGTTGATGACATTAGATTAGTAGTTGCATTAAATAACTAAATTCCCATTGTGATTAATTGAAATTTTGTCTTTAAGCAGAGAGTTATTTGTGACTATAAGCTTTGTGCTTAGAGAATGTATGTGTTTTTATCTGTCAGTATGGGAGGATATAAACTGCATCATTAGTGAAATTATTGGTTGTGTAATCCTTTGTGAAATATAATTCTAGGTATTTGATAGGGTATtgagtgtattttgtgtgtgtgtggatgtgtgtTTTGGGGTACGGGGAGAGGCGATGCTATTGGCCATCACTACCAACCAGGGTTTCAAAAAGTATTACCTAAGTAATTTCTTTTATCACTATCTCAACTGAGGAAGAAAAGGCTCACCACAAGTGGTGTGAAGGCTTTGGGTACTTAGTTCTAAAtttttttatggtaacatatacatagccacatttacagttttaaccattttaaggcatgtaattcagtggggttaggtacattcacaatgttgtgtaatgatcaccgctgtctacttgtaaaactttttcatcaccccaaacagaaactctgtgtgcaattaaagtaatgcatttctcttcttcttaa

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