Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HAT1P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:53162343-53163183  UCSC
Coordinates (T2T) chr8:53538866-53539706  UCSC
Coordinates (hg19) chr8:54074903-54075743  UCSC
Strand +
Parental Sequence NM_003642.4
Parental seq. overlap 460 bp
Parental seq. overlap (%) 27.8%
Genomic Region Intergenic
Retrocopy Summary HAT1P1, located on chr8:53162343-53163183, is a retrocopy of the parental gene HAT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HAT1
Full Name histone acetyltransferase 1
Also known as KAT1
Coordinate chr2:171922425-171983686
Strand +
Gene summary The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HAT1P1
Bonobo Pan paniscus HAT1P1
Gibbon Nomascus leucogenys HAT1P1
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HAT1P1
CTAATGCAATAATTCAATGAAGATATGGTAATAGAGGTACAATAGAAGTTCAAAATAAATAAGAAACATGTTAGACAGGTTTGTGAAATTCTTCAACTATGGTATCTGATAGGAGTGATGCTGAACAAGGCAGATGTTACCGACTAGATGTTAAAAGAAGATTAATTaGATTAATTAACCTGTGTAAGAAAGAGCCTAGGGAAAATGTAAAATGAGAAAATGTCTTAGACCAGAAAAACTGATGAATTCGATGAACCAAAGAGAAATAAGCATGCAACATGAACAGCCAGAAGAAAGTTTTCAGGAACTAGTGGAAGATTACTGATGTGTTATTGAAGGACTCATTCAAGAGTAAAGATTATACTACTCTGCACAAGAAGTTTCCAAGTGTCTGTACATCATCCTGTGAAAAATCTGATCATAACTTTAATTTCAAAATCTTGTACCATTTTGCATACCTTAAAAGTTATCTAGCTTATCTTTAGTTGAATATTTTCTTTTGGAGAGATTGTATATTTTAAAAAACTGTTTAGAATTTGTGAGCATATATT
>NM_003642.4
GATTCGTCCTTCCTCAGCCGCGGGTGATCGTAGCTCGGAAATGGCGGGATTTGGTGCTATGGAGAAATTTTTGGTAGAATATAAGAGTGCAGTGGAGAAGAAACTGGCAGAGTACAAATGTAACACCAACACAGCAATTGAACTAAAATTAGTTCGTTTTCCTGAAGATCTTGAAAATGACATTAGAACTTTCTTTCCTGAGTATACCCATCAACTCTTTGGGGATGATGAAACTGCTTTTGGTTACAAGGGTCTAAAGATCCTGTTATACTATATTGCTGGTAGCCTGTCAACAATGTTCCGTGTTGAATATGCATCTAAAGTTGATGAGAACTTTGACTGTGTAGAGGCAGATGATGTTGAGGGCAAAATTAGACAAATCATTCCACCTGGATTTTGCACAAACACGAATGATTTCCTTTCTTTACTGGAAAAGGAAGTTGATTTCAAGCCATTCGGAACCTTACTTCATACCTACTCAGTTCTCAGTCCAACAGGAGGAGAAAACTTTACCTTTCAGATATATAAGGCTGACATGACATGTAGAGGCTTTCGAGAATATCATGAAAGGCTTCAGACCTTTTTGATGTGGTTTATTGAAACTGCTAGCTTTATTGACGTGGATGATGAAAGATGGCACTACTTTCTAGTATTTGAGAAGTATAATAAGGATGGAGCTACGCTCTTTGCGACCGTAGGCTACATGACAGTCTATAATTACTATGTGTACCCAGACAAAACCCGGCCACGTGTAAGTCAGATGCTGATTTTGACTCCATTTCAAGGTCAAGGCCATGGTGCTCAACTTCTTGAAACAGTTCATAGATACTACACTGAATTTCCTACAGTTCTTGATATTACAGCGGAAGATCCATCCAAAAGCTATGTGAAATTACGAGACTTTGTGCTTGTGAAGCTTTGTCAAGATTTGCCCTGTTTTTCCCGGGAAAAATTAATGCAAGGATTCAATGAAGATATGGTGATAGAGGCACAACAGAAGTTCAAAATAAATAAGCAACACGCTAGAAGGGTTTATGAAATTCTTCGACTACTGGTAACTGACATGAGTGATGCCGAACAATACAGAAGCTACAGACTGGATATTAAAAGAAGACTAATTAGCCCATATAAGAAAAAGCAGAGAGATCTTGCTAAGATGAGAAAATGTCTCAGACCAGAAGAACTGACAAACCAGATGAACCAAATAGAAATAAGCATGCAACATGAACAGCTGGAAGAGAGTTTTCAGGAACTAGTGGAAGATTACCGGCGTGTTATTGAACGACTTGCTCAAGAGTAAAGATTATACTGCTCTGTACAGGAAGCTTGCAAATTTTCTGTACAATGTGCTGTGAAAAATCTGATGACTTTAATTTTAAAATCTTGTGACATTTTGCTTATACTAAAAGTTATCTATCTTTAGTTGAATATTTTCTTTTGGAGAGATTGTATATTTTAAAATACTGTTTAGAGTTTATGAGCATATATTGCATTTAAAGAAAGATAAAGCTTCTGAAATACTACTGCAATTGCTTCCCTTCTTAAACAGTATAATAAATGCTTAGTTGTGATATGTTAATGTGTGATGATATGATTCTTAAATACTTACAATAAACCTCATTCTTAAATACTTA

Publications

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