Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TRMT112P7
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:54479477-54479721  UCSC
Coordinates (T2T) chr8:54856740-54856984  UCSC
Coordinates (hg19) chr8:55392037-55392281  UCSC
Strand -
Parental Sequence NM_001372072.1
Parental seq. overlap 198 bp
Parental seq. overlap (%) 20.6%
Genomic Region Intergenic
Retrocopy Summary TRMT112P7, located on chr8:54479477-54479721, is a retrocopy of the parental gene TRMT112. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TRMT112
Full Name tRNA methyltransferase activator subunit 11-2
Also known as HSPC152|HSPC170|TRM112|TRMT11-2|hTrm112
Coordinate chr11:64316460-64318596
Strand -
Gene summary Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Bonobo Pan paniscus TRMT112P4
Gorilla Gorilla gorilla TRMT112P4
Green monkey Chlorocebus sabaeus TRMT112P4
Crab-eating macaque Macaca fascicularis TRMT112P4
Rhesus Macaca mulatta TRMT112P2
Baboon Papio anubis TRMT112P3
Chimpanzee Pan troglodytes Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TRMT112P7
ATGCACCACATGCTGCTCGAGCTGGATGTGTTAGAGGACACCTTGCAATGCGCAGAGTCTGGACATCTGTCCCACATCAGCCGTGGGGACCCCAACATGCTACTGAGTGATGAGGAAATGAAAGTTGACCACGCCACGCACCAGTTTCTTGCTTTATGACCACGTGTATCTTTGTTGATGTAGACCCTGTTCACTAGTGCTGCCATGCGCATCCCCAACCCTTGACCCAAAGACAAACCAAACAT
>NM_001372072.1
ACTGGAGCAGCTAATTTGCATATAGGAATGAGCTCCCACAAACACGAGAAGTTCCAGCAAGTTCGCCACTTCCGGTTCTCCTGGCTATCCAATAGCATCGAGAGGAGCATCCCCGGAAGTGAGGCAGCGGAGGACGACCTTTTTCCGGTTCCGGCCTGGCGAGAGTTTGTGCGGCGACATGAAACTGCTTACCCACAATCTGCTGAGCTCGCATGTGCGGGGGGTGGGGTCCCGTGGCTTCCCCCTGCGCCTCCAGGCCACCGAGGTCCGTATCTGCCCTGTGGAATTCAACCCCAACTTCGTGGCGCGTATGATACCTAAAGTGGAGTGGTCGGCGTTCCTGGAGGCGGCCGATAACTTGCGTCTGATCCAGGTGCCGAAAGGGCCGGTTGAGGGATATGAGGAGAATGAGGAGTTTCTGAGGACCATGCACCACCTGCTGCTGGAGGTGGAAGTGATAGAGGGCACCCTGCAGTGCCCGGAATCTGGACGTATGTTCCCCATCAGCCGCGGGATCCCCAACATGCTGCTGAGTGAAGAGGAAACTGAGAGTTGATTGTGCCAGGCGCCAGTTTTTCTTGTTATGACTGTGTATTTTTGTTGATCTATACCCTGTTTCCGAATTCTGCCGTGTGTATCCCCAACCCTTGACCCAATGACACCAAACACAGTGTTTTTGAGCTCGGTATTATATATTTTTTTCTCATTAAAGGTTTAAAACCAAAAGCGGTTTCTCTTTGCAGCAAATATACATTAAAATAGAGTCTCTGTACAGCCAAGGGCTCTGGGCCCTGGCTTGCCCCATGTCCCTGCGCCTCCCTGGCCAAACCCAAAAATAAATATAGTGTTATTGCTCTGCAGGGCATAGAGGCAGTGCTCTCCTACCCCCTGAGGAGGCTCGTTGGGAGCTGATGGGGAAGCCCTGGCCACCCCAGGGGTCCAGGGGCTGGAGTCTGC

Publications

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