Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SEC11B
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:54522489-54523375  UCSC
Coordinates (T2T) chr8:54899787-54900673  UCSC
Coordinates (hg19) chr8:55435049-55435935  UCSC
Strand -
Parental Sequence NM_014300.4
Parental seq. overlap 829 bp
Parental seq. overlap (%) 76.7%
Genomic Region Intragenic (MAPRE2)
Intragenic (RP1)
Intragenic (STK19)
Retrocopy Summary SEC11B, located on chr8:54522489-54523375, is a retrocopy of the parental gene SEC11A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SEC11A
Full Name SEC11 homolog A, signal peptidase complex subunit
Also known as 1810012E07Rik|SEC11L1|SPC18|SPCS4A|sid2895
Coordinate chr15:84669544-84716139
Strand -
Gene summary This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SEC11AP1
Bonobo Pan paniscus SEC11AP1
Gorilla Gorilla gorilla SEC11AP1
Orangutan Pongo abelii SEC11AP1
Gibbon Nomascus leucogenys SEC11AP1
Green monkey Chlorocebus sabaeus SEC11AP1
Crab-eating macaque Macaca fascicularis SEC11AP1
Rhesus Macaca mulatta SEC11AP1
Baboon Papio anubis SEC11AP1
Golden snub-nosed monkey Rhinopithecus roxellana SEC11AP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SEC11B
GTTCTGCCCGCTGGTCCTCGCACCCTCTCCCTTGCCGGTGTCCTGCTCGCCATCCCCACCATACTGTCTCTAGTCTTTTTGGATGATGTGCAGTGGATGAACAAGTGGCGGCTCTATTATCAAGTCCTAAATTTTGGAATGATTGTCTCATCAGCACTCATGATCTGGAAGGGGTTAATGGTAATAACTGGAAGTGAAAGTCCAATTGTGTTGCTCAGTGGCAGCATGGAACCTGCATTTCATAGAGGATATCTTCTCTTTCTAACAAATCGAGTTGAAGATCCCATACGAGTGGGAGAAATCGCTGTTCTAAGGATAGAAGGAAGAAAGATTCCTATAGTTCACCGAGTCTTGAAGATTCATGAAAAGCAAAATGGGCATATCAAGTTTTTGACCAAAGGAGATAATAATGCGGTTGATGACAGAGGCCTCTATAAACAAGATCAACATTGGCTAGAGAAAAAAGATGTCGTGGGGAGAGCCAGGGGATTTGTTCCTTATATTGGAATTGGGACGAGCCTCATGAATGACTATCCTAAACATAAGTATGAAGTGCTCTTTTTGCTGGGTTTATTTGTGCTGGTCCATCGTGAGTAAGAAGTCTGCCTTGCTGTTCCTGGGAAGATGCCACATTTTTTGTTACTGGATGTTTGGAGTAGATATTGGTCTGTGATTGGTGGAATGGAGAACACACGTGTTGGCGCTTCTTGGCAGCACTGGTTTGCATGAGTTTGTTTCCACGCCAGAGTTTTTGTGGGCGGCCGCATGTGCACCACAGAGTGCATTTGAGGGGACTTTCATTCACAGGATTTCATAGTTGTCATTGTCACACTTTCACATTTTTGTATACAGCAGTGAATTTTTTATATTAAAAGATTGAGCCAAAA
>NM_014300.4
AGTAGTTCCGCCCGCTGGTCATCGCGCCCTTTCCCCTGCCGGTGTCCTGCTCGCCGTCCCCGCCATGCTGTCTCTAGACTTTTTGGACGATGTGCGGCGGATGAACAAGCGGCAGCTCTATTATCAAGTCCTAAATTTTGGAATGATTGTCTCATCGGCACTAATGATCTGGAAGGGGTTAATGGTAATAACTGGAAGTGAAAGTCCGATTGTAGTGGTGCTCAGTGGCAGCATGGAACCTGCATTTCATAGAGGAGATCTTCTCTTTCTAACAAATCGAGTTGAAGATCCCATACGAGTGGGAGAAATTGTTGTTTTTAGGATAGAAGGAAGAGAGATTCCTATAGTTCACCGAGTCTTGAAGATTCATGAAAAGCAAAATGGGCATATCAAGTTTTTGACCAAAGGAGATAATAATGCGGTTGATGACCGAGGCCTCTATAAACAAGGACAACATTGGCTAGAGAAAAAAGATGTTGTGGGGAGAGCCAGGGGATTTGTTCCTTATATTGGAATTGTGACGATCCTCATGAATGACTATCCTAAATTTAAGTATGCAGTTCTCTTTTTGCTGGGTTTATTCGTGCTGGTTCATCGTGAGTAAGAAGCCTGCCTTGCTGTTCCTGGGAAGATGCCATAGTTTTCGTTACTGGATGTTTGGAGTAGATACTGGTCTGTGATTGGTGGAATGGAGAACACACGTGTTGGTGCTTCTGGGTAGCACTGGTTTGCATTAGTTTATGTTTCCATGCCAGAGTTTGTGTGGGCGGGCGCATGTGCACCACAGAGTGCACTCGAGGGGACTTTCAGTCACAGGATTTCATAATTGTCATTGTCACACTTTCAAATTTTTGTACATCAGTGAATTTTTTTATATTAAAAGGTTGAGCCAAAGCCCCCAGTGTTTGTATTTTGAAGCCAAGCTTCACTTCTAAAGTGCCTACAGAGACTTGTAAATGAAAATGCAGCTCTGCACGAGTTTGAAACCGTCATACCTCCTTCTATTAGGAATGGCATATACTGAGGTGGTCGTAAGTCTTAACTTCTAAAATTTTAAATAAAAGACTTTGCACATTGAA

Publications

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