Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PLK1P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:62143005-62144832  UCSC
Coordinates (T2T) chr8:62567046-62568879  UCSC
Coordinates (hg19) chr8:63055564-63057391  UCSC
Strand -
Parental Sequence NM_005030.6
Parental seq. overlap 1287 bp
Parental seq. overlap (%) 50.2%
Genomic Region Intergenic
Retrocopy Summary PLK1P1, located on chr8:62143005-62144832, is a retrocopy of the parental gene PLK1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PLK1
Full Name polo like kinase 1
Also known as PLK|STPK13
Coordinate chr16:23678889-23690367
Strand +
Gene summary The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PLK1P1
Bonobo Pan paniscus PLK1P1
Gorilla Gorilla gorilla PLK1P1
Orangutan Pongo abelii PLK1P1
Gibbon Nomascus leucogenys PLK1P1
Green monkey Chlorocebus sabaeus PLK1P1
Rhesus Macaca mulatta PLK1P1
Golden snub-nosed monkey Rhinopithecus roxellana PLK1P1
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PLK1P1
GGCCAGCCAGCTCCGCTACGCCCGCACCATGGTGGACAAGCTGCTGAGCTCGTGTTCTGGCAGCAACCGCTTCAAGGCCTCCTAATAGCCGCCCACCCCTCCGGACTGATGCCCTCCTGACTCCTACCTGCACCTGGGGCCCACATTGGTTGGCTCCCGCAGTGCCATGTCTGCAGTGTGCCCGCGAGCCCCGGGGGCTGGGCAGACCTGCATCATCCTTGAGGGTGGGGGTTGCTGTGTAAGTTATTTTTTGTACATGTTCAGGTGTGAGTTCTACAGCTTTGTCCCTTTCCTCTCAACCCCACCATATGAATTGCACAGAATATTTTTCTATTGAGTTCGGGACTGTCCTTTCCTTGGCTTTATATACATTAAACAGATGGGAATCGGAGCCTCTGCTGGGATCCACGTCTGCTGAGCAGCTCCAGGAACATGACTGCAGCGGTGACTGCGGGGAAGTGACACGGGCACCGGCCGTCCCTGGGAAAGCCGGGGTCCCCGGAGTTACAGCTCCCGGAGCTCTGGCGGCTGCTTTACCGGCTAAAGAGATCCCGGAGGTCCTAGTGGACCCGCGCAGCCGGCAGCGCTATGTGTGGGGCCGCTTTTTGGGCAAGGGCGGCTTTGCCAAGTGCTTCGAGATCTCAGACGCGGACAACAAGGTTGTGTTCGCGGGCAAGATTGTGCCTAAGTCGCTACTGCTCATGCCGCTCCAGAAGGAGATGTCCATGGGAATATCCATTCACCGCAGCCTTGCCCAGCAGCACGTCGTAGGATTCCATGGTTTTTTCGAGGACAACGACTTTGTGTTCGTGGTGTTGGAGCCCTGCCGCCGGAGGTCTCTCCTGGAGCTGCACAAGAGGAGGAAAGCCCTAACTGAGCCTGAGGCCCGACACTATGTTGTCTGCGGCAAATTGTGCTTGGCTGCCAGTACCTGCACTGAAACCGAGTTATTCAAGTTATTCACCGAGACCTCAAGCTGGGCAACTTTTTCCTGAATGAGTATCTGGAGGTGAAAATAGGGGACTTGGGACTGGCAACCAAAGTCGAATATGACGTCCCAGCCCGTCTCCCCATCACCTGCCTCACGATTCCACCGAGGTTTTCCATCGCTCCCAGCAGCCTGAACCCCAGCAACAGAAAGCCCCTCACGGTCCTCAATAAACACTTGGAGAACTCCCTGCCTGAGCGTCCCCGGGAAAAAGAAGAACCAGCAGTTTGAGAGACGCGTGAGGTGGTCGACTTCCACCTCAGTGATATGCTGCAGCAGCTGCACAGCGTCAGTGCCTCCAAGCCCTCGGAGGGAAGGCTGGTCAGGCAAGAGGAGGCTGAGGATCCTGCCTGCATCTCCATCTTCTGGGTCAGCAAGTGGGTGGACTATTCAGACAAGTAGGGCCCTGGGTATCAGCTGTGTGGTAACAGCCTGGAGGTGTTCTTCAATGATTGTAACAGCCTGCAGTACATAAAGTGTGATGGCACCGAGTCCTACCTCACCGTGAGTTCCCATCCCCATTCCATGATGAAGAAGATCACACTCCTTAAATATTTCCGCAATTACTTGAGCGAGCACTTCCTGAAGGCAGGTGCCAACATCACGCCGCGCGAAGGCGATGAGCTCGCCCGGCTGCCCTACCTGCGGACCTGGTTCCACACCCGCAGCGCCATCATCCTGCACCTCAGCAACGGCAGCATGCAGATCAACTTCTTCCAGGATCACACCAAGCTCACCTTGTGCCCACTGATGGCAGCCGTCACCTACATCGACGAGAACCGGAACTTCCGCACCTAACCACCTGAGTc
>NM_005030.6
GGAGGCTCTGCTCGGATCGAGGTCTGCAGCGCAGCTTCGGGAGCATGAGTGCTGCAGTGACTGCAGGGAAGCTGGCACGGGCACCGGCCGACCCTGGGAAAGCCGGGGTCCCCGGAGTTGCAGCTCCCGGAGCTCCGGCGGCGGCTCCACCGGCGAAAGAGATCCCGGAGGTCCTAGTGGACCCACGCAGCCGGCGGCGCTATGTGCGGGGCCGCTTTTTGGGCAAGGGCGGCTTTGCCAAGTGCTTCGAGATCTCGGACGCGGACACCAAGGAGGTGTTCGCGGGCAAGATTGTGCCTAAGTCTCTGCTGCTCAAGCCGCACCAGAGGGAGAAGATGTCCATGGAAATATCCATTCACCGCAGCCTCGCCCACCAGCACGTCGTAGGATTCCACGGCTTTTTCGAGGACAACGACTTCGTGTTCGTGGTGTTGGAGCTCTGCCGCCGGAGGTCTCTCCTGGAGCTGCACAAGAGGAGGAAAGCCCTGACTGAGCCTGAGGCCCGATACTACCTACGGCAAATTGTGCTTGGCTGCCAGTACCTGCACCGAAACCGAGTTATTCATCGAGACCTCAAGCTGGGCAACCTTTTCCTGAATGAAGATCTGGAGGTGAAAATAGGGGATTTTGGACTGGCAACCAAAGTCGAATATGACGGGGAGAGGAAGAAGACCCTGTGTGGGACTCCTAATTACATAGCTCCCGAGGTGCTGAGCAAGAAAGGGCACAGTTTCGAGGTGGATGTGTGGTCCATTGGGTGTATCATGTATACCTTGTTAGTGGGCAAACCACCTTTTGAGACTTCTTGCCTAAAAGAGACCTACCTCCGGATCAAGAAGAATGAATACAGTATTCCCAAGCACATCAACCCCGTGGCCGCCTCCCTCATCCAGAAGATGCTTCAGACAGATCCCACTGCCCGCCCAACCATTAACGAGCTGCTTAATGACGAGTTCTTTACTTCTGGCTATATCCCTGCCCGTCTCCCCATCACCTGCCTGACCATTCCACCAAGGTTTTCGATTGCTCCCAGCAGCCTGGACCCCAGCAACCGGAAGCCCCTCACAGTCCTCAATAAAGGCTTGGAGAACCCCCTGCCTGAGCGTCCCCGGGAAAAAGAAGAACCAGTGGTTCGAGAGACAGGTGAGGTGGTCGACTGCCACCTCAGTGACATGCTGCAGCAGCTGCACAGTGTCAATGCCTCCAAGCCCTCGGAGCGTGGGCTGGTCAGGCAAGAGGAGGCTGAGGATCCTGCCTGCATCCCCATCTTCTGGGTCAGCAAGTGGGTGGACTATTCGGACAAGTACGGCCTTGGGTATCAGCTCTGTGATAACAGCGTGGGGGTGCTcttcaatgactcaacacgcctcatcctctacaatgatggtgacagcctgcagtacatagagCGTGACGGCACTGAGTCCTACCTCACCGTGAGTTCCCATCCCAACTCCTTGATGAAGAAGATCACCCTCCTTAAATATTTCCGCAATTACATGAGCGAGCACTTGCTGAAGGCAGGTGCCAACATCACGCCGCGCGAAGGTGATGAGCTCGCCCGGCTGCCCTACCTACGGACCTGGTTCCGCACCCGCAGCGCCATCATCCTGCACCTCAGCAACGGCAGCGTGCAGATCAACTTCTTCCAGGATCACACCAAGCTCATCTTGTGCCCACTGATGGCAGCCGTGACCTACATCGACGAGAAGCGGGACTTCCGCACATACCGCCTGAGTCTCCTGGAGGAGTACGGCTGCTGCAAGGAGCTGGCCAGCCGGCTCCGCTACGCCCGCACTATGGTGGACAAGCTGCTGAGCTCACGCTCGGCCAGCAACCGTCTCAAGGCCTCCTAATAGCTGCCCTCCCCTCCGGACTGGTGCCCTCCTCACTCCCACCTGCATCTGGGGCCCATACTGGTTGGCTCCCGCGGTGCCATGTCTGCAGTGTGCCCCCCAGCCCCGGTGGCTGGGCAGAGCTGCATCATCCTTGCAGGTGGGGGTTGCTGTATAAGTTATTTTTGTACATGTTCGGGTGTGGGTTCTACAGCCTTGTCCCCCTCCCCCTCAACCCCACCATATGAATTGTACAGAATATTTCTATTGAATTCGGAACTGTCCTTTCCTTGGCTTTATGCACATTAAACAGATGTGAATATTC

Publications

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