Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AK6P3
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:6473630-6474288  UCSC
Coordinates (T2T) chr8:6228121-6228779  UCSC
Coordinates (hg19) chr8:6331151-6331809  UCSC
Strand -
Parental Sequence NM_016283.5_2
Parental seq. overlap 608 bp
Parental seq. overlap (%) 37.3%
Genomic Region Intragenic (MCPH1)
Retrocopy Summary AK6P3, located on chr8:6473630-6474288, is a retrocopy of the parental gene AK6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AK6
Full Name adenylate kinase 6
Also known as AD-004|CGI-137|CINAP|CIP|hCINAP
Coordinate chr5:69350984-69369824
Strand -
Gene summary This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AK6P1
Bonobo Pan paniscus AK6P2
Gorilla Gorilla gorilla AK6P3
Orangutan Pongo abelii AK6P2
Gibbon Nomascus leucogenys AK6P1
Green monkey Chlorocebus sabaeus AK6P2
Crab-eating macaque Macaca fascicularis AK6P1
Rhesus Macaca mulatta AK6P2
Baboon Papio anubis AK6P2
Golden snub-nosed monkey Rhinopithecus roxellana AK6P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AK6P3
TCAAAATCAGGATTGAAATACATTAATGTGGGTGATTTAGCTTGAGAAAAGCAATTGTATGACGACTATGATGAAGAGTATAATTGTCCCATTTTAGATGAAGACAGAGTAGCTGATGAGTTAGATAACCAAATGAGAGAATGTGGAGTTATTGTTGATTACCACGGTTGTGATTTCTTCCCTGAACGCTGGTTTCACATAGTTTTTGTGTTGAGAATAGATGCCAACATATTGTACGAAATACTTCAAATGAGGGGTTATAATGAGAAGAAACTAAAAGACAATATTCAGTGTGAGATTTTCCAAGTTCTTTATGAAGAAGCCACGGCATCCTACAAGGAAGAAGTTGTGCATCGGCTGCCCAGCAATAAACCAGAAGAGCTAGAAAATAATGTAGATCAGATCTTGAAATGGATTGAGCAGTGGATCAAAGATTATAACTCTTGACTTATAAGGCTAGCTACTTTACAATCACTCTTGCTGATATCTCTCTGCTGACATCATAGAAATTGTTTAAGTATCAGGAACGCTTTATTAAACTCATGTTGCAGGACCAGCAGGCGGATAGTATAAAGGTTTATGCCTATGTTTCTTTTTCTCCATGAGAAAGCTAAACATATGAAATACAACAAATATAGCATTGTTAAGGATTGAGACAg
>NM_016283.5_2
GAGGCGCCCGAAGCCGTCGCGGCGGGGACCATGTTGCTTCCGAACATCCTGCTCACCGGTACACCAGGGGTTGGAAAAACCACACTAGGCAAAGAACTTGCGTCAAAATCAGGACTGAAATACATTAATGTGGGTGATTTAGCTCGAGAAGAGCAATTGTATGATGGCTATGATGAAGAGTATGACTGTCCCATTTTAGATGAAGACAGAGTAGTTGATGAGTTAGATAACCAAATGAGAGAAGGTGGAGTTATTGTTGATTACCATGGTTGTGATTTCTTCCCTGAACGCTGGTTTCATATAGTTTTTGTGCTGAGAACAGATACCAATGTATTGTACGAAAGACTTGAAACAAGGGGTTATAATGAGAAGAAACTAACAGACAATATTCAGTGTGAGATTTTTCAAGTTCTTTATGAAGAAGCCACAGCATCCTACAAGGAAGAAATCGTGCATCAGCTGCCCAGTAATAAACCAGAAGAGCTAGAAAATAATGTAGATCAGATCTTGAAATGGATTGAGCAGTGGATCAAAGATCATAACTCTTGACTTATAAGGCTAGCTACTTAATAATCACTCTTGTTGATATCTCTGCCGACATCATAGAAATTGTTCAAGTGTCAGTAACACTTTATTAAAATCATGTTGCAGAACCAGCAGGTGGATAGTATATAGGTTTATGCCTGTGTTTCTTTTTCTCCATGAGAAAGCTAAACATGAAATATAATGAATATAGTATTATTAAGGATTGAGACAAAAACTGTGATTTTAATACTTAAATTGCTAAAGAATAAATAAATCTGACAAAATGGGTGGATATCTTTTAAGTTTATTACAGAAAAAAATGCAGATGATCTCTTAAAATAAAACTAAAGATAAAGCAACAGAGTATTCCTTTTTTCTTTCTTTAAATTAGAAAAAAAGTTAAGTGTTGTACTCGATAcaaagttcaaaaggtacaaaagagcatgttgaaaagttaggtctcccttccagaccaccctatccccaggcaccccaggttccttccctttaggaaataatgttactggtttcctatatgtctttttagaggttttatgcctgcacagtgtatatgtacatgtgtacattttttaaagaatataacagtatattatgcacactattctgtacctttcttttttcacttactatatttgaagattatatcatctcagtacagacctccctgttcttttttttagttgagatagatatacatatcatacaataaaatttaccattttgaagtgtataatcagaaccgggtatggtggcttatgcctgtaatcccagcaaatggggaggctgaggtggagaatcgcttgaggcaggagttcaagaccagcctgggcaacatagtgagaccttagactctaaaaataaacataaataaaatttataatccgttggtttttagcttattaacaaggttatgtaactgtcaccactgtggaggaagcagtgatgataaagggaactcctataccctttagcagtcactctctattctttcctcctcatccccttgcagtcactagtctactttctgtctctatggatttgcatattctggatatttcatataaatgggattatacagta

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