Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TPM4P3
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:69129576-69132014  UCSC
Coordinates (T2T) chr8:69558146-69560576  UCSC
Coordinates (hg19) chr8:70041811-70044249  UCSC
Strand +
Parental Sequence NM_003290.3
Parental seq. overlap 2026 bp
Parental seq. overlap (%) 81.1%
Genomic Region Intergenic
Retrocopy Summary TPM4P3, located on chr8:69129576-69132014, is a retrocopy of the parental gene TPM4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TPM4
Full Name tropomyosin 4
Also known as HEL-S-108
Coordinate chr19:16067507-16103005
Strand +
Gene summary This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TPM4P2
Bonobo Pan paniscus TPM4P2
Gorilla Gorilla gorilla TPM4P2
Orangutan Pongo abelii TPM4P1
Gibbon Nomascus leucogenys TPM4P2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TPM4P3
ACCTCAACTCCCTGGAGGCGGTGAAATGCAAGATCCAGGCCCCTGCAGTAGCAGGCGGACGAGGCGGAAGACCGCGCAGGGCCTGCAGCGGGAGCTGGACGGCAAGCGCGAGTGGCGCGAGAAAGCTGAAGGTGATGTGGCCACCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACAGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGTTGCAGATGAGAGTGAAAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAAAGGCTGACCGCAAATACGAGAAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCAGAGATGCGTGCGGAGGTGTCCGAACTAAAATGTGGTGACGTGGCAAAGAACTCAAGAATGTTACTAACAATCTGAAATCGCTGGAAGCTGCATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAAAGTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGAGAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACAGAAGAGTCTTGTTCCAACAGAAACTCCGGAGCTCCGTCGGTCTTTCTCTTCTCTTTTAAGAAGTTCCTTTTGTTATTGCCATCTTAGCTTTGCTGGAAATGTCAAGCAAATTATGAATACATGACCAAATATTTTGTATCGAAGAAGCTTTGAGCACCAGTTAAATCTCATTCCTTCCCCTTTTTTTTTCAAATGGCACCAGCTTTTTTAGCTCTCTTATTTTTTCCTTAAGTTGCATTTATTCCTAAGGTAGGCAGGATATTTCCTAGTTAAGCATACTTTCTTAAGACGGAGGCCATTTGGTTCCTGGGAGAATAGGCAGCCCCACACTTTGAAGAACACAGACCCCAGTATCTAGTCGTGGATATAATTAAAACACTAAAGACCATAACCTTTTGGGTCAACTGTTGGTCAAACTATAGGAGAGACCAGGGACCATCACATGGGTAGGGATTTTCCATCCAGAGCCAATAAAAGGGCTGGTAGGGGCCAGGGTGGCTATTGTGGGAAGTCATAACCCACAGATAGATTAACTTAAGAATCCTGGCCCTTCTCCACACTCCACCATGCAGAACAAACATCCTCTCAAGCAGTCAACGTACAACGCTTGGGAAATAGTCATAATTACCCACATATAGTAATTAATAGATGGTAAGTAATAGATCCTTGATGTGATGTTCTTTTGCATATTTCCCTGGCCGGCTTTCACCGGTGGCTTTCGTCTGTAAGGAAAGTTGTTCTCTGAAGAGCAAATGTCTCATTCCAATAATGACCCACTCAGCAGGAATATGGTAGAGTTCAGTCCAATTCAGATCAGCCATATCCAGAAGACTACAAGGCATTACTAAGTTGAGCAAAAGAGTTTTTATCTACTAGCGGAAAGGGCCTCTCTGGCAGCAGAGATTAAATATTGGCCCAACTTCATTTCCATACTTTAGGGAACAGCAAATTGAAGATTTACTTATCTAGGACTTGAATTCCTTCTTTGGGACCAAGTTAATAAAAGACCAAGAAACTCCTGATTAAACTGGATGATGAGGGATTCTGCAGACAGGGCTGCACGTATGGGCTTTGTTTGACTTCTCTTTTCTCAGTTAACATCTCAGAGCTGGAACATTCCACATTCCCCAGCAGCGTGTGGGGGCCGACTAAAGTTTACAATTCTGACTAAAAATCACCCTGCTTCTGGCTTATCTGAATCCCTTAcTATTTATTCAGCACCGCACTACCCAGGAAATACACTAGCAAATTGTGAATGGAATAAAATCCACACTTTACTTTAGATTCTTGCAACTGTATCATATGTAATAGTATCACTTTTTCTACATTTTGGTCAAATAAATTTTTACATAAACTA
>NM_003290.3
GTGCAGCTCTCGCCGGAGCCGAGCCCAGCCGAGCGTCCGCCGCTGCCCGTGCGCCTCTGCGCCTCCGCGCCATGGCCGGCCTCAACTCCCTGGAGGCGGTGAAACGCAAGATCCAGGCCCTGCAGCAGCAGGCGGACGAGGCGGAAGACCGCGCGCAGGGCCTGCagcgggagctggacggcgagcgcgagcggcgcgagaaaGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAGGAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCAGAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAAGAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTGGAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAACTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAAAAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAGACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTGGAAGAGAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAGACACTAAACGAACTTAACTGTATATAAGCAAAACAGAAGAGTCTTGTTCCAACAGAAACTCTGGAGCTCCGTGGGTCTTTCTCTTCTCTTGTAAGAAGTTCCTTTTGTTATTGCCATCTTCGCTTTGCTGGAAATGTCAAGCAAATTATGAATACATGACCAAATATTTTGTATCGGAGAAGCTTTGAGCACCAGTTAAATCTCATTCCTTCCCTTTTTTTTTCAAATGGCACCAGCTTTTTCAGCTCTCTTATTTTTTCCTTAAGTAGCATTTATTCCTAAGGTAGGCAGGGTATTTCCTAGTAAGCATACTTTCTTAAGACGGAGGCCATTTGGTTCCTGGGAGAATAGGCAGCCCCACACTTTGAAGAATACAGACCCCAGTATCTAGTCGTGGATATAATTAAAACGCTGAAGACCATAACCTTTTGGGTCAACTGTTGGTCAAACTATAGGAGAGACCAGGGACCATCACATGGGTAGGGATTTTCCATCCAGAGCCAATAAAAGGACTGGTGGGGGCCGGGGGTGGCTATTGTGGGAAGTCATAACCCACAGATAGATCAACCTAAGAATCCTGGCCCTTCTCCACTCTCCACCATGCAGGACAAACATCTTCTCAAGCAGTCAACGTAGAATGCTTGGGAAATAGTCATAATTACCCACATATAGTAATTAATAGATGGTAATTAATTGATCCTTGATGTGATGTTCTTTTGCATATTTCCTTCATTCTAAAGTTGTTCCCTggccgggagcgttggctttcgcctgtaatcccaacactttgggaggccaggacagatcacttgaggtcaggagttcgagaccagcccagccaacatggcgaaaccatgtctctactaaaaatacaaaaattatggtgacgcctgcctgtagtcccagctactcgggaggctgaggcaggaggatcgcttgaacccaggaagtggagactgcagtgagccgatatcgcaccacagcgctccagcctggtcgacagagtgagactccatctcaagaaaaaataaaaataaaGTTGTTCTCTGAAGAGCAAATGTCTCATTCCAGTAATGACCCACTCAGCAGGAATATGGTGGAGTTCAGTCCAATTCAGGTCAGCCATATCCAAAAGACCACAAGTCATTACTAAGTTGAGCAAAAGAGTTTTTATCTATTAGCAGAAAGGGCCTCTCTGGCAGCAGAGATTAAAAACTGGCCCAACTTCATTTCCATACTTCAGGGAACAGCAAATTGAGGATTTACTTATCTAGGACTTGAATTCCTTCTTTGGGACCAAGTTAATAAAAGACCAAGAAACTCCTGATTAAACTGGATAATGAAGGATTCTGTAGACAGGGCTGCACGTATCGGCTTTGTTTGACTTCTCTTTTCTCAGTTAACATCTCAGAGCTAGAACATTCCACATTCCCCAGCAGCGTGTGGGGGCTGACTAAAGTTTACAATTCCAACTAAAAATCACCCTGCTTCTGGCTTATCTGAATCCCTTACCCACCCCACCCCACCACCCTACTCCTATTTATTCAGCACCACACTACCCAGGAAATACACTAGCAAATTGTGCAATGGAATAAAATCCACACTTTAGATTCTTGCAACTGTATCATATGTAATAGTATCACTTTTTCTACATTTTGGTCAAATAAATTTTTACATAAACTA

Publications

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