Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BAG4P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:69856560-69860555  UCSC
Coordinates (T2T) chr8:70286143-70290138  UCSC
Coordinates (hg19) chr8:70768795-70772790  UCSC
Strand -
Parental Sequence NM_001204878.2
Parental seq. overlap 2914 bp
Parental seq. overlap (%) 66.9%
Genomic Region Intergenic
Retrocopy Summary BAG4P1, located on chr8:69856560-69860555, is a retrocopy of the parental gene BAG4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BAG4
Full Name BAG cochaperone 4
Also known as BAG-4|SODD
Coordinate chr8:38176855-38213301
Strand +
Gene summary The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BAG4P1
Bonobo Pan paniscus BAG4P1
Gorilla Gorilla gorilla BAG4P1
Orangutan Pongo abelii BAG4P1
Green monkey Chlorocebus sabaeus BAG4P1
Crab-eating macaque Macaca fascicularis BAG4P1
Rhesus Macaca mulatta BAG4P1
Baboon Papio anubis BAG4P1
Golden snub-nosed monkey Rhinopithecus roxellana BAG4P1
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BAG4P1
AATAAGATATTCAAGATAAGTATAGATTTAGAACTTAAAGATGTTAAACCATGTTAAAATTATTCCAAATACCAATATCAAAGAAAACTGAGTTGGTAATCTATCTCAGAAAAGATATGAACTTAAGAAGGAAAATAGTATTTATGATTTGTAGAATTGGTTCAACTTTTGACTTAATATTGACTTAGGACTGAATTCAAAGTTTTCTTGAAATTTCACATCTGGACTTTTTTAGGGCAGCGGAGCCCATGTCGGCCCTGAGGCGCTTGGGCTACGGCCCCAGTGACCATCTGTCCTACAGCCGCTACTACGGGCCTGGGGGTGGAGATGTGCCGGTGCACCCACCTCCACCTTTATACCCTTTTCACCCCGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGCCCGGCGGAGACCACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTGCTATCCCTCTGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGAGGAAGCCACCAAAGTTTGAATTCTTATACAAATGGAGCATACGGTCCAACATACCCCCCAGGCCCTGGGGCAAATACTGCCTCATACTCAGGGGCTTACTATGCACCTGGTTATACTCAGACCAGTTATTCCACGGTAGTTGCAAGTACTTACCGTTCACCTGGCACAGCCCAACTCCAGTCTCTGGAGTCTATCCCCAGCAGGACTGTCAGACTGAAGTACACCCTCTTAGGGGGCAGGTTGCAGGGTATCTAGCTTCACAGAACTCTGGAATGACCCTGCCCCATTATCCTTATGGAGATGGTAATCGTAGTGTTCCACAATCAGGACAAACTGTACGACCACGAGAGAATGTGTGGGCTTCTCCTGGTGCTTATGGAATGGGTGGCAGTTATCCCTGGCCTTCGTCAGCGCCCTCAGCACCACCTGACAATCTCTACATGACCTAAAGTACTTCACCATGGCCTAGCAGTGGCTCTCCTCAGTCACCCCCTACACCCCCACTCCAGCATACACCCCCACTCCAGCAGCCCAAGGATTCTTCATACCCCTATAGCCAATCAGATCAAAGCATGAACCGGCACAACTTCCCTTGCAGCGTCCATTAGTACGAATCCTCTGGGACAGTGAACAAGAATGATTCAGATCTTTCGGATTCCTAAGTCCAATATAGTGCTGAGCCTCAGCTGTATGGTAATGCCACCAGTGACCATCCCAACAATCAAGATTAAAGTAGCAGTCTTCCTGAAGAATGTGTACCTTCAGATGAAAGTACTCCTCCGAATATTAAAAAAATCATACATGTGGTGGAGAAGGTCCAGTATCTTGAACAAGAAGTAGAATAATTTGTAGGAAAAAAGACAGACTAAGCATACTGGCTTCTGGAAGAAATGCTAACCAAGGAACTTTTGGAACTGGATTCAGTTGAAACTGGGGGCCAGGACTCTGTACGGCAGGCCAGAAAAGAGGCTGTTTGTAAGATTCAGGCCATAGTGGAAAAATTAGAAAAAAAATTATGAAAGGATTTAGAACAAAGTGAAAGCCTGTTACTAACTTGACCAAAGAACACTTGATTTGGTTAATTACCCTCTTTTTGAAATGCCTGTTGATTACAAGAAGCAATACATTCAACTTTCCTTTGATTTTAAACTTGAAAACTGGCAAAGGAATGGAAGAATATTTCAGTCATGAGTTGTTTTCAGTTTTCAGACGAATGAATGTAATAGGAAACTATGGAGTTACCAATATTGCCGAGTAGACTCACTCCTTAAAAAATTTATGGATATCTGCAAGCTGCTTCTTATCAGCAGGAGGGAAACACACTTTACATAACAGGCTTATCAGAAACCTACAAGATGAAACTAGATATAATCTGAGACAAACAGGATGTGTTTTTTTAAACATCTGGATATCTTGTCACATTTTCGTACATTGTGACTGCTTTCAACATACACTTCATGTGTAATTACAGCTTAGACTTTAGCCTTCTTGGACTTCTGTTTTGTTTTATTATTTGCAGTTCAAAAATATAGTGTTATTCGCTACTTCTTGGTACCTTTTGTAGTAATATGTTTAATATAATTATTCAGGAGACTATATTGACAGCCAGAGAATATGGCAGTTCTGAAAGAATTTATATCTTTTCACCACTTGAATATACTGCAATGTGTAGAGAGTAAATTGTCTCCCTTTTTGTATAGATCATTAGGTTAGAGGTTTTTTTTTATACCACTTCTGCTGTTCATTGTAGTAGTGGAAGGTGAATTTGGAAATGGCATTGACATAAAATGAAAATGTTTACGGACATTTTTCTTTTTTGCTTTTTTATTGTATTTGGATAAAGATCTACTTAAAAATTACCTATTTTTTTTTCCCCAAAGTGTAATTATGTTTTCACTATTGCTGCTTCTATAGAGGGCATTGTGATAGAGAGATACAGATGAAACATTAAATGCCACAGCGAGTAGAAATGATGACTACAAAAAGTAAAAAATATTACTTGGTAATGTCATACTCCATCTAAAATATTAGTTTCATCTATGAGCAGATTTCAGCTCAGTTTATAGTTAAAAACAATGAGGGTAAAAGGGGATTCATGCTCAGGGAATGAATCAGCCATAGTTAGAGGGGGAAATTATTATTTTCTTCATTTAAAGGTAGATTTTGTGTTTATCTTTACTTCCCTGAATTGCATAAGATAAAATTGCCTTTTTAATAAAAAGACATTTATTACCATTATCAACAGTCATTTTAGAGCCTAATTTAAGAAAAGGATATTGAAAGAGTCTTTGTTGGCCTTGCTTGGGTAGCTCTATGCTGTTAGATAGAAGAGACTTTGGTAAATAACTTTTTATGTCTCAGGTGAGTACACAATATTGGTTCTTGGAAAAACAGCTGTTTCTTCATAAGATACCCAAGTGATAATTGTTTTCCCCTAGACTGTCAGGCCTATGATTAAATACTAAATCTATTAGCTGTATCCACTCATAAACCAAACCAAACCAACACAAACATATTAGATGAGGAGAGGAAATGCAGTAAAAATACTGGCTGGGTCTTATGGTTGGGATGAGTAATTTTATAAGATAATATGGTGATAGTTTTATTCTAGGATTTTATTTTTGGCCTAATACAGGAATGTTTTTTAAAAAGGCTTTTCTATGAAAATTAGAAATTTATACTTGAGATTAAAAGTCTAGAAGGGGGAGGACCTTAAAGCTAAGTTACCAGTAAGACAATGAATAATTCGGAAGAGAACACTACTGTTTTACTGACTAAGTGCCCAAGATGCCAATTTCCATGAAGTCTTGATt
>NM_001204878.2
AGGGCAGCGGATCCCATGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGTCCGTCCTACGGCCGCTACTACGGGCCTGGGGGTGGAGATGTGCCGGTACACCCACCTCCACCCTTATATCCTCTTCGCCCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGCCCGGCGGAGACCACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTATCCCTCGGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGAGGAAGCCACCAGAGTTTGAATTCTTATACAAATGGAGCGTATGGTCCAACATACCCCCCAGGCCCTGGGGCAAATACTGCCTCATACTCAGGGGCTTATTATGCACCTGGTTATACTCAGACCAGTTACTCCACAGAAGTTCCAAGTACTTACCGTTCATCTGGCAACAGCCCAACTCCAGTCTCTCGTTGGATCTATCCCCAGCAGGACTGTCAGACTGAAGCACCCCCTCTTAGGGGGCAGGTTCCAGGATATCCGCCTTCACAGAACCCTGGAATGACCCTGCCCCATTATCCTTATGGAGATGGTAATCGTAGTGTTCCACAATCAGGACCGACTGTACGACCACAAGAAGATGCGTGGGCTTCTCCTGGTGCTTATGGAATGGGTGGCCGTTATCCCTGGCCTTCATCAGCGCCCTCAGCACCACCCGGCAATCTCTACATGACTGAAAGTACTTCACCATGGCCTAGCAGTGGCTCTCCCCAGTCACCCCCTTCACCCCCAGTCCAGCAGCCCAAGGATTCTTCATACCCCTATAGCCAATCAGATCAAAGCATGAACCGGCACAACTTTCCTTGCAGTGTCCATCAGTACGAATCCTCGGGGACAGTGAACAATGATGATTCAGATCTTTTGGATTCCCAAGTCCAGTATAGTGCTGAGCCTCAGCTGTATGGTAATGCCACCAGTGACCATCCCAACAATCAAGATCAAAGTAGCAGTCTTCCTGAAGAATGTGTACCTTCAGATGAAAGTACTCCTCCGAGTATTAAAAAAATCATACATGTGCTGGAGAAGGTCCAGTATCTTGAACAAGAAGTAGAAGAATTTGTAGGAAAAAAGACAGACAAAGCATACTGGCTTCTGGAAGAAATGCTAACCAAGGAACTTTTGGAACTGGATTCAGTTGAAACTGGGGGCCAGGACTCTGTACGGCAGGCCAGAAAAGAGGCTGTTTGTAAGATTCAGGCCATACTGGAAAAATTAGAAAAAAAAGGATTATGAAAGGATTTAGAACAAAGTGGAAGCCTGTTACTAACTTGACCAAAGAACACTTGATTTGGTTAATTACCCTCTTTTTGAAATGCCTGTTGATGACAAGAAGCAATACATTCCAGCTTTCCTTTGATTTTATACTTGAAAAACTGGCAAAGGAATGGAAGAATATTTTAGTCATGAGTTGTTTTCAGTTTTCAGACGAATGAATGTAATAGGAAACTATGGAGTTACCAATATTGCCAAGTAGACTCACTCCTTAAAAAATTTATGGATATCTACAAGCTGCTTCTTACCAGCAGGAGGGAAACACACTTCACACAACAGGCTTATCAGAAACCTACCAGATGAAACTGGATATAATCTGAGACAAACAGGATGTGTTTTTTTAAACATCTGGATATCTTGTCACATTTTTGTACATTGTGACTGCTTTCAACATATACTTCATGTGTAATTATAGCTTAGACTTTAGCCTTCTTGGACTTCTGTTTTGTTTTGTTATTTGCAGTTTACAAATATAGTATTATTCTCTACTTCTTGGTACATTTTGTAGTAATATGTTTAATATAATTATTCAAGAGACTATATTGACAGCCAGATAGTATGGCAGTTCTGAAAAAATTTATATCTTTTCACCACTTGAATATACTGCAATGTGTAGTGAGTAAATTGTCTCCCTTTTTCTATAGATCATTAGGTTAGAGtttttttcttcttttttttttttttttttttttACCACTTCTGCTGTTCATGGTAGTAGTGGAAGGTAAATTTGGAAATGGCATTGACATAAAATGAAAATGTTTACGGACACTTTTCTTTTTTGCTTTTTTATTGTATTTGGATAAAGATCCACTTAAAAGTTATCTGttttttcctgttttttttttttttCCCCAAAGTGTAGTTATGTTTTCACTATTGCTGCTTCTATAGAGGGCATTGTGATAGAGAGTTACAGATGAAACATTAAATGCCACAGTGAGTAGAAATAATTACTACAAAAAGTAATAAATATGATTACTTGGTAATATCATTCTCCATCTAAAATACTAGTTTCACCTGTGAGCAGATTTCAGCTCAGTTTATAGTTAAAAACAATGAGGGTAAAATGGGATTCATGCTCAGGGAATGAATCAGCCATAGTTAGAGTGGGAAATTATTATTTTCTTCATTTAAAGGTAGATTTTATGTTTATTTCCCTAAATTGCATAAGATAAAATTGTCTGTTTAATAAAAAGACATTTATTACCATTATTAACAGTCATTTTAGAGCCAAATTTAAGAAAAGGATATTGAAAGGGTCTTTATTGGCCTTGTTTGGGTAACTCTATGCTGTTAGATAGAAGAGACTTAGGTAAATAACTTTTTATGTCTGAGGTGAGTACACAATATTGGTTCTTGGAAAAATAGCTGTTTCTTCATAAGATACCCAAGTGATAATTTTTTTTCCCCTAGACTGTCAGGCCTATGAGTAAATACTAAATCTATTAGCTGTCCCCACTCATAAACCAAACCAAACCAATACAAACAGATGAGGAGAGGAAATGTAGTAAAAATACTGGCTGGGTCTTATGATTGGGATGAGTGATTTTATAAGATAATATGGTGATAATTTTATTCTAGGATTTTATTTTTGGCCTAATATAGGAATGTTTAAAAAAGGCTTTTCTATGAAAATTAGAAATTTATACTTGAAATTAAAAGTCTAGAAGGGGGAGGACCTTAAAGCTAAGCTACCAGTAAGACAATGAATAATTCAGAAGAGAACACTATTCTTTTACTGACTGAGTGCCCAAGATGCCAATTTCCATGAAGTCTTGATTTATATATATGTACACATGTTATGCACATACATGTTTGTTTTCTAACAGTTattttttaagcttttgagataattttagacttacagaagagttgtaaaagtagtagagttcttgtatactctgcacccaccttgcccttatgttaacatcttacgtaacaatagaacatttgtcaaaattaagaaattaaccttgatataatactaactaaagtagaaagtttaaaaagtagagattttagtcttttcactaatgtccttttactgttccaagacccagccttgcatttagctatcatgcctacgtcctgtcttccagtctgtgacagtgtatcataacaggggatacctgatgttgtaatgtatttctggtgttgttaaccttgatcactatgctaaggtggtgtctgctaggattcgctactgtaaacttactgtgttttccttgtaattattgaatatttgctggagatacccggagactatgcaaatgtcccgtttctgcttaaacttttgctcattttactatccattggcagatcttgcttgtggcagttactactgtggtgttctaatggtgattttctatttctctcaatccttctacatttattattggaattcttctgtaaggaagagttgtcagttctGGATTTATATTTTTAACTATAATAAGATATTCAGGATAAGTATAGATTTAGAACTTAAAGATGTTAAATCATGTTAAAATTATTCCAAATACCAATATCAAAGAAAACTAAGTTGGTAATCTATCTCAGAAAATATATGAACTTAAGAAGGAAAATAGTATTTATGATTTGTAGAATTGGTTCAACTTTTGACTTAATACTGACTTTGGACTGAATTCAAAGTTTTCTTGAAATTTCACATCTGGACTTTTTAAAGTGTCTACATTTATATTACTTTGGGGATCATTTTGTCAAAGTCTTGAATAAAGTTACCCAGTCCTGGCATGATAAACACAA

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