Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SDCBPP2
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:69942886-69945074  UCSC
Coordinates (T2T) chr8:70372472-70374660  UCSC
Coordinates (hg19) chr8:70855121-70857309  UCSC
Strand +
Parental Sequence NM_001348339.2
Parental seq. overlap 1142 bp
Parental seq. overlap (%) 54.3%
Genomic Region Intergenic
Retrocopy Summary SDCBPP2, located on chr8:69942886-69945074, is a retrocopy of the parental gene SDCBP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SDCBP
Full Name syndecan binding protein
Also known as MDA-9|MDA9|ST1|SYCL|TACIP18
Coordinate chr8:58553261-58582860
Strand +
Gene summary The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SDCBPP1
Bonobo Pan paniscus SDCBPP1
Gorilla Gorilla gorilla SDCBPP1
Orangutan Pongo abelii SDCBPP1
Gibbon Nomascus leucogenys SDCBPP3
Green monkey Chlorocebus sabaeus SDCBPP2
Crab-eating macaque Macaca fascicularis SDCBPP1
Rhesus Macaca mulatta SDCBPP1
Baboon Papio anubis SDCBPP1
Golden snub-nosed monkey Rhinopithecus roxellana SDCBPP2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SDCBPP2
CAGTGACCGGAGGCGACAGCGGCAGCGAGTGGGTCCTTGTGAGCTAGAAGAATCCTGCAAAAATGTCTCTCTATCCATCTCTTGAAGACTTGAAGGAAGACAATGTAACTCAGGCTCAAACTGCTTTTTCTGCAAACCCTGCCAACCCAGCAATTTTGTCAGAAGCTGCTGCTCCCATCTCTCAAGATGGAAATCTCTATCCCAAACTATATCCGGAGCTCTCTCAATAATACATGGGCCTGAGTTGAAATGAAGAAGAAATACGTGCAAATGTGGCCGTGGTTTCTGGTGCATCAATTCAGAGGTAGTTGGTAGCAAGATCTTCCGGTATGATCTGTATGGTGGTTCCTGTAACTGAAAATGATGCTGGAATTCGTAGAGCAGAAATTAAACAAGGGATTCGCGAAGTCATTTTGTGTAAGGATCAAGATGGAAAAATTGGACTCAGGCTTAAATCAATAGATAATGATATATTTGTTCAGCTAGTCCAGGCTAATTCTCCAGCCTCATTGGTTGGTCTGAGATTTGGGGACCAAGTACTCCAGATCAGTGGTGAAAACTGCCGGGTGGAGCTCTGATAAAGCGCACAAGGTGCTCAAACAGGCTTTTGGAGAGAAGATTACCATGACATGACAATTCGTGACAGGCCCTTTGAACGGACGATTACCAAGCATAAGGATAGCACTGGACATGTTGGTTTTATCTTGAAAAAAGGAAAAATAACGTCCACAGTGATCCACAGTGAAAAACAGCTCTGCAGCCAGAAATGGTCTTCTCACGGAACATAACATCTATGAAATCAACAGACAGAATGTCACTGGATTGAAGAACTCTCAAATTGCAGACATACTGTCAACATATGGGACTGTAGTTACTATTACAATCATGCCTCCTTTTATCTTTGAACcGTGAGCATATTATTAAGCGGATGGCACCAAGCATTATGAAAAGCCTAATGGATCACACCATTCCTGAGGTTTAAAATTCACGGCACCACGGAAATGTAGCTCCAGTTTCCTTCTTTGGCAACTTCTGTATTATGCACATGAAGCTTTCCTGGAGCCAGCAAGCATATGCATGAGGACCTTTCTATCTTACATTATGGCTGGGAATCTTACTGTTTCATGTGATACCTTGTTCAGATTTCAAAATAGTTGTAGACTTATCCTGGTTTAACAGATGTGAAATTTTCAAGAGATTACTGACATTCCTAGAATAGTTTCTCTACTGGAAACCTGATGCTTTTATAAGCCATTGTGATTAGGATGACTGATACAGGCTTAGCTTTGCATGAGAACCAGTACCTTTCTCCTAGGTAGTGAGTAGTGCTATTCATATTACTTTAGTTCTATAGCATACTTCCATTTTTAACATGCTACCATAGTACATTTAGAATGATTGCCTTTGA
>NM_001348339.2
AGTGACCGGAGGCGGCGGCGGCGAGCGGTTCCTTGTGGGCTAGAAGAATCCTGCAAAAATGTCTCTCTATCCATCTCTCGAAGACTTGAAGGTAGACAAAGTAATTCAGGCTCAAACTGCTTTTTCTGCAAACCCTGCCAATCCAGCAATTTTGTCAGAAGCTTCTGCTCCTATCCCTCACGATGGAAATCTCTATCCCAGACTGTATCCAGAGCTCTCTCAATACATGGGGCTGAGTTTAAATGAAGAAGAAATACGTGCAAATGTGGCCGTGGTTTCTGGTGCACCACTTCAGGGGCTAGTCCAGGCTAATTCTCCAGCCTCATTGGTTGGTCTGAGATTTGGGGACCAAGTACTTCAGATCAATGGTGAAAACTGTGCAGGATGGAGCTCTGATAAAGCGCACAAGGTGCTCAAACAGGCTTTTGGAGAGAAGATTACCATGACCATTCGTGACAGGCCCTTTGAACGGACGATTACCATGCATAAGGATAGCACTGGACATGTTGGTTTTATCTTTAAAAATGGAAAAATAACATCCATAGTGAAAGATAGCTCTGCAGCCAGAAATGGTCTTCTCACGGAACATAACATCTGTGAAATCAATGGACAGAATGTCATTGGATTGAAGGACTCTCAAATTGCAGACATACTGTCAACATCTGGGACTGTAGTTACTATTACAATCATGCCTGCTTTTATCTTTGAACATATTATTAAGCGGATGGCACCAAGCATTATGAAAAGCCTAATGGACCACACCATTCCTGAGGTTTAAAATTCACGGCACCATGGAAATGTAGCTGAACGTCTCCAGTTTCCTTCTTTGGCAACTTCTGTATTATGCACGTGAAGCCTTCCCGGAGCCAGCGAGCATATGCTGCATGAGGACCTTTCTATCTTACATTATGGCTGGGAATCTTACTCTTTCATCTGATACCTTGTTCAGATTTCAAAATAGTTGTAGCCttatcctggttttacagatgtgaaactttcaagagatttactgactttcctaGAATAGTTTCTCTACTGGAAACCTGATGCTTTTATAAGCCATTGTGATTAGGATGACTGTTACAGGCTTAGCTTTGTGTGAAAACCAGTCACCTTTCTCCTAGGTAATGAGTAGTGCTGTTCATATTACTTTAGTTCTATAGCATACTTGCATCTTTAACATGCTATCATAGTACATTTAGAATGATTGCCTTTGATTTTTTTTTTAAATTCTGTGTGTGTGTGTGTAAAATGCCAATTAAGAACACTGGTTTCATTCCATGTAAGCATTAAACAGTGTATGTAGGTTTCAAGAGATTGTGATGATTCTTAAATTTTAACTACCTTCACTTAATATGCTTGAACTGTCGCCTTAACTATGTTAAGCATCTAGACTAAAAGCCAAAATATAATTATTGCTGCCTTTCTAAAAACCCAAAATGTAGTTCTCTATTAACCTGAAATGTACACTAGCCCAGAACAGTTTAATGGTACTTACTGAGCTATAGCATAGCTGCTTAGTTGTTTTTGAGATTTTTTAGTCAACACATAATGGAAACTTCTTTCTTCTAAAAGTTGCCAGTGCCACTTTTAAGAAGTGAATCACTATATGTGATGTAAAAGTTATTACACTAAACAGGATAAACTTTTGACTCCCCTTTTGTTCATTTGTGGATTAAGTGGTATAATACTTAATTTTGGCATTTGACTCTTAAGATTATGTAACCTAGCTACTTTGGGATGGTCTTAGAATATTTTTCTGATAACTTGTTCCTTTTCCTGACTCCTCCTTGCAAACAAAATGATAGTTGACACTTTATCCTGATTTTTTTCTTCTTTTTGGTTTATGTCTATTCTAATTAAATATGTATAAATAAAGTTACATTTTAGTCTGTC

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