Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BTF3P12
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:70273262-70274160  UCSC
Coordinates (T2T) chr8:70703184-70704082  UCSC
Coordinates (hg19) chr8:71185497-71186395  UCSC
Strand +
Parental Sequence NM_001207.5
Parental seq. overlap 832 bp
Parental seq. overlap (%) 79.3%
Genomic Region Intragenic (NCOA2)
Retrocopy Summary BTF3P12, located on chr8:70273262-70274160, is a retrocopy of the parental gene BTF3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BTF3
Full Name basic transcription factor 3
Also known as BETA-NAC|BTF3a|BTF3b|NACB
Coordinate chr5:73498442-73505667
Strand +
Gene summary This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BTF3P9
Bonobo Pan paniscus BTF3P9
Gorilla Gorilla gorilla BTF3P8
Orangutan Pongo abelii BTF3P9
Gibbon Nomascus leucogenys BTF3P10
Green monkey Chlorocebus sabaeus BTF3P7
Crab-eating macaque Macaca fascicularis BTF3P9
Rhesus Macaca mulatta BTF3P12
Baboon Papio anubis BTF3P12
Golden snub-nosed monkey Rhinopithecus roxellana BTF3P15
Marmoset Callithrix jacchus BTF3P28
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BTF3P12
GAGCTGCCATCTTGCATCCCCGTGTGTGTGCACCTAATCTCAGCTGGTTCCCCCGAGACCCCCTGAGCACCAACCCTAGTCCCCCGCGCAGCCCCTTATCCGCTGCGACAAGATGAAAGAAACAATCATGAACCAGGAAAAACTCGCCAAACTGCAGGCAAAAGTGCCCATTGGTGGAACTGCTCACAGAAAGAAGGTGGTTCACAGAACAGCCACAGCAAATGATAAAAAACGTCAGTTCTCCTTAAAGAAGTTAGAAATCTCTGGCATTGAAGAGGTGAATATGTTTACAAACCAAGCAACAGTGATCCACTTTAACAACCCTAAAGCCCAGACATCTCTGGCAGTGAACACTTTCACCATTACAGGCTATACTGAGACAAAGCAGCTGACAGAAATGCTACCCAGAATCTTAAACCAGCTTGGTGCAGGCAGTCTGACTAGTTTAAGGACTGGCTGAAGCACTGTCCAAACAATCTGTGGGTGGAAAAGCACCACTTACTACTGGAGAGAATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTGGATGAGGCTTCCAAGAATGAGGCAAACTGAAGTGAGTCAACTTCAGTGACTCAACTTCTGAAGACAAAACTTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATGGGTCTGATAAAATCTAGATCTCTAATATTTTTAAGCTCAAGTCCCTTGGACACTACAGCTCTTTTCAGTTTTTGCTTATACGCAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGTCTGTGAATAAAGTTTGAAACAAAGGTTAACGAAGTTCTTTGCCTAGTATACAGTTTTATTCTTTATTTCATTGACACCGATCTGTACACAGTAAA
>NM_001207.5
CCCTTTAGCTGCCATCTTGCGTCCCCGCGTGTGTGCGCCTAATCTCAGGTGGTCCACCCGAGACCCCTTGAGCACCAACCCTAGTCCCCCGCGCGGCCCCTTATTCGCTCCGACAAGATGAAAGAAACAATCATGAACCAGGAAAAACTCGCCAAACTGCAGGCACAAGTGCGCATTGGTGGGAAAGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAAAGATTAATAAAGTTCTTTGCCTAGTATACAGTTTTATTTTTTTATTTCATTGACACCGATCTGTACACAGTAAAAAAAATTGCTTATAGAAAGCTAATCATGGCATGTAATATGGCTGATAACCTTTGGAATTTGATTAAAGATTTAAAATCACGGTGTAGTGTAACAAAGGTGGTATAAAGTTCTCAGGTTTGAAAA

Publications

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